| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kenneth A Perkins, Caryn Lerman, Sarah Coddington, Christopher Jetton, Joshua L Karelitz, Annette Wilson, J Richard Jennings, Robert Ferrell, Andrew W Bergen, Neal L Benowit. Gene and gene by sex associations with initial sensitivity to nicotine in nonsmokers. Behavioural pharmacology. vol 19. issue 5-6. 2008-12-31. PMID:18690117. |
nicotine (0, 5, 10 microg/kg) was administered through nasal spray followed by mood, nicotine reward (e.g. |
2008-12-31 |
2023-08-12 |
Not clear |
| Kenneth A Perkins, Caryn Lerman, Amy Grottenthaler, Melinda M Ciccocioppo, Melissa Milanak, Cynthia A Conklin, Andrew W Bergen, Neal L Benowit. Dopamine and opioid gene variants are associated with increased smoking reward and reinforcement owing to negative mood. Behavioural pharmacology. vol 19. issue 5-6. 2008-12-31. PMID:18690118. |
we explored associations of gene variants in the dopamine, opioid, and serotonin pathways with smoking reward ('liking') and reinforcement (latency to first puff and total puffs) as a function of negative mood and expected versus actual nicotine content of the cigarette. |
2008-12-31 |
2023-08-12 |
Not clear |
| Matthias E Liechti, Athina Marko. Role of the glutamatergic system in nicotine dependence : implications for the discovery and development of new pharmacological smoking cessation therapies. CNS drugs. vol 22. issue 9. 2008-12-18. PMID:18698872. |
furthermore, compounds that increase glutamate release, such as antagonists at mglu(2) and mglu(3) receptors, ameliorated reward deficits associated with nicotine withdrawal in animals, and thus may alleviate the depression-like symptoms associated with nicotine withdrawal in humans. |
2008-12-18 |
2023-08-12 |
human |
| Neil E Paterson, David J K Balfour, Athina Marko. Chronic bupropion differentially alters the reinforcing, reward-enhancing and conditioned motivational properties of nicotine in rats. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 10. issue 6. 2008-11-18. PMID:18584463. |
the present studies also assessed the reward-enhancing effects of nicotine self-administration under different levels of access to nicotine, and the effects of enforced abstinence from self-administered nicotine on brain reward function and somatic signs. |
2008-11-18 |
2023-08-12 |
rat |
| Neil E Paterson, David J K Balfour, Athina Marko. Chronic bupropion differentially alters the reinforcing, reward-enhancing and conditioned motivational properties of nicotine in rats. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 10. issue 6. 2008-11-18. PMID:18584463. |
abstinence from 6h/d 7d/wk nicotine self-administration was associated with increased somatic signs of nicotine withdrawal and unchanged brain reward thresholds. |
2008-11-18 |
2023-08-12 |
rat |
| Neil E Paterson, David J K Balfour, Athina Marko. Chronic bupropion differentially alters the reinforcing, reward-enhancing and conditioned motivational properties of nicotine in rats. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 10. issue 6. 2008-11-18. PMID:18584463. |
chronic bupropion administration via subcutaneous osmotic minipump had no effect on nicotine self-administration, but attenuated nicotine-induced enhancement of brain reward function and enhanced the motivational properties of a previously nicotine-associated conditioned stimulus. |
2008-11-18 |
2023-08-12 |
rat |
| Neil E Paterson, David J K Balfour, Athina Marko. Chronic bupropion differentially alters the reinforcing, reward-enhancing and conditioned motivational properties of nicotine in rats. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 10. issue 6. 2008-11-18. PMID:18584463. |
rather, preclinical investigations suggest that bupropion attenuates nicotine-induced enhancement of brain reward function and reverses the anhedonic, somatic, and neurochemical correlates of nicotine withdrawal. |
2008-11-18 |
2023-08-12 |
rat |
| Weihua Huang, Thomas J Payne, Jennie Z Ma, Ming D L. A functional polymorphism, rs6280, in DRD3 is significantly associated with nicotine dependence in European-American smokers. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 147B. issue 7. 2008-11-17. PMID:18348205. |
nicotine enhances reward functions in the mesocorticolimbic dopamine system in general and the nucleus accumbens in particular. |
2008-11-17 |
2023-08-12 |
human |
| D Kota, B R Martin, M I Dama. Age-dependent differences in nicotine reward and withdrawal in female mice. Psychopharmacology. vol 198. issue 2. 2008-10-23. PMID:18338157. |
age-dependent differences in nicotine reward and withdrawal in female mice. |
2008-10-23 |
2023-08-12 |
mouse |
| A Mobascher, G Wintere. [Mechanisms of nicotine dependence]. Pneumologie (Stuttgart, Germany). vol 62. issue 9. 2008-10-06. PMID:18431714. |
this review summarises our current knowledge of the mechanisms of nicotine dependence, focussing mainly on the cellular effects of nicotine and the effects on three neurophysiological systems that contribute to nicotine dependence: a) reward system, b) cognition/attentional networks and c) stress response system. |
2008-10-06 |
2023-08-12 |
Not clear |
| A Mobascher, G Wintere. [Mechanisms of nicotine dependence]. Pneumologie (Stuttgart, Germany). vol 62. issue 9. 2008-10-06. PMID:18431714. |
the reward system that is connected with the mood regulatory system is activated by nicotine and other addictive substances. |
2008-10-06 |
2023-08-12 |
Not clear |
| Hidenori Sagara, Yoshihisa Kitamura, Satoru Esumi, Toshiaki Sendo, Hiroaki Araki, Yutaka Gomit. Motivational effects of nicotine as measured by the runway method using priming stimulation of intracranial self-stimulation behavior. Acta medica Okayama. vol 62. issue 4. 2008-10-06. PMID:18766205. |
subcutaneous injection of nicotine at a dose of 0.2mg/kg produced an increase in running speed to obtain the reward stimulation, and priming stimulation facilitated the motivational effect to obtain the electrical brain stimulation reward in the rats. |
2008-10-06 |
2023-08-12 |
rat |
| Younbyoung Chae, Jeung-Chan Lee, Kyung-Mo Park, O-Seok Kang, Hi-Joon Park, Hyejung Le. Subjective and autonomic responses to smoking-related visual cues. The journal of physiological sciences : JPS. vol 58. issue 2. 2008-09-25. PMID:18358080. |
nicotine, like several other abused drugs, is known to act on the reward system in the brain. |
2008-09-25 |
2023-08-12 |
human |
| Daria Rylkova, Jeffrey Boissoneault, Shani Isaac, Melissa Prado, Hina P Shah, Adrie W Bruijnzee. Effects of NPY and the specific Y1 receptor agonist [D-His(26)]-NPY on the deficit in brain reward function and somatic signs associated with nicotine withdrawal in rats. Neuropeptides. vol 42. issue 3. 2008-09-19. PMID:18468678. |
effects of npy and the specific y1 receptor agonist [d-his(26)]-npy on the deficit in brain reward function and somatic signs associated with nicotine withdrawal in rats. |
2008-09-19 |
2023-08-12 |
rat |
| Daria Rylkova, Jeffrey Boissoneault, Shani Isaac, Melissa Prado, Hina P Shah, Adrie W Bruijnzee. Effects of NPY and the specific Y1 receptor agonist [D-His(26)]-NPY on the deficit in brain reward function and somatic signs associated with nicotine withdrawal in rats. Neuropeptides. vol 42. issue 3. 2008-09-19. PMID:18468678. |
the aim of the present experiments was to investigate the effects of npy and the specific y1 receptor agonist [d-his(26)]-npy on the deficit in brain reward function and somatic signs associated with nicotine withdrawal in rats. |
2008-09-19 |
2023-08-12 |
rat |
| Daria Rylkova, Jeffrey Boissoneault, Shani Isaac, Melissa Prado, Hina P Shah, Adrie W Bruijnzee. Effects of NPY and the specific Y1 receptor agonist [D-His(26)]-NPY on the deficit in brain reward function and somatic signs associated with nicotine withdrawal in rats. Neuropeptides. vol 42. issue 3. 2008-09-19. PMID:18468678. |
the intracranial self-stimulation procedure was used to assess the effects of nicotine withdrawal on brain reward function as this procedure can provide a quantitative measure of emotional states in rodents. |
2008-09-19 |
2023-08-12 |
rat |
| Daria Rylkova, Jeffrey Boissoneault, Shani Isaac, Melissa Prado, Hina P Shah, Adrie W Bruijnzee. Effects of NPY and the specific Y1 receptor agonist [D-His(26)]-NPY on the deficit in brain reward function and somatic signs associated with nicotine withdrawal in rats. Neuropeptides. vol 42. issue 3. 2008-09-19. PMID:18468678. |
in the first experiment, npy did not prevent the elevations in brain reward thresholds associated with precipitated nicotine withdrawal and elevated the brain reward thresholds of the saline-treated control rats. |
2008-09-19 |
2023-08-12 |
rat |
| Daria Rylkova, Jeffrey Boissoneault, Shani Isaac, Melissa Prado, Hina P Shah, Adrie W Bruijnzee. Effects of NPY and the specific Y1 receptor agonist [D-His(26)]-NPY on the deficit in brain reward function and somatic signs associated with nicotine withdrawal in rats. Neuropeptides. vol 42. issue 3. 2008-09-19. PMID:18468678. |
similar to npy, [d-his(26)]-npy did not prevent the elevations in brain reward thresholds associated with precipitated nicotine withdrawal and elevated the brain reward thresholds of the saline-treated control rats. |
2008-09-19 |
2023-08-12 |
rat |
| Daria Rylkova, Jeffrey Boissoneault, Shani Isaac, Melissa Prado, Hina P Shah, Adrie W Bruijnzee. Effects of NPY and the specific Y1 receptor agonist [D-His(26)]-NPY on the deficit in brain reward function and somatic signs associated with nicotine withdrawal in rats. Neuropeptides. vol 42. issue 3. 2008-09-19. PMID:18468678. |
these findings indicate that npy and [d-his(26)]-npy attenuate somatic nicotine withdrawal signs, but do not prevent the deficit in brain reward function associated with precipitated nicotine withdrawal. |
2008-09-19 |
2023-08-12 |
rat |
| Steven R Laviolette, Nicole M Lauzon, Stephanie F Bishop, Ninglei Sun, Huibing Ta. Dopamine signaling through D1-like versus D2-like receptors in the nucleus accumbens core versus shell differentially modulates nicotine reward sensitivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 32. 2008-09-09. PMID:18685027. |
however, the specific roles of da d(1)-like and d(2)-like receptor subtypes in nicotine reward processing within these nac subregions have not been elucidated. |
2008-09-09 |
2023-08-12 |
Not clear |