| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Shabashov, E Shohami, R Yak. Inactivation of PKMζ in the NAc shell abolished cocaine-conditioned reward. Journal of molecular neuroscience : MN. vol 47. issue 3. 2013-04-11. PMID:22127928. |
here we show that inhibition of pkmζ in the nucleus accumbens (nac) shell, a major component of the reward system that plays an important role in mediating drug craving and relapse, by a selective inhibitor ζ inhibitory peptide (zip), abolished cocaine-induced conditioned place preference (cpp). |
2013-04-11 |
2023-08-12 |
Not clear |
| Mei-Hong Qiu, Wei Liu, Wei-Min Qu, Yoshihiro Urade, Jun Lu, Zhi-Li Huan. The role of nucleus accumbens core/shell in sleep-wake regulation and their involvement in modafinil-induced arousal. PloS one. vol 7. issue 9. 2013-03-06. PMID:23029032. |
we proposed that the nucleus accumbens (nac) that receives the ventral tegmental area dopamine inputs play an important role not only in reward and addiction but also in sleep-wake cycle and in mediating modafinil-induced arousal. |
2013-03-06 |
2023-08-12 |
Not clear |
| Przemysław Biliński, Andrzej Wojtyła, Lucyna Kapka-Skrzypczak, Roman Chwedorowicz, Małgorzata Cyranka, Tadeusz Studzińsk. Epigenetic regulation in drug addiction. Annals of agricultural and environmental medicine : AAEM. vol 19. issue 3. 2013-03-04. PMID:23020045. |
recent data suggest that repeated exposure to certain drugs promotes changes in levels of histone acetylation, phosphorylation and methylation, together with alterations in dna methylation levels in the neurons of the brain reward centre, localised in the nucleus accumbens (nac) region of the limbic system. |
2013-03-04 |
2023-08-12 |
Not clear |
| Takatoshi Hikida, Satoshi Yawata, Takashi Yamaguchi, Teruko Danjo, Toshikuni Sasaoka, Yanyan Wang, Shigetada Nakanish. Pathway-specific modulation of nucleus accumbens in reward and aversive behavior via selective transmitter receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 1. 2013-02-27. PMID:23248274. |
thus, reward and aversive learning is regulated by pathway-specific neural plasticity via selective transmitter receptors in the nac circuit. |
2013-02-27 |
2023-08-12 |
Not clear |
| Karina Possa Abrahao, Maria Lucia Oliveira Souza-Formigon. Behavioral sensitization to ethanol results in cross-sensitization to MK-801 but not to NMDA administered intra-accumbens. Behavioural brain research. vol 235. issue 2. 2013-02-25. PMID:22871257. |
few studies have directly investigated the subsequent neuroadaptations in the nucleus accumbens (nac), the central area of the brain reward system, after chronic ethanol administration. |
2013-02-25 |
2023-08-12 |
mouse |
| Haosheng Sun, Ian Maze, David M Dietz, Kimberly N Scobie, Pamela J Kennedy, Diane Damez-Werno, Rachael L Neve, Venetia Zachariou, Li Shen, Eric J Nestle. Morphine epigenomically regulates behavior through alterations in histone H3 lysine 9 dimethylation in the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 48. 2013-02-19. PMID:23197736. |
here, we show that chronic morphine, like cocaine, decreases g9a expression, and global levels of h3k9me2, in mouse nucleus accumbens (nac), a key brain reward region. |
2013-02-19 |
2023-08-12 |
mouse |
| Haosheng Sun, Ian Maze, David M Dietz, Kimberly N Scobie, Pamela J Kennedy, Diane Damez-Werno, Rachael L Neve, Venetia Zachariou, Li Shen, Eric J Nestle. Morphine epigenomically regulates behavior through alterations in histone H3 lysine 9 dimethylation in the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 48. 2013-02-19. PMID:23197736. |
through viral-mediated gene transfer and conditional mutagenesis, we found that overexpression of g9a in nac opposes morphine reward and locomotor sensitization and concomitantly promotes analgesic tolerance and naloxone-precipitated withdrawal, whereas downregulation of g9a in nac enhances locomotor sensitization and delays the development of analgesic tolerance. |
2013-02-19 |
2023-08-12 |
mouse |
| Jennifer R St Onge, Soyon Ahn, Anthony G Phillips, Stan B Floresc. Dynamic fluctuations in dopamine efflux in the prefrontal cortex and nucleus accumbens during risk-based decision making. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 47. 2013-02-01. PMID:23175840. |
pfc da may signal changes in reward availability that facilitates modification of choice biases, whereas nac da encodes integrated signals about reward rates, uncertainty, and choice, reflecting implementation of decision policies. |
2013-02-01 |
2023-08-12 |
rat |
| Jonathan P Britt, Faiza Benaliouad, Ross A McDevitt, Garret D Stuber, Roy A Wise, Antonello Bonc. Synaptic and behavioral profile of multiple glutamatergic inputs to the nucleus accumbens. Neuron. vol 76. issue 4. 2013-01-24. PMID:23177963. |
excitatory afferents to the nucleus accumbens (nac) are thought to facilitate reward seeking by encoding reward-associated cues. |
2013-01-24 |
2023-08-12 |
Not clear |
| Qian Bu, Zhengtao Hu, Feng Chen, Ruiming Zhu, Yi Deng, Xue Shao, Yan Li, Jinxuan Zhao, Hongyu Li, Baolai Zhang, Lei Lv, Guangyan Yan, Yinglan Zhao, Xiaobo Ce. Transcriptome analysis of long non-coding RNAs of the nucleus accumbens in cocaine-conditioned mice. Journal of neurochemistry. vol 123. issue 5. 2013-01-10. PMID:22957495. |
cocaine dependence involves in the brain's reward circuit as well as nucleus accumbens (nac), a key region of the mesolimbic dopamine pathway. |
2013-01-10 |
2023-08-12 |
mouse |
| Erik B Oleson, Joseph F Chee. Paradoxical effects of the endocannabinoid uptake inhibitor VDM11 on accumbal neural encoding of reward predictive cues. Synapse (New York, N.Y.). vol 66. issue 11. 2013-01-09. PMID:22807176. |
previous studies show that antagonizing ecb transmission decreases reward-directed behavior and nucleus accumbens (nac) encoding of reward predictive cues. |
2013-01-09 |
2023-08-12 |
Not clear |
| Erik B Oleson, Joseph F Chee. Paradoxical effects of the endocannabinoid uptake inhibitor VDM11 on accumbal neural encoding of reward predictive cues. Synapse (New York, N.Y.). vol 66. issue 11. 2013-01-09. PMID:22807176. |
we, therefore, hypothesized that elevating ecb levels would uniformly facilitate nac neural encoding of reward predictive cues and reward-directed behavior. |
2013-01-09 |
2023-08-12 |
Not clear |
| Xin-Ming Ma, Jian-Ping Huang, Xiaonan Xin, Yan Yan, Richard E Mains, Betty A Eippe. A role for kalirin in the response of rat medium spiny neurons to cocaine. Molecular pharmacology. vol 82. issue 4. 2012-12-21. PMID:22828798. |
its role in the gabaergic medium spiny neurons (msns) of the nucleus accumbens (nac) and striatum, the areas known to play a key role in the common reward pathway, is not as well understood. |
2012-12-21 |
2023-08-12 |
mouse |
| Grant W Mallory, Osama Abulseoud, Sun-Chul Hwang, Deborah A Gorman, Squire M Stead, Bryan T Klassen, Paola Sandroni, James C Watson, Kendall H Le. The nucleus accumbens as a potential target for central poststroke pain. Mayo Clinic proceedings. vol 87. issue 10. 2012-12-20. PMID:22980165. |
the nucleus accumbens (nac), a limbic structure within the ventral striatum that is involved in reward and pain processing, has emerged as an effective target for psychiatric disease. |
2012-12-20 |
2023-08-12 |
Not clear |
| Brad A Grueter, Patrick E Rothwell, Robert C Malenk. Integrating synaptic plasticity and striatal circuit function in addiction. Current opinion in neurobiology. vol 22. issue 3. 2012-11-19. PMID:22000687. |
these synaptic adaptations include changes in the nucleus accumbens (nac), a ventral striatal subregion important for drug reward and reinforcement, as well as the dorsal striatum, which may promote habitual drug use. |
2012-11-19 |
2023-08-12 |
Not clear |
| Kyle K Pitchers, Susanne Schmid, Andrea R Di Sebastiano, Xu Wang, Steven R Laviolette, Michael N Lehman, Lique M Coole. Natural reward experience alters AMPA and NMDA receptor distribution and function in the nucleus accumbens. PloS one. vol 7. issue 4. 2012-11-19. PMID:22529926. |
the current study determined whether sexual experience causes long-lasting changes in mating, or ionotropic glutamate receptor trafficking or function in the nucleus accumbens (nac), following 3 different reward abstinence periods: 1 day, 1 week, or 1 month after final mating session. |
2012-11-19 |
2023-08-12 |
rat |
| Kyle K Pitchers, Susanne Schmid, Andrea R Di Sebastiano, Xu Wang, Steven R Laviolette, Michael N Lehman, Lique M Coole. Natural reward experience alters AMPA and NMDA receptor distribution and function in the nucleus accumbens. PloS one. vol 7. issue 4. 2012-11-19. PMID:22529926. |
finally, whole-cell patch clamp electrophysiological recordings determined reduced ampa/nmda ratio of synaptic currents in nac shell neurons following stimulation of cortical afferents in sexually experienced males after all reward abstinence periods. |
2012-11-19 |
2023-08-12 |
rat |
| Giovanni Hernandez, Joseph F Chee. Effect of CB1 receptor blockade on food-reinforced responding and associated nucleus accumbens neuronal activity in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 33. 2012-11-02. PMID:22895729. |
nac neurons encoded reward-predictive cues as well as food reward delivery. |
2012-11-02 |
2023-08-12 |
rat |
| James E McCutcheon, Stephanie R Ebner, Amy L Loriaux, Mitchell F Roitma. Encoding of aversion by dopamine and the nucleus accumbens. Frontiers in neuroscience. vol 6. 2012-10-12. PMID:23055953. |
classically, the nucleus accumbens (nac) and the dopamine projection to it are considered an integral part of the brain's reward circuit, i.e., they direct approach and consumption behaviors and underlie positive reinforcement. |
2012-10-12 |
2023-08-12 |
rat |
| Ja Wook Koo, Michelle S Mazei-Robison, Dipesh Chaudhury, Barbara Juarez, Quincey LaPlant, Deveroux Ferguson, Jian Feng, Haosheng Sun, Kimberly N Scobie, Diane Damez-Werno, Marshall Crumiller, Yoshinori N Ohnishi, Yoko H Ohnishi, Ezekiell Mouzon, David M Dietz, Mary Kay Lobo, Rachael L Neve, Scott J Russo, Ming-Hu Han, Eric J Nestle. BDNF is a negative modulator of morphine action. Science (New York, N.Y.). vol 338. issue 6103. 2012-10-11. PMID:23042896. |
in contrast, optical stimulation of vta da terminals in nucleus accumbens (nac) completely reversed the suppressive effect of bdnf on morphine reward. |
2012-10-11 |
2023-08-12 |
Not clear |