| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kenneth Blum, Eliot Gardner, Marlene Oscar-Berman, Mark Gol. "Liking" and "wanting" linked to Reward Deficiency Syndrome (RDS): hypothesizing differential responsivity in brain reward circuitry. Current pharmaceutical design. vol 18. issue 1. 2012-05-31. PMID:22236117. |
addictive drugs have in common that they are voluntarily selfadministered, they enhance (directly or indirectly) dopaminergic synaptic function in the nucleus accumbens (nac), and they stimulate the functioning of brain reward circuitry (producing the "high" that drug users seek). |
2012-05-31 |
2023-08-12 |
Not clear |
| Xing-Xiang Peng, Edward B Ziff, Kenneth D Car. Effects of food restriction and sucrose intake on synaptic delivery of AMPA receptors in nucleus accumbens. Synapse (New York, N.Y.). vol 65. issue 10. 2012-05-30. PMID:21425350. |
considering the parallels between drug addiction and compulsive eating, plus the supranormal reward properties of sucrose, and the role of dieting as a risk factor in development of binge pathology, the present study used a biochemical subcellular fractionation approach to determine whether brief intake of a 10% sucrose solution increases synaptic delivery of ampa receptors in nac of chronically food-restricted (fr) relative to ad libitum fed (al) rats. |
2012-05-30 |
2023-08-12 |
human |
| Xing-Xiang Peng, Edward B Ziff, Kenneth D Car. Effects of food restriction and sucrose intake on synaptic delivery of AMPA receptors in nucleus accumbens. Synapse (New York, N.Y.). vol 65. issue 10. 2012-05-30. PMID:21425350. |
this may contribute to nac integrative mechanisms that mediate the enhanced behavioral responsiveness of fr subjects to phasic reward stimuli, including food and drugs. |
2012-05-30 |
2023-08-12 |
human |
| Ruud van Zessen, Jana L Phillips, Evgeny A Budygin, Garret D Stube. Activation of VTA GABA neurons disrupts reward consumption. Neuron. vol 73. issue 6. 2012-05-15. PMID:22445345. |
in addition, direct activation of vta gaba projections to the nucleus accumbens (nac) resulted in detectable gaba release but did not alter reward consumption. |
2012-05-15 |
2023-08-12 |
Not clear |
| Alessandra Lintas, Ning Chi, Nicole M Lauzon, Stephanie F Bishop, Ninglei Sun, Huibing Tan, Steven R Laviolett. Inputs from the basolateral amygdala to the nucleus accumbens shell control opiate reward magnitude via differential dopamine D1 or D2 receptor transmission. The European journal of neuroscience. vol 35. issue 2. 2012-05-08. PMID:22236063. |
the basolateral amygdala (bla), ventral tegmental area and nucleus accumbens (nac) form a functionally connected neural circuit involved in the processing of opiate-related reward and memory. |
2012-05-08 |
2023-08-12 |
rat |
| Alessandra Lintas, Ning Chi, Nicole M Lauzon, Stephanie F Bishop, Ninglei Sun, Huibing Tan, Steven R Laviolett. Inputs from the basolateral amygdala to the nucleus accumbens shell control opiate reward magnitude via differential dopamine D1 or D2 receptor transmission. The European journal of neuroscience. vol 35. issue 2. 2012-05-08. PMID:22236063. |
however, the role of da receptor signaling in the bla and its functional outputs to the nac during opiate reward processing is not currently understood. |
2012-05-08 |
2023-08-12 |
rat |
| Dave J Hayes, John Hoang, Andrew J Greensha. The role of nucleus accumbens shell GABA receptors on ventral tegmental area intracranial self-stimulation and a potential role for the 5-HT(2C) receptor. Journal of psychopharmacology (Oxford, England). vol 25. issue 12. 2012-04-26. PMID:21169393. |
these results suggest that a 5-ht(2c) and gaba(a) receptor-mediated neuronal relationship in the nac shell may be relevant for the regulation of brain reward pathways. |
2012-04-26 |
2023-08-12 |
Not clear |
| Michael D Roberts, Leigh Gilpin, Kyle E Parker, Thomas E Childs, Matthew J Will, Frank W Boot. Dopamine D1 receptor modulation in nucleus accumbens lowers voluntary wheel running in rats bred to run high distances. Physiology & behavior. vol 105. issue 3. 2012-04-16. PMID:22001493. |
dopamine signaling in the nucleus accumbens (nac) has been postulated to influence reward development towards drugs of abuse and exercise. |
2012-04-16 |
2023-08-12 |
rat |
| Michael D Roberts, Leigh Gilpin, Kyle E Parker, Thomas E Childs, Matthew J Will, Frank W Boot. Dopamine D1 receptor modulation in nucleus accumbens lowers voluntary wheel running in rats bred to run high distances. Physiology & behavior. vol 105. issue 3. 2012-04-16. PMID:22001493. |
a subset of generation 5-6 hvr and lvr rats were also used to study the mrna expression of key genes related to reward and addiction in the nac (i.e., drd1, drd5, drd2, nr4a2, fosb, and bdnf). |
2012-04-16 |
2023-08-12 |
rat |
| Jumpei Matsumoto, Susumu Urakawa, Etsuro Hori, Mariana F P de Araujo, Yasuo Sakuma, Taketoshi Ono, Hisao Nishij. Neuronal responses in the nucleus accumbens shell during sexual behavior in male rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 5. 2012-03-22. PMID:22302809. |
furthermore, nac shell neuronal activity was significantly different across the different phases of sexual behavior, and the number of nac shell neurons with delta oscillation, which is related to behavioral inhibition, and high gamma oscillation, which is related to reward perception, increased after ejaculation. |
2012-03-22 |
2023-08-12 |
rat |
| Inkyung Ahn, Jooyoung Par. Drug scheduling of cancer chemotherapy based on natural actor-critic approach. Bio Systems. vol 106. issue 2-3. 2012-02-07. PMID:21839140. |
in the framework of the nac approach, the drug dose is regarded as the control input, and the reward signal is defined as a function of the control input and the cell populations of tumor cells, normal cells, and immune cells. |
2012-02-07 |
2023-08-12 |
Not clear |
| Amy R Furay, Ross A McDevitt, Klaus A Miczek, John F Neumaie. 5-HT1B mRNA expression after chronic social stress. Behavioural brain research. vol 224. issue 2. 2011-12-21. PMID:21718722. |
the 5-ht(1b) receptor is expressed in nucleus accumbens (nac) projection neurons and modulates drug reward mechanisms and there is evidence suggesting that stress alters the regulation and function of these receptors. |
2011-12-21 |
2023-08-12 |
rat |
| Michael A McDannald, Ezequiel M Galarc. Measuring Pavlovian fear with conditioned freezing and conditioned suppression reveals different roles for the basolateral amygdala. Brain research. vol 1374. 2011-12-12. PMID:21172318. |
the nucleus accumbens core (nac), while not important to freezing, is important to the enhancement of instrumental responding by cues paired with food reward. |
2011-12-12 |
2023-08-12 |
rat |
| Amanda M Dossat, Nicole Lilly, Kristen Kay, Diana L William. Glucagon-like peptide 1 receptors in nucleus accumbens affect food intake. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 41. 2011-12-06. PMID:21994361. |
one such region is the nucleus accumbens (nac), which plays a role in reward and motivated behavior. |
2011-12-06 |
2023-08-12 |
rat |
| Amanda M Dossat, Nicole Lilly, Kristen Kay, Diana L William. Glucagon-like peptide 1 receptors in nucleus accumbens affect food intake. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 41. 2011-12-06. PMID:21994361. |
we conclude that that glp-1rs in the nac play a physiologic role in food intake control, and suggest that the glp-1 projection to nac core may link satiation signal processing in the hindbrain with forebrain processing of food reward. |
2011-12-06 |
2023-08-12 |
rat |
| Helena J V Rutherford, Sarah K Williams, Sheryl Moy, Linda C Mayes, Josephine M John. Disruption of maternal parenting circuitry by addictive process: rewiring of reward and stress systems. Frontiers in psychiatry. vol 2. 2011-11-10. PMID:21779252. |
therefore, addiction reflects the dysregulation between core reward systems, including the prefrontal cortex (pfc), ventral tegmental area (vta), and nucleus accumbens (nac), as well as the hypothalamic-pituitary-adrenal axis and extended amygdala of the stress system. |
2011-11-10 |
2023-08-12 |
human |
| Herbert E Covington, Ian Maze, HaoSheng Sun, Howard M Bomze, Kristine D DeMaio, Emma Y Wu, David M Dietz, Mary Kay Lobo, Subroto Ghose, Ezekiel Mouzon, Rachael L Neve, Carol A Tamminga, Eric J Nestle. A role for repressive histone methylation in cocaine-induced vulnerability to stress. Neuron. vol 71. issue 4. 2011-10-25. PMID:21867882. |
here, we identify repressive histone methylation in nucleus accumbens (nac), an important brain reward region, as a key mechanism linking cocaine exposure to increased stress vulnerability. |
2011-10-25 |
2023-08-12 |
mouse |
| Candice M Klingerman, Anand Patel, Valerie L Hedges, Robert L Meisel, Jill E Schneide. Food restriction dissociates sexual motivation, sexual performance, and the rewarding consequences of copulation in female Syrian hamsters. Behavioural brain research. vol 223. issue 2. 2011-10-24. PMID:21600244. |
in hamsters, formation of a conditioned place preference (cpp) for copulatory reward is reflected in increased nucleus accumbens (nac) neural activation, measured as immunocytochemical staining for c-fos, the protein product of the immediate-early gene, c-fos. |
2011-10-24 |
2023-08-12 |
Not clear |
| Xiu-Fang Lv, Ya Xu, Ji-Sheng Han, Cai-Lian Cu. Expression of activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) in the nucleus accumbens is critical for the acquisition, expression and reinstatement of morphine-induced conditioned place preference. Behavioural brain research. vol 223. issue 1. 2011-10-18. PMID:21549764. |
these findings suggest that expression of the arc/arg3.1 protein in the nac core is required for the acquisition, context-induced retrieval and reinstatement of morphine-associated reward memory, whereas arc/arg3.1 protein expression in the nac shell is only critical for the context-induced retrieval of memory. |
2011-10-18 |
2023-08-12 |
rat |
| Luis Hernández, Daniel Paredes, Pedro Rad. Feeding behavior as seen through the prism of brain microdialysis. Physiology & behavior. vol 104. issue 1. 2011-10-14. PMID:21549733. |
dopamine (da) in the nucleus accumbens (nac) correlates with food reward, stimulus saliency, and goal directed hyperlocomotion but in the ventromedial hypothalamus da correlates with satiety and hypolocomotion. |
2011-10-14 |
2023-08-12 |
Not clear |