| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brandon J Aragona, Jeremy J Day, Mitchell F Roitman, Nathan A Cleaveland, R Mark Wightman, Regina M Carell. Regional specificity in the real-time development of phasic dopamine transmission patterns during acquisition of a cue-cocaine association in rats. The European journal of neuroscience. vol 30. issue 10. 2010-02-26. PMID:19912327. |
drug seeking is significantly regulated by drug-associated cues and associative learning between environmental cues and cocaine reward is mediated by dopamine transmission within the nucleus accumbens (nac). |
2010-02-26 |
2023-08-12 |
rat |
| Wolfgang Hauber, Susanne Somme. Prefrontostriatal circuitry regulates effort-related decision making. Cerebral cortex (New York, N.Y. : 1991). vol 19. issue 10. 2009-12-14. PMID:19131436. |
experiment 1 revealed that bilateral excitotoxic lesions of the core subregion of the nac impaired effort-based decision making, that is, reduced the preference for the high effort-lr option when having the choice to obtain a low reward with little effort. |
2009-12-14 |
2023-08-12 |
rat |
| Sondra T Bland, Mark R Hutchinson, Steven F Maier, Linda R Watkins, Kirk W Johnso. The glial activation inhibitor AV411 reduces morphine-induced nucleus accumbens dopamine release. Brain, behavior, and immunity. vol 23. issue 4. 2009-12-09. PMID:19486648. |
the present studies extend this line of investigation by exploring whether glial activation may also affect extracellular levels of dopamine (da) in the nucleus accumbens (nac) shell, a neurochemical corollary of morphine-induced drug reward, during a challenge dose of morphine in experiments both with and without precipitated withdrawal. |
2009-12-09 |
2023-08-12 |
rat |
| Yao-Ying Ma, Li Meng, Chang-Yong Guo, Ji-Sheng Han, David Yue-Wei Lee, Cai-Lian Cu. Dose- and time-dependent, context-induced elevation of dopamine and its metabolites in the nucleus accumbens of morphine-induced CPP rats. Behavioural brain research. vol 204. issue 1. 2009-12-01. PMID:19539657. |
the dopamine (da) projections from the ventral tegmental area to the nucleus accumbens (nac) are the key component of the brain reward circuitry. |
2009-12-01 |
2023-08-12 |
rat |
| Su-Mi Park, Ron P A Gaykema, Lisa E Goehle. How does immune challenge inhibit ingestion of palatable food? Evidence that systemic lipopolysaccharide treatment modulates key nodal points of feeding neurocircuitry. Brain, behavior, and immunity. vol 22. issue 8. 2009-11-17. PMID:18562160. |
the findings from this study point to a network of brain regions (lh, pvt, nac, and bla) previously implicated in the modulation of feeding behavior, reward, and arousal that may also contribute to neural substrates involved in the reorganization of behavioral priorities that occurs during sickness. |
2009-11-17 |
2023-08-12 |
Not clear |
| V L Hedges, S Chakravarty, E J Nestler, R L Meise. Delta FosB overexpression in the nucleus accumbens enhances sexual reward in female Syrian hamsters. Genes, brain, and behavior. vol 8. issue 4. 2009-09-11. PMID:19566711. |
animals with aav-mediated overexpression of delta fosb in the nac showed evidence of sexual reward in a conditioned place preference paradigm under conditions in which control animals receiving an injection of aav-green fluorescent protein (gfp) into the nac did not. |
2009-09-11 |
2023-08-12 |
Not clear |
| Darlene H Brunzell, Yann S Mineur, Rachael L Neve, Marina R Picciott. Nucleus accumbens CREB activity is necessary for nicotine conditioned place preference. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 8. 2009-09-02. PMID:19212318. |
previous studies have implicated nucleus accumbens (nac) creb activity in the modulation of cocaine and morphine reward, and have shown that nicotine conditioned place preference (cpp) is associated with nac creb activation. |
2009-09-02 |
2023-08-12 |
mouse |
| Makoto Ito, Kenji Doy. Validation of decision-making models and analysis of decision variables in the rat basal ganglia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 31. 2009-08-21. PMID:19657038. |
the major findings of this study were as follows: (1) modified versions of an action-value learning model captured a variety of choice strategies of rats, including win-stay-lose-switch and persevering behavior, and predicted rats' choice sequences better than the best multistep markov model; and (2) information about action values and future actions was coded in both the nac and vp, but was less dominant than information about trial types, selected actions, and reward outcome. |
2009-08-21 |
2023-08-12 |
rat |
| Matthew R Campioni, Ming Xu, Daniel S McGehe. Stress-induced changes in nucleus accumbens glutamate synaptic plasticity. Journal of neurophysiology. vol 101. issue 6. 2009-08-03. PMID:19357347. |
the nucleus accumbens (nac), a motor-limbic interface linked to motivation and reward, receives inputs from each of these stress-affected brain regions, raising the possibility that its function might also be altered in response to stress. |
2009-08-03 |
2023-08-12 |
mouse |
| Zheng-xiong Xi, Krista Spiller, Eliot L Gardne. Mechanism-based medication development for the treatment of nicotine dependence. Acta pharmacologica Sinica. vol 30. issue 6. 2009-07-31. PMID:19434058. |
in addition, chronic nicotine treatment increases endocannabinoid levels in the mesolimbic da system, which indirectly modulates nac da release and nicotine reward. |
2009-07-31 |
2023-08-12 |
Not clear |
| Ke-chun Yang, Guo-zhang Jin, Jie W. Mysterious alpha6-containing nAChRs: function, pharmacology, and pathophysiology. Acta pharmacologica Sinica. vol 30. issue 6. 2009-07-31. PMID:19498417. |
by modulating da release in the nucleus accumbens (nac) and modulating gaba release onto daergic neurons in the ventral tegmental area (vta), alpha6*-nachrs may play important roles in the mediation of nicotine reward and addiction. |
2009-07-31 |
2023-08-12 |
mouse |
| Matthew B Wilkinson, Guanghua Xiao, Arvind Kumar, Quincey LaPlant, William Renthal, Devanjan Sikder, Thomas J Kodadek, Eric J Nestle. Imipramine treatment and resiliency exhibit similar chromatin regulation in the mouse nucleus accumbens in depression models. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 24. 2009-07-17. PMID:19535594. |
here, we use chromatin immunoprecipitation (chip)-chip assays--chip followed by genome wide promoter array analyses--to study the effects of chronic defeat stress on chromatin regulation in the mouse nucleus accumbens (nac), a key brain reward region implicated in depression. |
2009-07-17 |
2023-08-12 |
mouse |
| Mark E Walton, James Groves, Katie A Jennings, Paula L Croxson, Trevor Sharp, Matthew F S Rushworth, David M Bannerma. Comparing the role of the anterior cingulate cortex and 6-hydroxydopamine nucleus accumbens lesions on operant effort-based decision making. The European journal of neuroscience. vol 29. issue 8. 2009-07-13. PMID:19385990. |
taken together, this implies that only acc lesions, and not 6-hydroxydopamine nac lesions as performed here, cause a bias away from investing effort for greater reward when choosing between competing options |
2009-07-13 |
2023-08-12 |
rat |
| Cory A Blaiss, Patricia H Jana. The nucleus accumbens core and shell are critical for the expression, but not the consolidation, of Pavlovian conditioned approach. Behavioural brain research. vol 200. issue 1. 2009-06-18. PMID:19159648. |
we found that neither post-training reversible inactivation with the gaba receptor agonists muscimol and baclofen nor inhibition of protein synthesis with anisomycin (ani) in either the core or shell regions of the nac had an effect on approach to a reward port in response to a reward-predictive cue (conditioned stimulus, cs+). |
2009-06-18 |
2023-08-12 |
rat |
| William J Berglind, Timothy W Whitfield, Ryan T LaLumiere, Peter W Kalivas, Jacqueline F McGint. A single intra-PFC infusion of BDNF prevents cocaine-induced alterations in extracellular glutamate within the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 12. 2009-04-21. PMID:19321768. |
the glutamatergic pathway arising in the dorsomedial prefrontal cortex (dmpfc) and projecting to the nucleus accumbens (nac) core is a critical component of the reward circuitry that underlies reinstatement to cocaine-seeking behavior. |
2009-04-21 |
2023-08-12 |
Not clear |
| George A Rogge, Douglas C Jones, Thomas Green, Eric Nestler, Michael J Kuha. Regulation of CART peptide expression by CREB in the rat nucleus accumbens in vivo. Brain research. vol 1251. 2009-04-20. PMID:19046951. |
production of mrna from the cocaine- and amphetamine-regulated transcript (cart) gene is regulated by cocaine and other drugs of abuse in the nucleus accumbens (nac), a brain reward region. |
2009-04-20 |
2023-08-12 |
rat |
| George A Rogge, Douglas C Jones, Thomas Green, Eric Nestler, Michael J Kuha. Regulation of CART peptide expression by CREB in the rat nucleus accumbens in vivo. Brain research. vol 1251. 2009-04-20. PMID:19046951. |
since over expression of creb was shown to decrease cocaine-mediated reward, we hypothesized that cart could be a target gene for creb in the nac and that over expression of creb would increase cart peptide levels. |
2009-04-20 |
2023-08-12 |
rat |
| George A Rogge, Douglas C Jones, Thomas Green, Eric Nestler, Michael J Kuha. Regulation of CART peptide expression by CREB in the rat nucleus accumbens in vivo. Brain research. vol 1251. 2009-04-20. PMID:19046951. |
the finding that creb can regulate the levels of cart mrna and peptides in vivo in the nac supports a role for cart peptides in psychostimulant-induced reward and reinforcement. |
2009-04-20 |
2023-08-12 |
rat |
| William A Carlezon, Mark J Thoma. Biological substrates of reward and aversion: a nucleus accumbens activity hypothesis. Neuropharmacology. vol 56 Suppl 1. 2009-04-15. PMID:18675281. |
the nucleus accumbens (nac) is a critical element of the mesocorticolimbic system, a brain circuit implicated in reward and motivation. |
2009-04-15 |
2023-08-12 |
Not clear |
| Elena H Chartoff, Maria Papadopoulou, Matt L MacDonald, Aram Parsegian, David Potter, Christine Konradi, William A Carlezo. Desipramine reduces stress-activated dynorphin expression and CREB phosphorylation in NAc tissue. Molecular pharmacology. vol 75. issue 3. 2009-03-16. PMID:19106229. |
the nucleus accumbens (nac) is a critical brain area for reward and motivated behavior. |
2009-03-16 |
2023-08-12 |
rat |