| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jennifer A Dinieri, Christina L Nemeth, Aram Parsegian, Tiffany Carle, Vsevolod V Gurevich, Eugenia Gurevich, Rachael L Neve, Eric J Nestler, William A Carlezo. Altered sensitivity to rewarding and aversive drugs in mice with inducible disruption of cAMP response element-binding protein function within the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 6. 2009-03-06. PMID:19211892. |
we examined how disruption of creb activity affects brain reward processes using intracranial self-stimulation (icss) and inducible bitransgenic mice with enriched expression of mcreb in forebrain regions including the nac. |
2009-03-06 |
2023-08-12 |
mouse |
| Jennifer A Dinieri, Christina L Nemeth, Aram Parsegian, Tiffany Carle, Vsevolod V Gurevich, Eugenia Gurevich, Rachael L Neve, Eric J Nestler, William A Carlezo. Altered sensitivity to rewarding and aversive drugs in mice with inducible disruption of cAMP response element-binding protein function within the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 6. 2009-03-06. PMID:19211892. |
together with previous findings, these studies raise the possibility that disruption of creb in the nac influences motivation by simultaneously facilitating reward and reducing depressive-like states such as anhedonia and dysphoria. |
2009-03-06 |
2023-08-12 |
mouse |
| Taku Nagai, Toshitaka Nabeshima, Kiyofumi Yamad. Basic and translational research on proteinase-activated receptors: regulation of nicotine reward by the tissue plasminogen activator (tPA) - plasmin system via proteinase-activated receptor 1. Journal of pharmacological sciences. vol 108. issue 4. 2009-02-19. PMID:19098386. |
we show that the tissue plasminogen activator (tpa) - plasmin system regulates nicotine-induced reward and dopamine release in the nucleus accumbens (nac) by activating proteinase-activated receptor 1 (par(1)). |
2009-02-19 |
2023-08-12 |
mouse |
| László Köles, Zoltán Gerevich, Holger Kittner, Ute Krügel, Heike Franke, Péter Illé. [Purinergic modulation of the brain dopaminergic transmission: behavioral-pharmacologic conclusions]. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 10. issue 2. 2008-12-03. PMID:18959141. |
dopaminergic neurotransmission in the nac is essential in the regulation of motor activity and reward. |
2008-12-03 |
2023-08-12 |
Not clear |
| Lino Becerra, David Borsoo. Signal valence in the nucleus accumbens to pain onset and offset. European journal of pain (London, England). vol 12. issue 7. 2008-11-10. PMID:18226937. |
of particular interest is the nucleus accumbens (nac), a brain substrate known to be involved in reward-aversion processing, whose activation valence has been observed to be opposite in response to reward or aversive stimuli. |
2008-11-10 |
2023-08-12 |
human |
| Kyoung-Shim Kim, Ko-Woon Lee, In-Sun Baek, Chae-Moon Lim, Vaishnav Krishnan, Ja-Kyeong Lee, Eric J Nestler, Pyung-Lim Ha. Adenylyl cyclase-5 activity in the nucleus accumbens regulates anxiety-related behavior. Journal of neurochemistry. vol 107. issue 1. 2008-11-03. PMID:18673448. |
type 5 adenylyl cyclase (ac5) is highly concentrated in the dorsal striatum and nucleus accumbens (nac), two brain areas which have been implicated in motor function, reward, and emotion. |
2008-11-03 |
2023-08-12 |
mouse |
| Deanna L Wallace, Vincent Vialou, Loretta Rios, Tiffany L Carle-Florence, Sumana Chakravarty, Arvind Kumar, Danielle L Graham, Thomas A Green, Anne Kirk, Sergio D Iñiguez, Linda I Perrotti, Michel Barrot, Ralph J DiLeone, Eric J Nestler, Carlos A Bolaños-Guzmá. The influence of DeltaFosB in the nucleus accumbens on natural reward-related behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 41. 2008-11-03. PMID:18842886. |
here, we demonstrate that two powerful natural reward behaviors, sucrose drinking and sexual behavior, increase levels of deltafosb in the nac. |
2008-11-03 |
2023-08-12 |
Not clear |
| Brandon J Aragona, Nathan A Cleaveland, Garret D Stuber, Jeremy J Day, Regina M Carelli, R Mark Wightma. Preferential enhancement of dopamine transmission within the nucleus accumbens shell by cocaine is attributable to a direct increase in phasic dopamine release events. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 35. 2008-09-18. PMID:18753384. |
preferential enhancement of dopamine transmission within the nucleus accumbens (nac) shell is a fundamental aspect of the neural regulation of cocaine reward. |
2008-09-18 |
2023-08-12 |
Not clear |
| Thomas F Tropea, Barry E Kosofsky, Anjali M Rajadhyaksh. Enhanced CREB and DARPP-32 phosphorylation in the nucleus accumbens and CREB, ERK, and GluR1 phosphorylation in the dorsal hippocampus is associated with cocaine-conditioned place preference behavior. Journal of neurochemistry. vol 106. issue 4. 2008-09-12. PMID:18554320. |
these data suggest that the formation of contextual drug reward associations involves recruitment of the dhc-nac circuit with activation of the darpp-32/creb pathway in the nac and the erk/creb pathway in the dhc. |
2008-09-12 |
2023-08-12 |
mouse |
| Steven R Laviolette, Nicole M Lauzon, Stephanie F Bishop, Ninglei Sun, Huibing Ta. Dopamine signaling through D1-like versus D2-like receptors in the nucleus accumbens core versus shell differentially modulates nicotine reward sensitivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 32. 2008-09-09. PMID:18685027. |
however, the specific roles of da d(1)-like and d(2)-like receptor subtypes in nicotine reward processing within these nac subregions have not been elucidated. |
2008-09-09 |
2023-08-12 |
Not clear |
| Gabriele Hampp, Jürgen A Ripperger, Thijs Houben, Isabelle Schmutz, Christian Blex, Stéphanie Perreau-Lenz, Irene Brunk, Rainer Spanagel, Gudrun Ahnert-Hilger, Johanna H Meijer, Urs Albrech. Regulation of monoamine oxidase A by circadian-clock components implies clock influence on mood. Current biology : CB. vol 18. issue 9. 2008-08-04. PMID:18439826. |
rewards such as food, sex, and drugs influence this system in part by modulating dopamine neurotransmission in the mesolimbic dopamine reward circuit, including the ventral tegmental area (vta) and the ventral striatum (nac). |
2008-08-04 |
2023-08-12 |
mouse |
| X Cen, A Nitta, D Ibi, Y Zhao, M Niwa, K Taguchi, M Hamada, Y Ito, Y Ito, L Wang, T Nabeshim. Identification of Piccolo as a regulator of behavioral plasticity and dopamine transporter internalization. Molecular psychiatry. vol 13. issue 4. 2008-04-17. PMID:18195717. |
piccolo downexpression by antisense technique augmented meth-induced behavioral sensitization, conditioned reward and synaptic dopamine accumulation in nac. |
2008-04-17 |
2023-08-12 |
mouse |
| William Renthal, Ian Maze, Vaishnav Krishnan, Herbert E Covington, Guanghua Xiao, Arvind Kumar, Scott J Russo, Ami Graham, Nadia Tsankova, Tod E Kippin, Kerry A Kerstetter, Rachael L Neve, Stephen J Haggarty, Timothy A McKinsey, Rhonda Bassel-Duby, Eric N Olson, Eric J Nestle. Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron. vol 56. issue 3. 2008-01-08. PMID:17988634. |
chronic, but not acute, exposure to cocaine or stress decreases hdac5 function in the nucleus accumbens (nac), a major brain reward region, which allows for increased histone acetylation and transcription of hdac5 target genes. |
2008-01-08 |
2023-08-12 |
Not clear |
| Alexandra Jean, Grégory Conductier, Christine Manrique, Constantin Bouras, Philippe Berta, René Hen, Yves Charnay, Joël Bockaert, Valérie Compa. Anorexia induced by activation of serotonin 5-HT4 receptors is mediated by increases in CART in the nucleus accumbens. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 41. 2007-11-28. PMID:17913892. |
we hypothesized that anorexia may involve altered signaling events within the nucleus accumbens (nac), a brain structure involved in reward. |
2007-11-28 |
2023-08-12 |
mouse |
| Matthias E Liechti, Loic Lhuillier, Klemens Kaupmann, Athina Marko. Metabotropic glutamate 2/3 receptors in the ventral tegmental area and the nucleus accumbens shell are involved in behaviors relating to nicotine dependence. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 34. 2007-09-11. PMID:17715344. |
metabotropic glutamate (mglu) 2/3 receptors regulate glutamate and dopamine release in the ventral tegmental area (vta) and the nucleus accumbens (nac) shell, two brain areas critically involved in reward and motivational processes. |
2007-09-11 |
2023-08-12 |
rat |
| Graham A Cousens, Jacob T Beckle. Antagonism of nucleus accumbens M(2) muscarinic receptors disrupts operant responding for sucrose under a progressive ratio reinforcement schedule. Behavioural brain research. vol 181. issue 1. 2007-08-24. PMID:17499370. |
since methoctramine has a greater affinity for m(2) receptors compared to pirenzepine, which has a greater relative affinity for m(1) and m(3) receptors, these findings suggest that m(2) machrs within the nac regulate behavioral processes underling the acquisition of reward. |
2007-08-24 |
2023-08-12 |
Not clear |
| Joseph F Cheer, Brandon J Aragona, Michael L A V Heien, Andrew T Seipel, Regina M Carelli, R Mark Wightma. Coordinated accumbal dopamine release and neural activity drive goal-directed behavior. Neuron. vol 54. issue 2. 2007-05-31. PMID:17442245. |
intracranial self-stimulation (icss) activates the neural pathways that mediate reward, including dopaminergic terminal areas such as the nucleus accumbens (nac). |
2007-05-31 |
2023-08-12 |
Not clear |
| Jeremy J Day, Regina M Carell. The nucleus accumbens and Pavlovian reward learning. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 13. issue 2. 2007-05-25. PMID:17404375. |
the nac is required for a number of reward-related behaviors and processes specific information about reward availability, value, and context. |
2007-05-25 |
2023-08-12 |
human |
| Hiroyuki Mizoguchi, Kiyofumi Yamada, Minae Niwa, Akihiro Mouri, Tomoko Mizuno, Yukihiro Noda, Atsumi Nitta, Shigeyoshi Itohara, Yoshiko Banno, Toshitaka Nabeshim. Reduction of methamphetamine-induced sensitization and reward in matrix metalloproteinase-2 and -9-deficient mice. Journal of neurochemistry. vol 100. issue 6. 2007-05-01. PMID:17348864. |
these results suggest that both mmp-2 and mmp-9 play a crucial role in meth-induced behavioural sensitization and reward by regulating meth-induced dopamine release and uptake in the nac. |
2007-05-01 |
2023-08-12 |
mouse |
| Z Dong, J Cao, L X. Opiate withdrawal modifies synaptic plasticity in subicular-nucleus accumbens pathway in vivo. Neuroscience. vol 144. issue 3. 2007-04-11. PMID:17141960. |
subiculum receives output of hippocampal ca1 neurons and projects glutamatergic synapses onto nucleus accumbens (nac), the subicular-nac pathway linking memory and reward system. |
2007-04-11 |
2023-08-12 |
rat |