| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Taku Nagai, Toshitaka Nabeshima, Kazuhiro Takuma, Kiyofumi Yamad. [Role of tissue plasminogen activator in the rewarding effect of morphine]. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence. vol 41. issue 1. 2006-05-30. PMID:16619846. |
our findings demonstrate a novel function of the tpa-plasmin system in regulating dopamine release in the nac, which is involved in the morphine reward. |
2006-05-30 |
2023-08-12 |
mouse |
| Kenneth Blum, Brian Meshkin, B William Down. DNA based customized nutraceutical "gene therapy" utilizing a genoscore: a hypothesized paradigm shift of a novel approach to the diagnosis, stratification, prognosis and treatment of inflammatory processes in the human. Medical hypotheses. vol 66. issue 5. 2006-05-25. PMID:16403602. |
we also propose that manipulation of neurochemical reward circuitry in the mesolimbic brain region providing dopamine release at the nucleus accumbens (nac), will have both pain and stress relief benefists, which are a cornerstone to the human inflammatory process. |
2006-05-25 |
2023-08-12 |
human |
| Guojun Chen, Josef T Kittler, Stephen J Moss, Zhen Ya. Dopamine D3 receptors regulate GABAA receptor function through a phospho-dependent endocytosis mechanism in nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 9. 2006-04-11. PMID:16510729. |
the dopamine d3 receptor, which is highly enriched in nucleus accumbens (nac), has been suggested to play an important role in reinforcement and reward. |
2006-04-11 |
2023-08-12 |
Not clear |
| William A Carlezon, Cécile Béguin, Jennifer A DiNieri, Michael H Baumann, Michele R Richards, Mark S Todtenkopf, Richard B Rothman, Zhongze Ma, David Y-W Lee, Bruce M Cohe. Depressive-like effects of the kappa-opioid receptor agonist salvinorin A on behavior and neurochemistry in rats. The Journal of pharmacology and experimental therapeutics. vol 316. issue 1. 2006-03-31. PMID:16223871. |
at a dose that caused the depressive-like effects in both the fst and icss assays, salva decreased extracellular concentrations of dopamine (da) within the nucleus accumbens (nac), a critical component of brain reward circuitry, without affecting extracellular concentrations of serotonin (5-ht). |
2006-03-31 |
2023-08-12 |
rat |
| V Menon, D J Leviti. The rewards of music listening: response and physiological connectivity of the mesolimbic system. NeuroImage. vol 28. issue 1. 2006-01-11. PMID:16023376. |
here, we use functional and effective connectivity analyses to show for the first time that listening to music strongly modulates activity in a network of mesolimbic structures involved in reward processing including the nucleus accumbens (nac) and the ventral tegmental area (vta), as well as the hypothalamus and insula, which are thought to be involved in regulating autonomic and physiological responses to rewarding and emotional stimuli. |
2006-01-11 |
2023-08-12 |
human |
| Andrew M J Young, Paula M Moran, Michael H Josep. The role of dopamine in conditioning and latent inhibition: what, when, where and how? Neuroscience and biobehavioral reviews. vol 29. issue 6. 2005-10-27. PMID:16045987. |
it is well established that dopamine is released in the nucleus accumbens (nac) in animals in rewarding or reinforcing situations, and widely believed that this release is the substrate of, or at least closely related to, the experience of reward. |
2005-10-27 |
2023-08-12 |
Not clear |
| Anna Molander, Bo Söderpal. Accumbal strychnine-sensitive glycine receptors: an access point for ethanol to the brain reward system. Alcoholism, clinical and experimental research. vol 29. issue 1. 2005-05-25. PMID:15654288. |
ethanol (etoh), like other drugs of abuse, increases extracellular dopamine (da) levels in the nucleus accumbens (nac) of the brain reward system, an effect that may be of importance for alcohol addiction. |
2005-05-25 |
2023-08-12 |
Not clear |
| David W Self, Kwang-Ho Cho. Extinction-induced neuroplasticity attenuates stress-induced cocaine seeking: a state-dependent learning hypothesis. Stress (Amsterdam, Netherlands). vol 7. issue 3. 2005-04-28. PMID:15764012. |
we previously reported that extinction training, a form of inhibitory learning that progressively reduces cocaine-seeking behaviour when reward is withheld, reverses this deficit by up-regulating glur1 and glur2/3 subunits of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (ampa) glutamate receptors in the nac. |
2005-04-28 |
2023-08-12 |
Not clear |
| David W Self, Kwang-Ho Cho. Extinction-induced neuroplasticity attenuates stress-induced cocaine seeking: a state-dependent learning hypothesis. Stress (Amsterdam, Netherlands). vol 7. issue 3. 2005-04-28. PMID:15764012. |
recent studies indicate that both environmental stress and the frustrative stress of withholding reward during extinction of drug self-administration induce similar neurochemical events in the nac. |
2005-04-28 |
2023-08-12 |
Not clear |
| Mitchell F Roitman, Robert A Wheeler, Regina M Carell. Nucleus accumbens neurons are innately tuned for rewarding and aversive taste stimuli, encode their predictors, and are linked to motor output. Neuron. vol 45. issue 4. 2005-04-25. PMID:15721244. |
the nucleus accumbens (nac) is a key component of the brain's reward pathway, yet little is known of how nac cells respond to primary rewarding or aversive stimuli. |
2005-04-25 |
2023-08-12 |
rat |
| Carl R Lupica, Arthur C Riegel, Alexander F Hoffma. Marijuana and cannabinoid regulation of brain reward circuits. British journal of pharmacology. vol 143. issue 2. 2005-04-22. PMID:15313883. |
here we describe the cellular circuitry of the vta and the nac, define the sites within these areas at which cannabinoids alter synaptic processes, and discuss the relevance of these actions to the regulation of reinforcement and reward. |
2005-04-22 |
2023-08-12 |
Not clear |
| Anh Hai Tran, Ryoi Tamura, Teruko Uwano, Tsuneyuki Kobayashi, Motoya Katsuki, Taketoshi On. Dopamine D1 receptors involved in locomotor activity and accumbens neural responses to prediction of reward associated with place. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 6. 2005-04-22. PMID:15684065. |
the present study investigated the specific contribution of dopamine d1 receptor (d1r) in mediating reward, locomotor activity, and spatial associative processes and in regulating nac neural responses. |
2005-04-22 |
2023-08-12 |
mouse |
| Anh Hai Tran, Ryoi Tamura, Teruko Uwano, Tsuneyuki Kobayashi, Motoya Katsuki, Taketoshi On. Dopamine D1 receptors involved in locomotor activity and accumbens neural responses to prediction of reward associated with place. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 6. 2005-04-22. PMID:15684065. |
thus, the present results suggest that d1r may be an important determinant in brain stimulation reward (icss) and participates in coding for a type of reward prediction of nac neurons and in spatial learning. |
2005-04-22 |
2023-08-12 |
mouse |
| Gaetano Di Chiara, Valentina Bassareo, Sandro Fenu, Maria Antonietta De Luca, Liliana Spina, Cristina Cadoni, Elio Acquas, Ezio Carboni, Valentina Valentini, Daniele Lecc. Dopamine and drug addiction: the nucleus accumbens shell connection. Neuropharmacology. vol 47 Suppl 1. 2004-12-20. PMID:15464140. |
intracranial self-administration studies with mixtures of d1 and d2 receptor agonists point to the nac shell as the critical site of da reward. |
2004-12-20 |
2023-08-12 |
Not clear |
| Gaetano Di Chiara, Valentina Bassareo, Sandro Fenu, Maria Antonietta De Luca, Liliana Spina, Cristina Cadoni, Elio Acquas, Ezio Carboni, Valentina Valentini, Daniele Lecc. Dopamine and drug addiction: the nucleus accumbens shell connection. Neuropharmacology. vol 47 Suppl 1. 2004-12-20. PMID:15464140. |
stimulation of nac shell da transmission by addictive drugs is shared by a natural reward like food but lacks its adaptive properties (habituation and inhibition by predictive stimuli). |
2004-12-20 |
2023-08-12 |
Not clear |
| Ken T Wakabayashi, Howard L Fields, Saleem M Nicol. Dissociation of the role of nucleus accumbens dopamine in responding to reward-predictive cues and waiting for reward. Behavioural brain research. vol 154. issue 1. 2004-12-08. PMID:15302107. |
microinjection of d1 or d2 dopamine receptor antagonists into the nac did not affect the length of time animals were willing to wait for reward (fail point), but did reduce the proportion of cues to which the animal responded. |
2004-12-08 |
2023-08-12 |
rat |
| Ken T Wakabayashi, Howard L Fields, Saleem M Nicol. Dissociation of the role of nucleus accumbens dopamine in responding to reward-predictive cues and waiting for reward. Behavioural brain research. vol 154. issue 1. 2004-12-08. PMID:15302107. |
these results suggest that waiting for reward without increased caloric energy expenditure does not require nac dopamine. |
2004-12-08 |
2023-08-12 |
rat |
| Olivera Pluzarev, Subhash C Pande. Modulation of CREB expression and phosphorylation in the rat nucleus accumbens during nicotine exposure and withdrawal. Journal of neuroscience research. vol 77. issue 6. 2004-11-06. PMID:15334606. |
these results suggest the possibility that decreased creb activity in the shell of nac may be associated with abnormal reward mechanisms during nicotine withdrawal after chronic exposure. |
2004-11-06 |
2023-08-12 |
rat |
| Remigijus Lape, John A Dan. Complex response to afferent excitatory bursts by nucleus accumbens medium spiny projection neurons. Journal of neurophysiology. vol 92. issue 3. 2004-11-04. PMID:15331641. |
the nucleus accumbens (nac) of the ventral striatum is involved in attention, motivation, movement, learning, reward, and addiction. |
2004-11-04 |
2023-08-12 |
mouse |
| Rachel F Genn, Soyon Ahn, Anthony G Phillip. Attenuated dopamine efflux in the rat nucleus accumbens during successive negative contrast. Behavioral neuroscience. vol 118. issue 4. 2004-09-20. PMID:15301614. |
these data are consistent with the hypothesis that da efflux in the nac reflects the current incentive valence of sucrose reward and its influence on initiation of individual bouts of sucrose consumption. |
2004-09-20 |
2023-08-12 |
rat |