| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eugenia Shekhtman, Joel C Geerling, Arthur D Loew. Aldosterone-sensitive neurons of the nucleus of the solitary tract: multisynaptic pathway to the nucleus accumbens. The Journal of comparative neurology. vol 501. issue 2. 2007-03-27. PMID:17226797. |
the nucleus accumbens (nac) is part of a forebrain system implicated in reward, motivation, and learning. |
2007-03-27 |
2023-08-12 |
rat |
| Kyle S Smith, Kent C Berridg. Opioid limbic circuit for reward: interaction between hedonic hotspots of nucleus accumbens and ventral pallidum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 7. 2007-03-13. PMID:17301168. |
mu-opioid stimulation of cubic millimeter hedonic hotspots in either the nucleus accumbens shell (nac) or the ventral pallidum (vp) amplifies hedonic "liking" reactions to sweetness and appetitive "wanting" for food reward. |
2007-03-13 |
2023-08-12 |
Not clear |
| Yan Zhou, Jacob Bendor, Lauren Hofmann, Matthew Randesi, Ann Ho, Mary Jeanne Kree. Mu opioid receptor and orexin/hypocretin mRNA levels in the lateral hypothalamus and striatum are enhanced by morphine withdrawal. The Journal of endocrinology. vol 191. issue 1. 2006-12-29. PMID:17065397. |
in this study, we investigated the effects of acute morphine administration, chronic intermittent escalating-dose morphine administration and spontaneous withdrawal from chronic morphine on mrna levels of mu opioid receptor (mop-r), and the opioid peptides pro-opiomelanocortin (pomc) and preprodynorphin (ppdyn) in several key brain regions of the rat, associated with drug reward and motivated behaviors: lateral hypothalamus (lat.hyp), nucleus accumbens (nac) core, amygdala, and caudate-putamen (cpu). |
2006-12-29 |
2023-08-12 |
rat |
| Donald C Cooper, William D Klipec, Melissa A Fowler, Emin D Ozka. A role for the subiculum in the brain motivation/reward circuitry. Behavioural brain research. vol 174. issue 2. 2006-12-20. PMID:16870273. |
the ventral subiculum (vsub) is an interface between the hippocampal formation and structures in the brain reward circuitry, such as the nucleus accumbens (nac) and prefrontal cortex (pfc). |
2006-12-20 |
2023-08-12 |
Not clear |
| Arlene C Pak, Charles R Ashby, Christian A Heidbreder, Maria Pilla, Jeremy Gilbert, Zheng-Xiong Xi, Eliot L Gardne. The selective dopamine D3 receptor antagonist SB-277011A reduces nicotine-enhanced brain reward and nicotine-paired environmental cue functions. The international journal of neuropsychopharmacology. vol 9. issue 5. 2006-12-11. PMID:16942635. |
increasing evidence suggests that enhanced dopamine (da) neurotransmission in the nucleus accumbens (nac) may play a role in mediating the reward and reinforcement produced by addictive drugs and in the attentional processing of drug-associated environmental cues. |
2006-12-11 |
2023-08-12 |
rat |
| Mark S Todtenkopf, Aram Parsegian, Alipi Naydenov, Rachael L Neve, Christine Konradi, William A Carlezo. Brain reward regulated by AMPA receptor subunits in nucleus accumbens shell. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 45. 2006-11-28. PMID:17093088. |
drugs of abuse alter expression of ampa-type glutamate receptor subunits (glurs) in the nucleus accumbens (nac), a key component of brain reward systems. |
2006-11-28 |
2023-08-12 |
rat |
| Elena Butovsky, Ana Juknat, Judith Elbaz, Maytal Shabat-Simon, Raya Eilam, Abraham Zangen, Miriam Altstein, Zvi Voge. Chronic exposure to Delta9-tetrahydrocannabinol downregulates oxytocin and oxytocin-associated neurophysin in specific brain areas. Molecular and cellular neurosciences. vol 31. issue 4. 2006-11-22. PMID:16513365. |
; 7 days) to rats, downregulates the expression of oxytocin-neurophysin (ot-np) mrna and of ot and oxytocin-associated np (npot) immunoreactivity in nucleus accumbens (nac) and ventral tegmental area (vta), brain areas involved in reward and addiction. |
2006-11-22 |
2023-08-12 |
rat |
| Ashley Acheson, Andrew M Farrar, Michele Patak, Kathryn A Hausknecht, Artur K Kieres, Seulgi Choi, Harriet de Wit, Jerry B Richard. Nucleus accumbens lesions decrease sensitivity to rapid changes in the delay to reinforcement. Behavioural brain research. vol 173. issue 2. 2006-11-01. PMID:16884790. |
to investigate the neural mechanisms that mediate delay discounting, the present study examined the effects of excitotoxic lesions of the nucleus accumbens (nac) on discounting of reward value by delay and probability. |
2006-11-01 |
2023-08-12 |
rat |
| Ashley Acheson, Andrew M Farrar, Michele Patak, Kathryn A Hausknecht, Artur K Kieres, Seulgi Choi, Harriet de Wit, Jerry B Richard. Nucleus accumbens lesions decrease sensitivity to rapid changes in the delay to reinforcement. Behavioural brain research. vol 173. issue 2. 2006-11-01. PMID:16884790. |
nac lesions impaired the ability to adapt to frequent between session changes in the delay to reward but did not increase or decrease discounting when the delay was held constant across sessions. |
2006-11-01 |
2023-08-12 |
rat |
| Ashley Acheson, Andrew M Farrar, Michele Patak, Kathryn A Hausknecht, Artur K Kieres, Seulgi Choi, Harriet de Wit, Jerry B Richard. Nucleus accumbens lesions decrease sensitivity to rapid changes in the delay to reinforcement. Behavioural brain research. vol 173. issue 2. 2006-11-01. PMID:16884790. |
nac lesions may disrupt the ability of the animals to predict the timing of delayed rewards when the delay to reward is changed frequently. |
2006-11-01 |
2023-08-12 |
rat |
| Mark R Stefani, Bita Moghadda. Rule learning and reward contingency are associated with dissociable patterns of dopamine activation in the rat prefrontal cortex, nucleus accumbens, and dorsal striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 34. 2006-09-28. PMID:16928870. |
we measured dopamine release in the prefrontal cortex (pfc), nucleus accumbens (nac), and dorsal striatum (ds) of rats exposed to the same maze apparatus under three behavioral conditions: a set-shift task in which reward depended on discrimination learning and extradimensional set-shifting, a yoked condition in which reward was intermittent and not under the control of the subject, and a "reward-retrieval" variant in which reward was certain on every trial. |
2006-09-28 |
2023-08-12 |
human |
| Mark R Stefani, Bita Moghadda. Rule learning and reward contingency are associated with dissociable patterns of dopamine activation in the rat prefrontal cortex, nucleus accumbens, and dorsal striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 34. 2006-09-28. PMID:16928870. |
predictable, noncontingent reward was associated with increased dopamine levels in the nac and ds. |
2006-09-28 |
2023-08-12 |
human |
| Zheng-Xiong Xi, Jeremy G Gilbert, Xiao-Qing Peng, Arlene C Pak, Xia Li, Eliot L Gardne. Cannabinoid CB1 receptor antagonist AM251 inhibits cocaine-primed relapse in rats: role of glutamate in the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 33. 2006-09-12. PMID:16914679. |
given the importance of dopamine, glutamate, and gaba in cocaine reward and relapse, we studied the effects of am251 [n-(piperidin-1-yl)-5-(4-iodophonyl)-1-(2,4-dichlorophenyl)-4-methyl-1h-pyrazole-3-carboxamide], a novel highly selective cb1 receptor antagonist, on cocaine-primed reinstatement of drug-seeking behavior and on cocaine-induced changes in extracellular da, glutamate, and gaba in the nucleus accumbens (nac) under reinstatement conditions. |
2006-09-12 |
2023-08-12 |
rat |
| Kaushik Misra, Subhash C Pande. The decreased cyclic-AMP dependent-protein kinase A function in the nucleus accumbens: a role in alcohol drinking but not in anxiety-like behaviors in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 7. 2006-09-05. PMID:16192983. |
the nucleus accumbens (nac) brain structures have been implicated in the reward and reinforcing properties of ethanol. |
2006-09-05 |
2023-08-12 |
rat |
| Birgit Abler, Henrik Walter, Susanne Erk, Hannes Kammerer, Manfred Spitze. Prediction error as a linear function of reward probability is coded in human nucleus accumbens. NeuroImage. vol 31. issue 2. 2006-08-14. PMID:16487726. |
first, during the expectation period of the task, the fmri signal in the human nucleus accumbens (nac) increased linearly with the probability of the reward. |
2006-08-14 |
2023-08-12 |
human |
| Birgit Abler, Henrik Walter, Susanne Erk, Hannes Kammerer, Manfred Spitze. Prediction error as a linear function of reward probability is coded in human nucleus accumbens. NeuroImage. vol 31. issue 2. 2006-08-14. PMID:16487726. |
second, during the outcome phase, activity in the nac coded the prediction error as a linear function of reward probabilities. |
2006-08-14 |
2023-08-12 |
human |
| Birgit Abler, Henrik Walter, Susanne Erk, Hannes Kammerer, Manfred Spitze. Prediction error as a linear function of reward probability is coded in human nucleus accumbens. NeuroImage. vol 31. issue 2. 2006-08-14. PMID:16487726. |
third, we found that the nac signal was correlated with individual differences in sensation seeking and novelty seeking, indicating a link between individual fmri activation of the dopamine system in a probabilistic paradigm and personality traits previously suggested to be linked with reward processing. |
2006-08-14 |
2023-08-12 |
human |
| Tao A Zhang, Adam W Hendricson, Richard A Morriset. Dual synaptic sites of D(1)-dopaminergic regulation of ethanol sensitivity of NMDA receptors in nucleus accumbens. Synapse (New York, N.Y.). vol 58. issue 1. 2006-06-28. PMID:16037948. |
these data suggest that d(1)-like receptors modulate both the presynaptic and postsynaptic effects of ethanol on nmda receptor-mediated synaptic transmission in nucleus accumbens (nac) and that these interactions may contribute to ethanol-induced neuroadaptation of the reward pathway. |
2006-06-28 |
2023-08-12 |
Not clear |
| Elyssa B Margolis, Hagar Lock, Vladimir I Chefer, Toni S Shippenberg, Gregory O Hjelmstad, Howard L Field. Kappa opioids selectively control dopaminergic neurons projecting to the prefrontal cortex. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 8. 2006-06-13. PMID:16477003. |
whereas dopamine (da) in the mpfc has been implicated in working memory and attentional processes, da in the nac is required for responding to reward predictive cues. |
2006-06-13 |
2023-08-12 |
Not clear |
| Mohammad-Reza Zarrindast, Bibi-Nasrin Azami, Parvin Rostami, Ameneh Rezayo. Repeated administration of dopaminergic agents in the nucleus accumbens and morphine-induced place preference. Behavioural brain research. vol 169. issue 2. 2006-06-08. PMID:16472879. |
it is concluded that repeated injections of dopamine receptors agents followed by 5 days free of the drugs in the nac can affect morphine reward. |
2006-06-08 |
2023-08-12 |
rat |