| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qian Bu, Zhengtao Hu, Feng Chen, Ruiming Zhu, Yi Deng, Xue Shao, Yan Li, Jinxuan Zhao, Hongyu Li, Baolai Zhang, Lei Lv, Guangyan Yan, Yinglan Zhao, Xiaobo Ce. Transcriptome analysis of long non-coding RNAs of the nucleus accumbens in cocaine-conditioned mice. Journal of neurochemistry. vol 123. issue 5. 2013-01-10. PMID:22957495. |
cocaine dependence involves in the brain's reward circuit as well as nucleus accumbens (nac), a key region of the mesolimbic dopamine pathway. |
2013-01-10 |
2023-08-12 |
mouse |
| Erik B Oleson, Joseph F Chee. Paradoxical effects of the endocannabinoid uptake inhibitor VDM11 on accumbal neural encoding of reward predictive cues. Synapse (New York, N.Y.). vol 66. issue 11. 2013-01-09. PMID:22807176. |
previous studies show that antagonizing ecb transmission decreases reward-directed behavior and nucleus accumbens (nac) encoding of reward predictive cues. |
2013-01-09 |
2023-08-12 |
Not clear |
| Erik B Oleson, Joseph F Chee. Paradoxical effects of the endocannabinoid uptake inhibitor VDM11 on accumbal neural encoding of reward predictive cues. Synapse (New York, N.Y.). vol 66. issue 11. 2013-01-09. PMID:22807176. |
we, therefore, hypothesized that elevating ecb levels would uniformly facilitate nac neural encoding of reward predictive cues and reward-directed behavior. |
2013-01-09 |
2023-08-12 |
Not clear |
| Xin-Ming Ma, Jian-Ping Huang, Xiaonan Xin, Yan Yan, Richard E Mains, Betty A Eippe. A role for kalirin in the response of rat medium spiny neurons to cocaine. Molecular pharmacology. vol 82. issue 4. 2012-12-21. PMID:22828798. |
its role in the gabaergic medium spiny neurons (msns) of the nucleus accumbens (nac) and striatum, the areas known to play a key role in the common reward pathway, is not as well understood. |
2012-12-21 |
2023-08-12 |
mouse |
| Grant W Mallory, Osama Abulseoud, Sun-Chul Hwang, Deborah A Gorman, Squire M Stead, Bryan T Klassen, Paola Sandroni, James C Watson, Kendall H Le. The nucleus accumbens as a potential target for central poststroke pain. Mayo Clinic proceedings. vol 87. issue 10. 2012-12-20. PMID:22980165. |
the nucleus accumbens (nac), a limbic structure within the ventral striatum that is involved in reward and pain processing, has emerged as an effective target for psychiatric disease. |
2012-12-20 |
2023-08-12 |
Not clear |
| Brad A Grueter, Patrick E Rothwell, Robert C Malenk. Integrating synaptic plasticity and striatal circuit function in addiction. Current opinion in neurobiology. vol 22. issue 3. 2012-11-19. PMID:22000687. |
these synaptic adaptations include changes in the nucleus accumbens (nac), a ventral striatal subregion important for drug reward and reinforcement, as well as the dorsal striatum, which may promote habitual drug use. |
2012-11-19 |
2023-08-12 |
Not clear |
| Kyle K Pitchers, Susanne Schmid, Andrea R Di Sebastiano, Xu Wang, Steven R Laviolette, Michael N Lehman, Lique M Coole. Natural reward experience alters AMPA and NMDA receptor distribution and function in the nucleus accumbens. PloS one. vol 7. issue 4. 2012-11-19. PMID:22529926. |
the current study determined whether sexual experience causes long-lasting changes in mating, or ionotropic glutamate receptor trafficking or function in the nucleus accumbens (nac), following 3 different reward abstinence periods: 1 day, 1 week, or 1 month after final mating session. |
2012-11-19 |
2023-08-12 |
rat |
| Kyle K Pitchers, Susanne Schmid, Andrea R Di Sebastiano, Xu Wang, Steven R Laviolette, Michael N Lehman, Lique M Coole. Natural reward experience alters AMPA and NMDA receptor distribution and function in the nucleus accumbens. PloS one. vol 7. issue 4. 2012-11-19. PMID:22529926. |
finally, whole-cell patch clamp electrophysiological recordings determined reduced ampa/nmda ratio of synaptic currents in nac shell neurons following stimulation of cortical afferents in sexually experienced males after all reward abstinence periods. |
2012-11-19 |
2023-08-12 |
rat |
| Giovanni Hernandez, Joseph F Chee. Effect of CB1 receptor blockade on food-reinforced responding and associated nucleus accumbens neuronal activity in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 33. 2012-11-02. PMID:22895729. |
nac neurons encoded reward-predictive cues as well as food reward delivery. |
2012-11-02 |
2023-08-12 |
rat |
| James E McCutcheon, Stephanie R Ebner, Amy L Loriaux, Mitchell F Roitma. Encoding of aversion by dopamine and the nucleus accumbens. Frontiers in neuroscience. vol 6. 2012-10-12. PMID:23055953. |
classically, the nucleus accumbens (nac) and the dopamine projection to it are considered an integral part of the brain's reward circuit, i.e., they direct approach and consumption behaviors and underlie positive reinforcement. |
2012-10-12 |
2023-08-12 |
rat |
| Ja Wook Koo, Michelle S Mazei-Robison, Dipesh Chaudhury, Barbara Juarez, Quincey LaPlant, Deveroux Ferguson, Jian Feng, Haosheng Sun, Kimberly N Scobie, Diane Damez-Werno, Marshall Crumiller, Yoshinori N Ohnishi, Yoko H Ohnishi, Ezekiell Mouzon, David M Dietz, Mary Kay Lobo, Rachael L Neve, Scott J Russo, Ming-Hu Han, Eric J Nestle. BDNF is a negative modulator of morphine action. Science (New York, N.Y.). vol 338. issue 6103. 2012-10-11. PMID:23042896. |
in contrast, optical stimulation of vta da terminals in nucleus accumbens (nac) completely reversed the suppressive effect of bdnf on morphine reward. |
2012-10-11 |
2023-08-12 |
Not clear |
| Jennifer L Warner-Schmidt, Eric F Schmidt, John J Marshall, Amanda J Rubin, Margarita Arango-Lievano, Michael G Kaplitt, Ines Ibañez-Tallon, Nathaniel Heintz, Paul Greengar. Cholinergic interneurons in the nucleus accumbens regulate depression-like behavior. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 28. 2012-10-05. PMID:22733786. |
a large number of studies have demonstrated that the nucleus accumbens (nac) is a critical site in the neuronal circuits controlling reward responses, motivation, and mood, but the neuronal cell type(s) underlying these processes are not yet known. |
2012-10-05 |
2023-08-12 |
mouse |
| Tünde Molnár, László Héja, Zsuzsa Emri, Agnes Simon, Gabriella Nyitrai, Ildikó Pál, Julianna Kardo. Activation of astroglial calcium signaling by endogenous metabolites succinate and gamma-hydroxybutyrate in the nucleus accumbens. Frontiers in neuroenergetics. vol 3. 2012-10-02. PMID:22180742. |
recently, astroglial ca(2+) transients evoked by the major citric acid cycle metabolite succinate (suc) and gamma-hydroxybutyrate (ghb) that enters the citric acid cycle via suc have been described in the brain reward area, the nucleus accumbens (nac). |
2012-10-02 |
2023-08-12 |
mouse |
| Luis Núñez-Jaramillo, José A Rangel-Hernández, Belén Burgueño-Zúñiga, María I Mirand. Activation of nucleus accumbens NMDA receptors differentially affects appetitive or aversive taste learning and memory. Frontiers in behavioral neuroscience. vol 6. 2012-10-02. PMID:22529783. |
taste memory depends on motivational and post-ingestional consequences; thus, it can be aversive (e.g., conditioned taste aversion, cta) if a novel, palatable taste is paired with visceral malaise, or it can be appetitive if no intoxication appears after novel taste consumption, and a taste preference is developed.the nucleus accumbens (nac) plays a role in hedonic reactivity to taste stimuli, and recent findings suggest that reward and aversion are differentially encoded by the activity of nac neurons. |
2012-10-02 |
2023-08-12 |
Not clear |
| Juan Li, Nuyun Liu, Kangrong Lu, Lei Zhang, Jingjing Gu, Fukun Guo, Shengli An, Lin Zhang, Lu Zhan. Cocaine-induced dendritic remodeling occurs in both D1 and D2 dopamine receptor-expressing neurons in the nucleus accumbens. Neuroscience letters. vol 517. issue 2. 2012-09-14. PMID:22561554. |
repeated exposure to cocaine can induce persistent alterations in the brain's reward system, including increases in the number of dendrites and spine density on medium-sized spiny neurons (msns) in the nucleus accumbens (nac). |
2012-09-14 |
2023-08-12 |
mouse |
| Erik B Oleson, Mark J Ferris, Rodrigo A España, Jill Harp, Sara R Jone. Effects of the histamine H₁ receptor antagonist and benztropine analog diphenylpyraline on dopamine uptake, locomotion and reward. European journal of pharmacology. vol 683. issue 1-3. 2012-09-13. PMID:22445882. |
aside from producing the desired histamine reducing effects, many antihistamines can also elicit psychomotor activation and reward, both of which are associated with increased dopamine concentrations in the nucleus accumbens (nac). |
2012-09-13 |
2023-08-12 |
Not clear |
| Anne Marie Wissman, Renee M May, Catherine S Woolle. Ultrastructural analysis of sex differences in nucleus accumbens synaptic connectivity. Brain structure & function. vol 217. issue 2. 2012-09-04. PMID:21987050. |
despite robust sex differences in behavioral responses to drugs of abuse, relatively little is known about structural sex differences in synaptic connectivity of reward circuits such as in the nucleus accumbens (nac). |
2012-09-04 |
2023-08-12 |
rat |
| Anne Marie Wissman, Renee M May, Catherine S Woolle. Ultrastructural analysis of sex differences in nucleus accumbens synaptic connectivity. Brain structure & function. vol 217. issue 2. 2012-09-04. PMID:21987050. |
these findings underscore the importance of including both males and females in studies of reward circuitry, and of considering variation along the rostro-caudal axis of the nac in future studies. |
2012-09-04 |
2023-08-12 |
rat |
| Vincent Vialou, Jian Feng, Alfred J Robison, Stacy M Ku, Deveroux Ferguson, Kimberly N Scobie, Michelle S Mazei-Robison, Ezekiell Mouzon, Eric J Nestle. Serum response factor and cAMP response element binding protein are both required for cocaine induction of ΔFosB. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 22. 2012-08-06. PMID:22649236. |
here, we demonstrate a necessary role for two transcription factors, camp response element binding protein (creb) and serum response factor (srf), in mediating this induction within the mouse nucleus accumbens (nac), a key brain reward region. |
2012-08-06 |
2023-08-12 |
mouse |
| Thorfinn T Riday, Barry E Kosofsky, C J Malang. The rewarding and locomotor-sensitizing effects of repeated cocaine administration are distinct and separable in mice. Neuropharmacology. vol 62. issue 4. 2012-07-27. PMID:22197517. |
these data suggest that the effects of repeated cocaine exposure on reward and motor processes are dissociable in mice, and that reduction of excitatory neurotransmission in the nac may predict altered motor function independently from changes in reward perception. |
2012-07-27 |
2023-08-12 |
mouse |