| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexis W Ary, Kevin D Lominac, Melissa G Wroten, Amy R Williams, Rianne R Campbell, Osnat Ben-Shahar, Georg von Jonquieres, Matthias Klugmann, Karen K Szumlinsk. Imbalances in prefrontal cortex CC-Homer1 versus CC-Homer2 expression promote cocaine preference. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 19. 2013-08-06. PMID:23658151. |
together, these data provide novel evidence in support of opposing roles for constitutively expressed homer1 and homer2 isoforms in regulating mpfc glutamate transmission in vivo and support the hypothesis that cocaine-elicited increases in the relative amount of mpfc homer2 versus homer1 signaling produces abnormalities in nac glutamate transmission that enhance vulnerability to cocaine reward. |
2013-08-06 |
2023-08-12 |
mouse |
| Venkata Siva Sai Sujith Sajja, Matthew Galloway, Farhad Ghoddoussi, Andrea Kepsel, Pamela VandeVor. Effects of blast-induced neurotrauma on the nucleus accumbens. Journal of neuroscience research. vol 91. issue 4. 2013-08-05. PMID:23335267. |
the nucleus accumbens (nac) plays an important role in reward, addiction, aggression, and fear pathways. |
2013-08-05 |
2023-08-12 |
Not clear |
| E Lizárraga-Mollinedo, C Alvarez, E Fernández-Millán, F Escrivá, C González-Martín, E Salas, J M Pérez-Ortiz, L F Alguaci. Undernutrition upregulates fumarate hydratase in the rat nucleus accumbens. Metabolic brain disease. vol 28. issue 1. 2013-08-02. PMID:23160834. |
this work has been focused to investigate fh activity in the nucleus accumbens (nac) of undernourished rats, taking into account that malnutrition has been related to increased responsiveness to food and drug reward. |
2013-08-02 |
2023-08-12 |
rat |
| Bryan B Gore, Larry S Zweife. Genetic reconstruction of dopamine D1 receptor signaling in the nucleus accumbens facilitates natural and drug reward responses. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 20. 2013-08-02. PMID:23678109. |
using conditional reconstruction of functional d1r signaling in d1r knock-out mice, we define distinct requirements of d1r in subregions of the nucleus accumbens (nac) for specific dimensions of reward. |
2013-08-02 |
2023-08-12 |
mouse |
| Bryan B Gore, Larry S Zweife. Genetic reconstruction of dopamine D1 receptor signaling in the nucleus accumbens facilitates natural and drug reward responses. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 20. 2013-08-02. PMID:23678109. |
however, d1r expression in either the nac(core) or the nac(shell) improves instrumental responding for reward. |
2013-08-02 |
2023-08-12 |
mouse |
| Bryan B Gore, Larry S Zweife. Genetic reconstruction of dopamine D1 receptor signaling in the nucleus accumbens facilitates natural and drug reward responses. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 20. 2013-08-02. PMID:23678109. |
in contrast, neither nac(core) nor nac(shell) d1r is sufficient to promote motivation to work for reward in a progressive ratio task or for motor learning. |
2013-08-02 |
2023-08-12 |
mouse |
| Xia Li, Zheng-Xiong Xi, Athina Marko. Metabotropic glutamate 7 (mGlu7) receptor: a target for medication development for the treatment of cocaine dependence. Neuropharmacology. vol 66. 2013-07-02. PMID:22546614. |
systemic or local administration of amn082 into the nucleus accumbens (nac), a critical brain region involved in reward and drug dependence processes, inhibited the reinforcing and motivational effects of cocaine, heroin and ethanol, as assessed by the intravenous drug self-administration procedure. |
2013-07-02 |
2023-08-12 |
Not clear |
| M Waraczynski, W Zwifelhofer, L Kueh. Brain stimulation reward is altered by affecting dopamine-glutamate interactions in the central extended amygdala. Neuroscience. vol 224. 2013-06-17. PMID:22906479. |
this work compares the effects on brain stimulation reward (bsr) when combining d2 dopamine receptor and ampa glutamate receptor manipulations in the sublenticular central extended amygdala (sleac) and the nucleus accumbens shell (nac shell). |
2013-06-17 |
2023-08-12 |
rat |
| Mia Ericson, Peipei Chau, Louise Adermark, Bo Söderpal. Rising taurine and ethanol concentrations in nucleus accumbens interact to produce the dopamine-activating effects of alcohol. Advances in experimental medicine and biology. vol 775. 2013-06-12. PMID:23392937. |
ethanol is known to increase extracellular levels of both dopamine and taurine in the nucleus accumbens (nac), a part of the brain reward system, but the two events have not been connected. |
2013-06-12 |
2023-08-12 |
human |
| Mia Ericson, Peipei Chau, Louise Adermark, Bo Söderpal. Rising taurine and ethanol concentrations in nucleus accumbens interact to produce the dopamine-activating effects of alcohol. Advances in experimental medicine and biology. vol 775. 2013-06-12. PMID:23392937. |
these data also -provide support for the notion that the nac is the primary target for ethanol in its dopamine-activating effect after systemic administration and that taurine is a prominent participant in activating the brain reward system. |
2013-06-12 |
2023-08-12 |
human |
| Changjiu Zhao, Ming L. Neuroanatomical substrates of the disruptive effect of olanzapine on rat maternal behavior as revealed by c-Fos immunoreactivity. Pharmacology, biochemistry, and behavior. vol 103. issue 2. 2013-06-11. PMID:22960130. |
acute olanzapine treatment dose-dependently disrupted various components of maternal behavior (e.g., pup retrieval, pup licking, nest building, crouching) and increased c-fos immunoreactivity in the medial prefrontal cortex (mpfc), nucleus accumbens shell and core (nas and nac), dorsolateral striatum (dlst), ventral lateral septum (lsv), central amygdala (cea) and ventral tegmental area (vta), important brain areas generally implicated in the incentive motivation and reward processing. |
2013-06-11 |
2023-08-12 |
human |
| Ramesh Chandra, Jeffrey D Lenz, Amy M Gancarz, Dipesh Chaudhury, Gabrielle L Schroeder, Ming-Hu Han, Joseph F Cheer, David M Dietz, Mary Kay Lob. Optogenetic inhibition of D1R containing nucleus accumbens neurons alters cocaine-mediated regulation of Tiam1. Frontiers in molecular neuroscience. vol 6. 2013-06-10. PMID:23745104. |
these d1-msns in the nucleus accumbens (nac) positively regulate drug seeking, reward, and locomotor behavioral effects as well as the morphological adaptations of psychostimulant drugs. |
2013-06-10 |
2023-08-12 |
rat |
| Ulf J Müller, Jürgen Voges, Johann Steiner, Imke Galazky, Hans-Jochen Heinze, Michaela Möller, Jared Pisapia, Casey Halpern, Arthur Caplan, Bernhard Bogerts, Jens Kuh. Deep brain stimulation of the nucleus accumbens for the treatment of addiction. Annals of the New York Academy of Sciences. vol 1282. 2013-06-03. PMID:23227826. |
in this review, beginning with an introduction of deep brain stimulation (dbs), we highlight the importance of the nucleus accumbens (nac) in the context of the reward circuitry and addictive behavior. |
2013-06-03 |
2023-08-12 |
Not clear |
| Pamela J Kennedy, Jian Feng, A J Robison, Ian Maze, Ana Badimon, Ezekiell Mouzon, Dipesh Chaudhury, Diane M Damez-Werno, Stephen J Haggarty, Ming-Hu Han, Rhonda Bassel-Duby, Eric N Olson, Eric J Nestle. Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation. Nature neuroscience. vol 16. issue 4. 2013-05-21. PMID:23475113. |
induction of histone acetylation in the nucleus accumbens (nac), a key brain reward region, promotes cocaine-induced alterations in gene expression. |
2013-05-21 |
2023-08-12 |
mouse |
| Kyle K Pitchers, Vincent Vialou, Eric J Nestler, Steven R Laviolette, Michael N Lehman, Lique M Coole. Natural and drug rewards act on common neural plasticity mechanisms with ΔFosB as a key mediator. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 8. 2013-04-24. PMID:23426671. |
drugs of abuse induce neuroplasticity in the natural reward pathway, specifically the nucleus accumbens (nac), thereby causing development and expression of addictive behavior. |
2013-04-24 |
2023-08-12 |
rat |
| Kyle K Pitchers, Vincent Vialou, Eric J Nestler, Steven R Laviolette, Michael N Lehman, Lique M Coole. Natural and drug rewards act on common neural plasticity mechanisms with ΔFosB as a key mediator. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 8. 2013-04-24. PMID:23426671. |
moreover, the onset, but not the longer-term expression, of enhanced amphetamine reward was correlated with a transient increase in dendritic spines in the nac. |
2013-04-24 |
2023-08-12 |
rat |
| Kyle K Pitchers, Vincent Vialou, Eric J Nestler, Steven R Laviolette, Michael N Lehman, Lique M Coole. Natural and drug rewards act on common neural plasticity mechanisms with ΔFosB as a key mediator. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 8. 2013-04-24. PMID:23426671. |
next, a critical role for the transcription factor Δfosb in sex experience-induced enhanced amphetamine reward and associated increases in dendritic spines on nac neurons was established using viral vector gene transfer of the dominant-negative binding partner Δjund. |
2013-04-24 |
2023-08-12 |
rat |
| Kyle K Pitchers, Vincent Vialou, Eric J Nestler, Steven R Laviolette, Michael N Lehman, Lique M Coole. Natural and drug rewards act on common neural plasticity mechanisms with ΔFosB as a key mediator. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 8. 2013-04-24. PMID:23426671. |
moreover, it was demonstrated that sexual experience-induced enhanced drug reward, Δfosb, and spinogenesis are dependent on mating-induced dopamine d1 receptor activation in the nac. |
2013-04-24 |
2023-08-12 |
rat |
| Kyle K Pitchers, Vincent Vialou, Eric J Nestler, Steven R Laviolette, Michael N Lehman, Lique M Coole. Natural and drug rewards act on common neural plasticity mechanisms with ΔFosB as a key mediator. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 8. 2013-04-24. PMID:23426671. |
pharmacological blockade of d1 receptor, but not d2 receptor, in the nac during sexual behavior attenuated Δfosb induction and prevented increased spinogenesis and sensitized amphetamine reward. |
2013-04-24 |
2023-08-12 |
rat |
| D Shabashov, E Shohami, R Yak. Inactivation of PKMζ in the NAc shell abolished cocaine-conditioned reward. Journal of molecular neuroscience : MN. vol 47. issue 3. 2013-04-11. PMID:22127928. |
inactivation of pkmζ in the nac shell abolished cocaine-conditioned reward. |
2013-04-11 |
2023-08-12 |
Not clear |