| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zahra Taslimi, Reza Arezoomandan, Alireza Omranifard, Mohadeseh Ghalandari-Shamami, Esmail Riahi, Abbas Ali Vafaei, Ali Rashidy-Pour, Abbas Haghparas. Orexin A in the ventral tegmental area induces conditioned place preference in a dose-dependent manner: involvement of D1/D2 receptors in the nucleus accumbens. Peptides. vol 37. issue 2. 2014-06-23. PMID:22885169. |
additionally, d1 and d2 dopamine receptors in the nucleus accumbens (nac) have critical roles in motivation and reward. |
2014-06-23 |
2023-08-12 |
rat |
| Seyedeh-Najmeh Katebi, Yasaman Razavi, Shabnam Zeighamy Alamdary, Fariba Khodagholi, Abbas Haghparas. Morphine could increase apoptotic factors in the nucleus accumbens and prefrontal cortex of rat brain's reward circuitry. Brain research. vol 1540. 2014-06-23. PMID:24096212. |
the nucleus accumbens (nac) and prefrontal cortex (pfc) are two parts of neuronal reward circuit involved in motivated and goal-directed behaviors. |
2014-06-23 |
2023-08-12 |
rat |
| Seyedeh-Najmeh Katebi, Yasaman Razavi, Shabnam Zeighamy Alamdary, Fariba Khodagholi, Abbas Haghparas. Morphine could increase apoptotic factors in the nucleus accumbens and prefrontal cortex of rat brain's reward circuitry. Brain research. vol 1540. 2014-06-23. PMID:24096212. |
this study was designed to evaluate the effect of morphine on apoptosis by measuring the expression of apoptotic proteins in two important regions, the nac and pfc, in the rat brain's reward circuitry. |
2014-06-23 |
2023-08-12 |
rat |
| Masago Ishikawa, Mami Otaka, Peter A Neumann, Zhijian Wang, James M Cook, Oliver M Schlüter, Yan Dong, Yanhua H Huan. Exposure to cocaine regulates inhibitory synaptic transmission from the ventral tegmental area to the nucleus accumbens. The Journal of physiology. vol 591. issue 19. 2014-06-20. PMID:23918773. |
synaptic projections from the ventral tegmental area (vta) to the nucleus accumbens (nac) make up the backbone of the brain reward pathway, a neural circuit that mediates behavioural responses elicited by natural rewards as well as by cocaine and other drugs of abuse. |
2014-06-20 |
2023-08-12 |
rat |
| Laura N Smith, Jakub P Jedynak, Miles R Fontenot, Carly F Hale, Karen C Dietz, Makoto Taniguchi, Feba S Thomas, Benjamin C Zirlin, Shari G Birnbaum, Kimberly M Huber, Mark J Thomas, Christopher W Cowa. Fragile X mental retardation protein regulates synaptic and behavioral plasticity to repeated cocaine administration. Neuron. vol 82. issue 3. 2014-06-20. PMID:24811383. |
we find that fmrp functions in the adult nucleus accumbens (nac), a critical addiction-related brain region, to mediate behavioral sensitization but not cocaine reward. |
2014-06-20 |
2023-08-13 |
mouse |
| Marta Peciña, Mercedes Martínez-Jauand, Tiffany Love, Joseph Heffernan, Pedro Montoya, Colin Hodgkinson, Christian S Stohler, David Goldman, Jon-Kar Zubiet. Valence-specific effects of BDNF Val66Met polymorphism on dopaminergic stress and reward processing in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 17. 2014-06-09. PMID:24760847. |
brain-derived neurotrophic factor (bdnf) levels in dopaminergic (da) cells within the ventral tegmental area (vta)/nucleus accumbens (nac) circuitry appear to be a candidate mechanism for the neuroadaptive changes that follow stress and reward responses in animal models. |
2014-06-09 |
2023-08-13 |
human |
| Gemma L Dalton, Anthony G Phillips, Stan B Floresc. Preferential involvement by nucleus accumbens shell in mediating probabilistic learning and reversal shifts. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 13. 2014-05-19. PMID:24672007. |
different subregions of nucleus accumbens (nac) have been implicated in reward seeking, promoting flexible approach responses, suppressing nonrewarded actions, and facilitating shifts between different discrimination strategies. |
2014-05-19 |
2023-08-12 |
rat |
| Gemma L Dalton, Anthony G Phillips, Stan B Floresc. Preferential involvement by nucleus accumbens shell in mediating probabilistic learning and reversal shifts. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 13. 2014-05-19. PMID:24672007. |
we investigated the effects of inactivation of the nac shell and core on probabilistic reversal learning using an operant task wherein a "correct" response delivered reward on 80% of trials, and an "incorrect" response was reinforced on 20% of trials. |
2014-05-19 |
2023-08-12 |
rat |
| Gemma L Dalton, Anthony G Phillips, Stan B Floresc. Preferential involvement by nucleus accumbens shell in mediating probabilistic learning and reversal shifts. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 13. 2014-05-19. PMID:24672007. |
these results suggest the nac shell and core facilitate reward seeking in a distinct yet complementary manner when the relationship between specific actions and reward is uncertain or ambiguous and cognitive flexibility is required. |
2014-05-19 |
2023-08-12 |
rat |
| Sara Karimi, Maryam Radahmadi, Mohammad Fazilati, Hamid Azizi-Malekabadi, Hojjatallah Alae. Roles of the nucleus accumbens (shell) in the acquisition and expression of morphine-induced conditioned behavior in freely moving rats. International journal of preventive medicine. vol 5. issue 3. 2014-05-15. PMID:24829709. |
da function in the nac is critical for goal-oriented behaviors, including those motivated by drug and brain stimulation reward. |
2014-05-15 |
2023-08-13 |
rat |
| Laura E Been, Nancy A Staffend, Avery Tucker, Robert L Meise. Vesicular glutamate transporter 2 and tyrosine hydroxylase are not co-localized in Syrian hamster nucleus accumbens afferents. Neuroscience letters. vol 550. 2014-04-11. PMID:23850605. |
the nucleus accumbens (nac) is an important brain region for motivation, reinforcement, and reward. |
2014-04-11 |
2023-08-12 |
mouse |
| Jennifer Keller, Christina B Young, Elizabeth Kelley, Katherine Prater, Daniel J Levitin, Vinod Meno. Trait anhedonia is associated with reduced reactivity and connectivity of mesolimbic and paralimbic reward pathways. Journal of psychiatric research. vol 47. issue 10. 2014-04-04. PMID:23791396. |
we found that trait anhedonia was negatively correlated with pleasantness ratings of music stimuli and with activation of key brain structures involved in reward processing, including nucleus accumbens (nac), basal forebrain and hypothalamus which are linked by the medial forebrain bundle to the ventral tegmental area (vta). |
2014-04-04 |
2023-08-12 |
human |
| Kimberly N Scobie, Diane Damez-Werno, HaoSheng Sun, NingYi Shao, Amy Gancarz, Clarisse H Panganiban, Caroline Dias, JaWook Koo, Paola Caiafa, Lewis Kaufman, Rachael L Neve, David M Dietz, Li Shen, Eric J Nestle. Essential role of poly(ADP-ribosyl)ation in cocaine action. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 5. 2014-04-03. PMID:24449909. |
repeated cocaine administration, including self-administration, increased global levels of parp-1 and its mark par in mouse nucleus accumbens (nac), a key brain reward region. |
2014-04-03 |
2023-08-12 |
mouse |
| P Trifilieff, B Feng, E Urizar, V Winiger, R D Ward, K M Taylor, D Martinez, H Moore, P D Balsam, E H Simpson, J A Javitc. Increasing dopamine D2 receptor expression in the adult nucleus accumbens enhances motivation. Molecular psychiatry. vol 18. issue 9. 2014-03-25. PMID:23711983. |
overexpression of postsynaptic d2r in the nac selectively increased motivation without altering consummatory behavior, the representation of the value of the reinforcer, or the capacity to use reward associated cues in flexible ways. |
2014-03-25 |
2023-08-12 |
Not clear |
| Meaghan C Creed, Niels R Ntamati, Kelly R Ta. VTA GABA neurons modulate specific learning behaviors through the control of dopamine and cholinergic systems. Frontiers in behavioral neuroscience. vol 8. 2014-03-10. PMID:24478655. |
the mesolimbic reward system is primarily comprised of the ventral tegmental area (vta) and the nucleus accumbens (nac) as well as their afferent and efferent connections. |
2014-03-10 |
2023-08-12 |
Not clear |
| Jennifer Francois, John Huxter, Michael W Conway, John P Lowry, Mark D Tricklebank, Gary Gilmou. Differential contributions of infralimbic prefrontal cortex and nucleus accumbens during reward-based learning and extinction. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 2. 2014-03-03. PMID:24403158. |
the present results offer a unique temporal perspective on how nac may promote actions directed toward anticipated positive outcome throughout learning, while ifc might suppress actions that no longer result in reward, but only during critical periods of learning. |
2014-03-03 |
2023-08-12 |
human |
| Kanako Saji, Yumiko Ikeda, Woochan Kim, Yoshitoshi Shingai, Amane Tateno, Hidehiko Takahashi, Yoshiro Okubo, Haruhisa Fukayama, Hidenori Suzuk. Acute NK₁ receptor antagonist administration affects reward incentive anticipation processing in healthy volunteers. The international journal of neuropsychopharmacology. vol 16. issue 7. 2014-02-10. PMID:23406545. |
because neurokinin-1 (nk₁) receptor, the cognate receptor for substance p (sp), is highly expressed in the nac, we hypothesized that the sp/nk₁ receptor system might play a role in positive reward processing in the nac in humans. |
2014-02-10 |
2023-08-12 |
human |
| Kanako Saji, Yumiko Ikeda, Woochan Kim, Yoshitoshi Shingai, Amane Tateno, Hidehiko Takahashi, Yoshiro Okubo, Haruhisa Fukayama, Hidenori Suzuk. Acute NK₁ receptor antagonist administration affects reward incentive anticipation processing in healthy volunteers. The international journal of neuropsychopharmacology. vol 16. issue 7. 2014-02-10. PMID:23406545. |
therefore, we conducted a functional mri (fmri) study to assess the effects of an nk₁ receptor antagonist on human reward processing through a monetary incentive delay task that is known to elicit robust activation in the nac especially during gain anticipation. |
2014-02-10 |
2023-08-12 |
human |
| Abbas Haghparast, Alireza Omranifard, Reza Arezoomandan, Mohadeseh Ghalandari-Shamami, Zahra Taslimi, Abbas Ali Vafaei, Ali Rashidy-Pou. Involvement of dopaminergic receptors of the rat nucleus accumbens in decreasing the conditioned place preference induced by lateral hypothalamus stimulation. Neuroscience letters. vol 556. 2014-02-10. PMID:24103377. |
also, it has been indicated that orexin activates the mesolimbic dopamine projecting neurons to the nucleus accumbens (nac) and promotes the development of reward in rodents. |
2014-02-10 |
2023-08-12 |
rat |
| S D Schlussman, M Buonora, A J Brownstein, Y Zhang, A Ho, M J Kree. Regional mRNA expression of GABAergic receptor subunits in brains of C57BL/6J and 129P3/J mice: strain and heroin effects. Brain research. vol 1523. 2014-02-04. PMID:23732339. |
in this study, we examined the contribution of the gabaergic system in the cortex, nucleus accumbens (nac), caudate putamen (cpu) and the region containing the substantia nigra and ventral tegmental area (sn/vta) to heroin reward by measuring mrna levels of 7 of the most commonly expressed gaba-a receptor subunits, and both gaba-b receptor subunits, in these same mice following saline (control) or heroin administration in a cpp design. |
2014-02-04 |
2023-08-12 |
mouse |