| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongjie Chen, Hao Qiang, Kaichun Fan, Shousen Wang, Zhaocong Zhen. The snoRNA MBII-52 regulates cocaine-induced conditioned place preference and locomotion in mice. PloS one. vol 9. issue 6. 2015-10-26. PMID:24979384. |
cocaine dependence involves in the brain's reward circuit as well as nucleus accumbens (nac), a key region of the mesolimbic dopamine pathway. |
2015-10-26 |
2023-08-13 |
mouse |
| Shin-ichi Adachi, Ai Eguchi, Kazuhiro Sakamoto, Hiroki Asano, Yasuko Manabe, Shigenobu Matsumura, Satoshi Tsuzuki, Kazuo Inoue, Tohru Fushik. Behavioral palatability of dietary fatty acids correlates with the intracellular calcium ion levels induced by the fatty acids in GPR120-expressing cells. Biomedical research (Tokyo, Japan). vol 35. issue 6. 2015-10-22. PMID:25743342. |
we also showed that the lcfa (1% linoleic acid) increased the extracellular dopamine (da) level in the nucleus accumbens (nac), which participates in reward behavior. |
2015-10-22 |
2023-08-13 |
mouse |
| M E Bocarsly, N M Aven. A high-fat diet or galanin in the PVN decreases phosphorylation of CREB in the nucleus accumbens. Neuroscience. vol 248. 2015-10-20. PMID:23747305. |
gal has recently been shown to inhibit opiate reward, which in turn, decreases camp response element-binding protein (creb) in the nucleus accumbens (nac). |
2015-10-20 |
2023-08-12 |
rat |
| Erin K Z Kirschmann, Jocelyn C Mauna, Cory M Willis, Rebecca L Foster, Amanda M Chipman, Edda Thiel. Appetitive cue-evoked ERK signaling in the nucleus accumbens requires NMDA and D1 dopamine receptor activation and regulates CREB phosphorylation. Learning & memory (Cold Spring Harbor, N.Y.). vol 21. issue 11. 2015-10-13. PMID:25322796. |
we previously demonstrated that exposure to an appetitive cs causes an increase in the activation of extracellular signal-regulated kinase (erk) and cyclic-amp response-element binding protein (creb) in the nucleus accumbens (nac) of rats, and that cs-evoked erk activation is critical for cs control over reward seeking. |
2015-10-13 |
2023-08-13 |
rat |
| Analía Valdomero, María C Perondi, Otto A Orsingher, Gabriel R Cuadr. Exogenous GM1 ganglioside increases accumbal BDNF levels in rats. Behavioural brain research. vol 278. 2015-09-28. PMID:25453740. |
this study was performed to investigate the possibility that gm1 may induce changes in bdnf levels in the nucleus accumbens (nac), a core structure in the brain's reward circuitry, of rats submitted to three conditioning sessions with cocaine (10 mg/kg, i.p.). |
2015-09-28 |
2023-08-13 |
rat |
| Jukka Kupila, Olli Kärkkäinen, Virpi Laukkanen, Merja Häkkinen, Hannu Kautiainen, Jari Tiihonen, Markus Storvi. [³H]Ifenprodil binding in post-mortem brains of Cloninger type 1 and 2 alcoholics: a whole-hemisphere autoradiography study. Psychiatry research. vol 231. issue 3. 2015-09-24. PMID:25616726. |
nr2b-containing nmda receptors in the nac are involved in both non-opioid and opioid receptor-mediated reward. |
2015-09-24 |
2023-08-13 |
human |
| Caroline Dias, David Dietz, Michelle Mazei-Robison, Haosheng Sun, Diane Damez-Werno, Deveroux Ferguson, Matthew Wilkinson, Jane Magida, Virginia Gao, Rachael Neve, Eric J Nestle. Dishevelled-2 regulates cocaine-induced structural plasticity and Rac1 activity in the nucleus accumbens. Neuroscience letters. vol 598. 2015-09-14. PMID:25957559. |
chronic cocaine exposure increases the density of dendritic spines on medium spiny neurons (msns), the predominant neuronal cell type of the nucleus accumbens (nac), a key brain reward region. |
2015-09-14 |
2023-08-13 |
Not clear |
| Stan B Floresc. The nucleus accumbens: an interface between cognition, emotion, and action. Annual review of psychology. vol 66. 2015-09-09. PMID:25251489. |
a primary tenet of this review is that, rather than serving as a "reward" center, the nac plays a key role in action selection, integrating cognitive and affective information processed by frontal and temporal lobe regions to augment the efficiency and vigor of appetitively or aversively motivated behaviors. |
2015-09-09 |
2023-08-13 |
Not clear |
| Rebecca Gregory, Hu Cheng, Heather A Rupp, Dale R Sengelaub, Julia R Heima. Oxytocin increases VTA activation to infant and sexual stimuli in nulliparous and postpartum women. Hormones and behavior. vol 69. 2015-08-24. PMID:25562711. |
because they have been shown to be associated with reward, the ventral tegmental area (vta) and nucleus accumbens (nac) were targeted as areas of expected alterations in activity. |
2015-08-24 |
2023-08-13 |
human |
| Margarita Arango-Lievano, Michael G Kaplit. [Depression and addiction comorbidity: towards a common molecular target?]. Medecine sciences : M/S. vol 31. issue 5. 2015-08-17. PMID:26059306. |
in particular, p11 in the chat+ cells or drd1+ msn of the nac, controls depressive-like behavior or cocaine reward, respectively. |
2015-08-17 |
2023-08-13 |
mouse |
| Jun Gao, Ning Zhu, Min Feng, Xiaolu Meng, Nan Su. Intra-nucleus-accumbens SKF38393 improved the impaired acquisition of morphine-conditioned place preference in depression-like rats. PsyCh journal. vol 1. issue 1. 2015-08-15. PMID:26272664. |
here, we address the effect of depression on morphine reward and its underlying d1- and d2-like effects in the nac and/or the gp. |
2015-08-15 |
2023-08-13 |
rat |
| Xincai Ji, Sucharita Saha, Gilles E Marti. The origin of glutamatergic synaptic inputs controls synaptic plasticity and its modulation by alcohol in mice nucleus accumbens. Frontiers in synaptic neuroscience. vol 7. 2015-08-10. PMID:26257641. |
it is widely accepted that long-lasting changes of synaptic strength in the nucleus accumbens (nac), a brain region involved in drug reward, mediate acute and chronic effects of alcohol. |
2015-08-10 |
2023-08-13 |
mouse |
| Youngsun T Cho, Stephen Fromm, Amanda E Guyer, Allison Detloff, Daniel S Pine, Julie L Fudge, Monique Erns. Nucleus accumbens, thalamus and insula connectivity during incentive anticipation in typical adults and adolescents. NeuroImage. vol 66. 2015-08-06. PMID:23069809. |
studies of incentive processing have repeatedly demonstrated activation of nucleus accumbens (nac), thalamus, and anterior insula, three key components of reward neurocircuitry. |
2015-08-06 |
2023-08-12 |
Not clear |
| Youngsun T Cho, Stephen Fromm, Amanda E Guyer, Allison Detloff, Daniel S Pine, Julie L Fudge, Monique Erns. Nucleus accumbens, thalamus and insula connectivity during incentive anticipation in typical adults and adolescents. NeuroImage. vol 66. 2015-08-06. PMID:23069809. |
specifically, this is the first study to demonstrate in humans the key role of thalamus projections onto the nac in support of reward processing. |
2015-08-06 |
2023-08-12 |
Not clear |
| Takuya Funayama, Yumiko Ikeda, Amane Tateno, Hidehiko Takahashi, Yoshiro Okubo, Haruhisa Fukayama, Hidenori Suzuk. Modafinil augments brain activation associated with reward anticipation in the nucleus accumbens. Psychopharmacology. vol 231. issue 16. 2015-08-04. PMID:24682502. |
the nucleus accumbens (nac) works as a key brain structure of the reward system, in which reward-related neural activity is well correlated with dopamine release from mesolimbic dopaminergic neurons. |
2015-08-04 |
2023-08-12 |
Not clear |
| Edita Navratilova, Jennifer Yanhua Xie, Diana Meske, Chaoling Qu, Kozo Morimura, Alec Okun, Naohisa Arakawa, Michael Ossipov, Howard L Fields, Frank Porrec. Endogenous opioid activity in the anterior cingulate cortex is required for relief of pain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 18. 2015-07-24. PMID:25948274. |
pain is aversive, and its relief elicits reward mediated by dopaminergic signaling in the nucleus accumbens (nac), a part of the mesolimbic reward motivation pathway. |
2015-07-24 |
2023-08-13 |
rat |
| Haiyin Wu, Brian O'Neill, Dawn D Han, Keerthi Thirtamara-Rajamani, Yanlin Wang, Howard H G. Restoration of cocaine stimulation and reward by reintroducing wild type dopamine transporter in adult knock-in mice with a cocaine-insensitive dopamine transporter. Neuropharmacology. vol 86. 2015-07-14. PMID:24835281. |
in an earlier study we showed that aav-datwt injections in regions covering the lateral nucleus accumbens (nac) and lateral caudate-putamen (cpu) restored cocaine stimulation but not cocaine reward. |
2015-07-14 |
2023-08-13 |
mouse |
| Courtney M Cameron, R Mark Wightman, Regina M Carell. Dynamics of rapid dopamine release in the nucleus accumbens during goal-directed behaviors for cocaine versus natural rewards. Neuropharmacology. vol 86. 2015-07-14. PMID:25174553. |
overall, the results reveal the dynamics of rapid dopamine signaling in discrete locations in the nac across reward conditions, and provide novel insight into the functional role of this system in reward-seeking behaviors. |
2015-07-14 |
2023-08-13 |
rat |
| Joan Y Holgate, Selena E Bartlet. Early Life Stress, Nicotinic Acetylcholine Receptors and Alcohol Use Disorders. Brain sciences. vol 5. issue 3. 2015-07-03. PMID:26136145. |
this review discusses the impact of early life stress on nac structure and function, how these changes affect cholinergic signaling within the mesolimbic reward pathway and the role nicotinic acetylcholine receptors (nachrs) play in this process. |
2015-07-03 |
2023-08-13 |
Not clear |
| Daniel C Castro, Shannon L Cole, Kent C Berridg. Lateral hypothalamus, nucleus accumbens, and ventral pallidum roles in eating and hunger: interactions between homeostatic and reward circuitry. Frontiers in systems neuroscience. vol 9. 2015-06-30. PMID:26124708. |
the study of the neural bases of eating behavior, hunger, and reward has consistently implicated the lateral hypothalamus (lh) and its interactions with mesocorticolimbic circuitry, such as mesolimbic dopamine projections to nucleus accumbens (nac) and ventral pallidum (vp), in controlling motivation to eat. |
2015-06-30 |
2023-08-13 |
Not clear |