| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shayla E Russell, Daniel J Puttick, Allison M Sawyer, David N Potter, Stephen Mague, William A Carlezon, Elena H Chartof. Nucleus Accumbens AMPA Receptors Are Necessary for Morphine-Withdrawal-Induced Negative-Affective States in Rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 21. 2017-07-03. PMID:27225765. |
here, we show that microinjection of the ampar antagonist nbqx into the nac shell of morphine-dependent rats prevented naloxone-induced conditioned place aversions and decreases in sensitivity to brain stimulation reward, but had no effect on somatic withdrawal signs. |
2017-07-03 |
2023-08-13 |
rat |
| Takahiro Kato, Soichiro Ide, Masabumi Minam. Pain relief induces dopamine release in the rat nucleus accumbens during the early but not late phase of neuropathic pain. Neuroscience letters. vol 629. 2017-06-29. PMID:27369326. |
the neuronal pathway from the ventral tegmental area to the nucleus accumbens (nac) is critical in the mesolimbic dopamine (da) reward circuit, and dysfunction of this pathway has been implicated in depression. |
2017-06-29 |
2023-08-13 |
rat |
| Scott E Kanoski, Matthew R Hayes, Karolina P Skibick. GLP-1 and weight loss: unraveling the diverse neural circuitry. American journal of physiology. Regulatory, integrative and comparative physiology. vol 310. issue 10. 2017-06-27. PMID:27030669. |
particular attention is devoted to discussion regarding the numerous neural substrates through which glp-1 and glp-1 analogs act to reduce food intake and body weight, including various hypothalamic nuclei (arcuate nucleus of the hypothalamus, periventricular hypothalamus, lateral hypothalamic area), hindbrain nuclei (parabrachial nucleus, medial nucleus tractus solitarius), hippocampus (ventral subregion; vhp), and nuclei embedded within the mesolimbic reward circuitry [ventral tegmental area (vta) and nucleus accumbens (nac)]. |
2017-06-27 |
2023-08-13 |
Not clear |
| Elizabeth A Heller, Peter J Hamilton, Dominika D Burek, Sonia I Lombroso, Catherine J Peña, Rachael L Neve, Eric J Nestle. Targeted Epigenetic Remodeling of the Cdk5 Gene in Nucleus Accumbens Regulates Cocaine- and Stress-Evoked Behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 17. 2017-06-19. PMID:27122028. |
the current study provides evidence for the causal role of cdk5 epigenetic remodeling in nac in cdk5 gene expression and in the control of reward and stress responses. |
2017-06-19 |
2023-08-13 |
Not clear |
| Nesrin F Basaran, R Levent Buyukuysal, M Sertac Yilmaz, Sami Aydin, Sinan Cavun, William R Millingto. The effect of Gly-Gln [ß-endorphin30-31] on morphine-evoked serotonin and GABA efflux in the nucleus accumbens of conscious rats. Neuropeptides. vol 58. 2017-02-13. PMID:26861257. |
in an earlier study, we found that gly-gln inhibits morphine-induced dopamine efflux in the nucleus accumbens (nac), consistent with its ability to inhibit morphine reward. |
2017-02-13 |
2023-08-13 |
rat |
| R Renteria, Z M Jeanes, R A Mangieri, E Y Maier, D M Kircher, T R Buske, R A Morriset. Using In Vitro Electrophysiology to Screen Medications: Accumbal Plasticity as an Engram of Alcohol Dependence. International review of neurobiology. vol 126. 2016-12-27. PMID:27055622. |
the nucleus accumbens (nac) is a central component of the mesocorticolimbic reward system. |
2016-12-27 |
2023-08-13 |
Not clear |
| Takatoshi Hikida, Makiko Morita, Tom Macpherso. Neural mechanisms of the nucleus accumbens circuit in reward and aversive learning. Neuroscience research. vol 108. 2016-12-26. PMID:26827817. |
in this review, we outline the functional dissociation of nac d1- and d2-expressing neurons of the basal ganglia in reward and aversive learning, as well as drug addiction. |
2016-12-26 |
2023-08-13 |
Not clear |
| Sarah J Baracz, Nicholas A Everett, Iain S McGregor, Jennifer L Cornis. Oxytocin in the nucleus accumbens core reduces reinstatement of methamphetamine-seeking behaviour in rats. Addiction biology. vol 21. issue 2. 2016-12-20. PMID:25399704. |
recent findings demonstrated a reduction in meth-induced reward by oxytocin administration into the nucleus accumbens (nac) core. |
2016-12-20 |
2023-08-13 |
rat |
| In-Jee You, Sherie R Wright, Alvaro L Garcia-Garcia, Andrew R Tapper, Paul D Gardner, George F Koob, E David Leonardo, Laura M Bohn, Sunmee We. 5-HT1A Autoreceptors in the Dorsal Raphe Nucleus Convey Vulnerability to Compulsive Cocaine Seeking. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 5. 2016-12-14. PMID:26324408. |
in addition, using designer receptors exclusively activated by designer drugs (dreadds) technology, we found that stimulation of the serotonergic dorsal raphe nucleus (drn) afferents to the nucleus accumbens (nac) abolishes cocaine reward and promotes antidepressive-like behaviors. |
2016-12-14 |
2023-08-13 |
mouse |
| Petra Suchankova, Jörgen A Engel, Elisabet Jerlha. Sub-chronic Ghrelin Receptor Blockade Attenuates Alcohol- and Amphetamine-Induced Locomotor Stimulation in Mice. Alcohol and alcoholism (Oxford, Oxfordshire). vol 51. issue 2. 2016-12-13. PMID:26330568. |
the findings that ghrelin receptors (ghs-r1a) are expressed in reward-related areas, including the nucleus accumbens (nac) and ventral tegmental area (vta), suggest that ghrelin is a novel reward regulator. |
2016-12-13 |
2023-08-13 |
mouse |
| Elena H Chartoff, Shayla R Ebner, Angela Sparrow, David Potter, Phillip M Baker, Michael E Ragozzino, Mitchell F Roitma. Relative Timing Between Kappa Opioid Receptor Activation and Cocaine Determines the Impact on Reward and Dopamine Release. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 4. 2016-11-08. PMID:26239494. |
using intracranial self-stimulation and fast scan cyclic voltammetry, we found that cocaine-induced increases in brain stimulation reward and evoked dopamine release in the nac core were potentiated when cocaine was administered within 1 h of salva, but attenuated when administered 24 h after salva. |
2016-11-08 |
2023-08-13 |
rat |
| Jessica R Gugusheff, Sung Eun Bae, Alexandra Rao, Iain J Clarke, Lucilla Poston, Paul D Taylor, Clive W Coen, Beverly S Muhlhausle. Sex and age-dependent effects of a maternal junk food diet on the mu-opioid receptor in rat offspring. Behavioural brain research. vol 301. 2016-10-20. PMID:26718219. |
this study aimed to determine the impact of a maternal junk food (jf) diet on mu-opioid receptor (mur) expression and ligand binding in two key regions of the reward pathway, the nucleus accumbens (nac) and the ventral tegmental area (vta) in rats during the early suckling (postnatal day (pnd) 1 and 7) and late suckling/early post-weaning (pnd 21 and 28) periods. |
2016-10-20 |
2023-08-13 |
rat |
| Y Li, S Ge, N Li, L Chen, S Zhang, J Wang, H Wu, X Wang, X Wan. NMDA and dopamine D1 receptors within NAc-shell regulate IEG proteins expression in reward circuit during cocaine memory reconsolidation. Neuroscience. vol 315. 2016-10-19. PMID:26674058. |
we aimed to clarify the regulatory role of the nac in the cocaine memory reconsolidation process, by examining the effect of applying different pharmacological interventions to the nac on zif 268 and fos b expression in the entire reward circuit after cocaine memory reactivation. |
2016-10-19 |
2023-08-13 |
Not clear |
| Rhona B C Clarke, Bo Söderpalm, Amir Lotfi, Mia Ericson, Louise Adermar. Involvement of Inhibitory Receptors in Modulating Dopamine Signaling and Synaptic Activity Following Acute Ethanol Exposure in Striatal Subregions. Alcoholism, clinical and experimental research. vol 39. issue 12. 2016-10-06. PMID:26614538. |
alcohol acts on both inhibitory and excitatory receptor systems resulting in a net increase in dopamine output in the ventral striatum (nucleus accumbens [nac]), which is implicated in drug reward. |
2016-10-06 |
2023-08-13 |
Not clear |
| Mitra Heshmati, Sam A Golden, Madeline L Pfau, Daniel J Christoffel, Elena L Seeley, Michael E Cahill, Lena A Khibnik, Scott J Russ. Mefloquine in the nucleus accumbens promotes social avoidance and anxiety-like behavior in mice. Neuropharmacology. vol 101. 2016-10-05. PMID:26471420. |
direct infusion of mefloquine into the nucleus accumbens (nac), a key brain reward region, increased stress-induced social avoidance and anxiety behavior. |
2016-10-05 |
2023-08-13 |
mouse |
| Lauren N Beloate, Peyton W Weems, Graham R Casey, Ian C Webb, Lique M Coole. Nucleus accumbens NMDA receptor activation regulates amphetamine cross-sensitization and deltaFosB expression following sexual experience in male rats. Neuropharmacology. vol 101. 2016-09-22. PMID:26391065. |
moreover, sexual experience induces neural plasticity within the nucleus accumbens (nac), including induction of deltafosb, which plays a key role in amph reward cross-sensitization. |
2016-09-22 |
2023-08-13 |
rat |
| Lauren N Beloate, Peyton W Weems, Graham R Casey, Ian C Webb, Lique M Coole. Nucleus accumbens NMDA receptor activation regulates amphetamine cross-sensitization and deltaFosB expression following sexual experience in male rats. Neuropharmacology. vol 101. 2016-09-22. PMID:26391065. |
together, these results provide evidence that nac nmda receptor activation during sexual behavior plays a key role in mating-induced cfos and deltafosb expression and subsequent experience-induced cross-sensitization to amph reward. |
2016-09-22 |
2023-08-13 |
rat |
| Fatemeh Yazdi, Mahboubeh Jahangirvand, Amir-Hossein Pirasteh, Marzieh Moradi, Abbas Haghparas. Functional interaction between OX2 and CB1 receptors in the ventral tegmental area and the nucleus accumbens in response to place preference induced by chemical stimulation of the lateral hypothalamus. Pharmacology, biochemistry, and behavior. vol 139. issue Pt A. 2016-09-22. PMID:26494513. |
the findings of this study showed that the ox2 receptor has a critical role in modulating reward circuit in the vta and nac, when the lh was stimulated by carbachol. |
2016-09-22 |
2023-08-13 |
Not clear |
| Kia J Jackson, Pretal P Muldoon, Carrie Walters, Mohamad Imad Dama. Neuronal calcium/calmodulin-dependent protein kinase II mediates nicotine reward in the conditioned place preference test in mice. Behavioural pharmacology. vol 27. issue 1. 2016-09-19. PMID:26292186. |
the findings from this study show that camkii mediates nicotine reward and suggest that increases in camkii activity in the vta and nac are relevant to nicotine reward behaviors. |
2016-09-19 |
2023-08-13 |
mouse |
| Jen-Hau Yang, Ruey-Ming Lia. Dissociable contribution of nucleus accumbens and dorsolateral striatum to the acquisition of risk choice behavior in the rat. Neurobiology of learning and memory. vol 126. 2016-09-14. PMID:26551356. |
the pattern of choice behavior appeared in risk-seeking when p=0.5 to obtain 2 pellets, and was risk-averse when larger reward resulted in lower p. the nac lesion significantly disrupted the acquisition of the aforementioned risk choice behavior and apparently shifted the choice into a risk-averse style for all three reward ratios. |
2016-09-14 |
2023-08-13 |
rat |