| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jen-Hau Yang, Ruey-Ming Lia. Dissociable contribution of nucleus accumbens and dorsolateral striatum to the acquisition of risk choice behavior in the rat. Neurobiology of learning and memory. vol 126. 2016-09-14. PMID:26551356. |
neither the gross motor action nor the discrimination of different reward magnitudes was impaired by the lesions affecting either the nac or dls as assessed by an additional experiment. |
2016-09-14 |
2023-08-13 |
rat |
| Jen-Hau Yang, Ruey-Ming Lia. Dissociable contribution of nucleus accumbens and dorsolateral striatum to the acquisition of risk choice behavior in the rat. Neurobiology of learning and memory. vol 126. 2016-09-14. PMID:26551356. |
these findings suggest that firstly there is heterogeneity between nac and dls with respect to risk-based decision making, and that secondly the nac is involved and critical to the acquisition of behavioral choice under risk, specially when the expected value of the reward under the two choice options is equal. |
2016-09-14 |
2023-08-13 |
rat |
| Tara J Aitken, Venuz Y Greenfield, Kate M Wassu. Nucleus accumbens core dopamine signaling tracks the need-based motivational value of food-paired cues. Journal of neurochemistry. vol 136. issue 5. 2016-08-22. PMID:26715366. |
here, we used fast-scan cyclic voltammetry to monitor dopamine concentration changes in the nac core of rats during a pavlovian-to-instrumental transfer task in which the motivating influence of two cues, each signaling a distinct food reward (sucrose or food pellets), over an action earning a third unique food reward (polycose) was assessed in a state of hunger and of satiety. |
2016-08-22 |
2023-08-13 |
rat |
| Luna Prieto-Garcia, Emil Egecioglu, Erik Studer, Lars Westberg, Elisabet Jerlha. Ghrelin and GHS-R1A signaling within the ventral and laterodorsal tegmental area regulate sexual behavior in sexually naïve male mice. Psychoneuroendocrinology. vol 62. 2016-08-18. PMID:26398679. |
the ability of ghrelin to regulate reinforcement involves the cholinergic-dopaminergic reward link, which encompasses a cholinergic projection from the laterodorsal tegmental area (ldtg) to the ventral tegmental area (vta) together with mesolimbic dopaminergic projections from the vta to the nucleus accumbens (nac). |
2016-08-18 |
2023-08-13 |
mouse |
| HaoSheng Sun, Jennifer A Martin, Craig T Werner, Zi-Jun Wang, Diane M Damez-Werno, Kimberly N Scobie, Ning-Yi Shao, Caroline Dias, Jacqui Rabkin, Ja Wook Koo, Amy M Gancarz, Ezekiell A Mouzon, Rachael L Neve, Li Shen, David M Dietz, Eric J Nestle. BAZ1B in Nucleus Accumbens Regulates Reward-Related Behaviors in Response to Distinct Emotional Stimuli. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 14. 2016-08-15. PMID:27053203. |
here, we demonstrate that baz1b, an accessory subunit of the iswi family of chromatin remodeling complexes, is upregulated in the nucleus accumbens (nac), a key brain reward region, in both chronic cocaine-treated mice and mice that are resilient to chronic social defeat stress. |
2016-08-15 |
2023-08-13 |
mouse |
| HaoSheng Sun, Jennifer A Martin, Craig T Werner, Zi-Jun Wang, Diane M Damez-Werno, Kimberly N Scobie, Ning-Yi Shao, Caroline Dias, Jacqui Rabkin, Ja Wook Koo, Amy M Gancarz, Ezekiell A Mouzon, Rachael L Neve, Li Shen, David M Dietz, Eric J Nestle. BAZ1B in Nucleus Accumbens Regulates Reward-Related Behaviors in Response to Distinct Emotional Stimuli. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 14. 2016-08-15. PMID:27053203. |
together, these findings suggest important roles for baz1b and its associated chromatin remodeling complexes in nac in the regulation of reward behaviors to distinct emotional stimuli and highlight the stimulus-specific nature of the actions of these regulatory proteins. |
2016-08-15 |
2023-08-13 |
mouse |
| Masroor Shariff, Maryka Quik, Joan Holgate, Michael Morgan, Omkar L Patkar, Vincent Tam, Arnauld Belmer, Selena E Bartlet. Neuronal Nicotinic Acetylcholine Receptor Modulators Reduce Sugar Intake. PloS one. vol 11. issue 3. 2016-08-08. PMID:27028298. |
interestingly, increased sugar consumption has been shown to repeatedly elevate dopamine levels in the nucleus accumbens (nac), in the mesolimbic reward pathway of the brain similar to many drugs of abuse. |
2016-08-08 |
2023-08-13 |
Not clear |
| D Y Sakae, F Marti, S Lecca, F Vorspan, E Martín-García, L J Morel, A Henrion, J Gutiérrez-Cuesta, A Besnard, N Heck, E Herzog, S Bolte, V F Prado, M A M Prado, F Bellivier, C B Eap, S Crettol, P Vanhoutte, J Caboche, A Gratton, L Moquin, B Giros, R Maldonado, S Daumas, M Mameli, S Jamain, S El Mestikaw. The absence of VGLUT3 predisposes to cocaine abuse by increasing dopamine and glutamate signaling in the nucleus accumbens. Molecular psychiatry. vol 20. issue 11. 2016-08-02. PMID:26239290. |
tonically active cholinergic interneurons (tans) from the nucleus accumbens (nac) are centrally involved in reward behavior. |
2016-08-02 |
2023-08-13 |
mouse |
| Maggie C Evans, Vincent W Clark, Patrick J Manning, Dirk De Ridder, John N J Reynold. Optimizing Deep Brain Stimulation of the Nucleus Accumbens in a Reward Preference Rat Model. Neuromodulation : journal of the International Neuromodulation Society. vol 18. issue 7. 2016-07-27. PMID:26268572. |
as a first step, we used a rat model of nucleus accumbens (nac) dbs to rigorously compare the relative reward values of different stimulation paradigms. |
2016-07-27 |
2023-08-13 |
rat |
| Xi Chen, Xin Shu, Zhu-Kai Cong, Zheng-Yao Jiang, Hong Jian. Nesfatin-1 acts on the dopaminergic reward pathway to inhibit food intake. Neuropeptides. vol 53. 2016-07-22. PMID:26299312. |
recently, nesfatin-1 expression was also reported in the nucleus accumbens (nac), amygdaloid nucleus and insular cortex of mice, areas that are related to the control of reward behavior. |
2016-07-22 |
2023-08-13 |
mouse |
| Xi Chen, Xin Shu, Zhu-Kai Cong, Zheng-Yao Jiang, Hong Jian. Nesfatin-1 acts on the dopaminergic reward pathway to inhibit food intake. Neuropeptides. vol 53. 2016-07-22. PMID:26299312. |
using electrophysiology and electrochemical and behavioral tests, we investigated the effect of nesfatin-1 on the dopaminergic reward pathway between the ventral tegmental area (vta) and the nac. |
2016-07-22 |
2023-08-13 |
mouse |
| Eric J Nestle. Role of the Brain's Reward Circuitry in Depression: Transcriptional Mechanisms. International review of neurobiology. vol 124. 2016-07-18. PMID:26472529. |
here we focus on the nucleus accumbens (nac), a critical component of the brain's reward circuitry, in depression and other stress-related disorders. |
2016-07-18 |
2023-08-13 |
Not clear |
| Michael E Cahill, Rosemary C Bagot, Amy M Gancarz, Deena M Walker, HaoSheng Sun, Zi-Jun Wang, Elizabeth A Heller, Jian Feng, Pamela J Kennedy, Ja Wook Koo, Hannah M Cates, Rachael L Neve, Li Shen, David M Dietz, Eric J Nestle. Bidirectional Synaptic Structural Plasticity after Chronic Cocaine Administration Occurs through Rap1 Small GTPase Signaling. Neuron. vol 89. issue 3. 2016-06-28. PMID:26844834. |
dendritic spines are the sites of most excitatory synapses in the cns, and opposing alterations in the synaptic structure of medium spiny neurons (msns) of the nucleus accumbens (nac), a primary brain reward region, are seen at early versus late time points after cocaine administration. |
2016-06-28 |
2023-08-13 |
Not clear |
| Michael E Cahill, Rosemary C Bagot, Amy M Gancarz, Deena M Walker, HaoSheng Sun, Zi-Jun Wang, Elizabeth A Heller, Jian Feng, Pamela J Kennedy, Ja Wook Koo, Hannah M Cates, Rachael L Neve, Li Shen, David M Dietz, Eric J Nestle. Bidirectional Synaptic Structural Plasticity after Chronic Cocaine Administration Occurs through Rap1 Small GTPase Signaling. Neuron. vol 89. issue 3. 2016-06-28. PMID:26844834. |
here we investigate the time-dependent molecular and biochemical processes that regulate this bidirectional synaptic structural plasticity of nac msns and associated changes in cocaine reward in response to chronic cocaine exposure. |
2016-06-28 |
2023-08-13 |
Not clear |
| Michael E Cahill, Rosemary C Bagot, Amy M Gancarz, Deena M Walker, HaoSheng Sun, Zi-Jun Wang, Elizabeth A Heller, Jian Feng, Pamela J Kennedy, Ja Wook Koo, Hannah M Cates, Rachael L Neve, Li Shen, David M Dietz, Eric J Nestle. Bidirectional Synaptic Structural Plasticity after Chronic Cocaine Administration Occurs through Rap1 Small GTPase Signaling. Neuron. vol 89. issue 3. 2016-06-28. PMID:26844834. |
collectively, these findings provide a precise mechanism by which nuclear to synaptic interactions induce "metaplasticity" in nac msns, and we reveal the specific effects of this plasticity on reward behavior in a brain circuit-specific manner. |
2016-06-28 |
2023-08-13 |
Not clear |
| Bethany Remeniuk, Devki Sukhtankar, Alec Okun, Edita Navratilova, Jennifer Y Xie, Tamara King, Frank Porrec. Behavioral and neurochemical analysis of ongoing bone cancer pain in rats. Pain. vol 156. issue 10. 2016-06-27. PMID:25955964. |
the possibility that this increased nac da release reflected the reward of pain relief was tested by irreversible blockade of rostral anterior cingulate cortex (racc) μ-opioid receptors (mors). |
2016-06-27 |
2023-08-13 |
rat |
| Eduardo Prado, Michael Maes, Luiz Gustavo Piccoli, Marcela Baracat, Décio Sabattini Barbosa, Olavo Franco, Seetal Dodd, Michael Berk, Sandra Odebrecht Vargas Nune. N-acetylcysteine for therapy-resistant tobacco use disorder: a pilot study. Redox report : communications in free radical research. vol 20. issue 5. 2016-05-27. PMID:25729878. |
n-acetylcysteine (nac) may have efficacy in treating tobacco use disorder (tud) by reducing craving and smoking reward. |
2016-05-27 |
2023-08-13 |
Not clear |
| C Biesdorf, A-L Wang, B Topic, D Petri, H Milani, J P Huston, M A de Souza Silv. Dopamine in the nucleus accumbens core, but not shell, increases during signaled food reward and decreases during delayed extinction. Neurobiology of learning and memory. vol 123. 2016-05-26. PMID:26071677. |
here we examined the release of da in the nac during delivery of reward (food) and during extinction of food reward in the freely moving animal by use of in vivo microdialysis and hplc. |
2016-05-26 |
2023-08-13 |
rat |
| C Biesdorf, A-L Wang, B Topic, D Petri, H Milani, J P Huston, M A de Souza Silv. Dopamine in the nucleus accumbens core, but not shell, increases during signaled food reward and decreases during delayed extinction. Neurobiology of learning and memory. vol 123. 2016-05-26. PMID:26071677. |
1: (a) during a 20-min period of cued reward delivery, da increased significantly in the nac core, but not shell subregion; (b) for the next 60min period half of the rats underwent immediate extinction (with the cs light presented during non-reward) and the other half did not undergo extinction to the cue lights (cs was not presented during non-reward). |
2016-05-26 |
2023-08-13 |
rat |
| C Biesdorf, A-L Wang, B Topic, D Petri, H Milani, J P Huston, M A de Souza Silv. Dopamine in the nucleus accumbens core, but not shell, increases during signaled food reward and decreases during delayed extinction. Neurobiology of learning and memory. vol 123. 2016-05-26. PMID:26071677. |
1, during a 30-min period of cued reward delivery, da levels again increased significantly in the nac core but not in the nac shell. |
2016-05-26 |
2023-08-13 |
rat |