| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuan-Hao Chen, Eagle Yi-Kung Huang, Tung-Tai Kuo, Barry J Hoffer, Jonathan Miller, Yu-Ching Chou, Yung-Hsiao Chian. Dopamine release in the nucleus accumbens is altered following traumatic brain injury. Neuroscience. vol 348. 2017-09-26. PMID:28196657. |
mild-to-severe traumatic brain injury (tbi) is frequently associated with prolonged dysfunction of reward circuitry, including motivation and salience, which suggests alterations of dopamine (da) processing within the core and shell of the nucleus accumbens (nac). |
2017-09-26 |
2023-08-13 |
Not clear |
| Ryan W Eaton, Tyler Libey, Eberhard E Fet. Operant conditioning of neural activity in freely behaving monkeys with intracranial reinforcement. Journal of neurophysiology. vol 117. issue 3. 2017-09-13. PMID:28031396. |
to reward cell activity in unconstrained primates, we sought sites in nucleus accumbens (nac) whose stimulation reinforced operant responding. |
2017-09-13 |
2023-08-13 |
monkey |
| Anne L Collins, Tara J Aitken, Venuz Y Greenfield, Sean B Ostlund, Kate M Wassu. Nucleus Accumbens Acetylcholine Receptors Modulate Dopamine and Motivation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 12. 2017-09-11. PMID:27240658. |
disruption of nac muscarinic acetylcholine receptor activity attenuated, whereas blockade of nicotinic receptors augmented cue-induced invigoration of reward seeking. |
2017-09-11 |
2023-08-13 |
Not clear |
| Candace R Lewis, Ryan M Bastle, Tawny B Manning, Sarah M Himes, Paulette Fennig, Phoebe R Conrad, Jenna Colwell, Broc A Pagni, Lyndsay A Hess, Caitlin G Matekel, Jason M Newbern, M Foster Oliv. Interactions between Early Life Stress, Nucleus Accumbens MeCP2 Expression, and Methamphetamine Self-Administration in Male Rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 12. 2017-09-11. PMID:27312406. |
in addition, we show new evidence that both els and methamphetamine sa alter the expression of the epigenetic regulator methyl cpg-binding protein 2 (mecp2) in key brain reward regions, particularly in the nucleus accumbens (nac) core. |
2017-09-11 |
2023-08-13 |
rat |
| Liang Gong, Yingying Yin, Cancan He, Qing Ye, Feng Bai, Yonggui Yuan, Haisan Zhang, Luxian Lv, Hongxing Zhang, Chunming Xie, Zhijun Zhan. Disrupted reward circuits is associated with cognitive deficits and depression severity in major depressive disorder. Journal of psychiatric research. vol 84. 2017-09-11. PMID:27673704. |
the bilateral nucleus accumbens (nac) were selected as seeds to construct reward circuits across all subjects. |
2017-09-11 |
2023-08-13 |
human |
| Zachary V Johnson, Hasse Walum, Yao Xiao, Paula C Riefkohl, Larry J Youn. Oxytocin receptors modulate a social salience neural network in male prairie voles. Hormones and behavior. vol 87. 2017-09-07. PMID:27793769. |
in voles, otr density in the nucleus accumbens (nac)-a region important for social and reward learning-is associated with individual and species variation in social attachment behavior. |
2017-09-07 |
2023-08-13 |
Not clear |
| Christina K Kim, Li Ye, Joshua H Jennings, Nandini Pichamoorthy, Daniel D Tang, Ai-Chi W Yoo, Charu Ramakrishnan, Karl Deisserot. Molecular and Circuit-Dynamical Identification of Top-Down Neural Mechanisms for Restraint of Reward Seeking. Cell. vol 170. issue 5. 2017-09-01. PMID:28823561. |
here, we show that a specific subset of superficial mpfc projections to a subfield of nucleus accumbens (nac) neurons naturally encodes the decision to initiate or suppress reward seeking when faced with risk of punishment. |
2017-09-01 |
2023-08-13 |
Not clear |
| Shuntaro Kohnomi, Katsuko Ebihara, Masayuki Kobayash. Suppressive regulation of lateral inhibition between medium spiny neurons via dopamine D Neuroscience letters. vol 636. 2017-08-24. PMID:27793700. |
suppressive regulation of lateral inhibition between medium spiny neurons via dopamine d the nucleus accumbens (nac) shell is closely associated with reward, psychiatric disorders (depression or schizophrenia), and drug abuse. |
2017-08-24 |
2023-08-13 |
Not clear |
| Qiwen Hu, Eun Ji Kim, Jian Feng, Gregory R Grant, Elizabeth A Helle. Histone posttranslational modifications predict specific alternative exon subtypes in mammalian brain. PLoS computational biology. vol 13. issue 6. 2017-08-18. PMID:28609483. |
to address this, we have developed novel computational approaches to model the association between alternative splicing and histone posttranslational modifications in the nucleus accumbens (nac), a brain reward region. |
2017-08-18 |
2023-08-13 |
mouse |
| Ja Wook Koo, Benoit Labonté, Olivia Engmann, Erin S Calipari, Barbara Juarez, Zachary Lorsch, Jessica J Walsh, Allyson K Friedman, Jordan T Yorgason, Ming-Hu Han, Eric J Nestle. Essential Role of Mesolimbic Brain-Derived Neurotrophic Factor in Chronic Social Stress-Induced Depressive Behaviors. Biological psychiatry. vol 80. issue 6. 2017-08-11. PMID:26858215. |
these findings are paradoxical, as increased da signaling in nac normally promotes motivation and reward, and the influence of chronic phasic vta firing in the face of chronic stress is unknown. |
2017-08-11 |
2023-08-13 |
mouse |
| Paula A Gajewski, Gustavo Turecki, Alfred J Robiso. Differential Expression of FosB Proteins and Potential Target Genes in Select Brain Regions of Addiction and Depression Patients. PloS one. vol 11. issue 8. 2017-07-31. PMID:27494187. |
the transcription factor Δfosb is induced in the prefrontal cortex (pfc) and hippocampus (hpc) of rodents in response to stress or cocaine, and its expression in these regions is thought to regulate their "top down" control of reward circuitry, including the nucleus accumbens (nac). |
2017-07-31 |
2023-08-13 |
human |
| Jianbo Zhang, Na Wang, Bo Chen, Yi'nan Wang, Jing He, Xintong Cai, Hongbo Zhang, Shuguang Wei, Shengbin L. Blockade of Cannabinoid CB1 receptor attenuates the acquisition of morphine-induced conditioned place preference along with a downregulation of ERK, CREB phosphorylation, and BDNF expression in the nucleus accumbens and hippocampus. Neuroscience letters. vol 630. 2017-07-26. PMID:27461790. |
in the present study, we investigated the relationship between cb1r and the extracellular signal-regulated kinase (erk), camp response element-binding protein (creb), brain-derived neurotrophic factor (bdnf) signaling in the nucleus accumbens (nac) and hippocampus in morphine-induced conditioned place preference (cpp), which is used to assess the morphine-induced reward memory. |
2017-07-26 |
2023-08-13 |
mouse |
| Luis Prado, Jorge Luis-Islas, Osvaldo I Sandoval, Liliana Puron, Moreno M Gil, Alvaro Luna, Mario A Arias-García, Elvira Galarraga, Sidney A Simon, Ranier Gutierre. Activation of Glutamatergic Fibers in the Anterior NAc Shell Modulates Reward Activity in the aNAcSh, the Lateral Hypothalamus, and Medial Prefrontal Cortex and Transiently Stops Feeding. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 50. 2017-07-24. PMID:27974611. |
activation of glutamatergic fibers in the anterior nac shell modulates reward activity in the anacsh, the lateral hypothalamus, and medial prefrontal cortex and transiently stops feeding. |
2017-07-24 |
2023-08-13 |
mouse |
| Daniel Vallöf, Jesper Vestlund, Jörgen A Engel, Elisabet Jerlha. The Anorexigenic Peptide Neuromedin U (NMU) Attenuates Amphetamine-Induced Locomotor Stimulation, Accumbal Dopamine Release and Expression of Conditioned Place Preference in Mice. PloS one. vol 11. issue 5. 2017-07-19. PMID:27139195. |
this reward link consists of a dopamine projection from the ventral tegmental area to the nucleus accumbens (nac) suggesting that these brain areas are important for reward. |
2017-07-19 |
2023-08-13 |
mouse |
| Hee-Dae Kim, Jennifer Hesterman, Tanessa Call, Samantha Magazu, Elizabeth Keeley, Kristyna Armenta, Hope Kronman, Rachael L Neve, Eric J Nestler, Deveroux Ferguso. SIRT1 Mediates Depression-Like Behaviors in the Nucleus Accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 32. 2017-07-14. PMID:27511015. |
in the present study, we show that chronic social defeat stress, an ethologically validated model of depression in mice, increases sirt1 levels in the nucleus accumbens (nac), a key brain reward region. |
2017-07-14 |
2023-08-13 |
mouse |
| Eric J Nestle. Reflections on: "A general role for adaptations in G-Proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function". Brain research. vol 1645. 2017-07-13. PMID:26740398. |
we thus extended our hypothesis to suggest that, particularly within brain reward regions such as nac, camp pathway upregulation represents a common mechanism of reward tolerance and dependence shared by several classes of drugs of abuse. |
2017-07-13 |
2023-08-13 |
rat |
| Eric J Nestle. Reflections on: "A general role for adaptations in G-Proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function". Brain research. vol 1645. 2017-07-13. PMID:26740398. |
in certain brain regions, such as locus coeruleus, these adaptations mediate aspects of physical opiate dependence and withdrawal, whereas in nac they mediate reward tolerance and dependence that drives increased drug self-administration. |
2017-07-13 |
2023-08-13 |
rat |
| Jocelyn M Richard, Howard L Field. Mu-opioid receptor activation in the medial shell of nucleus accumbens promotes alcohol consumption, self-administration and cue-induced reinstatement. Neuropharmacology. vol 108. 2017-07-07. PMID:27089981. |
mu-opioid receptor activation in the medial shell of the nucleus accumbens (nac), a region implicated in multiple aspects of reward processing, elevates alcohol consumption while nac opioid antagonists reduce it. |
2017-07-07 |
2023-08-13 |
rat |
| Catarina Owesson-White, Anna M Belle, Natalie R Herr, Jessica L Peele, Preethi Gowrishankar, Regina M Carelli, R Mark Wightma. Cue-Evoked Dopamine Release Rapidly Modulates D2 Neurons in the Nucleus Accumbens During Motivated Behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 22. 2017-07-06. PMID:27251622. |
dopaminergic neurons that project from the ventral tegmental area (vta) to the nucleus accumbens (nac) fire in response to unpredicted rewards or to cues that predict reward delivery. |
2017-07-06 |
2023-08-13 |
rat |
| Catarina Owesson-White, Anna M Belle, Natalie R Herr, Jessica L Peele, Preethi Gowrishankar, Regina M Carelli, R Mark Wightma. Cue-Evoked Dopamine Release Rapidly Modulates D2 Neurons in the Nucleus Accumbens During Motivated Behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 22. 2017-07-06. PMID:27251622. |
these results demonstrate for the first time that dopamine-mediated responses after cues that predict reward availability are specifically linked to its actions at a subset of neurons in the nac containing d2rs. |
2017-07-06 |
2023-08-13 |
rat |