| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jia Liu, Karen Dietz, Georgia E Hodes, Scott J Russo, Patrizia Casacci. Widespread transcriptional alternations in oligodendrocytes in the adult mouse brain following chronic stress. Developmental neurobiology. vol 78. issue 2. 2018-10-09. PMID:28884925. |
in concert with these behavioral responses, transcriptional analysis of pfc, and nucleus accumbens (nac)-a brain region critical for reward response-revealed downregulation of transcripts encoding for myelin genes and oligodendrocyte-specific genes. |
2018-10-09 |
2023-08-13 |
mouse |
| Peter J Vollbrecht, Kathryn M Nesbitt, Omar S Mabrouk, Aaron M Chadderdon, Emily M Jutkiewicz, Robert T Kennedy, Carrie R Ferrari. Cocaine and desipramine elicit distinct striatal noradrenergic and behavioral responses in selectively bred obesity-resistant and obesity-prone rats. Behavioural brain research. vol 346. 2018-09-11. PMID:29129597. |
differences in the function of brain reward circuits, including in the nucleus accumbens (nac), have been shown in obesity-prone vs. obesity-resistant populations, leading many researchers to explore the role of striatal dopamine in obesity. |
2018-09-11 |
2023-08-13 |
rat |
| Marjan Sahafzadeh, Saeideh Karimi-Haghighi, Zahra Mousavi, Abbas Haghparas. Role of the orexin receptors within the nucleus accumbens in the drug priming-induced reinstatement of morphine seeking in the food deprived rats. Brain research bulletin. vol 137. 2018-08-31. PMID:29258865. |
the nucleus accumbens (nac) has an important role in the reward system and receives orexinergic projections of the lateral hypothalamus. |
2018-08-31 |
2023-08-13 |
rat |
| Ronny N Gentry, Brian Lee, Matthew R Roesc. Phasic dopamine release in the rat nucleus accumbens predicts approach and avoidance performance. Nature communications. vol 7. 2018-08-27. PMID:27786172. |
using a combined approach-avoidance task, we measured phasic da release in the nucleus accumbens (nac) of rats during presentation of cues that predicted reward, punishment or neutral outcomes and investigated individual differences based on avoidance performance. |
2018-08-27 |
2023-08-13 |
rat |
| Catherine C Steele, Jennifer R Peterson, Andrew T Marshall, Sarah L Stuebing, Kimberly Kirkpatric. Nucleus accumbens core lesions induce sub-optimal choice and reduce sensitivity to magnitude and delay in impulsive choice tasks. Behavioural brain research. vol 339. 2018-08-07. PMID:29146281. |
the nucleus accumbens core (nac) has long been recognized as an important contributor to the computation of reward value that is critical for impulsive choice behavior. |
2018-08-07 |
2023-08-13 |
rat |
| Catherine C Steele, Jennifer R Peterson, Andrew T Marshall, Sarah L Stuebing, Kimberly Kirkpatric. Nucleus accumbens core lesions induce sub-optimal choice and reduce sensitivity to magnitude and delay in impulsive choice tasks. Behavioural brain research. vol 339. 2018-08-07. PMID:29146281. |
nac lesions, in comparison to sham control lesions, produced suboptimal preferences that resulted in lower reward earning rates, and led to reduced sensitivity to magnitude and delay within the impulsive choice task. |
2018-08-07 |
2023-08-13 |
rat |
| Aimilia Lydia Kalafateli, Daniel Vallöf, Julia Winsa Jörnulf, Markus Heilig, Elisabet Jerlha. A cannabinoid receptor antagonist attenuates ghrelin-induced activation of the mesolimbic dopamine system in mice. Physiology & behavior. vol 184. 2018-08-01. PMID:29221808. |
reward modulation involves the mesolimbic dopamine system, consisting of the ventral tegmental area (vta) dopamine neurons targeting nucleus accumbens (nac), a system that ghrelin activates through vta-dependent mechanisms. |
2018-08-01 |
2023-08-13 |
mouse |
| J M Wenzel, J F Chee. Endocannabinoid Regulation of Reward and Reinforcement through Interaction with Dopamine and Endogenous Opioid Signaling. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 1. 2018-07-26. PMID:28653666. |
ecbs and their receptors functionally interact with opioid systems within the nac to support reward, most likely through augmenting da release. |
2018-07-26 |
2023-08-13 |
human |
| Xiao Han, Man-Yi Jing, Tai-Yun Zhao, Ning Wu, Rui Song, Jin L. Role of dopamine projections from ventral tegmental area to nucleus accumbens and medial prefrontal cortex in reinforcement behaviors assessed using optogenetic manipulation. Metabolic brain disease. vol 32. issue 5. 2018-07-23. PMID:28523568. |
taken together, excitation of the projection into the nac core, nac shell and il elicited positive behavior during reward. |
2018-07-23 |
2023-08-13 |
mouse |
| Kejing Yuan, Huan Sheng, Jiaojiao Song, Li Yang, Dongyang Cui, Qianqian Ma, Wen Zhang, Bin Lai, Ming Chen, Ping Zhen. Morphine treatment enhances glutamatergic input onto neurons of the nucleus accumbens via both disinhibitory and stimulating effect. Addiction biology. vol 22. issue 6. 2018-07-16. PMID:27549902. |
the nucleus accumbens (nac) is an important site where morphine treatment produces its reinforcing effect on reward. |
2018-07-16 |
2023-08-13 |
Not clear |
| Kejing Yuan, Huan Sheng, Jiaojiao Song, Li Yang, Dongyang Cui, Qianqian Ma, Wen Zhang, Bin Lai, Ming Chen, Ping Zhen. Morphine treatment enhances glutamatergic input onto neurons of the nucleus accumbens via both disinhibitory and stimulating effect. Addiction biology. vol 22. issue 6. 2018-07-16. PMID:27549902. |
however, how morphine treatment produces its reinforcing effect on reward in the nac remains to be clarified. |
2018-07-16 |
2023-08-13 |
Not clear |
| Chayaporn Reakkamnuan, Dania Cheaha, Ekkasit Kumarnsi. Nucleus accumbens local field potential power spectrums, phase-amplitude couplings and coherences following morphine treatment. Acta neurobiologiae experimentalis. vol 77. issue 3. 2018-07-06. PMID:29182612. |
however, neural signaling in the nucleus accumbens (nac) that might clarify reward process remained to be investigated. |
2018-07-06 |
2023-08-13 |
mouse |
| Ali Siahposht-Khachaki, Somayeh Ezzatpanah, Yasaman Razavi, Abbas Haghparas. NMDA receptor dependent changes in c-fos and p-CREB signaling following extinction and reinstatement of morphine place preference. Neuroscience letters. vol 662. 2018-06-29. PMID:29054430. |
neural circuitry comprising the ventral tegmental area, nucleus accumbens (nac), prefrontal cortex (pfc) and hippocampus (hip) has a main role in reward phenomena. |
2018-06-29 |
2023-08-13 |
rat |
| Hossein Khaleghzadeh-Ahangar, Abbas Haghparas. Intra-accumbal Cannabinoid Agonist Attenuated Reinstatement but not Extinction Period of Morphine-Induced Conditioned Place Preference; Evidence for Different Characteristics of Extinction Period and Reinstatement. Neurochemical research. vol 42. issue 11. 2018-06-26. PMID:28780734. |
the brain reward system consists of the ventral tegmental area that sends its dopaminergic projections to the forebrain, cortical areas, amygdala and largely to the nucleus accumbens (nac). |
2018-06-26 |
2023-08-13 |
rat |
| Sara E Morrison, Vincent B McGinty, Johann du Hoffmann, Saleem M Nicol. Limbic-motor integration by neural excitations and inhibitions in the nucleus accumbens. Journal of neurophysiology. vol 118. issue 5. 2018-06-19. PMID:28794196. |
however, there is little direct evidence that the signaling of individual nac neurons combines information about predicted reward and behavioral response. |
2018-06-19 |
2023-08-13 |
rat |
| Sara E Morrison, Vincent B McGinty, Johann du Hoffmann, Saleem M Nicol. Limbic-motor integration by neural excitations and inhibitions in the nucleus accumbens. Journal of neurophysiology. vol 118. issue 5. 2018-06-19. PMID:28794196. |
notably, there are important limits to the ability of nac neurons to integrate motivational information into behavior: in particular, updating of predicted reward value appears to occur on a relatively long timescale, since nac neurons fail to discriminate between cues with reward associations that change frequently. |
2018-06-19 |
2023-08-13 |
rat |
| Hui Ye, Jingxin Wang, Zichuan Tian, Fengfei Ma, James Dowell, Quentin Bremer, Gaoyuan Lu, Brian Baldo, Lingjun L. Quantitative Mass Spectrometry Reveals Food Intake-Induced Neuropeptide Level Changes in Rat Brain: Functional Assessment of Selected Neuropeptides as Feeding Regulators. Molecular & cellular proteomics : MCP. vol 16. issue 11. 2018-06-19. PMID:28864778. |
previous work has shown that neuropeptide gene expression levels in a forebrain reward site, the nucleus accumbens (nac), were changed by feeding. |
2018-06-19 |
2023-08-13 |
rat |
| Zahra Fatahi, Bahman Sadeghi, Abbas Haghparas. Involvement of cannabinoid system in the nucleus accumbens on delay-based decision making in the rat. Behavioural brain research. vol 337. 2018-06-08. PMID:28987618. |
the nucleus accumbens (nac) plays a fundamental role in decision making and anticipation of reward. |
2018-06-08 |
2023-08-13 |
rat |
| Hyeran Jang, Kanghoon Jung, Jaehoon Jeong, Sang Ki Park, Jerald D Kralik, Jaeseung Jeon. Nucleus accumbens shell moderates preference bias during voluntary choice behavior. Social cognitive and affective neuroscience. vol 12. issue 9. 2018-05-24. PMID:28992274. |
the nucleus accumbens (nac) shell lies anatomically at a critical intersection within the brain's reward system circuitry, however, its role in voluntary choice behavior remains unclear. |
2018-05-24 |
2023-08-13 |
rat |
| Tasha Ahmad, Ninglei Sun, Danika Lyons, Steven R Laviolett. Bi-directional cannabinoid signalling in the basolateral amygdala controls rewarding and aversive emotional processing via functional regulation of the nucleus accumbens. Addiction biology. vol 22. issue 5. 2018-05-16. PMID:27230434. |
next, using targeted microinfusions of an nmda receptor antagonist to either the core or shell (nash) subdivisions of the nac, we found that selective blockade of nmda transmission in the na shell, but not core, prevented both intra-bla cb1 blockade-mediated opiate reward potentiation and cb1 activation-mediated aversion effects. |
2018-05-16 |
2023-08-13 |
rat |