| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amanda C Burton, Gregory B Bissonette, Daniela Vazquez, Elyse M Blume, Maria Donnelly, Kendall C Heatley, Abhishek Hinduja, Matthew R Roesc. Previous cocaine self-administration disrupts reward expectancy encoding in ventral striatum. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 12. 2019-03-11. PMID:29728645. |
although nac is one of the first brain regions to be affected by drugs of abuse, we still do not know how neural correlates related to reward expectancy are affected by previous cocaine self-administration. |
2019-03-11 |
2023-08-13 |
rat |
| Amanda C Burton, Gregory B Bissonette, Daniela Vazquez, Elyse M Blume, Maria Donnelly, Kendall C Heatley, Abhishek Hinduja, Matthew R Roesc. Previous cocaine self-administration disrupts reward expectancy encoding in ventral striatum. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 12. 2019-03-11. PMID:29728645. |
further, compared to controls, cocaine-exposed rats showed significantly fewer neurons in the nac that were responsive during odor cues and reward delivery, and in the reward-responsive neurons that remained, diminished directional and value encoding was observed. |
2019-03-11 |
2023-08-13 |
rat |
| Mahsaneh Vatankhah, Saeideh Karimi-Haghighi, Abdolrahman Sarihi, Abbas Haghparas. Intra-accumbal administration of AMN082, a metabotropic glutamate receptor type 7 allosteric agonist, inhibits the acquisition but not the expression of morphine-induced conditioned place preference in rats. Neuroscience letters. vol 681. 2019-03-11. PMID:29800675. |
the nucleus accumbens (nac) plays a primary role in opioid reward. |
2019-03-11 |
2023-08-13 |
rat |
| Mahsaneh Vatankhah, Saeideh Karimi-Haghighi, Abdolrahman Sarihi, Abbas Haghparas. Intra-accumbal administration of AMN082, a metabotropic glutamate receptor type 7 allosteric agonist, inhibits the acquisition but not the expression of morphine-induced conditioned place preference in rats. Neuroscience letters. vol 681. 2019-03-11. PMID:29800675. |
previous documents have shown the extensive distributions of the different types of mglurs, including mglur7, in regions that are involved in opioid reward, such as the nac. |
2019-03-11 |
2023-08-13 |
rat |
| Ethan M Anderson, Erin B Larson, Daniel Guzman, Anne Marie Wissman, Rachael L Neve, Eric J Nestler, David W Sel. Overexpression of the Histone Dimethyltransferase G9a in Nucleus Accumbens Shell Increases Cocaine Self-Administration, Stress-Induced Reinstatement, and Anxiety. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 4. 2019-03-07. PMID:29217682. |
this reduction in g9a may enhance cocaine reward because overexpressing g9a in the nac decreases cocaine-conditioned place preference. |
2019-03-07 |
2023-08-13 |
rat |
| S Mohammad Ahmadi Soleimani, Mohammad Hossein Mohamadi M A H, Mohammad Reza Raoufy, Hossein Azizi, Mohammad Nasehi, Mohammad Reza Zarrindas. Acute morphine administration alters the power of local field potentials in mesolimbic pathway of freely moving rats: Involvement of dopamine receptors. Neuroscience letters. vol 686. 2019-03-07. PMID:30219483. |
increasing number of evidence support the role of ventral tegmental area (vta) and nucleus accumbens (nac) in mediating the opiate effects as the two critical components of brain reward pathway. |
2019-03-07 |
2023-08-13 |
rat |
| R M Bastle, R J Oliver, A S Gardiner, N S Pentkowski, F Bolognani, A M Allan, T Chaudhury, M St Peter, N Galles, C Smith, J L Neisewander, N I Perrone-Bizzozer. In silico identification and in vivo validation of miR-495 as a novel regulator of motivation for cocaine that targets multiple addiction-related networks in the nucleus accumbens. Molecular psychiatry. vol 23. issue 2. 2019-02-15. PMID:28044061. |
this small non-coding rna is also highly expressed within the nucleus accumbens (nac), a pivotal brain region underlying reward and motivation. |
2019-02-15 |
2023-08-13 |
mouse |
| Jimmie M Gmaz, James E Carmichael, Matthijs Aa van der Mee. Persistent coding of outcome-predictive cue features in the rat nucleus accumbens. eLife. vol 7. 2019-01-29. PMID:30234485. |
nac encodes outcome-related cue features such as the magnitude and identity of reward. |
2019-01-29 |
2023-08-13 |
rat |
| Ashley M Kopec, Caroline J Smith, Nathan R Ayre, Sean C Sweat, Staci D Bilb. Microglial dopamine receptor elimination defines sex-specific nucleus accumbens development and social behavior in adolescent rats. Nature communications. vol 9. issue 1. 2019-01-16. PMID:30254300. |
adolescence is a developmental period in which the mesolimbic dopaminergic "reward" circuitry of the brain, including the nucleus accumbens (nac), undergoes significant plasticity. |
2019-01-16 |
2023-08-13 |
rat |
| Yuanzhong Kai, Yanhua Li, Tingting Sun, Weiwei Yin, Yu Mao, Jie Li, Wen Xie, Shi Chen, Likui Wang, Juan Li, Zhi Zhang, Wenjuan Ta. A medial prefrontal cortex-nucleus acumens corticotropin-releasing factor circuitry for neuropathic pain-increased susceptibility to opioid reward. Translational psychiatry. vol 8. issue 1. 2019-01-09. PMID:29780165. |
taken together, these findings demonstrate a previously unknown and specific mpfc crf engagement of nac neuronal circuits, the sensitization of which facilitates behavioral responses to morphine reward in neuropathic pain states via crfr1s. |
2019-01-09 |
2023-08-13 |
mouse |
| David Ottenheimer, Jocelyn M Richard, Patricia H Jana. Ventral pallidum encodes relative reward value earlier and more robustly than nucleus accumbens. Nature communications. vol 9. issue 1. 2019-01-08. PMID:30341305. |
this reward-specific firing in vp is present in a greater proportion of the population and arises sooner following reward delivery than in nac. |
2019-01-08 |
2023-08-13 |
rat |
| Efrain A Ribeiro, Marine Salery, Joseph R Scarpa, Erin S Calipari, Peter J Hamilton, Stacy M Ku, Hope Kronman, Immanuel Purushothaman, Barbara Juarez, Mitra Heshmati, Marie Doyle, Casey Lardner, Dominicka Burek, Ana Strat, Stephen Pirpinias, Ezekiell Mouzon, Ming-Hu Han, Rachael L Neve, Rosemary C Bagot, Andrew Kasarskis, Ja Wook Koo, Eric J Nestle. Transcriptional and physiological adaptations in nucleus accumbens somatostatin interneurons that regulate behavioral responses to cocaine. Nature communications. vol 9. issue 1. 2018-12-12. PMID:30089879. |
the role of somatostatin interneurons in nucleus accumbens (nac), a key brain reward region, remains poorly understood due to the fact that these cells account for < 1% of nac neurons. |
2018-12-12 |
2023-08-13 |
Not clear |
| Yadi Li, Wenhua Zhou, Haibo Dong, Wenwen Shen, Jianbing Zhang, Feng Li, Lingjun Zhan. Lower Fractional Anisotropy in the Gray Matter of Amygdala-Hippocampus-Nucleus Accumbens Circuit in Methamphetamine Users: an In Vivo Diffusion Tensor Imaging Study. Neurotoxicity research. vol 33. issue 4. 2018-12-11. PMID:29038922. |
the basolateral amygdala (bla), hippocampal ventral subiculum, and nucleus accumbens (nac) comprise the amygdala-hippocampus-nac (ahn) circuit, which is implicated in drug seeking and reward. |
2018-12-11 |
2023-08-13 |
human |
| Zahra Fatahi, Abbas Haghparas. Activation of the cannabinoid system in the nucleus accumbens affects effort-based decision making. Pharmacology, biochemistry, and behavior. vol 165. 2018-12-11. PMID:29291421. |
our finding suggested that activation of the cannabinoid system in the nac impaired effort-based decision making and led to rats were less willing to invest the physical effort to gain large reward. |
2018-12-11 |
2023-08-13 |
rat |
| Zachary S Lorsch, Yong-Hwee Eddie Loh, Immanuel Purushothaman, Deena M Walker, Eric M Parise, Marine Salery, Michael E Cahill, Georgia E Hodes, Madeline L Pfau, Hope Kronman, Peter J Hamilton, Orna Issler, Benoit Labonté, Ann E Symonds, Matthew Zucker, Tie Yuan Zhang, Michael J Meaney, Scott J Russo, Li Shen, Rosemary C Bagot, Eric J Nestle. Estrogen receptor α drives pro-resilient transcription in mouse models of depression. Nature communications. vol 9. issue 1. 2018-12-11. PMID:29549264. |
we identify estrogen receptor α (erα) as the top regulator of pro-resilient transcriptional changes in the nucleus accumbens (nac), a key brain reward region implicated in depression. |
2018-12-11 |
2023-08-13 |
mouse |
| Rifka C Derman, Carrie R Ferrari. Enhanced incentive motivation in obesity-prone rats is mediated by NAc core CP-AMPARs. Neuropharmacology. vol 131. 2018-11-19. PMID:29291424. |
the nucleus accumbens (nac) mediates cue-triggered reward seeking and activity in the nac is enhanced in obesity-susceptible populations. |
2018-11-19 |
2023-08-13 |
human |
| Shi-Yu Peng, Bin Li, Kang Xi, Jian-Jun Wang, Jing-Ning Zh. Presynaptic α Neuroscience letters. vol 665. 2018-11-15. PMID:29195907. |
presynaptic α the nucleus accumbens (nac), integrating information from the prefrontal cortex and limbic structures, plays a critical role in reward and emotion regulation. |
2018-11-15 |
2023-08-13 |
Not clear |
| Juhwan Kim, Sueun Lee, Sohi Kang, Tae-Il Jeon, Man-Jong Kang, Tae-Hoon Lee, Yong Sik Kim, Key-Sun Kim, Heh-In Im, Changjong Moo. Regulator of G-Protein Signaling 4 (RGS4) Controls Morphine Reward by Glutamate Receptor Activation in the Nucleus Accumbens of Mouse Brain. Molecules and cells. vol 41. issue 5. 2018-10-30. PMID:29754475. |
the present study used a short hairpin rna (shrna)-mediated knock-down of rgs4 in the nac of the mouse brain to investigate the relationship between the activation of ionotropic glutamate receptors and rgs4 in the nac during morphine reward. |
2018-10-30 |
2023-08-13 |
mouse |
| Chuchu Qi, Baolin Guo, Keke Ren, Han Yao, Mengmeng Wang, Tangna Sun, Guohong Cai, Haiying Liu, Rui Li, Ceng Luo, Wenting Wang, Shengxi W. Chronic inflammatory pain decreases the glutamate vesicles in presynaptic terminals of the nucleus accumbens. Molecular pain. vol 14. 2018-10-22. PMID:29770746. |
reward system has been proved to be important to nociceptive behavior, and the nucleus accumbens (nac) is a key node in reward circuitry. |
2018-10-22 |
2023-08-13 |
mouse |
| Mrunal Rane, Rohit Manchand. Effects of location and extent of spine clustering on synaptic integration in striatal medium spiny neurons-a computational study. Medical & biological engineering & computing. vol 56. issue 7. 2018-10-15. PMID:29209962. |
the nucleus accumbens (nac) is known widely for its role in the reward circuit, which is dysregulated in a number of psychological disorders. |
2018-10-15 |
2023-08-13 |
Not clear |