| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Steven F Merkel, Allison M Andrews, Evan M Lutton, Roshanak Razmpour, Lee Anne Cannella, Servio H Ramire. Dexamethasone Attenuates the Enhanced Rewarding Effects of Cocaine Following Experimental Traumatic Brain Injury. Cell transplantation. vol 26. issue 7. 2018-05-14. PMID:28933216. |
these studies were performed in order to determine whether proinflammatory activity in the nucleus accumbens (nac), a key brain nucleus in the reward pathway, mediates enhanced cocaine-induced cpp in adolescent animals sustaining moderate cci-tbi. |
2018-05-14 |
2023-08-13 |
mouse |
| Steven F Merkel, Allison M Andrews, Evan M Lutton, Roshanak Razmpour, Lee Anne Cannella, Servio H Ramire. Dexamethasone Attenuates the Enhanced Rewarding Effects of Cocaine Following Experimental Traumatic Brain Injury. Cell transplantation. vol 26. issue 7. 2018-05-14. PMID:28933216. |
these results suggest that a portion of these monocytes may migrate to the brain in response to cci-tbi, potentially sparing the development of chronic neuroinflammation in regions associated with the reward circuitry such as the nac. |
2018-05-14 |
2023-08-13 |
mouse |
| Xiaoluan Xia, Lingzhong Fan, Chen Cheng, Simon B Eickhoff, Junjie Chen, Haifang Li, Tianzi Jian. Multimodal connectivity-based parcellation reveals a shell-core dichotomy of the human nucleus accumbens. Human brain mapping. vol 38. issue 8. 2018-04-02. PMID:28548226. |
the subdifferentiation of the nucleus accumbens (nac) has been extensively studied using neuroanatomy and histochemistry, yielding a well-accepted dichotomic shell/core architecture that reflects dissociable roles, such as in reward and aversion, respectively. |
2018-04-02 |
2023-08-13 |
human |
| Ashley E Lepack, Rosemary C Bagot, Catherine J Peña, Yong-Hwee E Loh, Lorna A Farrelly, Yang Lu, Samuel K Powell, Zachary S Lorsch, Orna Issler, Hannah M Cates, Carol A Tamminga, Henrik Molina, Li Shen, Eric J Nestler, C David Allis, Ian Maz. Aberrant H3.3 dynamics in NAc promote vulnerability to depressive-like behavior. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 44. 2018-03-26. PMID:27791098. |
here, we demonstrate a role for increased h3.3 dynamics in the nucleus accumbens (nac)-a key limbic brain reward region-in the regulation of aberrant social stress-mediated gene expression and the precipitation of depressive-like behaviors in mice. |
2018-03-26 |
2023-08-13 |
mouse |
| Jian Feng, Catherine J Pena, Immanuel Purushothaman, Olivia Engmann, Deena Walker, Amber N Brown, Orna Issler, Marie Doyle, Eileen Harrigan, Ezekiell Mouzon, Vincent Vialou, Li Shen, Meelad M Dawlaty, Rudolf Jaenisch, Eric J Nestle. Tet1 in Nucleus Accumbens Opposes Depression- and Anxiety-Like Behaviors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 8. 2018-03-23. PMID:28074830. |
we applied chronic social defeat stress, an ethologically validated mouse model of depression-like behaviors, and examined tet1 expression changes in nucleus accumbens (nac), a key brain reward region. |
2018-03-23 |
2023-08-13 |
mouse |
| Saki Minami, Hiroshi Satoyoshi, Soichiro Ide, Takeshi Inoue, Mitsuhiro Yoshioka, Masabumi Minam. Suppression of reward-induced dopamine release in the nucleus accumbens in animal models of depression: Differential responses to drug treatment. Neuroscience letters. vol 650. 2018-03-19. PMID:28432029. |
we investigated reward (30% sucrose intake)-induced da release in the nucleus accumbens (nac) and the effect of chronic treatment with the antidepressant escitalopram (5mg/kg, intraperitoneally twice daily for 3 weeks) in two animal models of depression. |
2018-03-19 |
2023-08-13 |
Not clear |
| HaoSheng Sun, Diane M Damez-Werno, Kimberly N Scobie, Ning-Yi Shao, Caroline Dias, Jacqui Rabkin, Katherine N Wright, Ezekiell Mouzon, Mohamed Kabbaj, Rachael Neve, Gustavo Turecki, Li Shen, Eric J Nestle. Regulation of BAZ1A and nucleosome positioning in the nucleus accumbens in response to cocaine. Neuroscience. vol 353. 2018-03-14. PMID:28412501. |
viral-mediated overexpression of baz1a in mouse nac reduces cocaine reward as assessed by conditioned place preference (cpp), but increases cocaine-induced locomotor activation. |
2018-03-14 |
2023-08-13 |
mouse |
| Kenneth Blum, Thomas Simpatico, Marcelo Febo, Chris Rodriquez, Kristina Dushaj, Mona Li, Eric R Braverman, Zsolt Demetrovics, Marlene Oscar-Berman, Rajendra D Badgaiya. Hypothesizing Music Intervention Enhances Brain Functional Connectivity Involving Dopaminergic Recruitment: Common Neuro-correlates to Abusable Drugs. Molecular neurobiology. vol 54. issue 5. 2018-03-09. PMID:27246565. |
fmri data has shown that music listening intensely modifies mesolimbic structural changes responsible for reward processing (e.g., nucleus accumbens [nac]) and may control the emotional stimuli's effect on autonomic and physiological responses (e.g., hypothalamus). |
2018-03-09 |
2023-08-13 |
Not clear |
| Lynda Whiting, James E McCutcheon, Christina N Boyle, Mitchell F Roitman, Thomas A Lut. The area postrema (AP) and the parabrachial nucleus (PBN) are important sites for salmon calcitonin (sCT) to decrease evoked phasic dopamine release in the nucleus accumbens (NAc). Physiology & behavior. vol 176. 2018-03-08. PMID:28342771. |
to determine whether and how peripheral amylin or sct affect mesolimbic reward circuitry we utilized fast scan cyclic voltammetry under anesthesia to measure phasic da release in the nac evoked by electrical stimulation of the vta in intact, ap lesioned and bilaterally pbn lesioned rats. |
2018-03-08 |
2023-08-13 |
rat |
| Ana M Fiallos, Sarah J Bricault, Lili X Cai, Hermoon A Worku, Matthew T Colonnese, Gil G Westmeyer, Alan Jasanof. Reward magnitude tracking by neural populations in ventral striatum. NeuroImage. vol 146. 2018-02-14. PMID:27789262. |
the largest and most reliable focus of reward magnitude tracking was observed in the shell region of the nucleus accumbens (nac). |
2018-02-14 |
2023-08-13 |
Not clear |
| Ana M Fiallos, Sarah J Bricault, Lili X Cai, Hermoon A Worku, Matthew T Colonnese, Gil G Westmeyer, Alan Jasanof. Reward magnitude tracking by neural populations in ventral striatum. NeuroImage. vol 146. 2018-02-14. PMID:27789262. |
in addition, local pharmacological inactivation of nac changed the profile of animals' responses to rewards of different magnitudes without altering mean reward response rates, further supporting a hypothesis that neural population activity in this region contributes to assessment of reward magnitudes. |
2018-02-14 |
2023-08-13 |
Not clear |
| S J Baracz, L M Parker, A S Suraev, N A Everett, A K Goodchild, I S McGregor, J L Cornis. Chronic Methamphetamine Self-Administration Dysregulates Oxytocin Plasma Levels and Oxytocin Receptor Fibre Density in the Nucleus Accumbens Core and Subthalamic Nucleus of the Rat. Journal of neuroendocrinology. vol 28. issue 4. 2018-02-08. PMID:26563756. |
recent findings have implicated the nucleus accumbens (nac) core and subthalamic nucleus (sth) in oxytocin modulation of acute meth reward and relapse to meth-seeking behaviour. |
2018-02-08 |
2023-08-13 |
rat |
| Erin S Calipari, Arthur Godino, Emily G Peck, Marine Salery, Nicholas L Mervosh, Joseph A Landry, Scott J Russo, Yasmin L Hurd, Eric J Nestler, Drew D Kiral. Granulocyte-colony stimulating factor controls neural and behavioral plasticity in response to cocaine. Nature communications. vol 9. issue 1. 2018-02-02. PMID:29339724. |
infusion of g-csf neutralizing antibody into nac blocks the ability of g-csf to modulate cocaine's behavioral effects, providing a direct link between central g-csf action in nac and cocaine reward. |
2018-02-02 |
2023-08-13 |
Not clear |
| Yo Oishi, Qi Xu, Lu Wang, Bin-Jia Zhang, Koji Takahashi, Yohko Takata, Yan-Jia Luo, Yoan Cherasse, Serge N Schiffmann, Alban de Kerchove d'Exaerde, Yoshihiro Urade, Wei-Min Qu, Zhi-Li Huang, Michael Lazaru. Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice. Nature communications. vol 8. issue 1. 2018-01-29. PMID:28963505. |
previous studies suggest that adenosine has a role affecting behavioural arousal in the nucleus accumbens (nac), a brain area critical for reinforcement and reward. |
2018-01-29 |
2023-08-13 |
mouse |
| S Nakanishi, T Hikida, S Yawat. Distinct dopaminergic control of the direct and indirect pathways in reward-based and avoidance learning behaviors. Neuroscience. vol 282. 2018-01-26. PMID:24769227. |
the nucleus accumbens (nac) plays a pivotal role in reward and aversive learning and learning flexibility. |
2018-01-26 |
2023-08-13 |
mouse |
| Diane M Damez-Werno, HaoSheng Sun, Kimberly N Scobie, Ningyi Shao, Jaclyn Rabkin, Caroline Dias, Erin S Calipari, Ian Maze, Catherine J Pena, Deena M Walker, Michael E Cahill, Ramesh Chandra, Amy Gancarz, Ezekiell Mouzon, Joseph A Landry, Hannah Cates, Mary-Kay Lobo, David Dietz, C David Allis, Ernesto Guccione, Gustavo Turecki, Paola Defilippi, Rachael L Neve, Yasmin L Hurd, Li Shen, Eric J Nestle. Histone arginine methylation in cocaine action in the nucleus accumbens. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 34. 2018-01-26. PMID:27506785. |
using chip-seq, we identified src kinase signaling inhibitor 1 (srcin1; also referred to as p140cap) as a key gene target for reduced h3r2me2a binding, and found that consequent srcin1 induction in the nac decreases src signaling, cocaine reward, and the motivation to self-administer cocaine. |
2018-01-26 |
2023-08-13 |
mouse |
| Torry S Dennis, Kevin D Beck, Tara P Cominski, Samara A M Bobzean, Eldo V Kuzhikandathil, Richard J Servatius, Linda I Perrott. Exposure to morphine-associated cues increases mu opioid receptor mRNA expression in the nucleus accumbens of Wistar Kyoto rats. Behavioural brain research. vol 313. 2018-01-25. PMID:27421830. |
the purpose of this study was to extend upon previous work from our laboratory by investigating conditioned morphine reward in adult male wky and sd rats, and to examine levels of kor mrna and mor mrna in the nac at baseline and after acquisition of morphine cpp. |
2018-01-25 |
2023-08-13 |
rat |
| Salil Saurav Pathak, Swati Maitra, Sumana Chakravarty, Arvind Kuma. Histone Lysine Demethylases of JMJD2 or KDM4 Family are Important Epigenetic Regulators in Reward Circuitry in the Etiopathology of Depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 4. 2018-01-19. PMID:27711046. |
recent research shows dysregulation in epigenetic regulatory mechanisms, particularly the transcriptionally repressive di- and tri-methylation of histone 3 lysine 9 (h3k9me2/me3) in nucleus accumbens (nac), a critical region of the reward pathway involved in the development of anhedonia, the hallmark of depression. |
2018-01-19 |
2023-08-13 |
mouse |
| Michael P Saddoris, Jonathan A Sugam, Regina M Carell. Prior Cocaine Experience Impairs Normal Phasic Dopamine Signals of Reward Value in Accumbens Shell. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 3. 2018-01-16. PMID:27604567. |
to quantify this, we voltammetrically measured real-time dopamine release in the nucleus accumbens (nac) core or shell while rats received unsignaled deliveries of either a small (1 pellet) or large (2 pellets) reward. |
2018-01-16 |
2023-08-13 |
rat |
| Claudia Wolf, Holger Mohr, Esther K Diekhof, Henning Vieker, Roberto Goya-Maldonado, Sarah Trost, Bernd Krämer, Maria Keil, Elisabeth B Binder, Oliver Grube. CREB1 Genotype Modulates Adaptive Reward-Based Decisions in Humans. Cerebral cortex (New York, N.Y. : 1991). vol 26. issue 7. 2018-01-15. PMID:26045569. |
we found significant creb1 genotype effects on choices to pursue increases of the reward outcome and on bold signal in the nac, ofc, insula cortex, cingulate gyrus, hippocampus, amygdala, and precuneus during these decisions in comparison with those decisions avoiding total reward loss. |
2018-01-15 |
2023-08-13 |
human |