| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniel C Castro, Rachel A Terry, Kent C Berridg. Orexin in Rostral Hotspot of Nucleus Accumbens Enhances Sucrose 'Liking' and Intake but Scopolamine in Caudal Shell Shifts 'Liking' Toward 'Disgust' and 'Fear'. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 8. 2018-01-15. PMID:26787120. |
within nac shell, orexin/hypocretin also has been reported to stimulate food intake and is implicated in reward, whereas blockade of muscarinic acetylcholine receptors by scopolamine suppresses intake and may have anti-reward effects. |
2018-01-15 |
2023-08-13 |
Not clear |
| Antonia Manduca, Michela Servadio, Ruth Damsteegt, Patrizia Campolongo, Louk Jmj Vanderschuren, Viviana Trezz. Dopaminergic Neurotransmission in the Nucleus Accumbens Modulates Social Play Behavior in Rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 9. 2018-01-09. PMID:26860202. |
nac dopamine has a well-known role in certain components of reward processes, such as incentive motivation. |
2018-01-09 |
2023-08-13 |
rat |
| Matthew Brodsky, Alec W Gibson, Denis Smirnov, Sunila G Nair, John F Neumaie. Striatal 5-HT6 Receptors Regulate Cocaine Reinforcement in a Pathway-Selective Manner. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 9. 2018-01-09. PMID:27032690. |
the nucleus accumbens (nac) in the ventral striatum integrates many neurochemical inputs including dopamine and serotonin projections from midbrain nuclei to modulate drug reward. |
2018-01-09 |
2023-08-13 |
rat |
| Alyssa L Peechatka, Amy C Jane. Association Between Reward Reactivity and Drug Use Severity is Substance Dependent: Preliminary Evidence From the Human Connectome Project. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 19. issue 6. 2017-12-27. PMID:28486710. |
blunted nucleus accumbens (nac) reactivity to reward is common across drug users. |
2017-12-27 |
2023-08-13 |
human |
| Alyssa L Peechatka, Amy C Jane. Association Between Reward Reactivity and Drug Use Severity is Substance Dependent: Preliminary Evidence From the Human Connectome Project. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 19. issue 6. 2017-12-27. PMID:28486710. |
as smokers may use nicotine to bolster nac reward function, we hypothesize that nac reactivity to reward will be related to volume of cigarette use, but not volume of alcohol use. |
2017-12-27 |
2023-08-13 |
human |
| William A Carlezon, Andrew D Krysta. Kappa-Opioid Antagonists for Psychiatric Disorders: From Bench to Clinical Trials. Depression and anxiety. vol 33. issue 10. 2017-12-26. PMID:27699938. |
the discovery of their potentially therapeutic effects evolved from preclinical research designed to characterize the molecular mechanisms by which experience causes neuroadaptations in the nucleus accumbens (nac), a key element of brain reward circuitry. |
2017-12-26 |
2023-08-13 |
Not clear |
| Jiangyong Ouyang, Ioana Carcea, Jennifer K Schiavo, Kymry T Jones, Ariana Rabinowitsch, Rhonda Kolaric, Soledad Cabeza de Vaca, Robert C Froemke, Kenneth D Car. Food restriction induces synaptic incorporation of calcium-permeable AMPA receptors in nucleus accumbens. The European journal of neuroscience. vol 45. issue 6. 2017-12-22. PMID:28112453. |
in this study we examined whether food restriction, in the absence of reward stimulus challenge, alters ampar subunit abundance in the nac psd. |
2017-12-22 |
2023-08-13 |
human |
| Sa-Ik Hong, Thi-Lien Nguyen, Shi-Xun Ma, Hyoung-Chun Kim, Seok-Yong Lee, Choon-Gon Jan. TRPV1 modulates morphine-induced conditioned place preference via p38 MAPK in the nucleus accumbens. Behavioural brain research. vol 334. 2017-12-11. PMID:28734766. |
however, the role of trpv1 on morphine-conditioned reward in addiction-related brain regions, such as the nucleus accumbens (nac), has not been previously established. |
2017-12-11 |
2023-08-13 |
mouse |
| Sa-Ik Hong, Thi-Lien Nguyen, Shi-Xun Ma, Hyoung-Chun Kim, Seok-Yong Lee, Choon-Gon Jan. TRPV1 modulates morphine-induced conditioned place preference via p38 MAPK in the nucleus accumbens. Behavioural brain research. vol 334. 2017-12-11. PMID:28734766. |
taken together, our findings suggest that trpv1 may modulate morphine-induced conditioned reward effects via the p38 mapk signaling pathway in the nac. |
2017-12-11 |
2023-08-13 |
mouse |
| Kendra L Kobrin, Danielle T Arena, Stephen C Heinrichs, Olivia H Nguyen, Gary B Kapla. Dopamine D1 receptor agonist treatment attenuates extinction of morphine conditioned place preference while increasing dendritic complexity in the nucleus accumbens core. Behavioural brain research. vol 322. issue Pt A. 2017-12-01. PMID:28089852. |
we examined the effect of d1r agonist skf81297 on the extinction of opioid cpp and associated dendritic morphology in the nucleus accumbens (nac), a region involved with reward integration and its extinction. |
2017-12-01 |
2023-08-13 |
mouse |
| Kendra L Kobrin, Danielle T Arena, Stephen C Heinrichs, Olivia H Nguyen, Gary B Kapla. Dopamine D1 receptor agonist treatment attenuates extinction of morphine conditioned place preference while increasing dendritic complexity in the nucleus accumbens core. Behavioural brain research. vol 322. issue Pt A. 2017-12-01. PMID:28089852. |
the d1r agonist's differential, rather than unidirectional, effects on dendritic morphology in the nac core suggests that it may be involved in encoding reward information depending on previously learned behavior. |
2017-12-01 |
2023-08-13 |
mouse |
| Omar Ouachikh, Carine Chassain, Guilhem Pagès, Franck Durif, Aziz Hafid. mGlu5 receptor antagonist blocks bromocriptine-induced conditioned place preference in bilateral mesolimbic-lesioned rat. Behavioural brain research. vol 317. 2017-11-29. PMID:27638036. |
the drt reinforcement effect is due to its action on the reward system, particularly on the nucleus accumbens (nac). |
2017-11-29 |
2023-08-13 |
rat |
| Caitlin A Orsini, Marci R Mitchell, Sara C Heshmati, Kristy G Shimp, Megan S Spurrell, Jennifer L Bizon, Barry Setlo. Effects of nucleus accumbens amphetamine administration on performance in a delay discounting task. Behavioural brain research. vol 321. 2017-11-29. PMID:28057530. |
to begin to address this, rats received acute microinjections of the indirect da agonist amphetamine directly into the nac prior to testing in a delay discounting task in which rats chose between a small, immediate and a large, delayed food reward. |
2017-11-29 |
2023-08-13 |
rat |
| Caitlin A Orsini, Marci R Mitchell, Sara C Heshmati, Kristy G Shimp, Megan S Spurrell, Jennifer L Bizon, Barry Setlo. Effects of nucleus accumbens amphetamine administration on performance in a delay discounting task. Behavioural brain research. vol 321. 2017-11-29. PMID:28057530. |
these findings suggest that, rather than specifically mediating impulsive choice, da neurotransmission in the nac is necessary for flexible adaptation of choice strategies in the presence of shifting reward contingencies. |
2017-11-29 |
2023-08-13 |
rat |
| Shanna L Resendez, Piper C Keyes, Jeremy J Day, Caely Hambro, Curtis J Austin, Francis K Maina, Lori N Eidson, Kirsten A Porter-Stransky, Natalie Nevárez, J William McLean, Morgan A Kuhnmuench, Anne Z Murphy, Tiffany A Mathews, Brandon J Aragon. Dopamine and opioid systems interact within the nucleus accumbens to maintain monogamous pair bonds. eLife. vol 5. 2017-11-28. PMID:27371827. |
finally, we also identified sex-specific alterations in kor binding density within the nac shell of paired males and demonstrate that this alteration contributes to the neuroprotective effect of pair bonding against drug reward. |
2017-11-28 |
2023-08-13 |
Not clear |
| Caesar G Imperio, Ashley J McFalls, Elizabeth M Colechio, Dustin R Masser, Kent E Vrana, Patricia S Grigson, Willard M Freema. Assessment of individual differences in the rat nucleus accumbens transcriptome following taste-heroin extended access. Brain research bulletin. vol 123. 2017-10-20. PMID:26733446. |
analysis of strand-specific whole genome rna-seq data revealed a number of genes differentially regulated in nac based on the suppression of the natural saccharine reward. |
2017-10-20 |
2023-08-13 |
rat |
| Meaghan Creed, Niels R Ntamati, Ramesh Chandra, Mary Kay Lobo, Christian Lüsche. Convergence of Reinforcing and Anhedonic Cocaine Effects in the Ventral Pallidum. Neuron. vol 92. issue 1. 2017-10-03. PMID:27667004. |
cocaine-evoked synaptic plasticity in the reward system, particularly the nucleus accumbens (nac), drives drug-adaptive behavior. |
2017-10-03 |
2023-08-13 |
Not clear |
| Joanna Peris, Kaley MacFadyen, Justin A Smith, Annette D de Kloet, Lei Wang, Eric G Kraus. Oxytocin receptors are expressed on dopamine and glutamate neurons in the mouse ventral tegmental area that project to nucleus accumbens and other mesolimbic targets. The Journal of comparative neurology. vol 525. issue 5. 2017-09-29. PMID:27615433. |
oxytocin (ot) has been implicated in mediating natural reward and ot-synthesizing neurons project to the ventral tegmental area (vta) and nucleus accumbens (nac); however, direct neuroanatomical evidence of ot regulation of da neurons within the vta is sparse. |
2017-09-29 |
2023-08-13 |
mouse |
| Jie Liang, Jia-Li Li, Ying Han, Yi-Xiao Luo, Yan-Xue Xue, Yàn Zhang, Yán Zhang, Li-Bo Zhang, Man-Li Chen, Lin Lu, Jie Sh. Calpain-GRIP Signaling in Nucleus Accumbens Core Mediates the Reconsolidation of Drug Reward Memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 37. 2017-09-29. PMID:28821652. |
these results suggest that calpain activity in the nac core is crucial for the reconsolidation of drug reward memory via the regulation of grip1 expression. |
2017-09-29 |
2023-08-13 |
rat |
| Sergueï O Fetisso. [Hunger and satiety factors in the regulation of pleasure associated with feeding behavior]. Biologie aujourd'hui. vol 210. issue 4. 2017-09-28. PMID:28327283. |
the dopamine (da) system of the mesolimbic projections plays a key role in behavioral reward in general and is also involved in regulating feeding-associated pleasure in the forebrain including the nucleus accumbens (nac) and the lateral hypothalamic area (lha). |
2017-09-28 |
2023-08-13 |
Not clear |