| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Biesdorf, A-L Wang, B Topic, D Petri, H Milani, J P Huston, M A de Souza Silv. Dopamine in the nucleus accumbens core, but not shell, increases during signaled food reward and decreases during delayed extinction. Neurobiology of learning and memory. vol 123. 2016-05-26. PMID:26071677. |
(b) when extinction (the absence of reward with the cue lights presented) was administered 24h after the last reward session, da again significantly decreased in the nac core, but not in the nac shell. |
2016-05-26 |
2023-08-13 |
rat |
| B Granseth, F K Andersson, S H Lindströ. The initial stage of reversal learning is impaired in mice hemizygous for the vesicular glutamate transporter (VGluT1). Genes, brain, and behavior. vol 14. issue 6. 2016-05-10. PMID:26113146. |
the vesicular glutamate transporter (vglut1) is preferentially expressed at modulatory synapses, including pfc neurons that project to components of the reward circuit (such as the nucleus accumbens, nac). |
2016-05-10 |
2023-08-13 |
mouse |
| Cody A Siciliano, Mark J Ferris, Sara R Jone. Cocaine self-administration disrupts mesolimbic dopamine circuit function and attenuates dopaminergic responsiveness to cocaine. The European journal of neuroscience. vol 42. issue 4. 2016-05-06. PMID:26037018. |
dopaminergic projections from the ventral midbrain to the nucleus accumbens (nac) have long been implicated in encoding associations between reward availability and environmental stimuli. |
2016-05-06 |
2023-08-13 |
rat |
| Xianglong Zhu, David Ottenheimer, Ralph J DiLeon. Activity of D1/2 Receptor Expressing Neurons in the Nucleus Accumbens Regulates Running, Locomotion, and Food Intake. Frontiers in behavioral neuroscience. vol 10. 2016-05-05. PMID:27147989. |
the nucleus accumbens (nac) is one brain region that has received attention for its role in the regulation of energy balance; its d1 and d2 receptor containing neurons have distinct functions in regulating reward behavior and require further examination. |
2016-05-05 |
2023-08-13 |
human |
| Georgia E Hodes, Madeline L Pfau, Immanuel Purushothaman, H Francisca Ahn, Sam A Golden, Daniel J Christoffel, Jane Magida, Anna Brancato, Aki Takahashi, Meghan E Flanigan, Caroline Ménard, Hossein Aleyasin, Ja Wook Koo, Zachary S Lorsch, Jian Feng, Mitra Heshmati, Minghui Wang, Gustavo Turecki, Rachel Neve, Bin Zhang, Li Shen, Eric J Nestler, Scott J Russ. Sex Differences in Nucleus Accumbens Transcriptome Profiles Associated with Susceptibility versus Resilience to Subchronic Variable Stress. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 50. 2016-04-19. PMID:26674863. |
in concert with these different behavioral responses, transcriptional analysis of nucleus accumbens (nac), a major brain reward region, by use of rna sequencing (rna-seq) revealed markedly different patterns of stress regulation of gene expression between the sexes. |
2016-04-19 |
2023-08-13 |
mouse |
| Duo Xu, Chen Su, Hau-Yueh Lin, Toby Manders, Jing Wan. Persistent neuropathic pain increases synaptic GluA1 subunit levels in core and shell subregions of the nucleus accumbens. Neuroscience letters. vol 609. 2016-04-15. PMID:26477778. |
the nucleus accumbens (nac) is a key component of the brain reward system, and it is composed of core and shell subregions. |
2016-04-15 |
2023-08-13 |
Not clear |
| Negar Baharlouei, Abdolrahman Sarihi, Alireza Komaki, Siamak Shahidi, Abbas Haghparas. Blockage of acquisition and expression of morphine-induced conditioned place preference in rats due to activation of glutamate receptors type II/III in nucleus accumbens. Pharmacology, biochemistry, and behavior. vol 135. 2016-04-12. PMID:26071679. |
mglu2/3 glutamate receptors in the nac have important roles in the reward pathway. |
2016-04-12 |
2023-08-13 |
rat |
| Hossein Khaleghzadeh-Ahangar, Abbas Haghparas. Intra-accumbal CB1 receptor blockade reduced extinction and reinstatement of morphine. Physiology & behavior. vol 149. 2016-04-11. PMID:26057574. |
the limbic dopaminergic reward system is the main target of morphine-like drugs which begins from the ventral tegmental area (vta) and sends its dopaminergic projections to the nucleus accumbens (nac), amygdala, hippocampus and prefrontal cortex. |
2016-04-11 |
2023-08-13 |
rat |
| Eric J Nestle. ∆FosB: a transcriptional regulator of stress and antidepressant responses. European journal of pharmacology. vol 753. 2016-03-14. PMID:25446562. |
such prolonged induction of Δfosb, within nucleus accumbens (nac), a key brain reward region, has been most studied in animal models of drug addiction, with considerable evidence indicating that Δfosb promotes reward and motivation and serves as a mechanism of drug sensitization and increased drug self-administration. |
2016-03-14 |
2023-08-13 |
mouse |
| Rhona Clarke, Louise Adermar. Dopaminergic Regulation of Striatal Interneurons in Reward and Addiction: Focus on Alcohol. Neural plasticity. vol 2015. 2016-03-08. PMID:26246915. |
the ventral striatum (nucleus accumbens (nac)) and its reciprocal connection with the ventral tegmental area (vta) represent a primary component of the reward system, but reward-guided learning also involves the dorsal striatum and dopaminergic inputs from the substantia nigra. |
2016-03-08 |
2023-08-13 |
Not clear |
| Michael D Reed, David G C Hildebrand, Gabrielle Santangelo, Anthony Moffa, Ashley S Pira, Lisa Rycyna, Mia Radic, Katherine Price, Jonathan Archbold, Kristi McConnell, Lauren Girard, Kristen Morin, Anna Tang, Marcelo Febo, James R Stella. Assessing contributions of nucleus accumbens shell subregions to reward-seeking behavior. Drug and alcohol dependence. vol 153. 2016-03-02. PMID:26048642. |
the nucleus accumbens (nac) plays a key role in brain reward processes including drug seeking and reinstatement. |
2016-03-02 |
2023-08-13 |
Not clear |
| Rahul Pandit, Esther M van der Zwaal, Mieneke C M Luijendijk, Maike A D Brans, Andrea J van Rozen, Ralph J A Oude Ophuis, Louk J M J Vanderschuren, Roger A H Adan, Susanne E la Fleu. Central melanocortins regulate the motivation for sucrose reward. PloS one. vol 10. issue 3. 2016-02-29. PMID:25811380. |
mc receptors are widely expressed in both hypothalamic and extra-hypothalamic brain regions, including nuclei involved in food reward and motivation, such as the nucleus accumbens (nac) and the ventral tegmental area. |
2016-02-29 |
2023-08-13 |
rat |
| Rosemary C Bagot, Eric M Parise, Catherine J Peña, Hong-Xing Zhang, Ian Maze, Dipesh Chaudhury, Brianna Persaud, Roger Cachope, Carlos A Bolaños-Guzmán, Joseph F Cheer, Joseph Cheer, Karl Deisseroth, Ming-Hu Han, Eric J Nestle. Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression. Nature communications. vol 6. 2016-02-29. PMID:25952660. |
enhanced glutamatergic transmission in the nucleus accumbens (nac), a region critical for reward and motivation, has been implicated in the pathophysiology of depression; however, the afferent source of this increased glutamate tone is not known. |
2016-02-29 |
2023-08-13 |
mouse |
| Yoko H Ohnishi, Yoshinori N Ohnishi, Takanori Nakamura, Mizuki Ohno, Pamela J Kennedy, Yasuyuki Ohkawa, Ohkawa Yasuyuki, Akinori Nishi, Rachael Neve, Teruhisa Tsuzuki, Eric J Nestle. PSMC5, a 19S Proteasomal ATPase, Regulates Cocaine Action in the Nucleus Accumbens. PloS one. vol 10. issue 5. 2016-02-02. PMID:25962134. |
Δfosb is a stable transcription factor which accumulates in the nucleus accumbens (nac), a key part of the brain's reward circuitry, in response to chronic exposure to cocaine or other drugs of abuse. |
2016-02-02 |
2023-08-13 |
Not clear |
| Scott M Thompson, Angy J Kallarackal, Mark D Kvarta, Adam M Van Dyke, Tara A LeGates, Xiang Ca. An excitatory synapse hypothesis of depression. Trends in neurosciences. vol 38. issue 5. 2016-01-19. PMID:25887240. |
here, we propose an excitatory synapse hypothesis of depression in which chronic stress and genetic susceptibility cause changes in the strength of subsets of glutamatergic synapses at multiple locations, including the prefrontal cortex (pfc), hippocampus, and nucleus accumbens (nac), leading to a dysfunction of corticomesolimbic reward circuitry that underlies many of the symptoms of depression. |
2016-01-19 |
2023-08-13 |
Not clear |
| Vasiliki Mitsi, Dimitra Terzi, Immanuel Purushothaman, Lefteris Manouras, Sevasti Gaspari, Rachael L Neve, Maria Stratinaki, Jian Feng, Li Shen, Venetia Zachario. RGS9-2--controlled adaptations in the striatum determine the onset of action and efficacy of antidepressants in neuropathic pain states. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 36. 2016-01-04. PMID:26305935. |
here, we use the murine spared-nerve injury model of neuropathic pain to investigate the mechanism by which rgs9-2 in the nucleus accumbens (nac), a brain region involved in mood, reward, and motivation, modulates the actions of tricyclic antidepressants (tcas). |
2016-01-04 |
2023-08-13 |
Not clear |
| Su Xu, Rao P Gullapalli, Douglas O Fros. Olanzapine antipsychotic treatment of adolescent rats causes long term changes in glutamate and GABA levels in the nucleus accumbens. Schizophrenia research. vol 161. issue 2-3. 2015-12-31. PMID:25487700. |
the nac is a key node in the brain's "reward" system, whose function is also disrupted in schizophrenia. |
2015-12-31 |
2023-08-13 |
rat |
| Ream Al-Hasani, Jordan G McCall, Gunchul Shin, Adrian M Gomez, Gavin P Schmitz, Julio M Bernardi, Chang-O Pyo, Sung Il Park, Catherine M Marcinkiewcz, Nicole A Crowley, Michael J Krashes, Bradford B Lowell, Thomas L Kash, John A Rogers, Michael R Brucha. Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and Reward. Neuron. vol 87. issue 5. 2015-11-23. PMID:26335648. |
understanding the discrete regional specificity by which nac dynorphinerigic cells regulate preference and aversion provides insight into motivated behaviors that are dysregulated in stress, reward, and psychiatric disease. |
2015-11-23 |
2023-08-13 |
Not clear |
| Ying Mu, Zhaoxiang Ren, Jia Jia, Bo Gao, Longtai Zheng, Guanghui Wang, Eitan Friedman, Xuechu Zhe. Inhibition of phosphodiesterase10A attenuates morphine-induced conditioned place preference. Molecular brain. vol 7. 2015-11-10. PMID:25252626. |
nucleus accumbens (nac) is a key region that mediates drug reward and addiction-related behaviors. |
2015-11-10 |
2023-08-13 |
Not clear |
| Nahid Roohi, Abdolrahman Sarihi, Siamak Shahidi, Mohammad Zarei, Abbas Haghparas. Microinjection of the mGluR5 antagonist MTEP into the nucleus accumbens attenuates the acquisition but not expression of morphine-induced conditioned place preference in rats. Pharmacology, biochemistry, and behavior. vol 126. 2015-11-09. PMID:25284131. |
little is known about the role of mglur5 in the nucleus accumbens (nac), as one of the important regions of the reward circuitry. |
2015-11-09 |
2023-08-13 |
human |