| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kimberly Kirkpatrick, Andrew T Marshall, Aaron P Smith, Juraj Koci, Yoonseong Par. Individual differences in impulsive and risky choice: effects of environmental rearing conditions. Behavioural brain research. vol 269. 2015-01-15. PMID:24769268. |
these results suggest a role for domain general processes in impulsive and risky choice and indicate the importance of the nac and/or pfc in timing, reward processing, and choice behavior. |
2015-01-15 |
2023-08-13 |
rat |
| S Fenu, E Espa, C Cadoni, G Di Chiar. Conditioned saccharin avoidance induced by infusion of amphetamine in the nucleus accumbens shell and morphine in the ventral tegmental area: behavioral and biochemical study. Behavioural brain research. vol 269. 2015-01-15. PMID:24780866. |
these observations are consistent with the existence of a strong relationship between csa and drug reward related to their ability to stimulate da transmission in the nac shell. |
2015-01-15 |
2023-08-13 |
rat |
| Marloes S Oudijn, Jitschak G Storosum, Elise Nelis, Damiaan Deny. Is deep brain stimulation a treatment option for anorexia nervosa? BMC psychiatry. vol 13. 2015-01-06. PMID:24175936. |
given the overlap in symptomatology and neurocircuitry between reward-related disorders such as obsessive compulsive disorder (ocd) and an, and the established efficacy of accumbal dbs in ocd, we hypothesize that dbs of the nucleus accumbens (nac) and other areas associated with reward, e.g. |
2015-01-06 |
2023-08-12 |
Not clear |
| Hannah M Cates, Mackenzie Thibault, Madeline Pfau, Elizabeth Heller, Andrew Eagle, Paula Gajewski, Rosemary Bagot, Christopher Colangelo, Thomas Abbott, Gabby Rudenko, Rachael Neve, Eric J Nestler, Alfred J Robiso. Threonine 149 phosphorylation enhances ΔFosB transcriptional activity to control psychomotor responses to cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 34. 2014-12-22. PMID:25143625. |
of particular interest is the transcription factor Δfosb, a truncated and stable fosb gene product whose expression in nucleus accumbens (nac), a key reward region, is induced by chronic exposure to virtually all drugs of abuse and regulates their psychomotor and rewarding effects. |
2014-12-22 |
2023-08-13 |
mouse |
| Małgorzata Frankowska, Joanna Jastrzębska, Ewa Nowak, Magdalena Białko, Edmund Przegaliński, Małgorzata Fili. The effects of N-acetylcysteine on cocaine reward and seeking behaviors in a rat model of depression. Behavioural brain research. vol 266. 2014-12-12. PMID:24613240. |
nac (25-100mg/kg) given acutely or repeatedly did not alter the co-occurrence of cocaine reward and depression but effectively reduced the cocaine-seeking behavior observed in both phenotypes. |
2014-12-12 |
2023-08-12 |
rat |
| Alessia Salamone, Stefania Zappettini, Massimo Grilli, Guendalina Olivero, Paula Agostinho, Angelo R Tomé, Jiayang Chen, Anna Pittaluga, Rodrigo A Cunha, Mario March. Prolonged nicotine exposure down-regulates presynaptic NMDA receptors in dopaminergic terminals of the rat nucleus accumbens. Neuropharmacology. vol 79. 2014-12-03. PMID:24373903. |
the presynaptic control of dopamine release in the nucleus accumbens (nac) by glutamate and acetylcholine has a profound impact on reward signaling. |
2014-12-03 |
2023-08-12 |
rat |
| Zhenyu Cai, Dalei Zhang, Ying Ying, Min Yan, Jianhua Yang, Fangyun Xu, Kiwan Oh, Zhenzhen H. Inhibitory modulation of CART peptides in accumbal neuron through decreasing interaction of CaMKIIα with dopamine D3 receptors. Brain research. vol 1557. 2014-12-03. PMID:24560901. |
previous studies in rats have shown that microinjections of cocaine- and amphetamine-regulated transcript (cart) peptide into the nucleus accumbens (nac; the area of the brain that mediates drug reward and reinforcement) attenuate the locomotor effects of psychostimulants. |
2014-12-03 |
2023-08-12 |
rat |
| A J Robison, Vincent Vialou, Hao-Sheng Sun, Benoit Labonte, Sam A Golden, Caroline Dias, Gustavo Turecki, Carol Tamminga, Scott Russo, Michelle Mazei-Robison, Eric J Nestle. Fluoxetine epigenetically alters the CaMKIIα promoter in nucleus accumbens to regulate ΔFosB binding and antidepressant effects. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 5. 2014-12-01. PMID:24240473. |
recent work in addiction models demonstrates that the transcription factor Δfosb and protein kinase calmodulin-dependent protein kinase ii (camkii) are co-regulated in nucleus accumbens (nac), a brain reward region implicated in both addiction and depression models including social defeat. |
2014-12-01 |
2023-08-12 |
mouse |
| Na Yan, Ning Chen, Honghua Zhu, Jianguo Zhang, Moira Sim, Yu Ma, Wei Wan. High-frequency stimulation of nucleus accumbens changes in dopaminergic reward circuit. PloS one. vol 8. issue 11. 2014-11-24. PMID:24244479. |
these findings indicated that unilateral nac stimulation inhibits the morphine-induced rats associated hyperactivation of excitatory neurotransmission in the mesocorticolimbic reward circuit. |
2014-11-24 |
2023-08-12 |
rat |
| Changjiu Zhao, Brian Earl Eisinger, Terri M Driessen, Stephen C Gammi. Addiction and reward-related genes show altered expression in the postpartum nucleus accumbens. Frontiers in behavioral neuroscience. vol 8. 2014-11-21. PMID:25414651. |
modular single-set enrichment test (mset) indicated that postpartum (relative to virgin) nac gene expression profile was significantly enriched for genes related to addiction and reward in five of five independently curated databases (e.g., malacards, phenopedia). |
2014-11-21 |
2023-08-13 |
mouse |
| Changjiu Zhao, Brian Earl Eisinger, Terri M Driessen, Stephen C Gammi. Addiction and reward-related genes show altered expression in the postpartum nucleus accumbens. Frontiers in behavioral neuroscience. vol 8. 2014-11-21. PMID:25414651. |
this study indicates for the first time that postpartum nac involves large scale gene expression alterations linked to addiction and reward. |
2014-11-21 |
2023-08-13 |
mouse |
| John A Richey, Alison Rittenberg, Lauren Hughes, Cara R Damiano, Antoinette Sabatino, Stephanie Miller, Eleanor Hanna, James W Bodfish, Gabriel S Dichte. Common and distinct neural features of social and non-social reward processing in autism and social anxiety disorder. Social cognitive and affective neuroscience. vol 9. issue 3. 2014-11-18. PMID:23223206. |
results suggest reward network dysfunction to both monetary and social rewards in sad and asd during reward anticipation and outcomes, but that nac hypoactivation during monetary reward anticipation differentiates asd from sad. |
2014-11-18 |
2023-08-12 |
Not clear |
| Natalie E Zlebnik, Valerie L Hedges, Marilyn E Carroll, Robert L Meise. Chronic wheel running affects cocaine-induced c-Fos expression in brain reward areas in rats. Behavioural brain research. vol 261. 2014-10-06. PMID:24342748. |
the mean fold change in cocaine-induced c-fos cell counts relative to saline-induced c-fos cell counts was significantly higher in exercising compared to control rats in the nac core, dorsomedial and dorsolateral cpu, the prelimbic area, and the ofc, indicating differential cocaine-specific cellular activation of brain reward circuitry between exercising and control animals. |
2014-10-06 |
2023-08-12 |
human |
| Jamie D Roitman, Amy L Loriau. Nucleus accumbens responses differentiate execution and restraint in reward-directed behavior. Journal of neurophysiology. vol 111. issue 2. 2014-08-26. PMID:24174652. |
nac neurons have been shown to respond to cues that predict reward availability, goal-directed behaviors aimed at obtaining them, and delivery of the reward itself. |
2014-08-26 |
2023-08-12 |
rat |
| Jamie D Roitman, Amy L Loriau. Nucleus accumbens responses differentiate execution and restraint in reward-directed behavior. Journal of neurophysiology. vol 111. issue 2. 2014-08-26. PMID:24174652. |
to dissociate these possibilities, we recorded the activity of nac neurons while rats performed a task in which two different cues both informed rats of reward availability but required them to either press a lever (go) or withhold pressing (nogo) to obtain the reward. |
2014-08-26 |
2023-08-12 |
rat |
| Karolina P Skibicka, Rozita H Shirazi, Cristina Rabasa-Papio, Mayte Alvarez-Crespo, Corinna Neuber, Heike Vogel, Suzanne L Dickso. Divergent circuitry underlying food reward and intake effects of ghrelin: dopaminergic VTA-accumbens projection mediates ghrelin's effect on food reward but not food intake. Neuropharmacology. vol 73. 2014-08-13. PMID:23770258. |
a d1-like or a d2 receptor antagonist was injected into the nac in combination with ghrelin microinjection into the vta to investigate whether this blockade attenuates ghrelin-induced food reward behavior. |
2014-08-13 |
2023-08-12 |
Not clear |
| Karolina P Skibicka, Rozita H Shirazi, Cristina Rabasa-Papio, Mayte Alvarez-Crespo, Corinna Neuber, Heike Vogel, Suzanne L Dickso. Divergent circuitry underlying food reward and intake effects of ghrelin: dopaminergic VTA-accumbens projection mediates ghrelin's effect on food reward but not food intake. Neuropharmacology. vol 73. 2014-08-13. PMID:23770258. |
pretreatment with either a d1-like or d2 receptor antagonist into the nac, completely blocked the reward effect of ghrelin, leaving chow intake intact. |
2014-08-13 |
2023-08-12 |
Not clear |
| Karolina P Skibicka, Rozita H Shirazi, Cristina Rabasa-Papio, Mayte Alvarez-Crespo, Corinna Neuber, Heike Vogel, Suzanne L Dickso. Divergent circuitry underlying food reward and intake effects of ghrelin: dopaminergic VTA-accumbens projection mediates ghrelin's effect on food reward but not food intake. Neuropharmacology. vol 73. 2014-08-13. PMID:23770258. |
taken together our data identify the vta to nac dopaminergic projections, along with d1-like and d2 receptors in the nac, as essential elements of the ghrelin responsive circuits controlling food reward behavior. |
2014-08-13 |
2023-08-12 |
Not clear |
| Karolina P Skibicka, Rozita H Shirazi, Cristina Rabasa-Papio, Mayte Alvarez-Crespo, Corinna Neuber, Heike Vogel, Suzanne L Dickso. Divergent circuitry underlying food reward and intake effects of ghrelin: dopaminergic VTA-accumbens projection mediates ghrelin's effect on food reward but not food intake. Neuropharmacology. vol 73. 2014-08-13. PMID:23770258. |
interestingly results also suggest that food reward behavior and simple intake of chow are controlled by divergent circuitry, where nac dopamine plays an important role in food reward but not in food intake. |
2014-08-13 |
2023-08-12 |
Not clear |
| Arlene Martínez-Rivera, Enrique Rodríguez-Borrero, María Matías-Alemán, Alexandra Montalvo-Acevedo, Kathleen Guerrero-Figuereo, Liz J Febo-Rodríguez, Amarilys Morales-Rivera, Carmen S Maldonado-Vlaa. Metabotropic glutamate receptor 5 within nucleus accumbens shell modulates environment-elicited cocaine conditioning expression. Pharmacology, biochemistry, and behavior. vol 110. 2014-07-15. PMID:23850523. |
the metabotropic glutamate receptors 5 (mglurs5) within the nucleus accumbens (nac) have been implicated in the modulation of psychostimulant reward. |
2014-07-15 |
2023-08-12 |
rat |