| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yossef Goffer, Duo Xu, Sarah E Eberle, James D'amour, Michelle Lee, David Tukey, Robert C Froemke, Edward B Ziff, Jing Wan. Calcium-permeable AMPA receptors in the nucleus accumbens regulate depression-like behaviors in the chronic neuropathic pain state. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 48. 2014-01-28. PMID:24285907. |
using this model, we show that chronic pain selectively increases the level of glua1 subunits of ampa-type glutamate receptors at the synapses of the nucleus accumbens (nac), a key component of the brain reward system. |
2014-01-28 |
2023-08-12 |
rat |
| Bo Jiang, Wei Wang, Fang Wang, Zhuang-Li Hu, Jun-Li Xiao, Si Yang, Jing Zhang, Xiao-Zhong Peng, Jin-Hui Wang, Jian-Guo Che. The stability of NR2B in the nucleus accumbens controls behavioral and synaptic adaptations to chronic stress. Biological psychiatry. vol 74. issue 2. 2014-01-17. PMID:23260228. |
it has been demonstrated that the glutamatergic system in nac plays an important role in the reward pathway, dysfunction of which would cause anhedonia, a core symptom of depression. |
2014-01-17 |
2023-08-12 |
Not clear |
| Masayuki Miyazaki, Yukihiro Noda, Akihiro Mouri, Kazuto Kobayashi, Masayoshi Mishina, Toshitaka Nabeshima, Kiyofumi Yamad. Role of convergent activation of glutamatergic and dopaminergic systems in the nucleus accumbens in the development of methamphetamine psychosis and dependence. The international journal of neuropsychopharmacology. vol 16. issue 6. 2014-01-15. PMID:23195702. |
the nucleus accumbens (nac), which controls psychomotor and reward behaviours, is an important interface between the limbic system and receives convergent projections from dopaminergic and glutamatergic terminals. |
2014-01-15 |
2023-08-12 |
mouse |
| Michael R Hagerty, Julian Isaacs, Leigh Brasington, Larry Shupe, Eberhard E Fetz, Steven C Crame. Case study of ecstatic meditation: fMRI and EEG evidence of self-stimulating a reward system. Neural plasticity. vol 2013. 2013-12-30. PMID:23738149. |
in particular, the extreme joy is associated not only with activation of cortical processes but also with activation of the nucleus accumbens (nac) in the dopamine/opioid reward system. |
2013-12-30 |
2023-08-12 |
human |
| J M Bessa, M Morais, F Marques, L Pinto, J A Palha, O F X Almeida, N Sous. Stress-induced anhedonia is associated with hypertrophy of medium spiny neurons of the nucleus accumbens. Translational psychiatry. vol 3. 2013-12-23. PMID:23736119. |
as the nac is a key component in the neural circuitry of reward, it has been hypothesized that anhedonia, a core symptom of depression, might be related to dysfunction of this brain region. |
2013-12-23 |
2023-08-12 |
rat |
| Juergen Voges, Ulf Müller, Bernhard Bogerts, Thomas Münte, Hans-Jochen Heinz. Deep brain stimulation surgery for alcohol addiction. World neurosurgery. vol 80. issue 3-4. 2013-12-05. PMID:22824557. |
motivated by an accidental observation, we used the nucleus accumbens (nac), which has a central position in the dopaminergic reward system for deep brain stimulation (dbs) of alcohol addiction. |
2013-12-05 |
2023-08-12 |
Not clear |
| Andrew C Meyer, Nichole M Neugebauer, Guangrong Zheng, Peter A Crooks, Linda P Dwoskin, Michael T Bard. Effects of VMAT2 inhibitors lobeline and GZ-793A on methamphetamine-induced changes in dopamine release, metabolism and synthesis in vivo. Journal of neurochemistry. vol 127. issue 2. 2013-12-02. PMID:23875705. |
these results suggest that selective inhibition of vmat2 produces a time-dependent decrease in da release in nac shell as a result of alterations in tyrosine hydroxylase activity, which may play a role in the ability of gz-793a to decrease meth reward. |
2013-12-02 |
2023-08-12 |
rat |
| David S Tukey, Michelle Lee, Duo Xu, Sarah E Eberle, Yossef Goffer, Toby R Manders, Edward B Ziff, Jing Wan. Differential effects of natural rewards and pain on vesicular glutamate transporter expression in the nucleus accumbens. Molecular brain. vol 6. 2013-11-27. PMID:23835161. |
both pain and rewards, however, have been shown to alter synaptic activities in the nucleus accumbens (nac), a key component of the brain reward system. |
2013-11-27 |
2023-08-12 |
Not clear |
| Deveroux Ferguson, Ja Wook Koo, Jian Feng, Elizabeth Heller, Jacqui Rabkin, Mitra Heshmati, William Renthal, Rachael Neve, Xiaochuan Liu, Ningyi Shao, Vittorio Sartorelli, Li Shen, Eric J Nestle. Essential role of SIRT1 signaling in the nucleus accumbens in cocaine and morphine action. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 41. 2013-11-26. PMID:24107942. |
here, we establish an essential role for sirt1 and sirt2 in regulating behavioral responses to cocaine and morphine through actions in the nucleus accumbens (nac), a key brain reward region. |
2013-11-26 |
2023-08-12 |
mouse |
| Deveroux Ferguson, Ja Wook Koo, Jian Feng, Elizabeth Heller, Jacqui Rabkin, Mitra Heshmati, William Renthal, Rachael Neve, Xiaochuan Liu, Ningyi Shao, Vittorio Sartorelli, Li Shen, Eric J Nestle. Essential role of SIRT1 signaling in the nucleus accumbens in cocaine and morphine action. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 41. 2013-11-26. PMID:24107942. |
in contrast, the local knockdown of sirt1 from the nac of floxed sirt1 mice decreases drug reward. |
2013-11-26 |
2023-08-12 |
mouse |
| Marwan N Baliki, Ali Mansour, Alex T Baria, Lejian Huang, Sara E Berger, Howard L Fields, A Vania Apkaria. Parceling human accumbens into putative core and shell dissociates encoding of values for reward and pain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 41. 2013-11-26. PMID:24107968. |
we examined functional connectivity for resting state, monetary reward, and thermal pain tasks, and for all three conditions observed that pcore and pshell of right nac exhibit distinct patterns of synchrony (functional connectivity) to prefrontal cortical and subcortical limbic targets within the right hemisphere. |
2013-11-26 |
2023-08-12 |
human |
| Marwan N Baliki, Ali Mansour, Alex T Baria, Lejian Huang, Sara E Berger, Howard L Fields, A Vania Apkaria. Parceling human accumbens into putative core and shell dissociates encoding of values for reward and pain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 41. 2013-11-26. PMID:24107968. |
overall, we demonstrate that the human nac can be parceled based on structural and functional connectivity, and that activity in these subdivisions differentially encodes values for expected pain relief and for expected monetary reward. |
2013-11-26 |
2023-08-12 |
human |
| Yukie Kawahara, Fumi Kaneko, Makiko Yamada, Yuki Kishikawa, Hiroshi Kawahara, Akinori Nish. Food reward-sensitive interaction of ghrelin and opioid receptor pathways in mesolimbic dopamine system. Neuropharmacology. vol 67. 2013-11-04. PMID:23220294. |
thus, natural food reward and systemic ghrelin activate mu and kappa opioid receptor pathways in the vta, respectively, resulting in opposite influences on dopamine release in the nac. |
2013-11-04 |
2023-08-12 |
rat |
| Jing Liang, Si-Si Ma, Yi-Jing Li, Xing-Jie Ping, Ling Hu, Cai-Lian Cu. Dynamic changes of tyrosine hydroxylase and dopamine concentrations in the ventral tegmental area-nucleus accumbens projection during the expression of morphine-induced conditioned place preference in rats. Neurochemical research. vol 37. issue 7. 2013-10-31. PMID:22396106. |
these results indicated that th and the phosphorylation of th ser(40) in the vta may be responsible for da synthesis and release in the nac during the behavioral expression of conditioned reward elicited by a drug-associated context. |
2013-10-31 |
2023-08-12 |
rat |
| Devesh Mishra, Karima Chergu. Ethanol inhibits excitatory neurotransmission in the nucleus accumbens of adolescent mice through GABAA and GABAB receptors. Addiction biology. vol 18. issue 4. 2013-10-29. PMID:21790906. |
we, therefore, assessed age differences in the ability of ethanol to modulate glutamatergic synaptic transmission in the mouse nucleus accumbens (nac), a brain region importantly involved in reward mechanisms. |
2013-10-29 |
2023-08-12 |
mouse |
| Susana Peciña, Kent C Berridg. Dopamine or opioid stimulation of nucleus accumbens similarly amplify cue-triggered 'wanting' for reward: entire core and medial shell mapped as substrates for PIT enhancement. The European journal of neuroscience. vol 37. issue 9. 2013-10-28. PMID:23495790. |
we tested the ability of dopamine stimulation (by amphetamine microinjection) vs. mu opioid stimulation [by d-ala, nme-phe, glyol-enkephalin (damgo) microinjection] of either the core or shell of the nac to amplify cue-triggered levels of motivation to pursue sucrose reward, measured with a pavlovian-instrumental transfer (pit) procedure, a relatively pure assay of incentive salience. |
2013-10-28 |
2023-08-12 |
Not clear |
| Danielle M Judice-Daher, José Lino O Buen. Lesions of the nucleus accumbens disrupt reinforcement omission effects in rats. Behavioural brain research. vol 252. 2013-10-28. PMID:23796973. |
recent neuroimaging studies in human revealed reward delivery enhances activity of subcortical structures (nac and amygdala), whereas reward omission reduces the activity in these same structures. |
2013-10-28 |
2023-08-12 |
human |
| Tatiana V Lipina, Paul J Fletcher, Frankie H Lee, Albert H C Wong, John C Rode. Disrupted-in-schizophrenia-1 Gln31Leu polymorphism results in social anhedonia associated with monoaminergic imbalance and reduction of CREB and β-arrestin-1,2 in the nucleus accumbens in a mouse model of depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 3. 2013-10-17. PMID:23011268. |
overall, we find neurobiological changes accompanying social anhedonia in the nac of disc1-q31l mutant mice, consistent with a role for disc1 in regulating social reward as an endophenotype of depression. |
2013-10-17 |
2023-08-12 |
mouse |
| Zhen-Yu Ren, Meng-Meng Liu, Yan-Xue Xue, Zeng-Bo Ding, Li-Fen Xue, Suo-Di Zhai, Lin L. A critical role for protein degradation in the nucleus accumbens core in cocaine reward memory. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 5. 2013-09-17. PMID:23303053. |
finally, infusions of lactacystin by itself into the nac core immediately after each training session or before the cpp retrieval test had no effect on the consolidation and retrieval of cocaine reward memory. |
2013-09-17 |
2023-08-12 |
rat |
| Colin M Stopper, Shahin Khayambashi, Stan B Floresc. Receptor-specific modulation of risk-based decision making by nucleus accumbens dopamine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 5. 2013-09-17. PMID:23303055. |
however, it remains unclear how da activity within the nac may regulate decision making involving reward uncertainty. |
2013-09-17 |
2023-08-12 |
rat |