| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Q Long, Y Hei, Q Luo, Y Tian, J Yang, J Li, L Wei, W Li. BMSCs transplantation improves cognitive impairment via up-regulation of hippocampal GABAergic system in a rat model of chronic cerebral hypoperfusion. Neuroscience. vol 311. 2016-09-14. PMID:26545982. |
our results showed that the 2vo model presented decreased capacities of learning and memory and down-regulated the expression of gaba, gad67 or gaba(b)r1 in the hippocampal ca1 subfield in comparison to the sham group (p<0.05), while administration of bmscs (experimental group) manifested increased performances of learning sessions and probe tasks, as well as up-regulated expression of gaba, gad67 or gaba(b)r1 compared with the control group i (p<0.05). |
2016-09-14 |
2023-08-13 |
rat |
| Silke J Hirsch, Nanda L Regmi, Shari G Birnbaum, Robert W Green. CA1-specific deletion of NMDA receptors induces abnormal renewal of a learned fear response. Hippocampus. vol 25. issue 11. 2016-08-29. PMID:25786918. |
ca1 hippocampal n-methyl-d-aspartate-receptors (nmdars) are necessary for contextually related learning and memory processes. |
2016-08-29 |
2023-08-13 |
Not clear |
| Hui Shao, Ze Mi, Wei-gang Ji, Cheng-huan Zhang, Teng Zhang, Shuan-cheng Ren, Zhi-ru Zh. Rhynchophylline Protects Against the Amyloid β-Induced Increase of Spontaneous Discharges in the Hippocampal CA1 Region of Rats. Neurochemical research. vol 40. issue 11. 2016-08-24. PMID:26441223. |
as an important structure associated with learning and memory, the hippocampus is one of the brain regions that are impaired very early in ad, and the hippocampal ca1 region is selectively vulnerable to soluble aβ oligomers. |
2016-08-24 |
2023-08-13 |
mouse |
| Jing-yi Tu, Ying Zhu, Shu-ling Shang, Xi Zhang, Hui Tang, Rui-min Wan. [Keap1-tat peptide attenuates oxidative stress damage in hippocampal CA1 region and learning and memory deficits following global cerebral ischemia]. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences. vol 48. issue 1. 2016-06-10. PMID:26885927. |
[keap1-tat peptide attenuates oxidative stress damage in hippocampal ca1 region and learning and memory deficits following global cerebral ischemia]. |
2016-06-10 |
2023-08-13 |
Not clear |
| Jing-yi Tu, Ying Zhu, Shu-ling Shang, Xi Zhang, Hui Tang, Rui-min Wan. [Keap1-tat peptide attenuates oxidative stress damage in hippocampal CA1 region and learning and memory deficits following global cerebral ischemia]. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences. vol 48. issue 1. 2016-06-10. PMID:26885927. |
to design keap1-tat peptide and explore its neuroprotective role on hipocampal ca1 neuron, as well as the effect on spacial learning and memory function following global cerebral ischemia. |
2016-06-10 |
2023-08-13 |
Not clear |
| Desheng Wang, Wen Zhen. Dietary cholesterol concentration affects synaptic plasticity and dendrite spine morphology of rabbit hippocampal neurons. Brain research. vol 1622. 2016-06-01. PMID:26188241. |
therefore, dietary cholesterol dose-dependently modulated both synaptic plasticity and dendrite spine morphologies of hippocampal ca1 neurons that could mediate learning and memory changes previously seen to result from feeding a cholesterol diet. |
2016-06-01 |
2023-08-13 |
rabbit |
| Pan Luo, Yun Lu, Changjun Li, Mei Zhou, Cheng Chen, Qing Lu, Xulin Xu, Zhi He, Lianjun Gu. Long-lasting spatial learning and memory impairments caused by chronic cerebral hypoperfusion associate with a dynamic change of HCN1/HCN2 expression in hippocampal CA1 region. Neurobiology of learning and memory. vol 123. 2016-05-26. PMID:26021557. |
long-lasting spatial learning and memory impairments caused by chronic cerebral hypoperfusion associate with a dynamic change of hcn1/hcn2 expression in hippocampal ca1 region. |
2016-05-26 |
2023-08-13 |
rat |
| Pan Luo, Yun Lu, Changjun Li, Mei Zhou, Cheng Chen, Qing Lu, Xulin Xu, Zhi He, Lianjun Gu. Long-lasting spatial learning and memory impairments caused by chronic cerebral hypoperfusion associate with a dynamic change of HCN1/HCN2 expression in hippocampal CA1 region. Neurobiology of learning and memory. vol 123. 2016-05-26. PMID:26021557. |
our data showed that cch induced a remarkable spatial learning and memory deficits in rats of 2vo 4, 8, and 12weeks group although neuronal loss only occurred after 4weeks of 2vo surgery in ca1. |
2016-05-26 |
2023-08-13 |
rat |
| Pan Luo, Yun Lu, Changjun Li, Mei Zhou, Cheng Chen, Qing Lu, Xulin Xu, Zhi He, Lianjun Gu. Long-lasting spatial learning and memory impairments caused by chronic cerebral hypoperfusion associate with a dynamic change of HCN1/HCN2 expression in hippocampal CA1 region. Neurobiology of learning and memory. vol 123. 2016-05-26. PMID:26021557. |
our findings indicate spatial learning and memory deficits in the cch model are associated with disturbed hcn1 and hcn2 surface expression in hippocampal ca1. |
2016-05-26 |
2023-08-13 |
rat |
| Shaniya Maimaiti, Chris DeMoll, Katie L Anderson, Ryan B Griggs, Bradley K Taylor, Nada M Porter, Olivier Thibaul. Short-lived diabetes in the young-adult ZDF rat does not exacerbate neuronal Ca(2+) biomarkers of aging. Brain research. vol 1621. 2016-05-23. PMID:25451110. |
because of robust evidence that in animal models of aging, ca(2+) dysregulation alters neuronal health, synaptic plasticity, and learning and memory processes, we tested the hypothesis that peripheral metabolic dysregulation could exacerbate ca(2+) dysfunction in hippocampal ca1 neurons. |
2016-05-23 |
2023-08-13 |
rat |
| Marissa J Schafer, Igor Dolgalev, Melissa J Alldred, Adriana Heguy, Stephen D Ginsber. Calorie Restriction Suppresses Age-Dependent Hippocampal Transcriptional Signatures. PloS one. vol 10. issue 7. 2016-05-10. PMID:26221964. |
we examined the influence of long-term cr on the ca1 hippocampal region, a key learning and memory brain area that is vulnerable to age-related pathologies, such as alzheimer's disease (ad). |
2016-05-10 |
2023-08-13 |
mouse |
| Helene A Fachim, Adriana C Pereira, Melina M Iyomasa-Pilon, Maria L N M Ros. Differential Expression of AMPA Subunits Induced by NMDA Intrahippocampal Injection in Rats. Frontiers in neuroscience. vol 10. 2016-02-25. PMID:26912994. |
it was observed the impairment of learning and memory functions, loss of neuronal cells, and glial proliferation in ca1 area of nmda compared with control groups, confirming the injury efficacy. |
2016-02-25 |
2023-08-13 |
rat |
| Jun-shan Huang, Wei-bo Zhang, Xing-min Zheng, Qiu-cheng Lin, Jing-yi Li, Zuo-dan Zhang, Jian Li. [Effects of Ruanmailing Oral Liquid on spatial learning and memory ability and expression of APE/Ref-1 in hippocampal CA1 region in rats with experimental vascular dementia]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. vol 7. issue 9. 2016-02-13. PMID:19747442. |
[effects of ruanmailing oral liquid on spatial learning and memory ability and expression of ape/ref-1 in hippocampal ca1 region in rats with experimental vascular dementia]. |
2016-02-13 |
2023-08-12 |
rat |
| Jun-shan Huang, Wei-bo Zhang, Xing-min Zheng, Qiu-cheng Lin, Jing-yi Li, Zuo-dan Zhang, Jian Li. [Effects of Ruanmailing Oral Liquid on spatial learning and memory ability and expression of APE/Ref-1 in hippocampal CA1 region in rats with experimental vascular dementia]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. vol 7. issue 9. 2016-02-13. PMID:19747442. |
to study the effects of ruanmailing oral liquid, a compound traditional chinese herbal medicine, on spatial learning and memory ability and expression of apurinic/apyrimidinic endonuclease/redox factor-1 (ape/ref-1) in hippocampal ca1 region in rats with experimental vascular dementia (vad). |
2016-02-13 |
2023-08-12 |
rat |
| Fen Guo, Xin-Yi Li, Xiao-Hui Wang, Jin-Shun Q. [Involvement of protein tyrosine kinases in β-amyloid protein-induced suppression of long-term potentiation in the rat hippocampal CA1 region in vivo]. Sheng li xue bao : [Acta physiologica Sinica]. vol 61. issue 3. 2016-02-02. PMID:19536439. |
injection of aβ(23-35) can significantly suppress the hfs-induced ltp in the ca1 area of rat hippocampus in vivo, implying that the aβ deposited in the brain of patients with alzheimer's disease may impair the function of learning and memory by suppressing the hippocampal ltp. |
2016-02-02 |
2023-08-12 |
rat |
| Oskar Karlsson, Anna-Lena Berg, Jörg Hanrieder, Gunnel Arnerup, Anna-Karin Lindström, Eva B Britteb. Intracellular fibril formation, calcification, and enrichment of chaperones, cytoskeletal, and intermediate filament proteins in the adult hippocampus CA1 following neonatal exposure to the nonprotein amino acid BMAA. Archives of toxicology. vol 89. issue 3. 2015-12-01. PMID:24798087. |
bmaa is a developmental neurotoxicant that can induce long-term learning and memory deficits, as well as regionally restricted neuronal degeneration and mineralization in the hippocampal ca1. |
2015-12-01 |
2023-08-13 |
rat |
| Sohaila Erfani, Mehdi Khaksari, Shahrbanoo Oryan, Nabi Shamsaei, Nahid Aboutaleb, Farnaz Nikbakht, Nida Jamali-Raeufy, Fazel Gorjipou. Visfatin reduces hippocampal CA1 cells death and improves learning and memory deficits after transient global ischemia/reperfusion. Neuropeptides. vol 49. 2015-12-01. PMID:25617953. |
visfatin reduces hippocampal ca1 cells death and improves learning and memory deficits after transient global ischemia/reperfusion. |
2015-12-01 |
2023-08-13 |
rat |
| Oleg Senkov, Andrey Mironov, Alexander Dityate. A novel versatile hybrid infusion-multielectrode recording (HIME) system for acute drug delivery and multisite acquisition of neuronal activity in freely moving mice. Frontiers in neuroscience. vol 9. 2015-11-23. PMID:26594144. |
here, we provide examples of bilateral injection and recordings of full spectrum of learning and memory related oscillations, i.e., theta (4-12 hz), gamma (40-100) and ripple activity (130-150 hz), in five hippocampal layers as well as in the ca1 and ca2 regions. |
2015-11-23 |
2023-08-13 |
mouse |
| J C Walton, Z Chen, J B Travers, R J Nelso. Exogenous melatonin reproduces the effects of short day lengths on hippocampal function in male white-footed mice, Peromyscus leucopus. Neuroscience. vol 248. 2015-11-03. PMID:23806713. |
extending the duration of melatonin exposure, by short-day exposure or via melatonin implants, impaired both schaffer collateral ltp in the ca1 region of the hippocampus and spatial learning and memory, and altered neuronal morphology in all hippocampal regions. |
2015-11-03 |
2023-08-12 |
mouse |
| Vasiliki Kyrargyri, Germán Vega-Flores, Agnès Gruart, José M Delgado-García, Lesley Prober. Differential contributions of microglial and neuronal IKKβ to synaptic plasticity and associative learning in alert behaving mice. Glia. vol 63. issue 4. 2015-10-29. PMID:25297800. |
to understand the consequences of such impairments in synaptic plasticity for learning and memory, we measured ca1 fepsps in behaving mice during instrumental conditioning. |
2015-10-29 |
2023-08-13 |
mouse |