| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bo-Lin Wang, Ling Xuan, Shi-Jie Dai, Li-Ting Ji, Chang-Yu Li, Yuan-Xiao Yan. [Protective effect of β-asarone on AD rat model induced by intracerebroventricular injection of Aβ₁₋₄₂ combined 2-VO and its mechanism]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 42. issue 24. 2019-05-08. PMID:29493157. |
rats' learning and memory abilities, cerebric regional blood flow, pathological changes in hippocampal ca1 region, the expression level of hif-1α and serum cat, sod and mda level were detected 4 weeks later. |
2019-05-08 |
2023-08-13 |
rat |
| Yangguang Ou, Stephen G Webe. Higher Aminopeptidase Activity Determined by Electroosmotic Push-Pull Perfusion Contributes to Selective Vulnerability of the Hippocampal CA1 Region to Oxygen Glucose Deprivation. ACS chemical neuroscience. vol 9. issue 3. 2019-05-07. PMID:29078045. |
it has been known for over a century that the hippocampus, the center for learning and memory in the brain, is selectively vulnerable to ischemic damage, with the ca1 being more vulnerable than the ca3. |
2019-05-07 |
2023-08-13 |
rat |
| Lin Xu, Xiaofei Qiu, Shuo Wang, Qingshan Wang, Xiu-Lan Zha. NMDA Receptor Antagonist MK801 Protects Against 1-Bromopropane-Induced Cognitive Dysfunction. Neuroscience bulletin. vol 35. issue 2. 2019-04-29. PMID:30569431. |
we found that the spatial learning and memory were significantly impaired in the 1-bp group, and this was associated with neurodegeneration in both the hippocampus (especially ca1 and ca3) and cortex. |
2019-04-29 |
2023-08-13 |
rat |
| Bin Wang, Qiong Wu, Lei Lei, Hailun Sun, Ntim Michael, Xuan Zhang, Ying Wang, Yue Zhang, Biying Ge, Xuefei Wu, Yue Wang, Yi Xin, Jie Zhao, Shao L. Long-term social isolation inhibits autophagy activation, induces postsynaptic dysfunctions and impairs spatial memory. Experimental neurology. vol 311. 2019-04-10. PMID:30219732. |
we discovered that long-term post-weaning social isolation (l-pwsi) produced marked deficits in spatial learning and memory and inhibited ca1 long-term potentiation (ltp), but paired-pulse facilitation (ppf) and input/output (i/o) curve were unaffected. |
2019-04-10 |
2023-08-13 |
mouse |
| Chen Bian, Yan Huang, Haitao Zhu, Yangang Zhao, Jikai Zhao, Jiqiang Zhan. Steroid Receptor Coactivator-1 Knockdown Decreases Synaptic Plasticity and Impairs Spatial Memory in the Hippocampus of Mice. Neuroscience. vol 377. 2019-03-11. PMID:29524638. |
the in vivo results showed that src-1 knockdown significantly decreased the expression of synaptic proteins and ca1 synapse density as well as psd thickness; src-1 knockdown also significantly impaired in vivo ltp and disrupted spatial learning and memory. |
2019-03-11 |
2023-08-13 |
mouse |
| Fang-Zhou Chen, Ying Zhao, Hui-Zhao Che. MicroRNA-98 reduces amyloid β-protein production and improves oxidative stress and mitochondrial dysfunction through the Notch signaling pathway via HEY2 in Alzheimer's disease mice. International journal of molecular medicine. vol 43. issue 1. 2019-02-28. PMID:30365070. |
the ad mice exhibited poorer learning and memory abilities, oxidative stress function, and morphological changes of pyramidal cells in the hippocampal ca1 region. |
2019-02-28 |
2023-08-13 |
mouse |
| Poonam Ruhal, Dinesh Dhingr. Inosine improves cognitive function and decreases aging-induced oxidative stress and neuroinflammation in aged female rats. Inflammopharmacology. vol 26. issue 5. 2019-02-20. PMID:29619603. |
in conclusion, inosine significantly improved learning and memory of aged female rats possibly through its antioxidant as well as anti-inflammatory effect and improvement of neuronal survival in the hippocampal ca1 region. |
2019-02-20 |
2023-08-13 |
rat |
| Qianqian Qi, Jing Xu, Peiyuan Lv, Yanhong Dong, Zhijuan Liu, Ming Hu, Yining Xiao, Yanqiu Jia, Wei Jin, Mingyue Fan, Dandan Zhang, Nan Men. DL-3-n-butylphthalide alleviates vascular cognitive impairment induced by chronic cerebral hypoperfusion by activating the Akt/Nrf2 signaling pathway in the hippocampus of rats. Neuroscience letters. vol 672. 2019-02-18. PMID:29175633. |
the obtained results indicate that both administrated doses of nbp significantly ameliorated the spatial learning and memory impairments as indicated by the morris water maze test while hematoxylin-eosin staining revealed that morphological defects in the ca1 area of hippocampus were improved. |
2019-02-18 |
2023-08-13 |
rat |
| Albert Orock, Sreemathi Logan, Ferenc Dea. Munc18-1 haploinsufficiency impairs learning and memory by reduced synaptic vesicular release in a model of Ohtahara syndrome. Molecular and cellular neurosciences. vol 88. 2019-01-31. PMID:29217410. |
munc18-1 heterozygous knock-out mice showed impaired spatial learning and memory in behavior tests as well as reduced synaptic plasticity in hippocampal ca1 long-term potentiation. |
2019-01-31 |
2023-08-13 |
mouse |
| An Schreurs, Victor Sabanov, Detlef Balschu. Distinct Properties of Long-Term Potentiation in the Dentate Gyrus along the Dorsoventral Axis: Influence of Age and Inhibition. Scientific reports. vol 7. issue 1. 2019-01-16. PMID:28698637. |
long-term potentiation (ltp), the best-investigated cellular correlate of learning and memory, has distinct properties along this axis in the ca1 region, but so far, little is known about longitudinal differences in dentate gyrus (dg). |
2019-01-16 |
2023-08-13 |
mouse |
| Azim Hedayatpour, Maryam Shiasi, Hamidreza Famitafreshi, Farid Abolhassani, Parisa Ebrahimnia, Tahmineh Mokhtari, Gholamreza Hassanzaeh, Morteza Karimian, Bashir Nazparvar, Narges Marefati, Masoomeh Dehghan Tarzjan. Co-Administration of Progesterone and Melatonin Attenuates Ischemia-Induced Hippocampal Damage in Rats. Journal of molecular neuroscience : MN. vol 66. issue 2. 2018-12-18. PMID:30182311. |
as indicated by the outcomes, co-administration of prog and mel can enhance learning and memory by surviving the pyramidal neurons and diminishing neural death by means of increasing neuroleptic factors in the hippocampal ca1 zone. |
2018-12-18 |
2023-08-13 |
rat |
| Ning Cao, Tuling Liao, Jiajing Liu, Zeng Fan, Quan Zeng, Junnian Zhou, Haiyun Pei, Jiafei Xi, Lijuan He, Lin Chen, Xue Nan, Yali Jia, Wen Yue, Xuetao Pe. Clinical-grade human umbilical cord-derived mesenchymal stem cells reverse cognitive aging via improving synaptic plasticity and endogenous neurogenesis. Cell death & disease. vol 8. issue 8. 2018-04-30. PMID:28796260. |
after 3 months of systematical regulation of huc-mscs, the hippocampal-dependent learning and memory ability was effectively improved in aged mice, and the synaptic plasticity was remarkably enhanced in ca1 area of the aged hippocampus; moreover, the neurobiological substrates that could impact on the function of hippocampal circuits were recovered in the aged hippocampus reflecting in: dendritic spine density enhanced, neural sheath and cytoskeleton restored, and postsynaptic density area increased. |
2018-04-30 |
2023-08-13 |
mouse |
| Khadijeh Esmaeilpour, Vahid Sheibani, Mohammad Shabani, Javad Mirnajafi-Zade. Low frequency electrical stimulation has time dependent improving effect on kindling-induced impairment in long-term potentiation in rats. Brain research. vol 1668. 2018-03-28. PMID:28532854. |
considering the important role of long-term potentiation (ltp) in learning and memory, in the present study the effectiveness of lfs on kindling-induced impairment in ltp induction was investigated in hippocampal ca1 area at different times post kindling stimulations. |
2018-03-28 |
2023-08-13 |
rat |
| S D Schmidt, C R G Furini, C G Zinn, L E Cavalcante, F F Ferreira, J A K Behling, J C Myskiw, I Izquierd. Modulation of the consolidation and reconsolidation of fear memory by three different serotonin receptors in hippocampus. Neurobiology of learning and memory. vol 142. issue Pt A. 2018-03-26. PMID:28034785. |
with focus on serotonin (5-ht), a well characterized neurotransmitter that has been strongly implicated in learning and memory, we investigated, in the ca1 region of the dorsal hippocampus, whether the latest discovered serotonergic receptors, 5-ht |
2018-03-26 |
2023-08-13 |
Not clear |
| Rongli Yang, Kun Hu, Jieyun Chen, Shiguang Zhu, Lei Li, Hailong Lu, Pingjing Li, Ruiguo Don. Necrostatin-1 protects hippocampal neurons against ischemia/reperfusion injury via the RIP3/DAXX signaling pathway in rats. Neuroscience letters. vol 651. 2018-03-26. PMID:28501693. |
global cerebral ischemia/reperfusion (i/r) induces selective neuronal injury in ca1 region of hippocampus, leading to severe impairment in behavior, learning and memory functions. |
2018-03-26 |
2023-08-13 |
rat |
| Corey G Duke, Andrew J Kennedy, Cristin F Gavin, Jeremy J Day, J David Sweat. Experience-dependent epigenomic reorganization in the hippocampus. Learning & memory (Cold Spring Harbor, N.Y.). vol 24. issue 7. 2018-03-26. PMID:28620075. |
using a hippocampus-dependent contextual threat learning and memory task, we report widespread, coordinated dna methylation changes in ca1 hippocampus of sprague-dawley rats specific to threat learning at genes involved in synaptic transmission. |
2018-03-26 |
2023-08-13 |
rat |
| Izumi Maezawa, Bende Zou, Jacopo Di Lucente, William S Cao, Conrado Pascual, Sahani Weerasekara, Man Zhang, Xinmin Simon Xie, Duy H Hua, Lee-Way Ji. The Anti-Amyloid-β and Neuroprotective Properties of a Novel Tricyclic Pyrone Molecule. Journal of Alzheimer's disease : JAD. vol 58. issue 2. 2018-03-16. PMID:28482635. |
interestingly, tp70 enhanced n-methyl-d-aspartate (nmda) receptor-mediated excitatory post-synaptic potential (epsp) in the hippocampal ca1 area, increased the magnitude of nmda-dependent hippocampal long-term potentiation (ltp), a cellular model of learning and memory, and prevented the aβ oligomer-impaired ltp. |
2018-03-16 |
2023-08-13 |
mouse |
| Kevin N Hascup, Erin R Hascu. Soluble Amyloid-β42 Stimulates Glutamate Release through Activation of the α7 Nicotinic Acetylcholine Receptor. Journal of Alzheimer's disease : JAD. vol 53. issue 1. 2018-01-29. PMID:27163813. |
because aβ42 binds the α7 nicotinic acetylcholine receptors (α7nachrs) located presynaptically on glutamatergic terminals, involved with hippocampal dependent learning and memory, we examined the effects of the human, monomeric isoform of aβ42 on glutamate release in the dentate gyrus (dg), ca3, and ca1, of isoflurane anesthetized, 6-9 month old male c57bl/6j mice. |
2018-01-29 |
2023-08-13 |
mouse |
| Muneaki Miyata, Tomohiko Maruo, Aika Kaito, Shujie Wang, Hideaki Yamamoto, Takeshi Fujiwara, Akira Mizoguchi, Kenji Mandai, Yoshimi Taka. Roles of afadin in the formation of the cellular architecture of the mouse hippocampus and dentate gyrus. Molecular and cellular neurosciences. vol 79. 2018-01-12. PMID:28041940. |
the hippocampal formation with tightly packed neurons, mainly at the dentate gyrus, ca3, ca2, and ca1 regions, constitutes a one-way neural circuit, which is associated with learning and memory. |
2018-01-12 |
2023-08-13 |
mouse |
| Charles H Cohan, Holly M Stradecki-Cohan, Kahlilia C Morris-Blanco, Nathalie Khoury, Kevin B Koronowski, Mehdi Youbi, Clinton B Wright, Miguel A Perez-Pinzo. Protein kinase C epsilon delays latency until anoxic depolarization through arc expression and GluR2 internalization. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 37. issue 12. 2017-12-18. PMID:28585865. |
global cerebral ischemia is a debilitating injury that damages the ca1 region of the hippocampus, an area important for learning and memory. |
2017-12-18 |
2023-08-13 |
Not clear |