| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yehong Du, Min Fu, Zhilin Huang, Xin Tian, Junjie Li, Yayan Pang, Weihong Song, Yu Tian Wang, Zhifang Don. TRPV1 activation alleviates cognitive and synaptic plasticity impairments through inhibiting AMPAR endocytosis in APP23/PS45 mouse model of Alzheimer's disease. Aging cell. vol 19. issue 3. 2021-05-10. PMID:32061032. |
meanwhile, upregulation of trpv1 ameliorated the deficits of hippocampal ca1 long-term potentiation (ltp) and spatial learning and memory through inhibiting glua2-containing α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (ampar) endocytosis. |
2021-05-10 |
2023-08-13 |
mouse |
| Yehong Du, Min Fu, Zhilin Huang, Xin Tian, Junjie Li, Yayan Pang, Weihong Song, Yu Tian Wang, Zhifang Don. TRPV1 activation alleviates cognitive and synaptic plasticity impairments through inhibiting AMPAR endocytosis in APP23/PS45 mouse model of Alzheimer's disease. Aging cell. vol 19. issue 3. 2021-05-10. PMID:32061032. |
), an agonist of trpv1, dramatically reversed the impairments of hippocampal ca1 ltp and spatial learning and memory in ad model mice. |
2021-05-10 |
2023-08-13 |
mouse |
| Hang Yu, Zhidian Wu, Xiaozhi Wang, Chang Gao, Run Liu, Fuxin Kang, Mingming Da. Protective effects of combined treatment with mild hypothermia and edaravone against cerebral ischemia/reperfusion injury via oxidative stress and Nrf2 pathway regulation. International journal of oncology. vol 57. issue 2. 2021-05-05. PMID:32626935. |
it was observed that mice treated by mcao had higher neurological deficit scores and oxidative stress levels, and low spatial learning and memory capacity; moreover, the ca1 region of the hippocampi of the mice exhibited reduced neuronal density and viability, and reduced mitochondrial dysfunction. |
2021-05-05 |
2023-08-13 |
mouse |
| Akinsola Raphael Akinyemi, Dingfeng Li, Juan Zhang, Qiang Li. hnRNPM deficiency leads to cognitive deficits via disrupting synaptic plasticity. Neuroscience letters. vol 751. 2021-04-30. PMID:33727124. |
in this study, we report that knockdown of hnrnpm in the ca1 hippocampal region of the mouse brain leads to learning and memory impairment. |
2021-04-30 |
2023-08-13 |
mouse |
| Kamilla G Haugland, Anniken Olberg, Andreas Lande, Kirsten B Kjelstrup, Vegard H Bru. Hippocampal growth hormone modulates relational memory and the dendritic spine density in CA1. Learning & memory (Cold Spring Harbor, N.Y.). vol 27. issue 2. 2021-04-26. PMID:31949035. |
to determine how gh affects the capacity for learning and memory by specific actions in one of the key areas, the hippocampus, we injected recombinant adeno-associated viruses (raavs) in male rats to express green fluorescent protein (gfp) combined with either gh, antagonizing gh (agh), or no hormone, in the dorsal ca1. |
2021-04-26 |
2023-08-13 |
rat |
| Ting Ye, Xinquan Li, Peng Zhou, Shu Ye, Huawu Gao, Rupeng Hua, Junlong Ma, Yan Wang, Biao Ca. Chrysophanol improves memory ability of d-galactose and Aβ 3 Biotech. vol 10. issue 3. 2021-03-02. PMID:32117672. |
an alzheimer's disease rat model was established using an intraperitoneal injection of d-galactose combined with an intracerebral injection of amyloid-β peptide (25-35), and the effect of chr on the learning and memory ability, the hippocampal neurons change, the ultrastructure of the hippocampal ca1 region, the protein levels of cam, camkk, camkiv, p-camkiv and p-tau in the hippocampus of rats were studied. |
2021-03-02 |
2023-08-13 |
rat |
| Manimaran Ramani, Kiara Miller, Namasivayam Ambalavanan, Lori L McMaho. Increased Excitability and Heightened Magnitude of Long-Term Potentiation at Hippocampal CA3-CA1 Synapses in a Mouse Model of Neonatal Hyperoxia Exposure. Frontiers in synaptic neuroscience. vol 12. 2021-01-26. PMID:33488380. |
the area ca1 region of the hippocampus that is crucial for spatial learning and memory is highly vulnerable to oxidative stress. |
2021-01-26 |
2023-08-13 |
mouse |
| Mohammad-Reza Zarrindast, Fatemeh Khakpa. State-dependent memory and its modulation by different brain areas and neurotransmitters. EXCLI journal. vol 19. 2020-10-06. PMID:33013265. |
our review of the literature revealed that: (a) re-administration of drugs on the same state induce state-dependent memory; (b) many neurotransmitters induce endogenous state-dependent memory; (c) there are cross state-dependent learning and memory between some drugs; (d) some sites of the brain including the ca1 areas of the hippocampus, central nucleus of the amygdala (cea), septum, ventral tegmental area (vta), and nucleus accumbens (nac) are involved in state-dependent memory. |
2020-10-06 |
2023-08-13 |
human |
| Razieh Kooshki, Mehdi Abbasnejad, Saeed Esmaeili-Mahani, Maryam Raoo. The Modulatory Role of Orexin 1 Receptor in CA1 on Orofacial Pain-induced Learning and Memory Deficits in Rats. Basic and clinical neuroscience. vol 8. issue 3. 2020-10-01. PMID:28781729. |
the modulatory role of orexin 1 receptor in ca1 on orofacial pain-induced learning and memory deficits in rats. |
2020-10-01 |
2023-08-13 |
rat |
| Zhilin Huang, Tao Tan, Yehong Du, Long Chen, Min Fu, Yanzhi Yu, Lu Zhang, Weihong Song, Zhifang Don. Low-Frequency Repetitive Transcranial Magnetic Stimulation Ameliorates Cognitive Function and Synaptic Plasticity in APP23/PS45 Mouse Model of Alzheimer's Disease. Frontiers in aging neuroscience. vol 9. 2020-09-30. PMID:28955219. |
furthermore, these behavioral changes were accompanied by the impairment of long-term potentiation (ltp) in the ca1 region of hippocampus, a brain region vital to spatial learning and memory. |
2020-09-30 |
2023-08-13 |
mouse |
| Zhilin Huang, Tao Tan, Yehong Du, Long Chen, Min Fu, Yanzhi Yu, Lu Zhang, Weihong Song, Zhifang Don. Low-Frequency Repetitive Transcranial Magnetic Stimulation Ameliorates Cognitive Function and Synaptic Plasticity in APP23/PS45 Mouse Model of Alzheimer's Disease. Frontiers in aging neuroscience. vol 9. 2020-09-30. PMID:28955219. |
more importantly, 2-week low-frequency rtms treatment markedly reversed the impairment of spatial learning and memory as well as hippocampal ca1 ltp. |
2020-09-30 |
2023-08-13 |
mouse |
| Xiao Li, Rui-Zhen Liu, Qi Zeng, Zhi-Hua Huang, Jian-Dong Zhang, Zong-Liang Liu, Jing Zeng, Hai Xia. 3'-Daidzein sulfonate sodium protects against memory impairment and hippocampal damage caused by chronic cerebral hypoperfusion. Neural regeneration research. vol 13. issue 9. 2020-09-30. PMID:30127116. |
results showed that dss treatment greatly improved the learning and memory deficits of rats with cch, reduced apoptosis of neurons in the hippocampal ca1, ca3 regions and dentate gyrus, and increased the phosphorylation of pka, erk1/2, and creb in the hippocampus. |
2020-09-30 |
2023-08-13 |
rat |
| Julie C Savage, Marie-Kim St-Pierre, Chin Wai Hui, Marie-Eve Trembla. Microglial Ultrastructure in the Hippocampus of a Lipopolysaccharide-Induced Sickness Mouse Model. Frontiers in neuroscience. vol 13. 2020-09-30. PMID:31920505. |
microglial cell bodies and processes were investigated in the hippocampus ca1, a region responsible for learning and memory that is often impacted after peripheral lps administration. |
2020-09-30 |
2023-08-13 |
mouse |
| Wei-Yi Gong, Rong Wang, Yuan Liu, He Jin, Zhi-Wei Zhao, Yu-Lan Wang, Hong-Yan Li, Xu Zhang, Jia-Xiang N. Chronic Monoarthritis Pain Accelerates the Processes of Cognitive Impairment and Increases the NMDAR Subunits NR2B in CA3 of Hippocampus from 5-month-old Transgenic APP/PS1 Mice. Frontiers in aging neuroscience. vol 9. 2020-09-29. PMID:28553223. |
pain behavior, learning and memory function, and the distribution and quantity of nmdar subunits (nr1, nr2a and nr2b) in hippocampal ca1 and ca3 regions were assessed. |
2020-09-29 |
2023-08-13 |
mouse |
| Azam Sadeghian, Yaghoub Fathollahi, Mohammad Javan, Amir Shojaei, Nastaran Kosarmadar, Mahmoud Rezaei, Javad Mirnajafi-Zade. Spatial Learning and Memory in Barnes Maze Test and Synaptic Potentiation in Schaffer Collateral-CA1 Synapses of Dorsal Hippocampus in Freely Moving Rats. Basic and clinical neuroscience. vol 10. issue 5. 2020-09-28. PMID:32284835. |
in this study, we investigated if learning and memory in the barnes maze test are accompanied by the occurrence of ltp in schaffer collateral to ca1 synapses in freely moving rats. |
2020-09-28 |
2023-08-13 |
rat |
| Azadeh Gholaminejad, Hamid Gholamipour-Badie, Mohammad Nasehi, Nasser Naghd. Prelimbic of Medial Prefrontal Cortex GABA Modulation through Testosterone on Spatial Learning and Memory. Iranian journal of pharmaceutical research : IJPR. vol 18. issue 3. 2020-09-28. PMID:32641952. |
our previous study indicated that microinjection of testosterone in ca1 impaired spatial learning and memory. |
2020-09-28 |
2023-08-13 |
Not clear |
| Qun Li, Chunxiao Yang, Xiaochen Zhang, Zhuo Yang, Tao Zhan. Arginine vasopressin attenuates dysfunction of hippocampal theta and gamma oscillations in chronic cerebral hypoperfusion via V1a receptor. Brain research bulletin. vol 153. 2020-09-24. PMID:31430514. |
the results showed that avp partly changed ca3 schaffer collateral (ca3-sc) power distribution in the rat model of 2vo via v1a receptor, increased theta synchrony between ca3-sc and ca1 areas, enhanced ca3-sc theta-middle gamma phase-phase coupling, and improved spatial learning and memory performance. |
2020-09-24 |
2023-08-13 |
rat |
| Masoumeh Kourosh-Arami, Alireza Komaki, Mohammad Taghi Joghataei, Monireh Mohsenzadega. Phospholipase Cβ3 in the hippocampus may mediate impairment of memory by long-term blockade of orexin 1 receptors assessed by the Morris water maze. Life sciences. vol 257. 2020-09-14. PMID:32622948. |
put together, our results suggest that the long-term inhibition of oxr1 plays a prominent role in spatial learning and memory, probably by attenuating plcβ3 in ca1 neurons. |
2020-09-14 |
2023-08-13 |
rat |
| Desheng Wan. Tumor Necrosis Factor-Alpha Alters Electrophysiological Properties of Rabbit Hippocampal Neurons. Journal of Alzheimer's disease : JAD. vol 68. issue 3. 2020-08-27. PMID:30909246. |
in conclusion, dietary cholesterol generated an in vivo model of chronic tnf-α elevation and tnf-α may underlie the learning and memory changes previously seen in the rabbit model of ad by acting as a bridge between dietary cholesterol and brain function and directly modulating the electrophysiological properties of hippocampal ca1 neurons. |
2020-08-27 |
2023-08-13 |
rabbit |
| Jing Wang, Yabing Chen, Changliang Zhang, Zou Xiang, Jie Ding, Xiaodong Ha. Learning and memory deficits and alzheimer's disease-like changes in mice after chronic exposure to microcystin-LR. Journal of hazardous materials. vol 373. 2020-08-24. PMID:30947040. |
mc-lr exposure at this concentration induced dysfunction of learning and memory, accompanied with apoptosis of neuronal cells (with 10% reduction of the neurons in the ca1 region and 15% in the ca2 region), reduction of spine density, accumulation of β-amyloid plaques 1-42 (aβ1-42), and enhanced phosphorylation of tau (p-tau) in the brain, which is characteristic of alzheimer's disease (ad). |
2020-08-24 |
2023-08-13 |
mouse |