| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ming Hu, Zhijuan Liu, Peiyuan Lv, Hebo Wang, Yifei Zhu, Qianqian Qi, Jing X. Autophagy and Akt/CREB signalling play an important role in the neuroprotective effect of nimodipine in a rat model of vascular dementia. Behavioural brain research. vol 325. issue Pt A. 2017-12-13. PMID:27923588. |
nimodipine significantly alleviated spatial learning and memory impairments and inhibited the loss of neurons in the ca1 region of the hippocampus. |
2017-12-13 |
2023-08-13 |
rat |
| Arjun V Masurkar, Kalyan V Srinivas, David H Brann, Richard Warren, Daniel C Lowes, Steven A Siegelbau. Medial and Lateral Entorhinal Cortex Differentially Excite Deep versus Superficial CA1 Pyramidal Neurons. Cell reports. vol 18. issue 1. 2017-11-22. PMID:28052245. |
our results reveal a heterogeneity in ec-ca1 connectivity that may help explain differential roles of ca1 pns in spatial and non-spatial learning and memory. |
2017-11-22 |
2023-08-13 |
Not clear |
| Yangang Zhao, Li He, Yuanyuan Zhang, Jikai Zhao, Zhi Liu, Fangzhou Xing, Mengying Liu, Ziqi Feng, Wei Li, Jiqiang Zhan. Estrogen receptor alpha and beta regulate actin polymerization and spatial memory through an SRC-1/mTORC2-dependent pathway in the hippocampus of female mice. The Journal of steroid biochemistry and molecular biology. vol 174. 2017-11-13. PMID:28789972. |
we then showed that erα and erβ antagonists induced a significant decrease in src-1, mtorc2 signaling, actin polymerization, and ca1 spine density, as well as impairments of learning and memory; however, ovariectomy-induced changes of these parameters could be significantly reversed by treatment with er agonists. |
2017-11-13 |
2023-08-13 |
mouse |
| Jingquan Gao, Hongmei Wu, Yonggang Cao, Shuang Liang, Caihong Sun, Peng Wang, Ji Wang, Hongli Sun, Lijie W. Maternal DHA supplementation protects rat offspring against impairment of learning and memory following prenatal exposure to valproic acid. The Journal of nutritional biochemistry. vol 35. 2017-10-23. PMID:27469996. |
the results showed that maternal feeding of dha to the prenatal exposed to vpa (1) prevented vpa-induced learning and memory impairment but did not change social-related behavior, (2) increased total dha content in offspring plasma and hippocampus, (3) rescued vpa-induced neuronal loss and apoptosis of pyramidal cells in hippocampal ca1, (4) influenced the content of malondialdehyde and glutathione and the activities of superoxide dismutase and glutathione in the hippocampus, (5) altered levels of apoptosis-related proteins (bcl-2, bax and caspase-3) and inhibited the activity of caspase-3 in offspring hippocampus and (6) enhanced relative levels of p-camkii and p-creb proteins in the hippocampus. |
2017-10-23 |
2023-08-13 |
rat |
| Morris H Scantlebury, Kyoung-Chul Chun, Shun-Chieh Ma, Jong M Rho, Do Young Ki. Adrenocorticotropic hormone protects learning and memory function in epileptic Kcna1-null mice. Neuroscience letters. vol 645. 2017-10-10. PMID:28249786. |
four times daily at a dose of 4 iu/kg (16 iu/kg/day) for 7days - prevented impairment of long-term potentiation (ltp) evoked with high-frequency stimulation in ca1 hippocampus and also restored spatial learning and memory on the barnes maze test. |
2017-10-10 |
2023-08-13 |
mouse |
| Dongmei Wang, Xiaozhuan Liu, Yumei Liu, Guomin Shen, Xiaoying Zhu, Sanqiang L. Treatment effects of Cardiotrophin-1 (CT-1) on streptozotocin-induced memory deficits in mice. Experimental gerontology. vol 92. 2017-10-04. PMID:28285145. |
daily treatment with ct-1 (1μg/day, icv) starting from the first dose of stz for 14days showed that ct-1 significantly improved learning and memory deficits, alleviated mitochondrial dysfunction, and increased synaptic density in the ca1 region of the hippocampus in icv-stz-treated mice. |
2017-10-04 |
2023-08-13 |
mouse |
| Xiangmin Xu, Yanjun Sun, Todd C Holmes, Alberto J Lópe. Noncanonical connections between the subiculum and hippocampal CA1. The Journal of comparative neurology. vol 524. issue 17. 2017-09-12. PMID:27150503. |
new insights into this understudied pathway will improve our understanding of reciprocal ca1-subicular connections and guide future studies on how the subiculum interacts with ca1 to regulate hippocampal circuit activity and learning and memory behaviors. |
2017-09-12 |
2023-08-13 |
Not clear |
| Xing-Hua Yue, Jia-Qing Tong, Zhao-Jun Wang, Jun Zhang, Xu Liu, Xiao-Jie Liu, Hong-Yan Cai, Jin-Shun Q. Steroid sulfatase inhibitor DU-14 protects spatial memory and synaptic plasticity from disruption by amyloid β protein in male rats. Hormones and behavior. vol 83. 2017-09-07. PMID:27222435. |
we found that: (1) du-14 effectively attenuated the aβ1-42-induced cognitive deficits in spatial learning and memory of rats in morris water maze test; (2) du-14 prevented aβ1-42-induced decrease in the cholinergic theta rhythm of hippocampal local field potential (lfp) in the ca1 region; (3) du-14 protected hippocampal synaptic plasticity against aβ1-42-induced suppression of long term potentiation (ltp). |
2017-09-07 |
2023-08-13 |
rat |
| Wei Yang, Chunyan Zhu, Yan Shen, Qi X. The pathogenic mechanism of dysbindin-1B toxic aggregation: BLOC-1 and intercellular vesicle trafficking. Neuroscience. vol 333. 2017-09-06. PMID:27421225. |
the results demonstrated that dys1b(+/+) mice exhibited spatial learning and memory deficits, which were accompanied by the shrinkage of apical and basal dendritic branches and the loss of dendritic spines in hippocampal ca1 neurons, as demonstrated by golgi staining. |
2017-09-06 |
2023-08-13 |
mouse |
| Wei Ouyang, Qichao Yan, Yu Zhang, Zhiheng Fa. Moderate injury in motor-sensory cortex causes behavioral deficits accompanied by electrophysiological changes in mice adulthood. PloS one. vol 12. issue 2. 2017-08-24. PMID:28196142. |
the motor function, learning and memory function, extracellular ca1 neural spikes were assessed during acute and subacute phase. |
2017-08-24 |
2023-08-13 |
mouse |
| Kevin N Hascup, Mary K Lynn, Patrick J Fitzgerald, Shari Randall, John J Kopchick, Heather A Boger, Andrzej Bartke, Erin R Hascu. Enhanced Cognition and Hypoglutamatergic Signaling in a Growth Hormone Receptor Knockout Mouse Model of Successful Aging. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 72. issue 3. 2017-08-10. PMID:27208894. |
spatial learning and memory were assessed using the morris water maze (mwm), whereas independent dentate gyrus (dg), ca3, and ca1 basal glutamate, release, and uptake measurements were conducted in isoflurane anesthetized mice utilizing an enzyme-based microelectrode array (mea) coupled with constant potential amperometry. |
2017-08-10 |
2023-08-13 |
mouse |
| Yanjing Cao, Zengmei Gou, Yifeng Du, Yongjun Fan, Lizhen Liang, Yongxing Yan, Ping Lin, Mudan Jin, Yifenf D. Glutamatergic and central cholinergic dysfunction in the CA1, CA2 and CA3 fields on spatial learning and memory in chronic cerebral ischemia-Induced vascular dementia of rats. Neuroscience letters. vol 620. 2017-07-24. PMID:27040427. |
glutamatergic and central cholinergic dysfunction in the ca1, ca2 and ca3 fields on spatial learning and memory in chronic cerebral ischemia-induced vascular dementia of rats. |
2017-07-24 |
2023-08-13 |
rat |
| Qian-Qian Yang, Wei-Zhen Xue, Rong-Xin Zou, Yi Xu, Yang Du, Shuang Wang, Lai Xu, Yuan-Zhi Chen, Hui-Li Wang, Xiang-Tao Che. β-Asarone Rescues Pb-Induced Impairments of Spatial Memory and Synaptogenesis in Rats. PloS one. vol 11. issue 12. 2017-07-11. PMID:27936013. |
and β-asarone effectively attenuated pb-induced reduction of spine density in hippocampal ca1 and dentate gyrus areas in a dose-dependent manner both in developmental and adult rats, meanwhile the pb-induced impairments of learning and memory were partially rescued. |
2017-07-11 |
2023-08-13 |
rat |
| Nilofer Husain, Qiang Yuan, Yi-Chun Yen, Olga Pletnikova, Dong Qianying Sally, Paul Worley, Zoë Bichler, H Shawn J. TRIAD3/RNF216 mutations associated with Gordon Holmes syndrome lead to synaptic and cognitive impairments via Arc misregulation. Aging cell. vol 16. issue 2. 2017-06-19. PMID:27995769. |
moreover, we demonstrate that the loss of endogenous triad3a in the mouse hippocampal ca1 region led to deficits in spatial learning and memory. |
2017-06-19 |
2023-08-13 |
mouse |
| Mehdi Khodamoradi, Majid Asadi-Shekaari, Saeed Esmaeili-Mahani, Khadije Esmaeilpour, Vahid Sheiban. Effects of genistein on cognitive dysfunction and hippocampal synaptic plasticity impairment in an ovariectomized rat kainic acid model of seizure. European journal of pharmacology. vol 786. 2017-03-10. PMID:27235295. |
finally, 7 days later, spatial learning and memory of animals were examined using the morris water maze (mwm) task, hippocampal e-ltp was assessed using in-vivo field potential recordings and the morphology of hippocampal ca1 area was examined using fluoro-jade c staining. |
2017-03-10 |
2023-08-13 |
rat |
| Mehdi Khodamoradi, Majid Asadi-Shekaari, Saeed Esmaeili-Mahani, Khadije Esmaeilpour, Vahid Sheiban. Effects of genistein on cognitive dysfunction and hippocampal synaptic plasticity impairment in an ovariectomized rat kainic acid model of seizure. European journal of pharmacology. vol 786. 2017-03-10. PMID:27235295. |
ka-induced generalized seizures resulted in spatial learning and memory impairment, e-ltp deficit and ca1 cell injury. |
2017-03-10 |
2023-08-13 |
rat |
| Gang Wang, Ling Chen, Xiaoyu Pan, Jiechun Chen, Liqun Wang, Weijie Wang, Ruochuan Cheng, Fan Wu, Xiaoqing Feng, Yingcong Yu, Han-Ting Zhang, James M O'Donnell, Ying X. The effect of resveratrol on beta amyloid-induced memory impairment involves inhibition of phosphodiesterase-4 related signaling. Oncotarget. vol 7. issue 14. 2017-02-09. PMID:26980711. |
mice microinfused with aβ1-42 into bilateral ca1 subregions displayed learning and memory impairment, as evidenced by reduced memory acquisition and retrieval in the water maze and retention in the passive avoidance tasks; it was also significant that neuroinflammatory and pro-apoptotic factors were increased in aβ1-42-treated mice. |
2017-02-09 |
2023-08-13 |
mouse |
| Na Qu, Xiang-Yu Zhou, Li Han, Lei Wang, Jia-Xin Xu, Teng Zhang, Jiang Chu, Qiao Chen, Jian-Zhi Wang, Qi Zhang, Qing Tia. Combination of PPT with LiCl Treatment Prevented Bilateral Ovariectomy-Induced Hippocampal-Dependent Cognition Deficit in Rats. Molecular neurobiology. vol 53. issue 2. 2016-11-14. PMID:25535091. |
after the combination treatment of these two drugs (ppt + licl), the improved learning and memory abilities of ovariectomized rats in morris water maze, increased dendritic spines in ca1 region, and decreased tau phosphorylation at ser-396 in hippocampus were observed. |
2016-11-14 |
2023-08-13 |
rat |
| Lei An, Tao Zhan. Comparison Impairments of Spatial Cognition and Hippocampal Synaptic Plasticity Between Prenatal and Postnatal Melamine Exposure in Male Adult Rats. Neurotoxicity research. vol 29. issue 2. 2016-10-14. PMID:26607910. |
hence, prenatal and postnatal exposures to melamine may have different effects on hippocampus-dependent learning and memory, which would most likely result from differentially adversely properties on the hippocampal ca1 synaptic function. |
2016-10-14 |
2023-08-13 |
rat |
| Caroline C Smith, Lindsey A Smith, Teruko M Bredemann, Lori L McMaho. 17β estradiol recruits GluN2B-containing NMDARs and ERK during induction of long-term potentiation at temporoammonic-CA1 synapses. Hippocampus. vol 26. issue 1. 2016-10-13. PMID:26190171. |
we also reported that this increase in glun2b-mediated nmdar current in area ca1 is causally related to the e2-induced increase in novel object recognition, tying together heightened synaptic function with improved learning and memory. |
2016-10-13 |
2023-08-13 |
rat |