| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kristopher D Langdon, Shirley Granter-Button, Carolyn W Harley, Frances Moody-Corbett, James Peeling, Dale Corbet. A cognitive rehabilitation paradigm effective in male rats lacks efficacy in female rats. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 34. issue 10. 2014-11-24. PMID:25052554. |
learning and memory abilities were evaluated using standard cognitive outcomes over the ensuing 6 months, followed by histologic analyses of hippocampal ca1 neurons. |
2014-11-24 |
2023-08-13 |
rat |
| Na Liu, Bin Xue, Hua Xing, Lin Xu, Shan-Xiang Jian. [Dopamine-dependent long-term depression in hippocampus of rat induced by exposure to spatial novelty.]. Sheng li xue bao : [Acta physiologica Sinica]. vol 61. issue 6. 2014-11-08. PMID:20029683. |
to study the role of long-term depression (ltd) in the mechanisms of learning and memory in hippocampus of rat, recordings were taken from freely moving animals that had undergone chronic implantation of a recording electrode in the hippocampus ca1 region and a bipolar stimulating electrode in the ipsilateral schaffer collateral-commissural pathway. |
2014-11-08 |
2023-08-12 |
rat |
| Wei-Lun Hsu, Yun-Li Ma, Ding-You Hsieh, Yen-Chen Liu, Eminy Hy Le. STAT1 negatively regulates spatial memory formation and mediates the memory-impairing effect of Aβ. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 3. 2014-09-10. PMID:24081304. |
we found that water maze training downregulated stat1 expression in the rat hippocampal ca1 area, and spatial learning and memory function was enhanced in stat1-knockout mice. |
2014-09-10 |
2023-08-12 |
mouse |
| Hongbo Zhang, Weijuan Gao, Tao Qian, Jinglong Tang, Jun L. Transcription factor changes following long term cerebral ischemia/reperfusion injury. Neural regeneration research. vol 8. issue 10. 2014-09-10. PMID:25206383. |
the present study established a rat model of cerebral ischemia/reperfusion injury using four-vessel occlusion and found that hippocampal ca1 neuronal morphology was damaged, and that there were reductions in hippocampal neuron number and dna-binding activity of camp response element binding protein and ccaat/enhancer binding protein, accompanied by decreased learning and memory ability. |
2014-09-10 |
2023-08-13 |
rat |
| Sha Liu, Honghai Wu, Gai Xue, Xin Ma, Jie Wu, Yabin Qin, Yanning Ho. Metabolic alteration of neuroactive steroids and protective effect of progesterone in Alzheimer's disease-like rats. Neural regeneration research. vol 8. issue 30. 2014-09-10. PMID:25206601. |
in the present study, amyloid beta (aβ) 25-35 (aβ25-35) injected into the bilateral hippocampus ca1 region significantly reduced learning and memory. |
2014-09-10 |
2023-08-13 |
rat |
| Yan-Chu Chen, Wei-Lun Hsu, Yun-Li Ma, Derek J C Tai, Eminy H Y Le. CREB SUMOylation by the E3 ligase PIAS1 enhances spatial memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 29. 2014-09-05. PMID:25031400. |
moreover, transduction of lenti-crebwt to rat ca1 area facilitated, whereas transduction of lenti-creb double sumo-mutant (crebk271rk290r) impaired, spatial learning and memory performance. |
2014-09-05 |
2023-08-13 |
rat |
| Yan-Chu Chen, Wei-Lun Hsu, Yun-Li Ma, Derek J C Tai, Eminy H Y Le. CREB SUMOylation by the E3 ligase PIAS1 enhances spatial memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 29. 2014-09-05. PMID:25031400. |
transduction of lenti-crebwt-sumo1 fusion vector to rat ca1 area showed a more significant effect in enhancing spatial learning and memory and creb sumoylation. |
2014-09-05 |
2023-08-13 |
rat |
| Yan-Chu Chen, Wei-Lun Hsu, Yun-Li Ma, Derek J C Tai, Eminy H Y Le. CREB SUMOylation by the E3 ligase PIAS1 enhances spatial memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 29. 2014-09-05. PMID:25031400. |
knock-down of pias1 expression in ca1 area by pias1 sirna transfection impaired spatial learning and memory and decreased endogenous creb sumoylation. |
2014-09-05 |
2023-08-13 |
rat |
| Qianqian Zhu, Kewei Xiao, Ming Yu, Minglu Niu, Chengqian Li, Yanxia Gao, Guo-Dong Li, Yu Zho. Ghrelin but not nesfatin-1 affects certain forms of learning and memory in both rats and mice. Brain research. vol 1541. 2014-07-28. PMID:24148307. |
we found that the micro infusion of ghrelin into the la or the ca1 interfered with certain types of learning and memory in both rats and mice, while nesfatin-1 had no effect. |
2014-07-28 |
2023-08-12 |
human |
| Tang Jinglong, Gao Weijuan, Li Jun, Qian Tao, Zhang Hongbo, Liu Shash. The molecular and electrophysiological mechanism of buyanghuanwu decoction in learning and memory ability of vascular dementia rats. Brain research bulletin. vol 99. 2014-07-14. PMID:24070657. |
our results suggested that increased erk2 and camkiiiy due to byhwd may partially account for its effect of neuroprotection standing against ischemic injury in the hippocampal ca1 region, and participated in the rebuilding of synapse, strengthened the expression of ltp, promoted the ability recover of learning and memory in vd rats. |
2014-07-14 |
2023-08-12 |
rat |
| Ming Shi, Fang Du, Yang Liu, Li Li, Jing Cai, Guo-Feng Zhang, Xiao-Fei Xu, Tian Lin, Hao-Ran Cheng, Xue-Dong Liu, Li-Ze Xiong, Gang Zha. Glial cell-expressed mechanosensitive channel TRPV4 mediates infrasound-induced neuronal impairment. Acta neuropathologica. vol 126. issue 5. 2014-06-02. PMID:24002225. |
among different frequencies and intensities, infrasound at 16 hz and 130 db impaired rat learning and memory abilities most severely after 7-14 days exposure, a time during which a prominent loss of hippocampal ca1 neurons was evident. |
2014-06-02 |
2023-08-12 |
rat |
| Panayiota Papadopoulos, Xin-Kang Tong, Edith Hame. Selective benefits of simvastatin in bitransgenic APPSwe,Ind/TGF-β1 mice. Neurobiology of aging. vol 35. issue 1. 2014-04-23. PMID:23954171. |
however, simvastatin failed to improve spatial learning and memory deficits and the decreased baseline levels of the memory-related protein early growth response-1 (egr-1) in the hippocampus ca1 area. |
2014-04-23 |
2023-08-12 |
mouse |
| Hao Li, Ming-Fang Liu, Jian-Gang Liu, Long-Tao Liu, Jie Guan, Ling-Ling Cai, Jia Hu, Yun We. [Effects of huannao yicong recipe extract on the learning and memory and related factors of Abeta generation in the brain of APP transgenic mice]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 33. issue 1. 2014-04-10. PMID:23596795. |
to study the effects of huannao yicong recipe (hnycr)extract on the learning and memory ability, and the expressions of amyloid precursor protein (app), beta-site app-cleaving enzyme 1 (bace1), presenilin-1 (ps-1), and beta amyloid protein (abeta)in hippocampus ca1 area of app transgenic mice, and to explore its mechanisms for treating alzheimer's disease (ad). |
2014-04-10 |
2023-08-12 |
mouse |
| Wei-Zu Li, Wang-Yang Wu, Huan Huang, Yang-Yang Wu, Yan-Yan Yi. Protective effect of bilobalide on learning and memory impairment in rats with vascular dementia. Molecular medicine reports. vol 8. issue 3. 2014-04-07. PMID:23835946. |
these results suggest that bb provides protection against learning and memory impairment by reducing free radical injury and inhibiting neuronal apoptosis in the brain cortex and hippocampal ca1 region in vd rats. |
2014-04-07 |
2023-08-12 |
rat |
| Forough Foolad, Fariba Khodaghol. Dietary supplementation with Salvia sahendica attenuates acetylcholinesterase activity and increases mitochondrial transcription factor A and antioxidant proteins in the hippocampus of amyloid beta-injected rats. The Journal of pharmacy and pharmacology. vol 65. issue 10. 2014-03-24. PMID:24028623. |
we evaluated the acetylcholinesterase (ache) inhibitory and potential antioxidant effects of salvia sahendica extract to investigate whether these molecules are involved in learning and memory improvement in rats injected with fibrillar amyloid beta (aβ) peptide in the ca1 region of their hippocampus. |
2014-03-24 |
2023-08-12 |
rat |
| Katja S Kroker, Jens Moreth, Lothar Kussmaul, Georg Rast, Holger Rosenbroc. Restoring long-term potentiation impaired by amyloid-beta oligomers: comparison of an acetylcholinesterase inhibitior and selective neuronal nicotinic receptor agonists. Brain research bulletin. vol 96. 2014-03-19. PMID:23639920. |
first, we demonstrated that amyloid beta (aβ)42 oligomers, which are believed to be the synaptotoxic aβ-species causally involved in the pathophysiology of alzheimer's disease, have a detrimental effect on long-term potentiation (ltp) in the ca1 region of rat hippocampal slices, a widely used cellular model of learning and memory. |
2014-03-19 |
2023-08-12 |
rat |
| Giuseppe D'Agostino, Jung Dae Kim, Zhong-Wu Liu, Jin Kwon Jeong, Shigetomo Suyama, Antonio Calignano, Xiao-Bing Gao, Michael Schwartz, Sabrina Dian. Prolyl endopeptidase-deficient mice have reduced synaptic spine density in the CA1 region of the hippocampus, impaired LTP, and spatial learning and memory. Cerebral cortex (New York, N.Y. : 1991). vol 23. issue 8. 2014-02-26. PMID:22767632. |
prolyl endopeptidase-deficient mice have reduced synaptic spine density in the ca1 region of the hippocampus, impaired ltp, and spatial learning and memory. |
2014-02-26 |
2023-08-12 |
mouse |
| Giuseppe D'Agostino, Jung Dae Kim, Zhong-Wu Liu, Jin Kwon Jeong, Shigetomo Suyama, Antonio Calignano, Xiao-Bing Gao, Michael Schwartz, Sabrina Dian. Prolyl endopeptidase-deficient mice have reduced synaptic spine density in the CA1 region of the hippocampus, impaired LTP, and spatial learning and memory. Cerebral cortex (New York, N.Y. : 1991). vol 23. issue 8. 2014-02-26. PMID:22767632. |
combining genetic, anatomical, electrophysiological, and behavioral approaches, we show that prep genetrap mice have decreased synaptic spine density in the ca1 region of the hippocampus, reduced hippocampal long-term potentiation, impaired hippocampal-mediated learning and memory, and reduced growth-associated protein-43 levels when compared with wild-type controls. |
2014-02-26 |
2023-08-12 |
mouse |
| Zhao-Lin Cai, Chun-Yang Wang, Xing-Yang Gu, Na-Jie Wang, Jin-Jing Wang, Wen-Xiao Liu, Peng Xiao, Chu-Hua L. Tenuigenin ameliorates learning and memory impairments induced by ovariectomy. Physiology & behavior. vol 118. 2014-02-12. PMID:23688946. |
step-through passive avoidance and y-maze tests were used to assess learning and memory abilities, and the number of nitric oxide synthase (nos) positive neurons and the synaptic measurement of hippocampal ca1 area were examined. |
2014-02-12 |
2023-08-12 |
mouse |
| Mehreen Kouser, Haley E Speed, Colleen M Dewey, Jeremy M Reimers, Allie J Widman, Natasha Gupta, Shunan Liu, Thomas C Jaramillo, Muhammad Bangash, Bo Xiao, Paul F Worley, Craig M Powel. Loss of predominant Shank3 isoforms results in hippocampus-dependent impairments in behavior and synaptic transmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 47. 2014-01-21. PMID:24259569. |
these mice exhibit a decrease in nmda/ampa excitatory postsynaptic current ratio in area ca1 of the hippocampus, reduced long-term potentiation in area ca1, and deficits in hippocampus-dependent spatial learning and memory. |
2014-01-21 |
2023-08-12 |
mouse |