| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mo-Li Zhu, Jie Zhang, Li-Juan Guo, Rui-Zhu Yue, Shan-Shan Li, Bao-Yue Cui, Shuang Guo, Qian-Qian Niu, Ya-Nan Yu, Huan-Huan Wang, Lin Yang, Ya-Ling Yin, Shuang-Xi Wang, He-Qin Zhan, Zhi-Tao Gao, Peng L. Amorphous selenium inhibits oxidative stress injury of neurons in vascular dementia rats by activating NMDAR pathway. European journal of pharmacology. 2023-07-02. PMID:37394029. |
the results showed that a sends could significantly improve the learning and memory ability of vd rats, restore the posterior arterial blood flow of the brain, improve the neuronal morphology and dendritic remodeling of pyramidal cells in hippocampal ca1 area, reduce the level of oxidative stress in vd rats, increase the expression of nr2a, psd95, camk ii proteins and reduce intracellular calcium ion concentration, but the addition of selective nr2a antagonist nvp-aamo77 eliminated these benefits. |
2023-07-02 |
2023-08-14 |
rat |
| Xiao-Ling Zhong, Bo-Ying Tong, Yi-Han Yang, Hui-Ling Zeng, Chi Lin, Yuan Jing, Ling-Ling He, Shi-Jing Yo. [Effect of transcutaneous electrical acupoint stimulation on learning and memory ability of chronic fatigue syndrome rats and its mechanisms]. Zhen ci yan jiu = Acupuncture research. vol 48. issue 4. 2023-05-15. PMID:37186194. |
to observe the effect of transcutaneous electrical acupoint stimulation (teas) on the histomorphological manifestations of hippocampal ca1 region and the expression of extracellular regulatory protein kinase (erk), cyclic adenosine response element binding protein (creb) and brain-derived neurotrophic factor (bdnf) in chronic fatigue syndrome (cfs) rats, so as to explore the mechanisms of teas in improving the learning and memory abilities of cfs rats. |
2023-05-15 |
2023-08-14 |
rat |
| Jinmei Zhang, Qiaojing Gao, Jun Gao, Liting Lv, Renfan Liu, Yi Wu, Xue Li, Yu Jin, Lu Wan. Moderate-Intensity Intermittent Training Alters the DNA Methylation Pattern of PDE4D Gene in Hippocampus to Improve the Ability of Spatial Learning and Memory in Aging Rats Reduced by D-Galactose. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979232. |
the morris water maze test was performed before and after miit to evaluate the spatial learning and memory ability, then to observe the synaptic ultrastructure of the hippocampus ca1 region, to detect the expression of synaptic-related protein synaptophysin (syp) and postsynaptic density protein 95 (psd95), and to detect the expression of pde4 subtypes, camp, and its signal pathway protein kinase a (pka)/camp response element binding protein (creb)/brain-derived neurotrophic factor (bdnf), and the pde4 methylation level. |
2023-03-29 |
2023-08-14 |
rat |
| Jinmei Zhang, Qiaojing Gao, Jun Gao, Liting Lv, Renfan Liu, Yi Wu, Xue Li, Yu Jin, Lu Wan. Moderate-Intensity Intermittent Training Alters the DNA Methylation Pattern of PDE4D Gene in Hippocampus to Improve the Ability of Spatial Learning and Memory in Aging Rats Reduced by D-Galactose. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979232. |
(4) conclusions: miit can improve the synaptic structure of the hippocampus ca1 area and improve the spatial learning and memory ability of aging rats, which may be related to the specific regulation of the pde4d gene methylation level and inhibition of pde4d expression. |
2023-03-29 |
2023-08-14 |
rat |
| Shole Jamali, Mohsen Parto Dezfouli, AmirAli Kalbasi, Mohammad Reza Daliri, Abbas Haghparas. Selective Modulation of Hippocampal Theta Oscillations in Response to Morphine versus Natural Reward. Brain sciences. vol 13. issue 2. 2023-02-25. PMID:36831866. |
the strong link between hippocampal theta oscillations (4-12 hz) and reward-associated learning and memory has raised the hypothesis that this rhythm in hippocampal ca1 might be differently modulated by drug- and natural-conditioned place preference (cpp). |
2023-02-25 |
2023-08-14 |
rat |
| Yukitoshi Izumi, Angela M Reiersen, Eric J Lenze, Steven J Mennerick, Charles F Zorumsk. SSRIs differentially modulate the effects of pro-inflammatory stimulation on hippocampal plasticity and memory via sigma 1 receptors and neurosteroids. Translational psychiatry. vol 13. issue 1. 2023-02-03. PMID:36737431. |
when hippocampal slices are exposed acutely to lipopolysaccharide (lps), a strong pro-inflammatory stimulus, basal synaptic transmission in the ca1 region remains intact, but induction of long-term potentiation (ltp), a form of synaptic plasticity thought to contribute to learning and memory, is completely disrupted. |
2023-02-03 |
2023-08-14 |
rat |
| Eleazar Ramírez-Hernández, Claudia Sánchez-Maldonado, Aleidy Patricio-Martínez, Ilhiucamina Daniel Limó. Amyloid-β (25-35) induces the morphological alteration of dendritic spines and decreases NR2B and PSD-95 expression in the hippocampus. Neuroscience letters. 2022-12-26. PMID:36572143. |
vehicle or aβ25-35 peptide (0.1 µg/µl) was bilaterally administered into the ca1 subfield of the rat hippocampus, then tested for spatial learning and memory in the morris water maze. |
2022-12-26 |
2023-08-14 |
rat |
| Anosha Kiran Ulfat, Shadab Batool, Fahad Iqbal, Naweed I Sye. Selective Menin Deletion in the Hippocampal CA1 Region Leads to Disruption of Contextual Memory in the Cells. vol 11. issue 24. 2022-12-23. PMID:36552783. |
selective menin deletion in the hippocampal ca1 region leads to disruption of contextual memory in the cholinergic neuronal networks in the hippocampus play a key role in the regulation of learning and memory in mammals. |
2022-12-23 |
2023-08-14 |
Not clear |
| Zhangbi Wu, Jialin Huang, Xiaojie Bai, Qunan Wang, Fen Wang, Jun Xu, Huiping Tang, Chunying Yin, Yu Wang, Feng Yu, Hong Zhan. Ginsenoside-Rg1 mitigates cardiac arrest-induced cognitive damage by modulating neuroinflammation and hippocampal plasticity. European journal of pharmacology. 2022-12-04. PMID:36463944. |
these ca/cpr rats displayed spatial learning and memory impairment in the morris water maze, as reflected in the compromised basal synaptic transmission and long-term potentiation (ltp) at the schaffer collateral of hippocampal ca1 area in vivo electrophysiology, whereas the ginsenoside-rg1 remarkably mitigated these alterations. |
2022-12-04 |
2023-08-14 |
rat |
| Jiyeon Seo, Hongik Hwang, Heesung Sohn, Eunsil Cho, Sunmin Jung, Soohyun Kim, Seung Min Um, Ji Yeon Kim, Muwon Kang, Yuri Choi, Jong-Hwan Kim, Mirang Kim, Seon-Young Kim, Sun-Kyung Lee, Joohong Ahnn, Hyewhon Rhim, Dong-Gyu Jo, Eunjoon Kim, Mikyoung Par. Cyclin Y regulates spatial learning and memory flexibility through distinct control of the actin pathway. Molecular psychiatry. 2022-11-26. PMID:36434054. |
furthermore, viral-mediated overexpression of a phosphomimetic cofilin-s3e in hippocampal ca1 regions enhanced ltp, weakened ltd, and improved spatial learning and memory flexibility, thus mirroring the phenotype of ccny ko mice. |
2022-11-26 |
2023-08-14 |
mouse |
| Yu Zhang, Linhu Du, Jinhua Yan, Qianxiang Bai, Qiao Niu, Yiqun Mo, Qunwei Zhang, Jisheng Ni. Prenatal benzo[a]pyrene exposure impairs hippocampal synaptic plasticity and cognitive function in SD rat offspring during adolescence and adulthood via HDAC2-mediated histone deacetylation. Ecotoxicology and environmental safety. vol 246. 2022-10-20. PMID:36265406. |
the learning and memory abilities of offspring were determined by morris water maze (mwm) test, while the number of dendritic branches and the density of dendritic spines in hippocampal ca1 and dg regions were evaluated by golgi-cox staining at pnd 45 and pnd 75. |
2022-10-20 |
2023-08-14 |
rat |
| Yu Zhang, Linhu Du, Jinhua Yan, Qianxiang Bai, Qiao Niu, Yiqun Mo, Qunwei Zhang, Jisheng Ni. Prenatal benzo[a]pyrene exposure impairs hippocampal synaptic plasticity and cognitive function in SD rat offspring during adolescence and adulthood via HDAC2-mediated histone deacetylation. Ecotoxicology and environmental safety. vol 246. 2022-10-20. PMID:36265406. |
our results showed that rats prenatally exposed to b[a]p exhibited impaired spatial learning and memory abilities and the number of dendritic branches and the density of dendritic spines in the hippocampal ca1 and dg regions were significantly reduced during adolescence and adulthood. |
2022-10-20 |
2023-08-14 |
rat |
| Viola von Bohlen Und Halbach, Simone Venz, Simon Nwakor, Christian Hentschker, Elke Hammer, Heike Junker, Andreas W Kuss, Oliver von Bohlen Und Halbach, Lars R Jense. Deficiency in FTSJ1 Affects Neuronal Plasticity in the Hippocampal Formation of Mice. Biology. vol 11. issue 7. 2022-09-14. PMID:36101392. |
ftsj1 has an impact on neuronal plasticity in the murine hippocampal area ca1 at the morphological and physiological levels, which, in conjunction with comparable changes in other cortical areas, might accumulate in disturbed learning and memory functions. |
2022-09-14 |
2023-08-14 |
mouse |
| Sanya Roysommuti, James Michael Wys. Brain-Derived Neurotrophic Factor Potentiates Entorhinal-Dentate but not Hippocampus CA1 Pathway in Adult Male Rats: A Mechanism of Taurine-Modulated BDNF on Learning and Memory. Advances in experimental medicine and biology. vol 1370. 2022-07-26. PMID:35882811. |
brain-derived neurotrophic factor potentiates entorhinal-dentate but not hippocampus ca1 pathway in adult male rats: a mechanism of taurine-modulated bdnf on learning and memory. |
2022-07-26 |
2023-08-14 |
rat |
| Nazanin Mozafari, Jalal Hassanshahi, Hamid Ostadebrahimi, Ali Shamsizadeh, Fatemeh Ayoobi, Elham Hakimizadeh, Mohammad Pak-Hashemi, Ayat Kaeid. Neuroprotective effect of Achillea millefolium aqueous extract against oxidative stress and apoptosis induced by chronic morphine in rat hippocampal CA1 neurons. Acta neurobiologiae experimentalis. vol 82. issue 2. 2022-07-14. PMID:35833817. |
this study evaluates the neuroprotective effect of achillea millefolium (ach) on chronic morphine‑induced learning and memory impairment, oxidative stress, and neuronal apoptosis in the ca1 region of the rat hippocampus. |
2022-07-14 |
2023-08-14 |
human |
| Nazanin Mozafari, Jalal Hassanshahi, Hamid Ostadebrahimi, Ali Shamsizadeh, Fatemeh Ayoobi, Elham Hakimizadeh, Mohammad Pak-Hashemi, Ayat Kaeid. Neuroprotective effect of Achillea millefolium aqueous extract against oxidative stress and apoptosis induced by chronic morphine in rat hippocampal CA1 neurons. Acta neurobiologiae experimentalis. vol 82. issue 2. 2022-07-14. PMID:35833817. |
based on the present study, ach improved spatial learning and memory defects, and reduced oxidative stress and apoptosis in the hippocampus ca1 region, in chronic morphine‑treated animals. |
2022-07-14 |
2023-08-14 |
human |
| Nuri Jeong, Annabelle C Singe. Learning from inhibition: Functional roles of hippocampal CA1 inhibition in spatial learning and memory. Current opinion in neurobiology. vol 76. 2022-07-10. PMID:35810533. |
learning from inhibition: functional roles of hippocampal ca1 inhibition in spatial learning and memory. |
2022-07-10 |
2023-08-14 |
Not clear |
| Nuri Jeong, Annabelle C Singe. Learning from inhibition: Functional roles of hippocampal CA1 inhibition in spatial learning and memory. Current opinion in neurobiology. vol 76. 2022-07-10. PMID:35810533. |
here, we review emerging evidence of ca1 hippocampal interneurons' role in local circuit computations that support spatial learning and memory and discuss open questions about ca1 interneurons in spatial learning. |
2022-07-10 |
2023-08-14 |
Not clear |
| Vajihe Imanpour, Parham Reis. The Effect of Orexin-2 and Endocannabinoid-1 Antagonists on Neuronal Activity of Hippocampal CA1 Pyramidal Neurons in Response to Tramadol in Rats. Advanced biomedical research. vol 11. 2022-06-20. PMID:35720213. |
ca1, as a major structure involved in learning and memory, has been shown to be affected by tramadol addiction. |
2022-06-20 |
2023-08-14 |
rat |
| Yoon-Sun Jang, Yo-Seob Lee, Dong-Hee Kim, Goo Taeg Oh, Won Kyung Jeon, Jung-Soo Ha. Peroxiredoxin 2 deletion impairs hippocampal-dependent memory via exacerbating transient ischemia-induced oxidative damage. Brain research bulletin. 2022-04-22. PMID:35452748. |
next, to evaluate neuronal degeneration and oxidative stress in the ca1 subregion of the hippocampus critical for learning and memory, we measured immunoreactive fluro-jade c (fjc)-positive signals and 4-hydroxy-2-trans-nonenal (4-hne) levels, respectively. |
2022-04-22 |
2023-08-13 |
mouse |