| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Saha, P K Datta, H Sheng, J D Morrow, M Wada, H L Moses, R D Beaucham. Synergistic induction of cyclooxygenase-2 by transforming growth factor-beta1 and epidermal growth factor inhibits apoptosis in epithelial cells. Neoplasia (New York, N.Y.). vol 1. issue 6. 2000-08-17. PMID:10935498. |
increased expression of cox-2 and production of prostaglandins appear to provide a survival advantage to transformed cells through the inhibition of apoptosis, increased attachment to extracellular matrix, increased invasiveness, and the stimulation of angiogenesis. |
2000-08-17 |
2023-08-12 |
human |
| B L Shacklett, C J Weber, K E Shaw, E M Keddie, M B Gardner, P Sonigo, P A Luci. The intracytoplasmic domain of the Env transmembrane protein is a locus for attenuation of simian immunodeficiency virus SIVmac in rhesus macaques. Journal of virology. vol 74. issue 13. 2000-08-10. PMID:10846063. |
these domains are suggested to play a role in envelope fusogenicity, interaction with the viral matrix protein during assembly, viral infectivity, binding of intracellular calmodulin, disruption of membranes, and induction of apoptosis. |
2000-08-10 |
2023-08-12 |
human |
| Y Hibin. [Functional arrangement of genomic DNA and structure of nuclear matrix]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 120. issue 6. 2000-08-08. PMID:10860485. |
nuclear matrix proteins are also potential candidates for the use as tumor prognostic factors and targets of anticancer drugs through apoptosis. |
2000-08-08 |
2023-08-12 |
rat |
| P Schedin, R Strange, T Mitrenga, P Wolfe, M Kaec. Fibronectin fragments induce MMP activity in mouse mammary epithelial cells: evidence for a role in mammary tissue remodeling. Journal of cell science. vol 113 ( Pt 5). 2000-07-26. PMID:10671369. |
we provide evidence that proteolytic fragments of the extracellular matrix glycoprotein, fibronectin, suppress growth and can promote apoptosis of mouse mammary epithelial cells. |
2000-07-26 |
2023-08-12 |
mouse |
| P Schedin, R Strange, T Mitrenga, P Wolfe, M Kaec. Fibronectin fragments induce MMP activity in mouse mammary epithelial cells: evidence for a role in mammary tissue remodeling. Journal of cell science. vol 113 ( Pt 5). 2000-07-26. PMID:10671369. |
treatment of tm-6 cells with exogenous fibronectin fragments (fn120) reduced cell number, and induced apoptosis and matrix degrading protease activity. |
2000-07-26 |
2023-08-12 |
mouse |
| K N Cowan, A Heilbut, T Humpl, C Lam, S Ito, M Rabinovitc. Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor. Nature medicine. vol 6. issue 6. 2000-07-24. PMID:10835689. |
pulmonary artery pressure and muscularization were reduced by myocyte apoptosis and loss of extracellular matrix, specifically elastin and tenascin-c. after 2 weeks, pulmonary artery pressure and structure normalized, and survival was 86%, compared with 0% in untreated or vehicle-treated rats. |
2000-07-24 |
2023-08-12 |
rat |
| A Compagni, G Christofor. Recent advances in research on multistage tumorigenesis. British journal of cancer. vol 83. issue 1. 2000-07-20. PMID:10883659. |
common to most tumours, several regulatory circuits are altered during multistage tumour progression, most importantly, the control of proliferation, the balance between cell survival and programmed cell death (apoptosis), the communication with neighbouring cells and the extracellular matrix, the induction of tumour neovascularization (angiogenesis) and, finally, tumour cell migration, invasion and metastatic dissemination. |
2000-07-20 |
2023-08-12 |
mouse |
| L M Taylor, L M Khachigia. Induction of platelet-derived growth factor B-chain expression by transforming growth factor-beta involves transactivation by Smads. The Journal of biological chemistry. vol 275. issue 22. 2000-07-11. PMID:10828062. |
transforming growth factor-beta (tgf-beta) regulates a diverse array of biological processes, such as proliferation, differentiation, extracellular matrix production, and apoptosis. |
2000-07-11 |
2023-08-12 |
Not clear |
| B Tian, T Takasu, C Henk. Functional role of cyclin A on induction of fibroblast apoptosis due to ligation of CD44 matrix receptor by anti-CD44 antibody. Experimental cell research. vol 257. issue 1. 2000-07-06. PMID:10854061. |
functional role of cyclin a on induction of fibroblast apoptosis due to ligation of cd44 matrix receptor by anti-cd44 antibody. |
2000-07-06 |
2023-08-12 |
Not clear |
| B Tian, T Takasu, C Henk. Functional role of cyclin A on induction of fibroblast apoptosis due to ligation of CD44 matrix receptor by anti-CD44 antibody. Experimental cell research. vol 257. issue 1. 2000-07-06. PMID:10854061. |
disruption of cell surface matrix receptor interaction with the extracellular matrix can trigger apoptosis. |
2000-07-06 |
2023-08-12 |
Not clear |
| B Tian, T Takasu, C Henk. Functional role of cyclin A on induction of fibroblast apoptosis due to ligation of CD44 matrix receptor by anti-CD44 antibody. Experimental cell research. vol 257. issue 1. 2000-07-06. PMID:10854061. |
we have found that ligation of the cell surface matrix adhesion receptor cd44 by anti-cd44 antibody induces cell detachment and triggers apoptosis. |
2000-07-06 |
2023-08-12 |
Not clear |
| A B Fog. Glomerular hypertension, abnormal glomerular growth, and progression of renal diseases. Kidney international. Supplement. vol 75. 2000-06-27. PMID:10828756. |
the interplay of these factors determines the balance of cell growth and proliferation versus cell death by necrosis or apoptosis, and the balance of matrix accumulation versus degradation. |
2000-06-27 |
2023-08-12 |
Not clear |
| P Lassus, P Roux, O Zugasti, A Philips, P Fort, U Hibne. Extinction of rac1 and Cdc42Hs signalling defines a novel p53-dependent apoptotic pathway. Oncogene. vol 19. issue 20. 2000-06-14. PMID:10828879. |
we show here that upon detachment from the extracellular matrix, fibroblasts undergo rapid apoptosis that can be rescued by constitutive activation of rac1 and cdc42hs gtpases. |
2000-06-14 |
2023-08-12 |
Not clear |
| E Bergin, J S Levine, J S Koh, W Liebertha. Mouse proximal tubular cell-cell adhesion inhibits apoptosis by a cadherin-dependent mechanism. American journal of physiology. Renal physiology. vol 278. issue 5. 2000-06-12. PMID:10807587. |
adhesion of epithelial cells to matrix is known to inhibit apoptosis. |
2000-06-12 |
2023-08-12 |
mouse |
| M Gourley, J S Williamso. Angiogenesis: new targets for the development of anticancer chemotherapies. Current pharmaceutical design. vol 6. issue 4. 2000-06-02. PMID:10788590. |
strategies for exploiting tumor angiogenesis for novel cancer drug discovery include: (i) inhibition of proteolytic enzymes that breakdown the extracellular matrix surrounding existing capillaries; (ii) inhibition of endothelial cell migration; (iii) inhibition of endothelial cell proliferation; (iv) enhancement of tumor endothelial cell apoptosis. |
2000-06-02 |
2023-08-12 |
Not clear |
| M Segelmark, C Barrett, W Pendergraft, R Falk, G Presto. Expression of p300-truncated fragments results in the modulation of apoptosis in rat mesangial cells. Kidney international. vol 57. issue 5. 2000-06-01. PMID:10792606. |
mesangial cell proliferation, apoptosis, and matrix deposition have pivotal roles in the pathogenesis of renal diseases such as diabetic nephropathy and glomerulonephritis. |
2000-06-01 |
2023-08-12 |
rat |
| P Clézardin, J Gligorov, P Delma. Mechanisms of action of bisphosphonates on tumor cells and prospects for use in the treatment of malignant osteolysis. Joint bone spine. vol 67. issue 1. 2000-05-31. PMID:10773965. |
also, experimental evidence suggest that bisphosphonates act on the tumor cells themselves, either by inhibiting mechanisms involved in the development of bone metastasis (tumor invasion, adhesion of tumor cells to the bone matrix) or by inducing apoptosis of tumor cells. |
2000-05-31 |
2023-08-12 |
Not clear |
| R Zhao, K Gish, M Murphy, Y Yin, D Notterman, W H Hoffman, E Tom, D H Mack, A J Levin. Analysis of p53-regulated gene expression patterns using oligonucleotide arrays. Genes & development. vol 14. issue 8. 2000-05-31. PMID:10783169. |
of 6000 genes examined for p53 regulatory responses, 107 induced and 54 repressed genes fell into categories of apoptosis and growth arrest, cytoskeletal functions, growth factors and their inhibitors, extracellular matrix, and adhesion genes. |
2000-05-31 |
2023-08-12 |
Not clear |
| K Brew, D Dinakarpandian, H Nagas. Tissue inhibitors of metalloproteinases: evolution, structure and function. Biochimica et biophysica acta. vol 1477. issue 1-2. 2000-05-24. PMID:10708863. |
the two-domain timps are of relatively small size, yet have been found to exhibit several biochemical and physiological/biological functions, including inhibition of active mmps, prommp activation, cell growth promotion, matrix binding, inhibition of angiogenesis and the induction of apoptosis. |
2000-05-24 |
2023-08-12 |
Not clear |
| M S Anggraeni, L Owen. The haemocytic origin of lymphoid organ spheroid cells in the penaeid prawn Penaeus monodon. Diseases of aquatic organisms. vol 40. issue 2. 2000-05-23. PMID:10782341. |
an apoptosis detection assay showed that los cells were often apoptotic whilst stromal matrix cells were not. |
2000-05-23 |
2023-08-12 |
Not clear |