| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| O Verborgt, G J Gibson, M B Schaffle. Loss of osteocyte integrity in association with microdamage and bone remodeling after fatigue in vivo. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 15. issue 1. 2000-02-11. PMID:10646115. |
the strong associations between microdamage, osteocyte apoptosis, and subsequent bone remodeling support the hypothesis that osteocyte apoptosis provides a key part of the activation or signaling mechanisms by which osteoclasts target bone for removal after fatigue-induced matrix injury. |
2000-02-11 |
2023-08-12 |
rat |
| M Sabatini, G Rolland, S Léonce, M Thomas, C Lesur, V Pérez, G de Nanteuil, J Bonne. Effects of ceramide on apoptosis, proteoglycan degradation, and matrix metalloproteinase expression in rabbit articular cartilage. Biochemical and biophysical research communications. vol 267. issue 1. 2000-02-08. PMID:10623638. |
effects of ceramide on apoptosis, proteoglycan degradation, and matrix metalloproteinase expression in rabbit articular cartilage. |
2000-02-08 |
2023-08-12 |
rabbit |
| M Sabatini, G Rolland, S Léonce, M Thomas, C Lesur, V Pérez, G de Nanteuil, J Bonne. Effects of ceramide on apoptosis, proteoglycan degradation, and matrix metalloproteinase expression in rabbit articular cartilage. Biochemical and biophysical research communications. vol 267. issue 1. 2000-02-08. PMID:10623638. |
ceramide also caused chondrocyte apoptosis at doses ranging from 10(-5) to 10(-4) m. this study supports the hypothesis that ceramide might play a mediatory role in both matrix degradation and apoptosis in processes of cartilage loss such as those observed in osteoarthritis. |
2000-02-08 |
2023-08-12 |
rabbit |
| M Y Park, R H Lee, S H Lee, J S Jun. Apoptosis induced by inhibition of contact with extracellular matrix in mouse collecting duct cells. Nephron. vol 83. issue 4. 2000-02-04. PMID:10575296. |
apoptosis induced by inhibition of contact with extracellular matrix in mouse collecting duct cells. |
2000-02-04 |
2023-08-12 |
mouse |
| M Y Park, R H Lee, S H Lee, J S Jun. Apoptosis induced by inhibition of contact with extracellular matrix in mouse collecting duct cells. Nephron. vol 83. issue 4. 2000-02-04. PMID:10575296. |
detachment from the matrix epithelial cells induces programmed cell death, and this cell detachment induced apoptosis has been referred to as 'anoikis'. |
2000-02-04 |
2023-08-12 |
mouse |
| M Y Park, R H Lee, S H Lee, J S Jun. Apoptosis induced by inhibition of contact with extracellular matrix in mouse collecting duct cells. Nephron. vol 83. issue 4. 2000-02-04. PMID:10575296. |
this study was undertaken to determine whether apoptosis is induced by inhibition of contact with extracellular matrix (ecm) in collecting duct cells and to investigate the signaling mechanisms of the process. |
2000-02-04 |
2023-08-12 |
mouse |
| Y Yamada, S Endo, H Nakae, Y Kamei, S Taniguchi, H Ishikura, T Tanaka, K Taki, K Inad. Nuclear matrix protein levels in burn patients with multiple organ dysfunction syndrome. Burns : journal of the International Society for Burn Injuries. vol 25. issue 8. 2000-02-04. PMID:10630850. |
in this study, we investigated multiple organ dysfunction syndrome (mods) and nuclear matrix protein (nmp), which is an indicator for apoptosis, in burn patients. |
2000-02-04 |
2023-08-12 |
human |
| K N Cowan, P L Jones, M Rabinovitc. Elastase and matrix metalloproteinase inhibitors induce regression, and tenascin-C antisense prevents progression, of vascular disease. The Journal of clinical investigation. vol 105. issue 1. 2000-01-28. PMID:10619858. |
our data suggest that proteinase inhibition is a novel strategy to induce regression of vascular disease because this overcomes the pluripotentiality of smc-matrix survival interactions and induces coordinated apoptosis and resorption of matrix. |
2000-01-28 |
2023-08-12 |
rat |
| G Li, R Fridman, H R Ki. Tissue inhibitor of metalloproteinase-1 inhibits apoptosis of human breast epithelial cells. Cancer research. vol 59. issue 24. 2000-01-24. PMID:10626822. |
consistently, the matrix metalloproteinases (mmps) or their inhibitors (timps) have been suggested to regulate apoptosis. |
2000-01-24 |
2023-08-12 |
human |
| M Vitale, T Di Matola, M Bifulco, A Casamassima, G Fenzi, G Ross. Apoptosis induced by denied adhesion to extracellular matrix (anoikis) in thyroid epithelial cells is p53 dependent but fails to correlate with modulation of p53 expression. FEBS letters. vol 462. issue 1-2. 2000-01-13. PMID:10580091. |
apoptosis induced by denied adhesion to extracellular matrix (anoikis) in thyroid epithelial cells is p53 dependent but fails to correlate with modulation of p53 expression. |
2000-01-13 |
2023-08-12 |
Not clear |
| J R Dynlacht, M Earles, J Henthorn, Z V Roberts, E W Howard, J D Seno, D Sparling, M D Stor. Degradation of the nuclear matrix is a common element during radiation-induced apoptosis and necrosis. Radiation research. vol 152. issue 6. 2000-01-04. PMID:10581529. |
degradation of the nuclear matrix is a common element during radiation-induced apoptosis and necrosis. |
2000-01-04 |
2023-08-12 |
human |
| J R Dynlacht, M Earles, J Henthorn, Z V Roberts, E W Howard, J D Seno, D Sparling, M D Stor. Degradation of the nuclear matrix is a common element during radiation-induced apoptosis and necrosis. Radiation research. vol 152. issue 6. 2000-01-04. PMID:10581529. |
disassembly of the nuclear lamina and degradation of the nuclear matrix protein lamin b occurred in cells undergoing radiation-induced apoptosis or necrosis. |
2000-01-04 |
2023-08-12 |
human |
| J R Dynlacht, M Earles, J Henthorn, Z V Roberts, E W Howard, J D Seno, D Sparling, M D Stor. Degradation of the nuclear matrix is a common element during radiation-induced apoptosis and necrosis. Radiation research. vol 152. issue 6. 2000-01-04. PMID:10581529. |
these data indicate that breakdown of the nuclear matrix may be a common element in radiation-induced apoptosis and necrosis, but that the mechanisms and temporal patterns of breakdown of the nuclear lamina during apoptosis are distinct from those of necrosis. |
2000-01-04 |
2023-08-12 |
human |
| Y Lu, Y Z Lin, R LaPushin, B Cuevas, X Fang, S X Yu, M A Davies, H Khan, T Furui, M Mao, R Zinner, M C Hung, P Steck, K Siminovitch, G B Mill. The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells. Oncogene. vol 18. issue 50. 2000-01-04. PMID:10597304. |
under anchorage-independent conditions, pten also induces anoikis, a form of apoptosis that occurs when cells are dissociated from the extracellular matrix, which is enhanced in conjunction with low serum culture conditions. |
2000-01-04 |
2023-08-12 |
Not clear |
| J Masumoto, S Taniguchi, K Ayukawa, H Sarvotham, T Kishino, N Niikawa, E Hidaka, T Katsuyama, T Higuchi, J Sagar. ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells. The Journal of biological chemistry. vol 274. issue 48. 1999-12-29. PMID:10567338. |
the cytoskeletal and/or nuclear matrix molecules responsible for morphological changes associated with apoptosis were identified using monoclonal antibodies (mabs). |
1999-12-29 |
2023-08-12 |
human |
| C Jiang, W Jiang, C Ip, H Ganther, J L. Selenium-induced inhibition of angiogenesis in mammary cancer at chemopreventive levels of intake. Molecular carcinogenesis. vol 26. issue 4. 1999-12-28. PMID:10569799. |
in cell culture, direct exposure of human umbilical vein endothelial cells to se induced cell death predominantly through apoptosis, decreased the gelatinolytic activities of matrix metalloproteinase-2, or both. |
1999-12-28 |
2023-08-12 |
human |
| L E Dike, C S Chen, M Mrksich, J Tien, G M Whitesides, D E Ingbe. Geometric control of switching between growth, apoptosis, and differentiation during angiogenesis using micropatterned substrates. In vitro cellular & developmental biology. Animal. vol 35. issue 8. 1999-12-02. PMID:10501083. |
past studies using micropatterned substrates coated with adhesive islands of extracellular matrix revealed that capillary endothelial cells can be geometrically switched between growth and apoptosis. |
1999-12-02 |
2023-08-12 |
Not clear |
| M Tamura, J Gu, H Tran, K M Yamad. PTEN gene and integrin signaling in cancer. Journal of the National Cancer Institute. vol 91. issue 21. 1999-11-30. PMID:10547389. |
thus, pten appears to be a unique tumor suppressor-with both lipid phosphatase and protein tyrosine phosphatase activities-that negatively regulates cell interactions with the extracellular matrix and that maintains cell sensitivity to apoptosis, e.g., after loss of cell contact with the extracellular matrix. |
1999-11-30 |
2023-08-12 |
human |
| A M Costa, S Peyrol, L C Pôrto, J P Comparin, J L Foyatier, A Desmoulièr. Mechanical forces induce scar remodeling. Study in non-pressure-treated versus pressure-treated hypertrophic scars. The American journal of pathology. vol 155. issue 5. 1999-11-30. PMID:10550323. |
our results show that, in hypertrophic scars, pressure therapy restores in part the extracellular matrix organization observed in normal scar and induces the disappearance of alpha-smooth muscle actin-expressing myofibroblasts, probably by apoptosis. |
1999-11-30 |
2023-08-12 |
Not clear |
| K M Edwards, C M Kam, J C Powers, J A Trapan. The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes. The Journal of biological chemistry. vol 274. issue 43. 1999-11-23. PMID:10521426. |
serine proteases (granzymes) contained within the cytoplasmic granules of cytotoxic t cells and natural killer cells play a variety of roles including the induction of target cell apoptosis, breakdown of extracellular matrix proteins and induction of cytokine secretion by bystander leukocytes. |
1999-11-23 |
2023-08-12 |
human |