| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K M Edwards, C M Kam, J C Powers, J A Trapan. The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes. The Journal of biological chemistry. vol 274. issue 43. 1999-11-23. PMID:10521426. |
serine proteases (granzymes) contained within the cytoplasmic granules of cytotoxic t cells and natural killer cells play a variety of roles including the induction of target cell apoptosis, breakdown of extracellular matrix proteins and induction of cytokine secretion by bystander leukocytes. |
1999-11-23 |
2023-08-12 |
human |
| H Okuda, M Adachi, M Miyazawa, Y Hinoda, K Ima. Protein kinase Calpha promotes apoptotic cell death in gastric cancer cells depending upon loss of anchorage. Oncogene. vol 18. issue 40. 1999-11-05. PMID:10523838. |
disruption of interactions between epithelial cells and extracellular matrix proteins leads to apoptosis of the cells, a phenomenon termed anoikis. |
1999-11-05 |
2023-08-12 |
human |
| S Otte, S Barnikol-Watanabe, G Vorbrüggen, N Hilschman. NUCB1, the Drosophila melanogaster homolog of the mammalian EF-hand proteins NEFA and nucleobindin. Mechanisms of development. vol 86. issue 1-2. 1999-11-04. PMID:10446275. |
although they have been discussed to be involved in autoimmunity, apoptosis and calcium homeostasis in the golgi apparatus and bone matrix, their exact role remains unknown. |
1999-11-04 |
2023-08-12 |
drosophila_melanogaster |
| S Song, P F Lamber. Different responses of epidermal and hair follicular cells to radiation correlate with distinct patterns of p53 and p21 induction. The American journal of pathology. vol 155. issue 4. 1999-11-04. PMID:10514395. |
epidermal cells responded to radiation by undergoing growth arrest, whereas the cells in the matrix of hair follicles underwent apoptosis but not growth arrest. |
1999-11-04 |
2023-08-12 |
mouse |
| B Tang, K de Castro, H E Barnes, W T Parks, L Stewart, E P Böttinger, D Danielpour, L M Wakefiel. Loss of responsiveness to transforming growth factor beta induces malignant transformation of nontumorigenic rat prostate epithelial cells. Cancer research. vol 59. issue 19. 1999-11-04. PMID:10519393. |
high-level expression of the dnr abolished the ability of tgf-beta to inhibit cell growth, to promote cell differentiation, and to induce apoptosis, and it partially blocked the induction of extracellular matrix gene expression. |
1999-11-04 |
2023-08-12 |
mouse |
| L Cao, V Lee, M E Adams, C Kiani, Y Zhang, W Hu, B B Yan. beta-Integrin-collagen interaction reduces chondrocyte apoptosis. Matrix biology : journal of the International Society for Matrix Biology. vol 18. issue 4. 1999-11-03. PMID:10517181. |
moreover, we showed that extracellular matrix (ecm) molecules in the culture media provide vital chondrocyte-matrix interactions; when media are changed, cells are deprived of matrix molecules and undergo apoptosis. |
1999-11-03 |
2023-08-12 |
Not clear |
| L Feng, R Balakir, P Precht, W E Horto. Bcl-2 regulates chondrocyte morphology and aggrecan gene expression independent of caspase activation and full apoptosis. Journal of cellular biochemistry. vol 74. issue 4. 1999-10-12. PMID:10440927. |
chondrocytes express a unique set of matrix proteins, including the proteoglycan aggrecan, and have been widely used to study the relationship between trophic factors and apoptosis. |
1999-10-12 |
2023-08-12 |
rat |
| B Zerega, S Cermelli, P Bianco, R Cancedda, F D Cancedd. Parathyroid hormone [PTH(1-34)] and parathyroid hormone-related protein [PTHrP(1-34)] promote reversion of hypertrophic chondrocytes to a prehypertrophic proliferating phenotype and prevent terminal differentiation of osteoblast-like cells. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 14. issue 8. 1999-09-30. PMID:10457260. |
these data indicate that pth/pthrp inhibit both the mineralization of a cartilage-like matrix and apoptosis (mimicked in the suspension culture) and the production of a mineralizing bone-like matrix, characterizing further differentiation of hypertrophic chondrocytes to osteoblasts like cells (mimicked in adhesion culture). |
1999-09-30 |
2023-08-12 |
chicken |
| Y Y Fan, J Zhang, R Barhoumi, R C Burghardt, N D Turner, J R Lupton, R S Chapki. Antagonism of CD95 signaling blocks butyrate induction of apoptosis in young adult mouse colonic cells. The American journal of physiology. vol 277. issue 2. 1999-09-23. PMID:10444408. |
to delineate the proapoptotic effect of butyrate and to avoid the confounding effects of detachment from the extracellular matrix, adherent cell apoptosis was monitored as loss of plasma membrane asymmetry and dissipation of mitochondrial membrane potential (deltapsi(mt)) by laser cytometry. |
1999-09-23 |
2023-08-12 |
mouse |
| M Fiore, F Degrass. Dimethyl sulfoxide restores contact inhibition-induced growth arrest and inhibits cell density-dependent apoptosis in hamster cells. Experimental cell research. vol 251. issue 1. 1999-09-14. PMID:10438575. |
these results converge to indicate that dmso restores contact inhibition-induced growth arrest and prevents high-density-dependent apoptosis and suggest that the effect of dmso may be mediated by intracellular signaling triggered by cell-extracellular matrix and cell-cell interactions. |
1999-09-14 |
2023-08-12 |
Not clear |
| A Marti, H Lazar, P Ritter, R Jagg. Transcription factor activities and gene expression during mouse mammary gland involution. Journal of mammary gland biology and neoplasia. vol 4. issue 2. 1999-09-08. PMID:10426393. |
each of these processes is likely to depend on the activity of specific sets of transcription factors in the mammary epithelium and stroma that ensure the timely and spatially coordinated expression of critical gene products such as mediators of apoptosis (e.g., caspase-1 and regulators of tissue remodeling events (e.g., matrix metalloproteinases). |
1999-09-08 |
2023-08-12 |
mouse |
| F T Thomas, J L Contreras, G Bilbao, C Ricordi, D Curiel, J M Thoma. Anoikis, extracellular matrix, and apoptosis factors in isolated cell transplantation. Surgery. vol 126. issue 2. 1999-09-02. PMID:10455898. |
anoikis, extracellular matrix, and apoptosis factors in isolated cell transplantation. |
1999-09-02 |
2023-08-12 |
monkey |
| M G Nievers, R Q Schaapveld, A Sonnenber. Biology and function of hemidesmosomes. Matrix biology : journal of the International Society for Matrix Biology. vol 18. issue 1. 1999-08-12. PMID:10367727. |
in addition, recent results indicate that the alpha6 beta4 integrin is involved in the transduction of signals that are induced by the extracellular matrix and which modulate processes as diverse as cell proliferation, differentiation, apoptosis, migration and tissue morphogenesis. |
1999-08-12 |
2023-08-12 |
mouse |
| W Wang, A Passanit. Extracellular matrix inhibits apoptosis and enhances endothelial cell differentiation by a NfkappaB-dependent mechanism. Journal of cellular biochemistry. vol 73. issue 3. 1999-08-02. PMID:10321832. |
extracellular matrix inhibits apoptosis and enhances endothelial cell differentiation by a nfkappab-dependent mechanism. |
1999-08-02 |
2023-08-12 |
human |
| W Wang, A Passanit. Extracellular matrix inhibits apoptosis and enhances endothelial cell differentiation by a NfkappaB-dependent mechanism. Journal of cellular biochemistry. vol 73. issue 3. 1999-08-02. PMID:10321832. |
ecv cell apoptosis was inhibited by e2 (taxol only) or attachment to extracellular matrix (ecm) (taxol or etoposide). |
1999-08-02 |
2023-08-12 |
human |
| T Kiya, T Endo, H Henmi, T Goto, Y Kitajima, K Manase, S Takahashi, R Kud. The effects of growth hormone on corpus luteum of superovulated rats. Endocrine research. vol 25. issue 2. 1999-07-29. PMID:10382680. |
one is apoptosis, and the other is destruction of extracellular matrix by mmp. |
1999-07-29 |
2023-08-12 |
rat |
| S A Abdalla, F Behzad, S Bsharah, S Kumar, S K Amini, S T O'Dwyer, N Y Haboub. Prognostic relevance of microvessel density in colorectal tumours. Oncology reports. vol 6. issue 4. 1999-07-27. PMID:10373667. |
furthermore, overall prognosis will also depend on other factors, such as oncogenes, extracellular matrix components, adhesion molecules, growth factors, degree of apoptosis and the mode of metastatic spread. |
1999-07-27 |
2023-08-12 |
Not clear |
| M Lot. The role of nitric oxide in articular cartilage damage. Rheumatic diseases clinics of North America. vol 25. issue 2. 1999-07-16. PMID:10356417. |
the production of no is associated with matrix degradation and chondrocyte apoptosis. |
1999-07-16 |
2023-08-12 |
human |
| M G Bachem, D Wendelin, W Schneiderhan, C Haug, U Zorn, H J Gross, A Schmid-Kotsas, A Grüner. Depending on their concentration oxidized low density lipoproteins stimulate extracellular matrix synthesis or induce apoptosis in human coronary artery smooth muscle cells. Clinical chemistry and laboratory medicine. vol 37. issue 3. 1999-07-15. PMID:10353478. |
depending on their concentration oxidized low density lipoproteins stimulate extracellular matrix synthesis or induce apoptosis in human coronary artery smooth muscle cells. |
1999-07-15 |
2023-08-12 |
human |
| M G Bachem, D Wendelin, W Schneiderhan, C Haug, U Zorn, H J Gross, A Schmid-Kotsas, A Grüner. Depending on their concentration oxidized low density lipoproteins stimulate extracellular matrix synthesis or induce apoptosis in human coronary artery smooth muscle cells. Clinical chemistry and laboratory medicine. vol 37. issue 3. 1999-07-15. PMID:10353478. |
our results demonstrate that low concentrations of oxldl are profibrogenic by stimulating extracellular matrix synthesis, whereas higher oxldl concentrations induce oxidative stress and apoptosis in coronary artery smooth muscle cells. |
1999-07-15 |
2023-08-12 |
human |