| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A L Boral, S Dessain, B A Chabne. Clinical evaluation of biologically targeted drugs: obstacles and opportunities. Cancer chemotherapy and pharmacology. vol 42 Suppl. 1998-10-07. PMID:9750025. |
these processes include cell cycle control, signal transduction pathways, apoptosis, telomere stability, angiogenesis, and interactions with the extracellular matrix. |
1998-10-07 |
2023-08-12 |
Not clear |
| Y Yamada, S Endo, T Kasai, S Koike, T Takakuwa, Y Inoue, M Niimi, Y Endo, G Wakabayashi, K Inad. Nuclear matrix protein, tumor necrosis factor-alpha, and nitrite/nitrate levels in patients with multiple organ dysfunction syndrome. Research communications in molecular pathology and pharmacology. vol 100. issue 1. 1998-09-16. PMID:9644723. |
nuclear matrix protein (nmp), an indicator of apoptosis, was analyzed in patients with multiple organ dysfunction syndrome (mods). |
1998-09-16 |
2023-08-12 |
Not clear |
| R Banjerdpongchai, P Wilairat, S Fucharoen, A Bunyaratve. Morphological alterations and apoptosis of endothelial cells induced by thalassemic serum in vitro. The Southeast Asian journal of tropical medicine and public health. vol 28 Suppl 3. 1998-09-14. PMID:9640618. |
such treated ecs presented morphological characteristics of apoptosis as shown by the appearance of compact cytosol, membrane blebbing, margination of nuclear matrix, condensed nuclei, and fragmented bodies. |
1998-09-14 |
2023-08-12 |
human |
| J P Iredale, R C Benyon, J Pickering, M McCullen, M Northrop, S Pawley, C Hovell, M J Arthu. Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. The Journal of clinical investigation. vol 102. issue 3. 1998-08-26. PMID:9691091. |
we suggest that apoptosis of activated hsc may vitally contribute to resolution of fibrosis by acting as a mechanism for removing the cell population responsible for both producing fibrotic neomatrix and protecting this matrix from degradation via their production of timps. |
1998-08-26 |
2023-08-12 |
rat |
| F Fukai, M Mashimo, K Akiyama, T Goto, S Tanuma, T Katayam. Modulation of apoptotic cell death by extracellular matrix proteins and a fibronectin-derived antiadhesive peptide. Experimental cell research. vol 242. issue 1. 1998-08-10. PMID:9665806. |
cell adhesion to the extracellular matrix (ecm) has been implicated in apoptosis in anchorage-dependent cell types. |
1998-08-10 |
2023-08-12 |
human |
| F G Gervais, N A Thornberry, S C Ruffolo, D W Nicholson, S Ro. Caspases cleave focal adhesion kinase during apoptosis to generate a FRNK-like polypeptide. The Journal of biological chemistry. vol 273. issue 27. 1998-08-06. PMID:9642276. |
it suppresses apoptosis by transducing survival signals that emanate from focal adhesions via the clustering of transmembrane integrins by components of the extracellular matrix. |
1998-08-06 |
2023-08-12 |
Not clear |
| A R Amin, S B Abramso. The role of nitric oxide in articular cartilage breakdown in osteoarthritis. Current opinion in rheumatology. vol 10. issue 3. 1998-08-03. PMID:9608331. |
in vitro, nitric oxide exerts detrimental effects on chondrocyte functions, including the inhibition of collagen and proteoglycan synthesis, enhanced apoptosis, and an inhibition of b1 integrin-dependent adhesion to the extra-cellular matrix. |
1998-08-03 |
2023-08-12 |
Not clear |
| W E Stehben. Apoptosis and matrix vesicles in the genesis of arterial aneurysms of cerebral arteries. Stroke. vol 29. issue 7. 1998-07-30. PMID:9660409. |
apoptosis and matrix vesicles in the genesis of arterial aneurysms of cerebral arteries. |
1998-07-30 |
2023-08-12 |
Not clear |
| J Li, V C Liang, T Sedgwick, J Wong, Y B Sh. Unique organization and involvement of GAGA factors in transcriptional regulation of the Xenopus stromelysin-3 gene. Nucleic acids research. vol 26. issue 12. 1998-07-29. PMID:9611250. |
expression of the matrix metalloproteinase (mmp) gene stromelysin-3 ( st3 ) has been shown to be tightly associated with cell migration and apoptosis inmammals and amphibians. |
1998-07-29 |
2023-08-12 |
human |
| S J Howell, K J Doan. Type VI collagen increases cell survival and prevents anti-beta 1 integrin-mediated apoptosis. Experimental cell research. vol 241. issue 1. 1998-07-08. PMID:9633532. |
in addition, less apoptosis was observed for both cell types on type vi collagen when beta 1 integrin--matrix interactions were disrupted. |
1998-07-08 |
2023-08-12 |
Not clear |
| F Vadillo Ortega, F Arechevaleta, J Beltrán Montoy. [Apoptosis and extracellular matrix degradation in chorio-amnion during labor and premature membrane rupture]. Ginecologia y obstetricia de Mexico. vol 66. 1998-07-02. PMID:9646577. |
[apoptosis and extracellular matrix degradation in chorio-amnion during labor and premature membrane rupture]. |
1998-07-02 |
2023-08-12 |
Not clear |
| M L Matter, Z Zhang, C Nordstedt, E Ruoslaht. The alpha5beta1 integrin mediates elimination of amyloid-beta peptide and protects against apoptosis. The Journal of cell biology. vol 141. issue 4. 1998-06-17. PMID:9585419. |
deposition of an insoluble abeta1-40 matrix around the alpha5beta1-expressing cells was reduced, and the cells showed less apoptosis than the control cells. |
1998-06-17 |
2023-08-12 |
Not clear |
| M Scatena, M Almeida, M L Chaisson, N Fausto, R F Nicosia, C M Giachell. NF-kappaB mediates alphavbeta3 integrin-induced endothelial cell survival. The Journal of cell biology. vol 141. issue 4. 1998-06-17. PMID:9585425. |
different extracellular matrix molecules were able to protect rat aorta- derived endothelial cells from apoptosis induced by serum withdrawal. |
1998-06-17 |
2023-08-12 |
rat |
| R Judware, T S McCormick, S Mohr, J K Yun, E G Lapetin. Propensity for macrophage apoptosis is related to the pattern of expression and function of integrin extracellular matrix receptors. Biochemical and biophysical research communications. vol 246. issue 2. 1998-06-15. PMID:9610392. |
propensity for macrophage apoptosis is related to the pattern of expression and function of integrin extracellular matrix receptors. |
1998-06-15 |
2023-08-12 |
Not clear |
| G Kroemer, B Dallaporta, M Resche-Rigo. The mitochondrial death/life regulator in apoptosis and necrosis. Annual review of physiology. vol 60. 1998-06-12. PMID:9558479. |
at a second level, the consequences of mitochondrial dysfunction (collapse of the mitochondrial inner transmembrane potential, uncoupling of the respiratory chain, hyperproduction of superoxide anions, disruption of mitochondrial biogenesis, outflow of matrix calcium and glutathione, and release of soluble intermembrane proteins) entails a bioenergetic catastrophe culminating in the disruption of plasma membrane integrity (necrosis) and/or the activation of specific apoptogenic proteases (caspases) by mitochondrial proteins that leak into the cytosol (cytochrome c, apoptosis-inducing factor) with secondary endonuclease activation (apoptosis). |
1998-06-12 |
2023-08-12 |
Not clear |
| I Pucci-Minafra, M Andriolo, L Basiricò, R Alessandro, C Luparello, C Buccellato, R Garbelli, S Minafr. Absence of regular alpha2(I) collagen chains in colon carcinoma biopsy fragments. Carcinogenesis. vol 19. issue 4. 1998-06-04. PMID:9600340. |
the extracellular matrix (ecm) is known to play an active role in numerous biological processes such as differentiation, apoptosis and cancer. |
1998-06-04 |
2023-08-12 |
Not clear |
| V Ophascharoensuk, M L Fero, J Hughes, J M Roberts, S J Shanklan. The cyclin-dependent kinase inhibitor p27Kip1 safeguards against inflammatory injury. Nature medicine. vol 4. issue 5. 1998-05-29. PMID:9585231. |
renal function was substantially decreased in nephritic p27-/- mice compared with control mice, and this was associated with increased glomerular cell proliferation, apoptosis and matrix protein accumulation. |
1998-05-29 |
2023-08-12 |
mouse |
| A Bardelli, P M Comogli. Scatter factor receptors are key players in a unique multistep program leading to invasive growth. Ciba Foundation symposium. vol 212. 1998-05-18. PMID:9524768. |
hgf/sf and hgf1/msp control a complex genetic program known as 'invasive growth' which leads to cell dissociation, proliferation, invasion of extracellular matrix, prevention of apoptosis, acquisition of polarity and tubule formation. |
1998-05-18 |
2023-08-12 |
Not clear |
| R S Fife, G W Sledge, C Procto. Effects of vitamin D3 on proliferation of cancer cells in vitro. Cancer letters. vol 120. issue 1. 1998-05-13. PMID:9570387. |
many factors contribute to this unrestrained proliferation, including increased metalloproteinase activity causing degradation of the extracellular matrix surrounding cancer cells, angiogenesis permitting easy access of the cells to the bloodstream and decrease or loss of programmed cell death, or apoptosis, an important mechanism for removal of abnormal or senescent cells. |
1998-05-13 |
2023-08-12 |
human |
| B Levkau, B Herren, H Koyama, R Ross, E W Raine. Caspase-mediated cleavage of focal adhesion kinase pp125FAK and disassembly of focal adhesions in human endothelial cell apoptosis. The Journal of experimental medicine. vol 187. issue 4. 1998-03-23. PMID:9463408. |
normal endothelial and epithelial cells undergo apoptosis when cell adhesion and spreading are prevented, implying a requirement for antiapoptotic signals from the extracellular matrix for cell survival. |
1998-03-23 |
2023-08-12 |
human |