| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A V Oleskin, I V Botvinko, E A Tsavkelov. [Colonial organization and intercellular communication of microorganisms]. Mikrobiologiia. vol 69. issue 3. 2000-09-25. PMID:10920799. |
special attention is given to such relevant phenomena as apoptosis, bacterial altruism, quorum effects, collective differentiation of microbial cells, and the formation of population-level structures such as an extracellular matrix. |
2000-09-25 |
2023-08-12 |
Not clear |
| M Pohl, R O Stuart, H Sakurai, S K Niga. Branching morphogenesis during kidney development. Annual review of physiology. vol 62. 2000-09-18. PMID:10845104. |
key branching morphogenetic molecules in this model include growth factors, transcription factors, distal effector molecules (such as extracellular matrix proteins, integrins, proteinases and their inhibitors), and genes regulating apoptosis and cell proliferation. |
2000-09-18 |
2023-08-12 |
Not clear |
| S Attwell, C Roskelley, S Dedha. The integrin-linked kinase (ILK) suppresses anoikis. Oncogene. vol 19. issue 33. 2000-09-07. PMID:10949937. |
disruption of integrin-extracellular matrix interactions in normal epithelial cells induces apoptosis, a process termed anoikis. |
2000-09-07 |
2023-08-12 |
mouse |
| M L Grooteclaes, S M Frisc. Evidence for a function of CtBP in epithelial gene regulation and anoikis. Oncogene. vol 19. issue 33. 2000-09-07. PMID:10949939. |
concomitantly, the cells become sensitive to anoikis (apoptosis of epithelial cells detached from extracellular matrix), potentially causing tumor suppression. |
2000-09-07 |
2023-08-12 |
human |
| B A Fischer, S Mundle, A A Col. Tumor necrosis factor-alpha induced DNA cleavage in human articular chondrocytes may involve multiple endonucleolytic activities during apoptosis. Microscopy research and technique. vol 50. issue 3. 2000-08-31. PMID:10891889. |
when the chondrocytes were cultured as explants with the articular matrix intact (ex vivo), neither il-1 beta, tnf alpha, the anti-fas antibody, nor fibronectin fragments were able to induce apoptosis in the chondrocytes. |
2000-08-31 |
2023-08-12 |
human |
| B A Fischer, S Mundle, A A Col. Tumor necrosis factor-alpha induced DNA cleavage in human articular chondrocytes may involve multiple endonucleolytic activities during apoptosis. Microscopy research and technique. vol 50. issue 3. 2000-08-31. PMID:10891889. |
these data suggest that apoptosis occurs in chondrocytes in which the matrix has been disrupted experimentally or destroyed by the osteoarthritic disease process. |
2000-08-31 |
2023-08-12 |
human |
| R Hernández-Alcoceba, L del Peso, J C Laca. The Ras family of GTPases in cancer cell invasion. Cellular and molecular life sciences : CMLS. vol 57. issue 1. 2000-08-31. PMID:10949581. |
the development of metastasis is a multistep process that requires coordinated activation of proliferation, motility, changes in normal cell-to-cell and cell-to-substrate contacts, degradation of extracellular matrix, inhibition of apoptosis, and adaptation to an inappropriate tissue environment. |
2000-08-31 |
2023-08-12 |
Not clear |
| J Wu, S L Liu, J L Zhu, P A Norton, S Nojiri, J B Hoek, M A Zer. Roles of tissue transglutaminase in ethanol-induced inhibition of hepatocyte proliferation and alpha 1-adrenergic signal transduction. The Journal of biological chemistry. vol 275. issue 29. 2000-08-24. PMID:10801782. |
others have shown that ttg has two distinctly different functions: it catalyzes protein cross-linking, which can lead to apoptosis and enhancement of extracellular matrix stability, and it can function as a g protein (galpha(h)). |
2000-08-24 |
2023-08-12 |
Not clear |
| P P Chiou, C H Kim, P Ormonde, J A Leon. Infectious hematopoietic necrosis virus matrix protein inhibits host-directed gene expression and induces morphological changes of apoptosis in cell cultures. Journal of virology. vol 74. issue 16. 2000-08-18. PMID:10906216. |
infectious hematopoietic necrosis virus matrix protein inhibits host-directed gene expression and induces morphological changes of apoptosis in cell cultures. |
2000-08-18 |
2023-08-12 |
Not clear |
| A Wellmann, C Thieblemont, S Pittaluga, A Sakai, E S Jaffe, P Siebert, M Raffel. Detection of differentially expressed genes in lymphomas using cDNA arrays: identification of clusterin as a new diagnostic marker for anaplastic large-cell lymphomas. Blood. vol 96. issue 2. 2000-08-17. PMID:10887098. |
clusterin is a highly conserved glycoprotein implicated in intercellular and cell matrix interactions, regulation of the complement system, lipid transport, stress responses, and apoptosis. |
2000-08-17 |
2023-08-12 |
human |
| C Ordoñez, R A Screaton, C Ilantzis, C P Stanner. Human carcinoembryonic antigen functions as a general inhibitor of anoikis. Cancer research. vol 60. issue 13. 2000-08-17. PMID:10910050. |
in this report, we show that cea and ceacam6, but not ceacam1, markedly inhibit the apoptosis of cells when deprived of their anchorage to the extracellular matrix, a process known as anoikis. |
2000-08-17 |
2023-08-12 |
human |
| S J Leuenroth, P S Grutkoski, A Ayala, H H Simm. The loss of Mcl-1 expression in human polymorphonuclear leukocytes promotes apoptosis. Journal of leukocyte biology. vol 68. issue 1. 2000-08-17. PMID:10914504. |
we have previously shown that pmn apoptosis is delayed by matrix adhesion and hypoxia; however, the mechanisms responsible for this delay are not well understood. |
2000-08-17 |
2023-08-12 |
human |
| D Saha, P K Datta, H Sheng, J D Morrow, M Wada, H L Moses, R D Beaucham. Synergistic induction of cyclooxygenase-2 by transforming growth factor-beta1 and epidermal growth factor inhibits apoptosis in epithelial cells. Neoplasia (New York, N.Y.). vol 1. issue 6. 2000-08-17. PMID:10935498. |
increased expression of cox-2 and production of prostaglandins appear to provide a survival advantage to transformed cells through the inhibition of apoptosis, increased attachment to extracellular matrix, increased invasiveness, and the stimulation of angiogenesis. |
2000-08-17 |
2023-08-12 |
human |
| B L Shacklett, C J Weber, K E Shaw, E M Keddie, M B Gardner, P Sonigo, P A Luci. The intracytoplasmic domain of the Env transmembrane protein is a locus for attenuation of simian immunodeficiency virus SIVmac in rhesus macaques. Journal of virology. vol 74. issue 13. 2000-08-10. PMID:10846063. |
these domains are suggested to play a role in envelope fusogenicity, interaction with the viral matrix protein during assembly, viral infectivity, binding of intracellular calmodulin, disruption of membranes, and induction of apoptosis. |
2000-08-10 |
2023-08-12 |
human |
| Y Hibin. [Functional arrangement of genomic DNA and structure of nuclear matrix]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 120. issue 6. 2000-08-08. PMID:10860485. |
nuclear matrix proteins are also potential candidates for the use as tumor prognostic factors and targets of anticancer drugs through apoptosis. |
2000-08-08 |
2023-08-12 |
rat |
| P Schedin, R Strange, T Mitrenga, P Wolfe, M Kaec. Fibronectin fragments induce MMP activity in mouse mammary epithelial cells: evidence for a role in mammary tissue remodeling. Journal of cell science. vol 113 ( Pt 5). 2000-07-26. PMID:10671369. |
we provide evidence that proteolytic fragments of the extracellular matrix glycoprotein, fibronectin, suppress growth and can promote apoptosis of mouse mammary epithelial cells. |
2000-07-26 |
2023-08-12 |
mouse |
| P Schedin, R Strange, T Mitrenga, P Wolfe, M Kaec. Fibronectin fragments induce MMP activity in mouse mammary epithelial cells: evidence for a role in mammary tissue remodeling. Journal of cell science. vol 113 ( Pt 5). 2000-07-26. PMID:10671369. |
treatment of tm-6 cells with exogenous fibronectin fragments (fn120) reduced cell number, and induced apoptosis and matrix degrading protease activity. |
2000-07-26 |
2023-08-12 |
mouse |
| K N Cowan, A Heilbut, T Humpl, C Lam, S Ito, M Rabinovitc. Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor. Nature medicine. vol 6. issue 6. 2000-07-24. PMID:10835689. |
pulmonary artery pressure and muscularization were reduced by myocyte apoptosis and loss of extracellular matrix, specifically elastin and tenascin-c. after 2 weeks, pulmonary artery pressure and structure normalized, and survival was 86%, compared with 0% in untreated or vehicle-treated rats. |
2000-07-24 |
2023-08-12 |
rat |
| A Compagni, G Christofor. Recent advances in research on multistage tumorigenesis. British journal of cancer. vol 83. issue 1. 2000-07-20. PMID:10883659. |
common to most tumours, several regulatory circuits are altered during multistage tumour progression, most importantly, the control of proliferation, the balance between cell survival and programmed cell death (apoptosis), the communication with neighbouring cells and the extracellular matrix, the induction of tumour neovascularization (angiogenesis) and, finally, tumour cell migration, invasion and metastatic dissemination. |
2000-07-20 |
2023-08-12 |
mouse |
| L M Taylor, L M Khachigia. Induction of platelet-derived growth factor B-chain expression by transforming growth factor-beta involves transactivation by Smads. The Journal of biological chemistry. vol 275. issue 22. 2000-07-11. PMID:10828062. |
transforming growth factor-beta (tgf-beta) regulates a diverse array of biological processes, such as proliferation, differentiation, extracellular matrix production, and apoptosis. |
2000-07-11 |
2023-08-12 |
Not clear |