| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Horlitz, U Sigwart, J Niebaue. [Statins do not prevent restenosis after coronary angioplasty: where to go from here?]. Herz. vol 26. issue 2. 2001-06-21. PMID:11349614. |
known mechanisms of restenotic lesion formation are smooth muscle cell proliferation, extracellular matrix production, remodeling and decreased programmed cell death (apoptosis). |
2001-06-21 |
2023-08-12 |
Not clear |
| S L Hsu, C C Cheng, Y R Shi, C W Chian. Proteolysis of integrin alpha5 and beta1 subunits involved in retinoic acid-induced apoptosis in human hepatoma Hep3B cells. Cancer letters. vol 167. issue 2. 2001-06-21. PMID:11369141. |
in this study, we examined the influence of cell-extracellular matrix interaction on the ability of atra to induce apoptosis. |
2001-06-21 |
2023-08-12 |
human |
| J L Contreras, G Bilbao, C A Smyth, X L Jiang, D E Eckhoff, S M Jenkins, F T Thomas, D T Curiel, J M Thoma. Cytoprotection of pancreatic islets before and soon after transplantation by gene transfer of the anti-apoptotic Bcl-2 gene. Transplantation. vol 71. issue 8. 2001-06-21. PMID:11374395. |
islet apoptosis has been documented after extracellular matrix disruption and exposure to proinflammatory cytokines, and during hypoxia before islet revascularization and rejection. |
2001-06-21 |
2023-08-12 |
mouse |
| J L Contreras, G Bilbao, C A Smyth, X L Jiang, D E Eckhoff, S M Jenkins, F T Thomas, D T Curiel, J M Thoma. Cytoprotection of pancreatic islets before and soon after transplantation by gene transfer of the anti-apoptotic Bcl-2 gene. Transplantation. vol 71. issue 8. 2001-06-21. PMID:11374395. |
bcl-2 transfection ex vivo protects these islets from apoptosis induced by disruption of the islet extracellular matrix during pancreatic digestion. |
2001-06-21 |
2023-08-12 |
mouse |
| F Remoué, D To Van, A M Schacht, M Picquet, O Garraud, J Vercruysse, A Ly, A Capron, G Rivea. Gender-dependent specific immune response during chronic human Schistosomiasis haematobia. Clinical and experimental immunology. vol 124. issue 1. 2001-06-14. PMID:11359443. |
a significantly higher nuclear matrix protein 41/7 secretion, an apoptosis marker, was specifically observed in mononuclear blood cell cultures of females suggesting that a specific cell death process was engaged in a gender-dependent manner. |
2001-06-14 |
2023-08-12 |
human |
| Y K Zhu, T Umino, X D Liu, H J Wang, D J Romberger, J R Spurzem, S I Rennar. Contraction of fibroblast-containing collagen gels: initial collagen concentration regulates the degree of contraction and cell survival. In vitro cellular & developmental biology. Animal. vol 37. issue 1. 2001-06-07. PMID:11249200. |
remodeling of extracellular matrix involves a number of steps including the recruitment, accumulation, and eventual apoptosis of parenchymal cells as well as the production, organization, and rearrangement of extracellular matrix produced by these cells. |
2001-06-07 |
2023-08-12 |
human |
| Y K Zhu, T Umino, X D Liu, H J Wang, D J Romberger, J R Spurzem, S I Rennar. Contraction of fibroblast-containing collagen gels: initial collagen concentration regulates the degree of contraction and cell survival. In vitro cellular & developmental biology. Animal. vol 37. issue 1. 2001-06-07. PMID:11249200. |
if the gels were maintained in the attached state which largely prevents contraction, apoptosis was significantly reduced, suggesting that contraction rather than matrix composition was a requirement for the increased apoptosis. |
2001-06-07 |
2023-08-12 |
human |
| J T Yu, R G Foster, D C Dea. Transcriptional repression by RB-E2F and regulation of anchorage-independent survival. Molecular and cellular biology. vol 21. issue 10. 2001-06-07. PMID:11313458. |
it is not until igf-1 expression diminishes (~16 h after loss of matrix contact) that epithelial cells deprived of matrix contact undergo apoptosis. |
2001-06-07 |
2023-08-12 |
Not clear |
| J T Yu, R G Foster, D C Dea. Transcriptional repression by RB-E2F and regulation of anchorage-independent survival. Molecular and cellular biology. vol 21. issue 10. 2001-06-07. PMID:11313458. |
this suggests that igf-1 expression is linked to cell adhesion and that it is the loss of igf-1 which dictates the onset of apoptosis after cells lose matrix contact. |
2001-06-07 |
2023-08-12 |
Not clear |
| J T Yu, R G Foster, D C Dea. Transcriptional repression by RB-E2F and regulation of anchorage-independent survival. Molecular and cellular biology. vol 21. issue 10. 2001-06-07. PMID:11313458. |
this feedback loop containing gsk-3beta, cyclin d, hdac-rb-e2f, and igf-1 then determines how long akt will remain active after cells lose matrix contact, and thus it serves to regulate the onset of apoptosis in such cells. |
2001-06-07 |
2023-08-12 |
Not clear |
| M P Pistillo, P L Tazzari, C Gaudiano, V Cilla, T Kato, T Matsui, K Nishioka, P Capanni, R Conte, G B Ferrar. Patients with neoplastic and nonneoplastic hematologic diseases acquire CTLA-4 antibodies after blood transfusion. Transfusion. vol 41. issue 4. 2001-06-07. PMID:11316895. |
a previous study showed that, in multiply transfused patients, an immune response against nuclear matrix proteins can be induced by wbcs undergoing apoptosis during rbc unit storage. |
2001-06-07 |
2023-08-12 |
Not clear |
| K Inoue, P Perrotte, C G Wood, J W Slaton, P Sweeney, C P Dinne. Gene therapy of human bladder cancer with adenovirus-mediated antisense basic fibroblast growth factor. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 6. issue 11. 2001-05-31. PMID:11106263. |
intralesional therapy with ad bfgf-as decreased the in vivo expression of bfgf and matrix metalloproteinase type 9 mrna and protein, and reduced microvessel density and enhanced endothelial cell apoptosis. |
2001-05-31 |
2023-08-12 |
mouse |
| K Inoue, P Perrotte, C G Wood, J W Slaton, P Sweeney, C P Dinne. Gene therapy of human bladder cancer with adenovirus-mediated antisense basic fibroblast growth factor. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 6. issue 11. 2001-05-31. PMID:11106263. |
these results suggest that ad bfgf-as therapy affects endothelial cells directly and tumor cells indirectly through down-regulation of bfgf and matrix metalloproteinase type 9, resulting in endothelial cell apoptosis and significant tumor growth inhibition. |
2001-05-31 |
2023-08-12 |
mouse |
| M Shakibaei, G Schulze-Tanzil, P de Souza, T John, M Rahmanzadeh, R Rahmanzadeh, H J Merke. Inhibition of mitogen-activated protein kinase kinase induces apoptosis of human chondrocytes. The Journal of biological chemistry. vol 276. issue 16. 2001-05-31. PMID:11278768. |
analysis by electron microscopy showed typical morphological signs of apoptosis, such as crescent-shaped clumps of heterochromatin, and a degraded pericellular matrix. |
2001-05-31 |
2023-08-12 |
human |
| F Aoudjit, K Vuor. Matrix attachment regulates Fas-induced apoptosis in endothelial cells: a role for c-flip and implications for anoikis. The Journal of cell biology. vol 152. issue 3. 2001-05-24. PMID:11157988. |
matrix attachment regulates fas-induced apoptosis in endothelial cells: a role for c-flip and implications for anoikis. |
2001-05-24 |
2023-08-12 |
Not clear |
| F Aoudjit, K Vuor. Matrix attachment regulates Fas-induced apoptosis in endothelial cells: a role for c-flip and implications for anoikis. The Journal of cell biology. vol 152. issue 3. 2001-05-24. PMID:11157988. |
cell attachment to extracellular matrix inhibits apoptosis in endothelial cells both in vitro and in vivo, but the molecular mechanisms underlying matrix-induced survival signals or detachment-induced apoptotic signals are unknown. |
2001-05-24 |
2023-08-12 |
Not clear |
| F Aoudjit, K Vuor. Matrix attachment regulates Fas-induced apoptosis in endothelial cells: a role for c-flip and implications for anoikis. The Journal of cell biology. vol 152. issue 3. 2001-05-24. PMID:11157988. |
we demonstrate here that matrix attachment is an efficient regulator of fas-mediated apoptosis in endothelial cells. |
2001-05-24 |
2023-08-12 |
Not clear |
| F Aoudjit, K Vuor. Matrix attachment regulates Fas-induced apoptosis in endothelial cells: a role for c-flip and implications for anoikis. The Journal of cell biology. vol 152. issue 3. 2001-05-24. PMID:11157988. |
thus, matrix attachment protects cells from fas-induced apoptosis, whereas matrix detachment results in susceptibility to fas-mediated cell death. |
2001-05-24 |
2023-08-12 |
Not clear |
| F Aoudjit, K Vuor. Matrix attachment regulates Fas-induced apoptosis in endothelial cells: a role for c-flip and implications for anoikis. The Journal of cell biology. vol 152. issue 3. 2001-05-24. PMID:11157988. |
matrix attachment modulates fas-mediated apoptosis at two different levels: by regulating the expression level of fas, and by regulating the expression level of c-flip, an endogenous antagonist of caspase-8. |
2001-05-24 |
2023-08-12 |
Not clear |
| F Aoudjit, K Vuor. Matrix attachment regulates Fas-induced apoptosis in endothelial cells: a role for c-flip and implications for anoikis. The Journal of cell biology. vol 152. issue 3. 2001-05-24. PMID:11157988. |
these studies identify matrix attachment as a survival factor against death receptor-mediated apoptosis and provide a molecular mechanism for anoikis and previously observed fas resistance in endothelial cells. |
2001-05-24 |
2023-08-12 |
Not clear |