| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S S Nadadur, M C Schladweiler, U P Kodavant. A pulmonary rat gene array for screening altered expression profiles in air pollutant-induced lung injury. Inhalation toxicology. vol 12. issue 12. 2001-01-03. PMID:11114790. |
pulmonary tissue injury and repair processes involve complex and coordinated cellular events such as necrosis, inflammation, cell growth/differentiation, apoptosis, and remodeling of extracellular matrix. |
2001-01-03 |
2023-08-12 |
rat |
| M E Cho. Mechanism of transforming growth factor-beta1 signaling:. Kidney international. Supplement. vol 77. 2001-01-02. PMID:10997691. |
transforming growth factor-beta1 (tgf-beta1) regulates diverse biologic activities including cell growth, cell death or apoptosis, cell differentiation, and extracellular matrix (ecm) synthesis. |
2001-01-02 |
2023-08-12 |
Not clear |
| H Makino, H Sugiyama, N Kashihar. Apoptosis and extracellular matrix-cell interactions in kidney disease. Kidney international. Supplement. vol 77. 2001-01-02. PMID:10997693. |
our recent study indicated that basement membrane matrix (a model for normal ecm components) prevented cultured mc from undergoing apoptosis after serum deprivation, thus promoting their survival, compared with type i collagen matrix (a model for abnormal ecm components). |
2001-01-02 |
2023-08-12 |
rat |
| P J Best, A Lerma. Endothelin in cardiovascular disease: from atherosclerosis to heart failure. Journal of cardiovascular pharmacology. vol 35. issue 4 Suppl 2. 2000-12-22. PMID:10976784. |
this peptide not only alters vascular tone and cardiac hemodynamics, but also has a substantial role in the regulation of cellular proliferation and apoptosis, activation of monocytes and cellular matrix production. |
2000-12-22 |
2023-08-12 |
Not clear |
| C M Ferguson, E M Schwarz, P R Reynolds, J E Puzas, R N Rosier, R J O'Keef. Smad2 and 3 mediate transforming growth factor-beta1-induced inhibition of chondrocyte maturation. Endocrinology. vol 141. issue 12. 2000-12-22. PMID:11108288. |
transforming growth factor-beta (tgf-beta) is a multifunctional regulator of a variety of cellular functions, including proliferation, differentiation, matrix synthesis, and apoptosis. |
2000-12-22 |
2023-08-12 |
Not clear |
| E Tonner, G J Allan, D J Flin. Hormonal control of plasmin and tissue-type plasminogen activator activity in rat milk during involution of the mammary gland. The Journal of endocrinology. vol 167. issue 2. 2000-12-15. PMID:11054640. |
since alpha(s2)-casein also binds plasminogen and tissue-type plasminogen activator (t-pa), resulting in the conversion of plasminogen to plasmin, and since igfbp-5 binds to plasminogen activator inhibitor-1 (pai-1), we investigated whether apoptosis and extracellular matrix (ecm) degradation might be coordinately controlled by gh and prl possibly acting through igfbp-5. |
2000-12-15 |
2023-08-12 |
rat |
| M R Piano, S D Kim, C Jarvi. Cellular events linked to cardiac remodeling in heart failure: targets for pharmacologic intervention. The Journal of cardiovascular nursing. vol 14. issue 4. 2000-11-21. PMID:10902101. |
rather, the syndrome of heart failure is more complex and is characterized by abnormal myocyte growth, proliferation of cells in the extracellular matrix, and myocyte cell loss (apoptosis)--all of which culminate in significant structural remodeling of the heart and loss of ventricular function. |
2000-11-21 |
2023-08-12 |
Not clear |
| G Arrode, C Boccaccio, J Lulé, S Allart, N Moinard, J P Abastado, A Alam, C Davrinch. Incoming human cytomegalovirus pp65 (UL83) contained in apoptotic infected fibroblasts is cross-presented to CD8(+) T cells by dendritic cells. Journal of virology. vol 74. issue 21. 2000-11-20. PMID:11024130. |
in this study, we show that infection by hcmv ad169 induced sensitization of mrc5 fibroblasts to tumor necrosis factor alpha-mediated apoptosis very early after virus inoculation and that pp65 contained in apoptotic cells came from the delivery of the matrix protein into the cell. |
2000-11-20 |
2023-08-12 |
human |
| M C Warren, E A Bump, D Medeiros, S J Braunhu. Oxidative stress-induced apoptosis of endothelial cells. Free radical biology & medicine. vol 29. issue 6. 2000-11-17. PMID:11025197. |
analysis of the events leading up to the first peak of apoptosis indicated that specific matrix metalloproteinases (mmps) were activated, suggesting that mmps may be involved in initiating the apoptotic process. |
2000-11-17 |
2023-08-12 |
Not clear |
| A M Mirza, A D Kohn, R A Roth, M McMaho. Oncogenic transformation of cells by a conditionally active form of the protein kinase Akt/PKB. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 11. issue 6. 2000-11-02. PMID:10910095. |
consistent with these observations, activation of m+ akt:er* suppressed the apoptosis of rat1 cells that occurs after the detachment of these cells from extracellular matrix. |
2000-11-02 |
2023-08-12 |
Not clear |
| A M Loening, I E James, M E Levenston, A M Badger, E H Frank, B Kurz, M E Nuttall, H H Hung, S M Blake, A J Grodzinsky, M W Lar. Injurious mechanical compression of bovine articular cartilage induces chondrocyte apoptosis. Archives of biochemistry and biophysics. vol 381. issue 2. 2000-10-31. PMID:11032407. |
a bovine cartilage explant system was used to evaluate the effects of injurious compression on chondrocyte apoptosis and matrix biochemical and biomechanical properties within intact cartilage. |
2000-10-31 |
2023-08-12 |
cattle |
| A M Loening, I E James, M E Levenston, A M Badger, E H Frank, B Kurz, M E Nuttall, H H Hung, S M Blake, A J Grodzinsky, M W Lar. Injurious mechanical compression of bovine articular cartilage induces chondrocyte apoptosis. Archives of biochemistry and biophysics. vol 381. issue 2. 2000-10-31. PMID:11032407. |
while chondrocyte apoptosis may therefore be one of the earliest responses to tissue injury, it is currently unclear whether this initial cellular response subsequently drives cartilage matrix degradation and changes in the biomechanical properties of the tissue. |
2000-10-31 |
2023-08-12 |
cattle |
| L H Xu, X Yang, C A Bradham, D A Brenner, A S Baldwin, R J Craven, W G Canc. The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. Involvement of death receptor-related signaling pathways. The Journal of biological chemistry. vol 275. issue 39. 2000-10-27. PMID:10899173. |
furthermore, breast tumor cells that were viable without matrix attachment also underwent apoptosis upon interruption of fak function, demonstrating that fak is a survival signal in breast tumor cells even in the absence of matrix signaling. |
2000-10-27 |
2023-08-12 |
human |
| A A Panteleyev, R Paus, A M Christian. Patterns of hairless (hr) gene expression in mouse hair follicle morphogenesis and cycling. The American journal of pathology. vol 157. issue 4. 2000-10-25. PMID:11021810. |
the co-localization of hr mrna with the site of the morphological defects in mutant skin implicates hr as a key factor in regulating basic cellular processes during catagen, including club hair formation, maintenance of dp-epithelial integrity, irs disintegration, and keratinocyte apoptosis in the hf matrix. |
2000-10-25 |
2023-08-12 |
mouse |
| M Rytömaa, K Lehmann, J Downwar. Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: inhibition by PKB/Akt but not Raf signalling. Oncogene. vol 19. issue 39. 2000-10-17. PMID:11002418. |
detachment of epithelial cells from extracellular matrix results in induction of apoptosis ('anoikis') which can be blocked by expression of activated ras or pkb/akt. |
2000-10-17 |
2023-08-12 |
Not clear |
| M Rytömaa, K Lehmann, J Downwar. Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: inhibition by PKB/Akt but not Raf signalling. Oncogene. vol 19. issue 39. 2000-10-17. PMID:11002418. |
expression of activated ras or pkb/akt blocks all the detectable events on the detachment-induced apoptosis signalling pathway, suggesting that pkb/akt acts at an early point in the pathway, providing the signal normally generated by matrix attachment. |
2000-10-17 |
2023-08-12 |
Not clear |
| G Bitan, L Scheibler, D F Mierke, M Rosenblatt, M Chore. Ligand-integrin alpha v beta 3 interaction determined by photoaffinity cross-linking: a challenge to the prevailing model. Biochemistry. vol 39. issue 36. 2000-10-13. PMID:10998238. |
integrin alpha(v)beta(3) plays a crucial role in angiogenesis, apoptosis, and bone remodeling, mainly by interacting with matrix proteins through recognition of an arg-gly-asp (rgd) motif. |
2000-10-13 |
2023-08-12 |
Not clear |
| Y B Shi, A Ishizuya-Ok. Thyroid hormone regulation of apoptotic tissue remodeling: implications from molecular analysis of amphibian metamorphosis. Progress in nucleic acid research and molecular biology. vol 65. 2000-10-13. PMID:11008485. |
particular focus is placed on the remodeling of the animal intestine, which involves both apoptosis (programmed cell death) of larval cells and de novo development of adult tissues, and the roles of thyroid hormone-induced genes that encode matrix metalloproteinases during this process. |
2000-10-13 |
2023-08-12 |
xenopus_laevis |
| A Ishizuya-Oka, Q Li, T Amano, S Damjanovski, S Ueda, Y B Sh. Requirement for matrix metalloproteinase stromelysin-3 in cell migration and apoptosis during tissue remodeling in Xenopus laevis. The Journal of cell biology. vol 150. issue 5. 2000-10-10. PMID:10974004. |
requirement for matrix metalloproteinase stromelysin-3 in cell migration and apoptosis during tissue remodeling in xenopus laevis. |
2000-10-10 |
2023-08-12 |
human |
| A Ishizuya-Oka, Q Li, T Amano, S Damjanovski, S Ueda, Y B Sh. Requirement for matrix metalloproteinase stromelysin-3 in cell migration and apoptosis during tissue remodeling in Xenopus laevis. The Journal of cell biology. vol 150. issue 5. 2000-10-10. PMID:10974004. |
the matrix metalloproteinase (mmp) stromelysin-3 (st3) was originally discovered as a gene whose expression was associated with human breast cancer carcinomas and with apoptosis during organogenesis and tissue remodeling. |
2000-10-10 |
2023-08-12 |
human |