| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Daniel, J Duffield, T Brunner, K Steinmann-Niggli, N Lods, H P Mart. Matrix metalloproteinase inhibitors cause cell cycle arrest and apoptosis in glomerular mesangial cells. The Journal of pharmacology and experimental therapeutics. vol 297. issue 1. 2001-05-03. PMID:11259528. |
we hypothesized that these features may be ameliorated by induction of cell cycle arrest and apoptosis as result of therapy with matrix metalloproteinase (mmp) inhibitors. |
2001-05-03 |
2023-08-12 |
rat |
| Z H Wang, D Yu, H K Li, V W Chow, C C Ng, H B Chan, S B Cheng, E C Che. Alteration of nuclear matrix protein composition of neuroblastoma cells after arsenic trioxide treatment. Anticancer research. vol 21. issue 1A. 2001-05-03. PMID:11299786. |
as early as 24 hours after as2o3 treatment, we began to observe the alteration of nuclear matrix proteins and apoptosis in tumor cells by tunel assay but not by dna ladder. |
2001-05-03 |
2023-08-12 |
mouse |
| Z H Wang, D Yu, H K Li, V W Chow, C C Ng, H B Chan, S B Cheng, E C Che. Alteration of nuclear matrix protein composition of neuroblastoma cells after arsenic trioxide treatment. Anticancer research. vol 21. issue 1A. 2001-05-03. PMID:11299786. |
our results also showed that before a mass range of apoptosis occurred, the composition of nuclear matrix proteins had altered. |
2001-05-03 |
2023-08-12 |
mouse |
| Z H Wang, D Yu, H K Li, V W Chow, C C Ng, H B Chan, S B Cheng, E C Che. Alteration of nuclear matrix protein composition of neuroblastoma cells after arsenic trioxide treatment. Anticancer research. vol 21. issue 1A. 2001-05-03. PMID:11299786. |
hence the alteration of nuclear matrix proteins, such as increased expression of hsc, may be a sensitive indicator for the detection of early apoptosis. |
2001-05-03 |
2023-08-12 |
mouse |
| C Jiang, Z Wang, H Ganther, J L. Caspases as key executors of methyl selenium-induced apoptosis (anoikis) of DU-145 prostate cancer cells. Cancer research. vol 61. issue 7. 2001-05-03. PMID:11306488. |
this process therefore resembled "anoikis," a special mode of apoptosis induction in which adherent cells lose contact with the extracellular matrix. |
2001-05-03 |
2023-08-12 |
human |
| C Wild-Bode, M Weller, A Rimner, J Dichgans, W Wic. Sublethal irradiation promotes migration and invasiveness of glioma cells: implications for radiotherapy of human glioblastoma. Cancer research. vol 61. issue 6. 2001-04-26. PMID:11289157. |
this hitherto unknown biological effect of irradiation is p53 independent, involves enhanced alphavbeta3 integrin expression, an altered profile of matrix metalloproteinase-2 and matrix metalloproteinase-9 (mmp-2 and mmp-9) expression and activity, altered membrane type 1 mmp and tissue inhibitor of metalloproteinases-2 expression, and an altered bcl-2/bax rheostat favoring resistance to apoptosis. |
2001-04-26 |
2023-08-12 |
human |
| F Silvestris, M Tucci, P Cafforio, F Dammacc. Fas-L up-regulation by highly malignant myeloma plasma cells: role in the pathogenesis of anemia and disease progression. Blood. vol 97. issue 5. 2001-04-19. PMID:11222356. |
these results strongly suggest that the deregulated apoptosis in myeloma clones plays an active role in the progressive destruction of the erythroid matrix by a cytotoxic mechanism based on up-regulation of fas-l. |
2001-04-19 |
2023-08-12 |
Not clear |
| A Reichert, N Heisterkamp, G Q Daley, J Groffe. Treatment of Bcr/Abl-positive acute lymphoblastic leukemia in P190 transgenic mice with the farnesyl transferase inhibitor SCH66336. Blood. vol 97. issue 5. 2001-04-19. PMID:11222386. |
this increase in activity leads to malignant transformation by interference with basic cellular functions such as the control of proliferation, adherence to stroma and extracellular matrix, and apoptosis. |
2001-04-19 |
2023-08-12 |
mouse |
| Y Zhao, M Wu, Y Shen, Z Zha. Analysis of nuclear apoptotic process in a cell-free system. Cellular and molecular life sciences : CMLS. vol 58. issue 2. 2001-04-19. PMID:11289311. |
we confirmed the results using whole-mount electron microscopy, and found that although the nuclear lamina was destroyed early, the nuclear matrix largely remained intact during the course of apoptosis. |
2001-04-19 |
2023-08-12 |
mouse |
| A W Eberhardt, A Yeager-Jones, H C Blai. Regional trabecular bone matrix degeneration and osteocyte death in femora of glucocorticoid- treated rabbits. Endocrinology. vol 142. issue 3. 2001-04-12. PMID:11181552. |
we conclude that exposure of bone matrix permeability and that regional cell death consistent with apoptosis is an early event in glucocorticoid-induced bone damage. |
2001-04-12 |
2023-08-12 |
Not clear |
| M X Wang, T B Gray, W C Park, P Prabhasawat, W Culbertson, R Forster, K Hanna, S C Tsen. Reduction in corneal haze and apoptosis by amniotic membrane matrix in excimer laser photoablation in rabbits. Journal of cataract and refractive surgery. vol 27. issue 2. 2001-04-12. PMID:11226800. |
reduction in corneal haze and apoptosis by amniotic membrane matrix in excimer laser photoablation in rabbits. |
2001-04-12 |
2023-08-12 |
human |
| A Gugssa, K V Balan, C Macias, M Ashraf, C M Lee, V W Hollis, J Wyche, W A Anderso. Fibronectin/fibroblast growth factor/cell matrix signaling pathways and reciprocal membrane interaction may be the regulators of cell growth and apoptosis in Trypanosoma musculi in co-cultures with fibroblasts. Journal of submicroscopic cytology and pathology. vol 32. issue 2. 2001-04-05. PMID:11085217. |
fibronectin/fibroblast growth factor/cell matrix signaling pathways and reciprocal membrane interaction may be the regulators of cell growth and apoptosis in trypanosoma musculi in co-cultures with fibroblasts. |
2001-04-05 |
2023-08-12 |
Not clear |
| P K Sha. Plaque disruption and thrombosis: potential role of inflammation and infection. Cardiology in review. vol 8. issue 1. 2001-04-05. PMID:11174871. |
inflammation with accumulation of activated mononuclear cells may play a potential role in plaque disruption through the elaboration of proteases, such as matrix degrading neutral metalloproteinases and other proteases, inhibition of function and/or survival, or promotion of apoptosis of matrix synthesizing smooth muscle cells. |
2001-04-05 |
2023-08-12 |
Not clear |
| D R Hurst, H Li, X Xu, V L Badisa, Y E Shi, Q X San. Development and characterization of a new polyclonal antibody specifically against tissue inhibitor of metalloproteinases 4 in human breast cancer. Biochemical and biophysical research communications. vol 281. issue 1. 2001-04-05. PMID:11178975. |
tissue inhibitors of metalloproteinases (timps) may regulate extracellular matrix turnover and cellular functions by modulating matrix metalloproteinase (mmp) activity and cell proliferation and apoptosis. |
2001-04-05 |
2023-08-12 |
human |
| Y Ibuki, R Got. Suppression of apoptosis by UVB irradiation: survival signaling via PI3-kinase/Akt pathway. Biochemical and biophysical research communications. vol 279. issue 3. 2001-03-29. PMID:11162442. |
however, we report here that uvb irradiation prevents induction of apoptosis in cells detached from the extracellular matrix under serum-free conditions. |
2001-03-29 |
2023-08-12 |
cattle |
| Y Ibuki, R Got. Suppression of apoptosis by UVB irradiation: survival signaling via PI3-kinase/Akt pathway. Biochemical and biophysical research communications. vol 279. issue 3. 2001-03-29. PMID:11162442. |
nih3t3 cells cultured in bovine serum albumin-coated dishes (detached from the extracellular matrix) underwent apoptosis under serum-free conditions, which was inhibited by uvb (<0.1 j/cm(2)) irradiation, keeping suspension conditions, as determined by chromatin condensation and the appearance of a subg1 dna fraction. |
2001-03-29 |
2023-08-12 |
cattle |
| D J Riley, S Thakker-Varia, F J Wilson, G J Poiani, C A Tozz. Role of proteolysis and apoptosis in regression of pulmonary vascular remodeling. Physiological research. vol 49. issue 5. 2001-03-22. PMID:11191362. |
we studied whether proteolysis of extracellular matrix proteins and apoptosis occur during reversal of remodeling produced by chronic hypoxia in the rat. |
2001-03-22 |
2023-08-12 |
rat |
| D J Riley, S Thakker-Varia, F J Wilson, G J Poiani, C A Tozz. Role of proteolysis and apoptosis in regression of pulmonary vascular remodeling. Physiological research. vol 49. issue 5. 2001-03-22. PMID:11191362. |
our results suggest that activation of enzymes, which degrade matrix proteins, and apoptosis play a role in resolution of vascular remodeling. |
2001-03-22 |
2023-08-12 |
rat |
| E Bonfoco, W Chen, R Paul, D A Cheresh, N R Coope. beta1 integrin antagonism on adherent, differentiated human neuroblastoma cells triggers an apoptotic signaling pathway. Neuroscience. vol 101. issue 4. 2001-03-01. PMID:11113363. |
integrin receptors mediate several functions including prevention of matrix detachment-induced apoptosis (anoikis) of several adherent cell types. |
2001-03-01 |
2023-08-12 |
human |
| N Mitsiades, W H Yu, V Poulaki, M Tsokos, I Stamenkovi. Matrix metalloproteinase-7-mediated cleavage of Fas ligand protects tumor cells from chemotherapeutic drug cytotoxicity. Cancer research. vol 61. issue 2. 2001-02-22. PMID:11212252. |
in the present work, we addressed the involvement of the fasl/fas signaling pathway in doxorubicin-induced apoptosis and the ability of matrix metalloproteinases (mmps) to proteolytically cleave fasl in tumor cells. |
2001-02-22 |
2023-08-12 |
Not clear |