| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Frank R Murphy, Razao Issa, Xiaoying Zhou, Shabna Ratnarajah, Hideaki Nagase, Michael J P Arthur, Christopher Benyon, John P Iredal. Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition: implications for reversibility of liver fibrosis. The Journal of biological chemistry. vol 277. issue 13. 2002-05-10. PMID:11796725. |
inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition: implications for reversibility of liver fibrosis. |
2002-05-10 |
2023-08-12 |
Not clear |
| C C Wykoff, C W Pugh, A L Harris, P H Maxwell, P J Ratcliff. The HIF pathway: implications for patterns of gene expression in cancer. Novartis Foundation symposium. vol 240. 2002-05-09. PMID:11727931. |
in addition to known hif target genes involved in angiogenesis, glucose metabolism and vasomotor control, these new targets include examples with functions in matrix metabolism, apoptosis, carbon dioxide metabolism and secondary cascades of transcriptional control. |
2002-05-09 |
2023-08-12 |
Not clear |
| Eugene Kissin, Joseph H Kor. Apoptosis and myofibroblasts in the pathogenesis of systemic sclerosis. Current rheumatology reports. vol 4. issue 2. 2002-05-08. PMID:11890878. |
tissue fibrosis is the result of a complex series of events focusing on regulation of fibroblast proliferation, synthesis of extracellular matrix, and apoptosis. |
2002-05-08 |
2023-08-12 |
Not clear |
| Victor M Bondar, David J McConke. Anoikis is regulated by BCL-2-independent pathways in human prostate carcinoma cells. The Prostate. vol 51. issue 1. 2002-05-08. PMID:11920957. |
loss of contact with the extracellular matrix (ecm) triggers a specialized form of apoptosis known as "anoikis" in normal epithelial cells. |
2002-05-08 |
2023-08-12 |
human |
| Y Feng, L Y Wang, T Cai, J W Jin, G F Zhou, L H Cao, X L Zh. All-trans-retinoic acid increased the expression of integrin alpha5beta1 and induced "anoikis" in SMMC-7721 hepatocarcinoma cell. Journal of experimental & clinical cancer research : CR. vol 20. issue 3. 2002-05-02. PMID:11718225. |
it is extensively shown that integrin can regulate various cellular functions, including apoptosis, probably by contributing to signal transduction processes through interaction with extracellular matrix (ecm) proteins. |
2002-05-02 |
2023-08-12 |
Not clear |
| K Johnson, K Pritzker, J Goding, R Terkeltau. The nucleoside triphosphate pyrophosphohydrolase isozyme PC-1 directly promotes cartilage calcification through chondrocyte apoptosis and increased calcium precipitation by mineralizing vesicles. The Journal of rheumatology. vol 28. issue 12. 2002-05-02. PMID:11764218. |
increased chondrocyte apoptosis and expression of annexin v occur at sites of matrix calcification in degenerative arthritis, and membrane limited chondrocyte apoptotic bodies containing ntppph may promote chondrocalcinosis by acting as mineralizing matrix vesicles (mv). |
2002-05-02 |
2023-08-12 |
Not clear |
| Belgin Selam, Umit A Kayisli, Juan A Garcia-Velasco, Aydin Aric. Extracellular matrix-dependent regulation of Fas ligand expression in human endometrial stromal cells. Biology of reproduction. vol 66. issue 1. 2002-04-23. PMID:11751256. |
induction of fasl expression by adhesion of endometrial stromal cells to the extracellular matrix may take part in the development of a relative immunotolerance by inducing apoptosis of cytotoxic t lymphocytes, which will allow further development of ectopic implants. |
2002-04-23 |
2023-08-12 |
human |
| Guenadi Kouniavsky, Marat Khaikin, Isabel Zvibel, Dov Zippel, Shlomo Brill, Zamir Halpern, Moshe Pap. Stromal extracellular matrix reduces chemotherapy-induced apoptosis in colon cancer cell lines. Clinical & experimental metastasis. vol 19. issue 1. 2002-04-22. PMID:11918083. |
stromal extracellular matrix reduces chemotherapy-induced apoptosis in colon cancer cell lines. |
2002-04-22 |
2023-08-12 |
human |
| Guenadi Kouniavsky, Marat Khaikin, Isabel Zvibel, Dov Zippel, Shlomo Brill, Zamir Halpern, Moshe Pap. Stromal extracellular matrix reduces chemotherapy-induced apoptosis in colon cancer cell lines. Clinical & experimental metastasis. vol 19. issue 1. 2002-04-22. PMID:11918083. |
several studies have shown that extracellular matrix reduces chemotherapeutic drugs-induced apoptosis in small cell lung cancer cells, myelomas and gliomas. |
2002-04-22 |
2023-08-12 |
human |
| Takashi Taga, Atsushi Suzuki, Ignacio Gonzalez-Gomez, Floyd H Gilles, Monique Stins, Hiroyuki Shimada, Lora Barsky, Kenneth I Weinberg, Walter E Lau. alpha v-Integrin antagonist EMD 121974 induces apoptosis in brain tumor cells growing on vitronectin and tenascin. International journal of cancer. vol 98. issue 5. 2002-04-18. PMID:11920637. |
this compound, a cyclic rgd-penta-peptide, is a potent inhibitor of angiogenesis, which induces apoptosis of growing endothelial cells through inhibition of their alpha v-integrin interaction with the matrix proteins vitronectin and tenascin. |
2002-04-18 |
2023-08-12 |
mouse |
| Takashi Taga, Atsushi Suzuki, Ignacio Gonzalez-Gomez, Floyd H Gilles, Monique Stins, Hiroyuki Shimada, Lora Barsky, Kenneth I Weinberg, Walter E Lau. alpha v-Integrin antagonist EMD 121974 induces apoptosis in brain tumor cells growing on vitronectin and tenascin. International journal of cancer. vol 98. issue 5. 2002-04-18. PMID:11920637. |
here we show that emd 121974 also induces apoptosis in the alpha v-integrin-expressing tumor cell lines u87 mg and daoy by detaching them from vitronectin and tenascin, matrix proteins known to be essential for brain tumor growth and invasion. |
2002-04-18 |
2023-08-12 |
mouse |
| Takashi Taga, Atsushi Suzuki, Ignacio Gonzalez-Gomez, Floyd H Gilles, Monique Stins, Hiroyuki Shimada, Lora Barsky, Kenneth I Weinberg, Walter E Lau. alpha v-Integrin antagonist EMD 121974 induces apoptosis in brain tumor cells growing on vitronectin and tenascin. International journal of cancer. vol 98. issue 5. 2002-04-18. PMID:11920637. |
thus, the alpha v-antagonist emd 121974 suppresses brain tumor growth through induction of apoptosis in both brain capillary and brain tumor cells by preventing their interaction with the matrix proteins vitronectin and tenascin. |
2002-04-18 |
2023-08-12 |
mouse |
| Susumu Otom. [Hair growth effect of minoxidil]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 119. issue 3. 2002-04-16. PMID:11915519. |
if the negative factors become dominant against cell proliferation factors according to fulfilling some time set by the biological clock for hair follicles, tgf beta induced in the matrix tissues evokes apoptosis of matrix cells and shifts the follicles from anagen to catagen. |
2002-04-16 |
2023-08-12 |
Not clear |
| Susumu Otom. [Hair growth effect of minoxidil]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 119. issue 3. 2002-04-16. PMID:11915519. |
the mode of action of hair growth effect of minoxidil is not completely elucidated, but the most plausible explanation proposed here is that minoxidil works as a sulfonylurea receptor (sur) activator and prolongs the anagen phase of hair follicles in the following manner: minoxidil (1) induces cell growth factors such as vegf, hgf, igf-1 and potentiates hgf and igf-1 actions by the activation of uncoupled sur on the plasma membrane of dermal papilla cells, (2) inhibits of tgf beta induced apoptosis of hair matrix cells by opening the kir 6.0 channel pore coupled with sur on the mitochondrial inner membrane, and (3) dilates hair follicle arteries and increases blood flow in dermal papilla by opening the kir 6.0 channel pore coupled with sur on the plasma membrane of vascular smooth muscle cells. |
2002-04-16 |
2023-08-12 |
Not clear |
| G Andrei, R Snoeck, D Schols, E De Clerc. Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncology research. vol 12. issue 9-10. 2002-04-12. PMID:11697818. |
different parameters of apoptosis, that is, (i) induction of cpp32 (caspase-3) protease activity, (ii) translocation of phosphatidylserine (ps) from the inner part of the plasma membrane to the outer layer, (iii) disintegration of the nuclear matrix protein (nmp), (iv) dna fragmentation, (v) number of cells in apoptotic phase following cell cycle analysis, showed that the mechanism of cell death following treatment with cdv is based on apoptosis. |
2002-04-12 |
2023-08-12 |
human |
| M A Esco, Z Wang, M L McDermott, M Kurpakus-Wheate. Potential role for laminin 5 in hypoxia-mediated apoptosis of human corneal epithelial cells. Journal of cell science. vol 114. issue Pt 22. 2002-04-10. PMID:11739635. |
laminin 5 functions to promote cell-matrix adhesion and therefore is hypothesized to abrogate apoptosis initiated through the loss of epithelial cell contact with extracellular matrix. |
2002-04-10 |
2023-08-12 |
human |
| M A Esco, Z Wang, M L McDermott, M Kurpakus-Wheate. Potential role for laminin 5 in hypoxia-mediated apoptosis of human corneal epithelial cells. Journal of cell science. vol 114. issue Pt 22. 2002-04-10. PMID:11739635. |
increased apoptosis in hypoxic epithelium at 7 days in culture correlated with decreased deposition of laminin 5 into the extracellular matrix, as determined by western blot analysis and immunofluorescence microscopy. |
2002-04-10 |
2023-08-12 |
human |
| M A Esco, Z Wang, M L McDermott, M Kurpakus-Wheate. Potential role for laminin 5 in hypoxia-mediated apoptosis of human corneal epithelial cells. Journal of cell science. vol 114. issue Pt 22. 2002-04-10. PMID:11739635. |
based on these results, it appears that mechanisms of hypoxia-mediated apoptosis in human corneal epithelial cells may be initiated by the loss of processed laminin 5 in the extracellular matrix or by the loss of laminin 5-epithelial cell communication and transmitted through mitochondria. |
2002-04-10 |
2023-08-12 |
human |
| M Rosas Peralt. [Mechanisms of progression in heart failure]. Archivos de cardiologia de Mexico. vol 71 Suppl 1. 2002-04-09. PMID:11565324. |
the role of apoptosis, extracellular matrix, biochemical and molecular changes, signaling pathways, cytokines, inflammatory response and gene expression are discussed as well as the new possible alternatives for therapy. |
2002-04-09 |
2023-08-12 |
Not clear |
| Daniela Grimm, Johann Bauer, Peter Kossmehl, Mehdi Shakibaei, Johann Schöberger, Holger Pickenhahn, Gundula Schulze-Tanzil, Roland Vetter, Christoph Eilles, Martin Paul, Augusto Cogol. Simulated microgravity alters differentiation and increases apoptosis in human follicular thyroid carcinoma cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 16. issue 6. 2002-04-05. PMID:11919168. |
these observations suggest that clinorotation elevates intermediate filaments, cell adhesion molecules, and extracellular matrix proteins and simultaneously induces apoptosis in follicular thyroid cancer cells. |
2002-04-05 |
2023-08-12 |
human |