| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenbiao Liu, Niels Reinmuth, Oliver Stoeltzing, Alexander A Parikh, Fan Fan, Syed A Ahmad, Young D Jung, Lee M Elli. Antiangiogenic therapy targeting factors that enhance endothelial cell survival. Seminars in oncology. vol 29. issue 3 Suppl 11. 2002-08-14. PMID:12138403. |
integrins may function as ec survival factors by preventing apoptosis by numerous mechanisms mediated by binding to the extracellular matrix. |
2002-08-14 |
2023-08-12 |
Not clear |
| Matthew J Hunt, Giorgio M Aru, Melvin R Hayden, Charles K Moore, Brian D Hoit, Suresh C Tyag. Induction of oxidative stress and disintegrin metalloproteinase in human heart end-stage failure. American journal of physiology. Lung cellular and molecular physiology. vol 283. issue 2. 2002-08-12. PMID:12114184. |
however, a complete separation between the matrix and the cell leads to apoptosis, dilatation, and failure. |
2002-08-12 |
2023-08-12 |
human |
| Magdalena M Serewko, Claudia Popa, Alison L Dahler, Louise Smith, Geoff M Strutton, William Coman, Anthony J Dicker, Nicholas A Saunder. Alterations in gene expression and activity during squamous cell carcinoma development. Cancer research. vol 62. issue 13. 2002-08-08. PMID:12097286. |
our analysis indicated that alterations in genes associated with extracellular matrix production and apoptosis are disrupted in preneoplastic cells, whereas later stages of neoplasia are associated with alterations in gene expression for genes involved in dna repair or epidermal growth factor (egf) receptor/mitogen-activated protein kinase kinase (mapkk)/mapk/activator protein-1 (ap-1) signaling. |
2002-08-08 |
2023-08-12 |
human |
| K Takamura, N Oka, A Akagi, K Okamoto, T Okada, T Fukuoka, A Hogaki, D Naito, Y Oobayashi, N Sato. EST analysis of genes that are expressed in the neural complex of Ciona intestinalis adults. Zoological science. vol 18. issue 9. 2002-08-06. PMID:11911079. |
among the clones matching previously identified proteins, about 80 clones represented proteins that are involved in the formation, maintenance of the structure, and function of the nervous system: 22 proteins are associated with signal transduction, five proteins are related to the synapse, 11 to transcription factors, nine to transporters, five to enzymes, and 13 to extracellular matrix and cytoskeletal components, and six to apoptosis. |
2002-08-06 |
2023-08-12 |
Not clear |
| Janine M Prince, Teresa C M Klinowska, Emma Marshman, Emma T Lowe, Ulrike Mayer, Jeff Miner, Daniel Aberdam, Dietmar Vestweber, Barry Gusterson, Charles H Streul. Cell-matrix interactions during development and apoptosis of the mouse mammary gland in vivo. Developmental dynamics : an official publication of the American Association of Anatomists. vol 223. issue 4. 2002-08-06. PMID:11921338. |
to explore the possibility that dynamic changes in cell-matrix interactions contribute to the onset of apoptosis during mammary involution in vivo, a detailed immunohistochemical analysis of the expression of integrin subunits and their extracellular matrix ligands during mouse mammary gland development has been performed. |
2002-08-06 |
2023-08-12 |
mouse |
| Janine M Prince, Teresa C M Klinowska, Emma Marshman, Emma T Lowe, Ulrike Mayer, Jeff Miner, Daniel Aberdam, Dietmar Vestweber, Barry Gusterson, Charles H Streul. Cell-matrix interactions during development and apoptosis of the mouse mammary gland in vivo. Developmental dynamics : an official publication of the American Association of Anatomists. vol 223. issue 4. 2002-08-06. PMID:11921338. |
this finding may provide a novel dynamic mechanism for inhibiting the transduction of extracellular matrix survival signals, thereby contributing to the onset of apoptosis in a developmental context in vivo. |
2002-08-06 |
2023-08-12 |
mouse |
| Suyun Huang, Lisa Mills, Badar Mian, Carmen Tellez, Marya McCarty, X-D Yang, Jean M Gudas, Menashe Bar-El. Fully humanized neutralizing antibodies to interleukin-8 (ABX-IL8) inhibit angiogenesis, tumor growth, and metastasis of human melanoma. The American journal of pathology. vol 161. issue 1. 2002-08-06. PMID:12107097. |
in vivo, abx-il8 treatment resulted in decreased expression of matrix metalloproteinase-2, and decreased vascularization (angiogenesis) of tumors concomitant with increased apoptosis of tumor cells. |
2002-08-06 |
2023-08-12 |
mouse |
| L A Hazlehurst, W S Dalto. Mechanisms associated with cell adhesion mediated drug resistance (CAM-DR) in hematopoietic malignancies. Cancer metastasis reviews. vol 20. issue 1-2. 2002-07-30. PMID:11831646. |
for hematopoietic tumors, cell adhesion to a single matrix, fibronectin is sufficient to inhibit apoptosis induced by mechanistically distinct cyctotoxics. |
2002-07-30 |
2023-08-12 |
human |
| Ursula Mirastschijski, Ulla Impola, Morten A Karsdal, Ulpu Saarialho-Kere, Magnus S Agre. Matrix metalloproteinase inhibitor BB-3103 unlike the serine proteinase inhibitor aprotinin abrogates epidermal healing of human skin wounds ex vivo. The Journal of investigative dermatology. vol 118. issue 1. 2002-07-25. PMID:11851876. |
lack of epithelialization was unlikely due to cytotoxicity because the matrix metalloproteinase inhibitor did neither influence viability of cultured epidermal keratinocytes nor apoptosis in wounds. |
2002-07-25 |
2023-08-12 |
human |
| Yoshiya Tanaka, Shingo Nakayamada, Hiroko Fujimoto, Yosuke Okada, Hisanori Umehara, Tohru Kataoka, Yasuhiro Minam. H-Ras/mitogen-activated protein kinase pathway inhibits integrin-mediated adhesion and induces apoptosis in osteoblasts. The Journal of biological chemistry. vol 277. issue 24. 2002-07-25. PMID:11934900. |
thus, we propose that h-ras signals followed by raf-1/mapk pathway but not pi3k not only reduces beta(1)-mediated adhesion of osteoblasts to matrix proteins but induces apoptosis presumably via the fas up-regulation and bcl-2 down-regulation. |
2002-07-25 |
2023-08-12 |
human |
| H Wang, A Davis, S Yu, K Ahme. Response of cancer cells to molecular interruption of the CK2 signal. Molecular and cellular biochemistry. vol 227. issue 1-2. 2002-07-24. PMID:11827168. |
significantly, the effects of the antisense odn on the ck2 activity in the nuclear matrix were relatively small compared to the much stronger induction of apoptosis in cells. |
2002-07-24 |
2023-08-12 |
Not clear |
| Amanda D Miller, Suresh C Tyag. Mutation in collagen gene induces cardiomyopathy in transgenic mice. Journal of cellular biochemistry. vol 85. issue 2. 2002-07-22. PMID:11948682. |
however, complete loss of integrin signaling due to disconnection from extracellular matrix (ecm) leads to apoptosis and dilatation. |
2002-07-22 |
2023-08-12 |
mouse |
| William J Murdoch, Anna C McDonne. Roles of the ovarian surface epithelium in ovulation and carcinogenesis. Reproduction (Cambridge, England). vol 123. issue 6. 2002-07-19. PMID:12052228. |
tumour necrosis factor alpha progressively induces matrix metalloproteinase gene expression, apoptosis and inflammatory necrosis. |
2002-07-19 |
2023-08-12 |
human |
| Yun Zhao, Dawn A Gever. Regulation of Smad3 expression in bleomycin-induced pulmonary fibrosis: a negative feedback loop of TGF-beta signaling. Biochemical and biophysical research communications. vol 294. issue 2. 2002-07-16. PMID:12051713. |
transforming growth factor-beta (tgf-beta) is a multifunctional cytokine involved in controlling critical cellular activities including proliferation, differentiation, extracellular matrix production, and apoptosis. |
2002-07-16 |
2023-08-12 |
Not clear |
| Harry C Blair, Mone Zaidi, Paul H Schlesinge. Mechanisms balancing skeletal matrix synthesis and degradation. The Biochemical journal. vol 364. issue Pt 2. 2002-07-15. PMID:12023876. |
bone is regulated by evolutionarily conserved signals that balance continuous differentiation of bone matrix-producing cells against apoptosis and matrix removal. |
2002-07-15 |
2023-08-12 |
Not clear |
| Harry C Blair, Mone Zaidi, Paul H Schlesinge. Mechanisms balancing skeletal matrix synthesis and degradation. The Biochemical journal. vol 364. issue Pt 2. 2002-07-15. PMID:12023876. |
removal of mineralized matrix involves apoptosis of matrix cells and differentiation of acid-secreting cells (osteoclasts) from macrophage precursors. |
2002-07-15 |
2023-08-12 |
Not clear |
| M P McNamara, K A Bjornstad, P Y Chang, W Chou, S J Lockett, E A Blakel. Modulation of lens cell adhesion molecules by particle beams. Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB). vol 17 Suppl 1. 2002-07-12. PMID:11776988. |
cell adhesion molecules (cams) are proteins which anchor cells to each other and to the extracellular matrix (ecm), but whose functions also include signal transduction, differentiation, and apoptosis. |
2002-07-12 |
2023-08-12 |
human |
| Ian A Darby, Teresa Bisucci, Brigitte Pittet, Stefania Garbin, Giulio Gabbiani, Alexis Desmoulièr. Skin flap-induced regression of granulation tissue correlates with reduced growth factor and increased metalloproteinase expression. The Journal of pathology. vol 197. issue 1. 2002-07-12. PMID:12081196. |
the additive effect of reduced growth factor expression, increased extracellular matrix turnover, and nitric oxide generation may result in the fibroblast and vascular cell apoptosis seen during the rapid remodelling of this tissue. |
2002-07-12 |
2023-08-12 |
rat |
| D R Pfeiffer, T E Gunter, R Eliseev, K M Broekemeier, K K Gunte. Release of Ca2+ from mitochondria via the saturable mechanisms and the permeability transition. IUBMB life. vol 52. issue 3-5. 2002-07-09. PMID:11798034. |
in addition, the permeability transition or pt, which may also remove ca2+ from the mitochondrial matrix, is intimately involved in other important functions such as apoptosis. |
2002-07-09 |
2023-08-12 |
Not clear |
| Kevin M McGowan, Xuemei Tong, Emma Colucci-Guyon, Francina Langa, Charles Babinet, Pierre A Coulomb. Keratin 17 null mice exhibit age- and strain-dependent alopecia. Genes & development. vol 16. issue 11. 2002-07-05. PMID:12050118. |
we report that k17 null mice develop severe alopecia during the first week postbirth, correlating with hair fragility, alterations in follicular histology, and apoptosis in matrix cells. |
2002-07-05 |
2023-08-12 |
mouse |