| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jonathan R Green, Philippe Clézardi. Mechanisms of bisphosphonate effects on osteoclasts, tumor cell growth, and metastasis. American journal of clinical oncology. vol 25. issue 6 Suppl 1. 2003-02-04. PMID:12562045. |
as a result of these biochemical effects on the mevalonate pathway, bisphosphonates appear to modulate the expression of bcl-2 leading to caspase-dependent apoptosis, inhibit matrix metalloproteinases, downregulate alphavbeta3 and alphavbeta5 integrins, and increase expression of osteoprotegerin, thereby antagonizing osteoclastogenesis. |
2003-02-04 |
2023-08-12 |
Not clear |
| Changhai Din. Do NSAIDs affect the progression of osteoarthritis? Inflammation. vol 26. issue 3. 2003-01-30. PMID:12083420. |
in vitro studies showed several types of nsaids (e.g., sodium salicylate, indomethacin) inhibited the synthesis of cartilage matrix component, but some types of nsaids (e.g., aceclofenac, meloxicam, nimesulide) increased the matrix component synthesis and protected the chondrocytes against apoptosis, while others (e.g., piroxicam) had no effects. |
2003-01-30 |
2023-08-12 |
Not clear |
| Sabrina Di Bartolomeo, Angelo Spined. Ordering ceramide-induced cell detachment and apoptosis in human neuroepithelioma. Neuroscience letters. vol 334. issue 3. 2003-01-28. PMID:12453617. |
we studied whether cell detachment from the matrix, observed during ceramide-induced apoptosis, is secondary to completion of the apoptotic program. |
2003-01-28 |
2023-08-12 |
human |
| Hiromichi Iwasaki, Hitoshi Inoue, Yasuhiko Mitsuke, Adel Badran, Satoshi Ikegaya, Takanori Ued. Doxycycline induces apoptosis by way of caspase-3 activation with inhibition of matrix metalloproteinase in human T-lymphoblastic leukemia CCRF-CEM cells. The Journal of laboratory and clinical medicine. vol 140. issue 6. 2003-01-23. PMID:12486404. |
doxycycline induces apoptosis by way of caspase-3 activation with inhibition of matrix metalloproteinase in human t-lymphoblastic leukemia ccrf-cem cells. |
2003-01-23 |
2023-08-12 |
human |
| Dagmara Piestrzeniewicz-Ulanska, Magdalena Brys, Andrzej Semczuk, Jerzy A Jakowicki, Wanda M Krajewsk. Expression of TGF-beta type I and II receptors in normal and cancerous human endometrium. Cancer letters. vol 186. issue 2. 2003-01-10. PMID:12213293. |
transforming growth factor-beta (tgf-beta) belongs to a superfamily of structurally related polypeptides involved in various biological processes, including cell growth, proliferation and differentiation, angiogenesis, apoptosis, and extracellular matrix remodeling. |
2003-01-10 |
2023-08-12 |
human |
| Rosa Maria Borzi, Ilaria Mazzetti, Giorgia Magagnoli, Samantha Paoletti, Mariagrazia Uguccioni, Rita Gatti, Guido Orlandini, Luca Cattini, Andrea Facchin. Growth-related oncogene alpha induction of apoptosis in osteoarthritis chondrocytes. Arthritis and rheumatism. vol 46. issue 12. 2003-01-10. PMID:12483724. |
chondrocyte apoptosis is considered to be a major determinant of cartilage damage in oa, a disease resulting from the aberrant production of inflammatory mediators (cytokines and chemokines) and effectors (matrix metalloproteinases and reactive oxygen and nitrogen species) by chondrocytes. |
2003-01-10 |
2023-08-12 |
Not clear |
| Kirill Rosen, Wen Shi, Bruno Calabretta, Jorge Filmu. Cell detachment triggers p38 mitogen-activated protein kinase-dependent overexpression of Fas ligand. A novel mechanism of Anoikis of intestinal epithelial cells. The Journal of biological chemistry. vol 277. issue 48. 2003-01-08. PMID:12356751. |
many cell types undergo apoptosis when they are detached from the extracellular matrix (ecm). |
2003-01-08 |
2023-08-12 |
Not clear |
| A Mobasher. Role of chondrocyte death and hypocellularity in ageing human articular cartilage and the pathogenesis of osteoarthritis. Medical hypotheses. vol 58. issue 3. 2003-01-07. PMID:12018969. |
although nitric oxide and fas ligand have been shown to be inducers of chondrocyte apoptosis in vitro and in vivo, the contribution of other triggers such as hypoxia, matrix acidosis, abnormal shear stress and catabolic cytokines like interleukin-1beta and tumour necrosis factor alpha has not been examined. |
2003-01-07 |
2023-08-12 |
human |
| Morten A Karsdal, Lykke Larsen, Michael T Engsig, Henriette Lou, Mercedes Ferreras, Andre Lochter, Jean-Marie Delaissé, Niels T Foge. Matrix metalloproteinase-dependent activation of latent transforming growth factor-beta controls the conversion of osteoblasts into osteocytes by blocking osteoblast apoptosis. The Journal of biological chemistry. vol 277. issue 46. 2003-01-02. PMID:12226090. |
matrix metalloproteinase-dependent activation of latent transforming growth factor-beta controls the conversion of osteoblasts into osteocytes by blocking osteoblast apoptosis. |
2003-01-02 |
2023-08-12 |
mouse |
| Morten A Karsdal, Lykke Larsen, Michael T Engsig, Henriette Lou, Mercedes Ferreras, Andre Lochter, Jean-Marie Delaissé, Niels T Foge. Matrix metalloproteinase-dependent activation of latent transforming growth factor-beta controls the conversion of osteoblasts into osteocytes by blocking osteoblast apoptosis. The Journal of biological chemistry. vol 277. issue 46. 2003-01-02. PMID:12226090. |
upon termination of bone matrix synthesis, osteoblasts either undergo apoptosis or differentiate into osteocytes or bone lining cells. |
2003-01-02 |
2023-08-12 |
mouse |
| Morten A Karsdal, Lykke Larsen, Michael T Engsig, Henriette Lou, Mercedes Ferreras, Andre Lochter, Jean-Marie Delaissé, Niels T Foge. Matrix metalloproteinase-dependent activation of latent transforming growth factor-beta controls the conversion of osteoblasts into osteocytes by blocking osteoblast apoptosis. The Journal of biological chemistry. vol 277. issue 46. 2003-01-02. PMID:12226090. |
in this study, we investigated the role of matrix metalloproteinases (mmps) and growth factors in the differentiation of osteoblasts into osteocytes and in osteoblast apoptosis. |
2003-01-02 |
2023-08-12 |
mouse |
| A Mezzogiorno, V Esposit. Potential role for high and low molecular weight tissue transglutaminases in transforming mammalian cell properties. Current drug targets. Immune, endocrine and metabolic disorders. vol 1. issue 3. 2002-12-23. PMID:12477288. |
tissue transglutaminase (ttgase, ttg) is known as being implicated in the intracellular cross-linking of proteins occurring in a growing series of physiological conditions including--just to mention the most relevant ones--programmed cell death (apoptosis), cell adhesion, growth, spreading and differentiation, tumor growth, metastasis, cell adhesion, proliferation, differentiation, extra cellular matrix (ecm) stabilization. |
2002-12-23 |
2023-08-12 |
Not clear |
| C Gerner, J Gotzmann, U Fröhwein, C Schamberger, A Ellinger, G Sauerman. Proteome analysis of nuclear matrix proteins during apoptotic chromatin condensation. Cell death and differentiation. vol 9. issue 6. 2002-12-18. PMID:12032676. |
the nuclear matrix (nm) is considered a proteinaceous scaffold spatially organizing the interphase nucleus, the integrity of which is affected during apoptosis. |
2002-12-18 |
2023-08-12 |
Not clear |
| X Leschelle, V Robert, S Delpal, B Mouillé, C Mayeur, P Martel, F Blachie. Isolation of pig colonic crypts for cytotoxic assay of luminal compounds: effects of hydrogen sulfide, ammonia, and deoxycholic acid. Cell biology and toxicology. vol 18. issue 3. 2002-12-17. PMID:12083425. |
using colonocytes isolated with edta, we found that the initial cell viability, estimated by the membrane integrity and oxidative capacity measurement, fell rapidly despite several experimental attempts to preserve it such as the use of a medium designed to increase the adherence of epithelial cells and of a coated extracellular matrix, the presence in the culture medium of the oxidative substrate butyrate, and the use of an inhibitor of the caspases involved in cell apoptosis. |
2002-12-17 |
2023-08-12 |
human |
| Francis J Giles, Hagop M Kantarjian, B Nebiyou Bekele, Jorge E Cortes, Stephan Faderl, Deborah A Thomas, Taghi Manshouri, Anna Rogers, Michael J Keating, Moshe Talpaz, Susan O'Brien, Maher Albita. Bone marrow cyclooxygenase-2 levels are elevated in chronic-phase chronic myeloid leukaemia and are associated with reduced survival. British journal of haematology. vol 119. issue 1. 2002-12-13. PMID:12358901. |
cox-2 may also reduce apoptosis and reduce cellular attachment to the extracellular matrix (ecm). |
2002-12-13 |
2023-08-12 |
Not clear |
| K J Langenbach, T A Rand. Inhibition of dystroglycan binding to laminin disrupts the PI3K/AKT pathway and survival signaling in muscle cells. Muscle & nerve. vol 26. issue 5. 2002-12-13. PMID:12402286. |
because apoptosis is an early feature of muscular dystrophy in vivo, and perturbation of cell-extracellular matrix associations is known to induce apoptosis, we investigated the role of dystroglycan-laminin interactions in the propagation and maintenance of cell survival signals in muscle cells. |
2002-12-13 |
2023-08-12 |
Not clear |
| K J Langenbach, T A Rand. Inhibition of dystroglycan binding to laminin disrupts the PI3K/AKT pathway and survival signaling in muscle cells. Muscle & nerve. vol 26. issue 5. 2002-12-13. PMID:12402286. |
we found that disrupting the interaction between alpha-dystroglycan and the extracellular matrix protein laminin induces apoptosis in muscle cells. |
2002-12-13 |
2023-08-12 |
Not clear |
| Rolf Christofferson, Lena Claesson-Welsh, Carin Muh. [Anti-angiogenic drugs probable complement in cancer therapy]. Lakartidningen. vol 99. issue 42. 2002-12-09. PMID:12448292. |
in addition, substances that are inhibitors of matrix metalloproteinases or agents that induce programmed cell death (apoptosis) of endothelial cells are being tested. |
2002-12-09 |
2023-08-12 |
Not clear |
| James A Wallace, Susan Alexander, Eduardo Y Estrada, Curt Hines, Lee Anna Cunningham, Gary A Rosenber. Tissue inhibitor of metalloproteinase-3 is associated with neuronal death in reperfusion injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 22. issue 11. 2002-12-04. PMID:12439287. |
tissue inhibitor of metalloproteinase-3 (timp-3), which is bound to the extracellular matrix, has been shown to promote apoptosis in cancer cell lines by inhibiting cell surface sheddases. |
2002-12-04 |
2023-08-12 |
rat |
| O Fuch. [Role of cytokine signaling pathways of the transforming growth factor-beta (TGF-beta) family in the regulation of hematopoiesis]. Casopis lekaru ceskych. vol 141 Suppl. 2002-12-03. PMID:12428417. |
this family regulates a broad spectrum of biological functions, including cell proliferation, differentiation, apoptosis, migration, and extracellular matrix production. |
2002-12-03 |
2023-08-12 |
Not clear |