| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takashi Taga, Atsushi Suzuki, Ignacio Gonzalez-Gomez, Floyd H Gilles, Monique Stins, Hiroyuki Shimada, Lora Barsky, Kenneth I Weinberg, Walter E Lau. alpha v-Integrin antagonist EMD 121974 induces apoptosis in brain tumor cells growing on vitronectin and tenascin. International journal of cancer. vol 98. issue 5. 2002-04-18. PMID:11920637. |
this compound, a cyclic rgd-penta-peptide, is a potent inhibitor of angiogenesis, which induces apoptosis of growing endothelial cells through inhibition of their alpha v-integrin interaction with the matrix proteins vitronectin and tenascin. |
2002-04-18 |
2023-08-12 |
mouse |
| Takashi Taga, Atsushi Suzuki, Ignacio Gonzalez-Gomez, Floyd H Gilles, Monique Stins, Hiroyuki Shimada, Lora Barsky, Kenneth I Weinberg, Walter E Lau. alpha v-Integrin antagonist EMD 121974 induces apoptosis in brain tumor cells growing on vitronectin and tenascin. International journal of cancer. vol 98. issue 5. 2002-04-18. PMID:11920637. |
here we show that emd 121974 also induces apoptosis in the alpha v-integrin-expressing tumor cell lines u87 mg and daoy by detaching them from vitronectin and tenascin, matrix proteins known to be essential for brain tumor growth and invasion. |
2002-04-18 |
2023-08-12 |
mouse |
| Takashi Taga, Atsushi Suzuki, Ignacio Gonzalez-Gomez, Floyd H Gilles, Monique Stins, Hiroyuki Shimada, Lora Barsky, Kenneth I Weinberg, Walter E Lau. alpha v-Integrin antagonist EMD 121974 induces apoptosis in brain tumor cells growing on vitronectin and tenascin. International journal of cancer. vol 98. issue 5. 2002-04-18. PMID:11920637. |
thus, the alpha v-antagonist emd 121974 suppresses brain tumor growth through induction of apoptosis in both brain capillary and brain tumor cells by preventing their interaction with the matrix proteins vitronectin and tenascin. |
2002-04-18 |
2023-08-12 |
mouse |
| Susumu Otom. [Hair growth effect of minoxidil]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 119. issue 3. 2002-04-16. PMID:11915519. |
if the negative factors become dominant against cell proliferation factors according to fulfilling some time set by the biological clock for hair follicles, tgf beta induced in the matrix tissues evokes apoptosis of matrix cells and shifts the follicles from anagen to catagen. |
2002-04-16 |
2023-08-12 |
Not clear |
| Susumu Otom. [Hair growth effect of minoxidil]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 119. issue 3. 2002-04-16. PMID:11915519. |
the mode of action of hair growth effect of minoxidil is not completely elucidated, but the most plausible explanation proposed here is that minoxidil works as a sulfonylurea receptor (sur) activator and prolongs the anagen phase of hair follicles in the following manner: minoxidil (1) induces cell growth factors such as vegf, hgf, igf-1 and potentiates hgf and igf-1 actions by the activation of uncoupled sur on the plasma membrane of dermal papilla cells, (2) inhibits of tgf beta induced apoptosis of hair matrix cells by opening the kir 6.0 channel pore coupled with sur on the mitochondrial inner membrane, and (3) dilates hair follicle arteries and increases blood flow in dermal papilla by opening the kir 6.0 channel pore coupled with sur on the plasma membrane of vascular smooth muscle cells. |
2002-04-16 |
2023-08-12 |
Not clear |
| G Andrei, R Snoeck, D Schols, E De Clerc. Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncology research. vol 12. issue 9-10. 2002-04-12. PMID:11697818. |
different parameters of apoptosis, that is, (i) induction of cpp32 (caspase-3) protease activity, (ii) translocation of phosphatidylserine (ps) from the inner part of the plasma membrane to the outer layer, (iii) disintegration of the nuclear matrix protein (nmp), (iv) dna fragmentation, (v) number of cells in apoptotic phase following cell cycle analysis, showed that the mechanism of cell death following treatment with cdv is based on apoptosis. |
2002-04-12 |
2023-08-12 |
human |
| M A Esco, Z Wang, M L McDermott, M Kurpakus-Wheate. Potential role for laminin 5 in hypoxia-mediated apoptosis of human corneal epithelial cells. Journal of cell science. vol 114. issue Pt 22. 2002-04-10. PMID:11739635. |
laminin 5 functions to promote cell-matrix adhesion and therefore is hypothesized to abrogate apoptosis initiated through the loss of epithelial cell contact with extracellular matrix. |
2002-04-10 |
2023-08-12 |
human |
| M A Esco, Z Wang, M L McDermott, M Kurpakus-Wheate. Potential role for laminin 5 in hypoxia-mediated apoptosis of human corneal epithelial cells. Journal of cell science. vol 114. issue Pt 22. 2002-04-10. PMID:11739635. |
increased apoptosis in hypoxic epithelium at 7 days in culture correlated with decreased deposition of laminin 5 into the extracellular matrix, as determined by western blot analysis and immunofluorescence microscopy. |
2002-04-10 |
2023-08-12 |
human |
| M A Esco, Z Wang, M L McDermott, M Kurpakus-Wheate. Potential role for laminin 5 in hypoxia-mediated apoptosis of human corneal epithelial cells. Journal of cell science. vol 114. issue Pt 22. 2002-04-10. PMID:11739635. |
based on these results, it appears that mechanisms of hypoxia-mediated apoptosis in human corneal epithelial cells may be initiated by the loss of processed laminin 5 in the extracellular matrix or by the loss of laminin 5-epithelial cell communication and transmitted through mitochondria. |
2002-04-10 |
2023-08-12 |
human |
| M Rosas Peralt. [Mechanisms of progression in heart failure]. Archivos de cardiologia de Mexico. vol 71 Suppl 1. 2002-04-09. PMID:11565324. |
the role of apoptosis, extracellular matrix, biochemical and molecular changes, signaling pathways, cytokines, inflammatory response and gene expression are discussed as well as the new possible alternatives for therapy. |
2002-04-09 |
2023-08-12 |
Not clear |
| Daniela Grimm, Johann Bauer, Peter Kossmehl, Mehdi Shakibaei, Johann Schöberger, Holger Pickenhahn, Gundula Schulze-Tanzil, Roland Vetter, Christoph Eilles, Martin Paul, Augusto Cogol. Simulated microgravity alters differentiation and increases apoptosis in human follicular thyroid carcinoma cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 16. issue 6. 2002-04-05. PMID:11919168. |
these observations suggest that clinorotation elevates intermediate filaments, cell adhesion molecules, and extracellular matrix proteins and simultaneously induces apoptosis in follicular thyroid cancer cells. |
2002-04-05 |
2023-08-12 |
human |
| Michelle P Bendeck, Michelle Conte, Mingyu Zhang, Nafiseh Nili, Bradley H Strauss, Stephanie M Farwel. Doxycycline modulates smooth muscle cell growth, migration, and matrix remodeling after arterial injury. The American journal of pathology. vol 160. issue 3. 2002-04-02. PMID:11891205. |
the tetracyclines function as antibiotics by inhibiting bacterial protein synthesis, but recent work has shown that they are pluripotent drugs that affect many mammalian cell functions including proliferation, migration, apoptosis, and matrix remodeling. |
2002-04-02 |
2023-08-12 |
rat |
| Carlos L Arteaga, Fadlo Khuri, Geoffrey Krystal, Said Sebt. Overview of rationale and clinical trials with signal transduction inhibitors in lung cancer. Seminars in oncology. vol 29. issue 1 Suppl 4. 2002-04-02. PMID:11894010. |
most cellular proto-oncogenes encode proteins that participate in signaling pathways by which cells receive and execute instructions that lead to mitogenesis, differentiation, lineage determination, cell migration, extracellular matrix production, and apoptosis, among others. |
2002-04-02 |
2023-08-12 |
Not clear |
| M Cattaruzza, M M Berger, M Ochs, A Fayyazi, L Füzesi, J Richter, M Hecke. Deformation-induced endothelin B receptor-mediated smooth muscle cell apoptosis is matrix-dependent. Cell death and differentiation. vol 9. issue 2. 2002-03-27. PMID:11840172. |
isolated smc from these rabbit blood vessels as well as from the aorta and vena cava of the rat, when cultured on a collagen or laminin matrix, uniformly revealed an etb-r-mediated increase in apoptosis upon exposure to mechanical deformation plus exogenous et-1 (10 nmol/l). |
2002-03-27 |
2023-08-12 |
rat |
| M Cattaruzza, M M Berger, M Ochs, A Fayyazi, L Füzesi, J Richter, M Hecke. Deformation-induced endothelin B receptor-mediated smooth muscle cell apoptosis is matrix-dependent. Cell death and differentiation. vol 9. issue 2. 2002-03-27. PMID:11840172. |
however, when grown on a fibronectin matrix, the cultured smc did not respond with an increase in apoptosis under otherwise identical experimental conditions. |
2002-03-27 |
2023-08-12 |
rat |
| A Anwar, A A Zahid, K J Scheidegger, M Brink, P Delafontain. Tumor necrosis factor-alpha regulates insulin-like growth factor-1 and insulin-like growth factor binding protein-3 expression in vascular smooth muscle. Circulation. vol 105. issue 10. 2002-03-27. PMID:11889017. |
insulin-like growth factor-1 (igf-1) prevents apoptosis, promotes matrix formation, and can decrease tnf-alpha or il-1beta--induced proteoglycan degradation. |
2002-03-27 |
2023-08-12 |
Not clear |
| A Calender, C Vercherat, P Gaudray, J A Chayviall. Deregulation of genetic pathways in neuroendocrine tumors. Annals of oncology : official journal of the European Society for Medical Oncology. vol 12 Suppl 2. 2002-03-26. PMID:11762348. |
might be related to each step of the cell life, from mitosis to dna transcription, membrane receptor signalling and growth factor production, protein catabolism and extracellular matrix synthesis, and from transcription regulation to apoptosis and response to hypoxia and cellular stress. |
2002-03-26 |
2023-08-12 |
human |
| Oscar H L Bing, Chester H Conrad, Marvin O Boluyt, Kathleen G Robinson, Wesley W Brook. Studies of prevention, treatment and mechanisms of heart failure in the aging spontaneously hypertensive rat. Heart failure reviews. vol 7. issue 1. 2002-03-20. PMID:11790924. |
the roles of the extracellular matrix, apoptosis, intracellular calcium, beta-adrenergic stimulation, microtubules, and oxygen supply-demand relationships in ultimately mediating myocardial tissue dysfunction are reviewed. |
2002-03-20 |
2023-08-12 |
rat |
| D G Jayne, R M Heath, O Dewhurst, N Scott, P J Guillo. Extracellular matrix proteins and chemoradiotherapy: alpha5beta1 integrin as a predictive marker in rectal cancer. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. vol 28. issue 1. 2002-03-12. PMID:11869010. |
to investigate the effects of extracellular matrix (ecm) protein expression on the rates of apoptosis and proliferation in rectal cancers and subsequent response to chemoradiotherapy (crt). |
2002-03-12 |
2023-08-12 |
Not clear |
| Akihisa Matsuda, Yasuhiro Suzuki, Kazunao Kondo, Yasuhiko Ikeda, Kazuo Umemur. Hypercholesterolemia induces regression in neointimal thickening due to apoptosis of vascular smooth muscle cells in the hamster endothelial injury model. Cardiovascular research. vol 53. issue 2. 2002-03-11. PMID:11827703. |
although matrix metalloproteinase may play a key role in plaque rupture, apoptosis of vascular smooth muscle cells (vsmcs), which is induced by cholesterol and its oxides may also contribute to instability and rupture of plaque. |
2002-03-11 |
2023-08-12 |
Not clear |