| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juan Arredondo, Vu Thuong Nguyen, Alexander I Chernyavsky, Dani Bercovich, Avi Orr-Urtreger, Douglas E Vetter, Sergei A Grand. Functional role of alpha7 nicotinic receptor in physiological control of cutaneous homeostasis. Life sciences. vol 72. issue 18-19. 2003-04-04. PMID:12628457. |
we studied in vitro effects of functional inactivation of alpha7 receptor on the expression of apoptosis regulators in keratinocytes (kc) lacking alpha7 nachr, and extracellular matrix regulators in the skin of alpha7 knockout (ko) mice. |
2003-04-04 |
2023-08-12 |
mouse |
| Christopher S Adams, Irving M Shapir. The fate of the terminally differentiated chondrocyte: evidence for microenvironmental regulation of chondrocyte apoptosis. Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists. vol 13. issue 6. 2003-03-28. PMID:12499240. |
since the induction of apoptosis is spatially and temporally linked to the removal of the cartilage matrix, current studies have examined the apoptogenic activity of ca(2+)-, pi-, and rgd-containing peptides of extracellular matrix proteins. |
2003-03-28 |
2023-08-12 |
Not clear |
| G R Nigri, C Brini, G M LaMuraglia, F Vietr. [Photodynamic therapy in cardiac and vascular surgery]. Il Giornale di chirurgia. vol 23. issue 8-9. 2003-03-26. PMID:12564301. |
these free radicals are able to induce apoptosis of the smooth muscle cells that had absorbed the photosensitizer; they also induce changes in the extracellular matrix, reducing cell migration. |
2003-03-26 |
2023-08-12 |
Not clear |
| Emilia Maneiro, Miguel A Martín, María C de Andres, Maria J López-Armada, José L Fernández-Sueiro, Pilar del Hoyo, Fausto Galdo, Joaquin Arenas, Francisco J Blanc. Mitochondrial respiratory activity is altered in osteoarthritic human articular chondrocytes. Arthritis and rheumatism. vol 48. issue 3. 2003-03-25. PMID:12632423. |
osteoarthritis (oa) is a degenerative rheumatic disease that is associated with extracellular matrix degradation and chondrocyte apoptosis in the articular cartilage. |
2003-03-25 |
2023-08-12 |
human |
| Hafiz Ahmed, Mario A Bianchet, L Mario Amzel, Jun Hirabayashi, Ken-Ichi Kasai, Yuko Giga-Hama, Hideki Tohda, Gerardo R Vast. Novel carbohydrate specificity of the 16-kDa galectin from Caenorhabditis elegans: binding to blood group precursor oligosaccharides (type 1, type 2, Talpha, and Tbeta) and gangliosides. Glycobiology. vol 12. issue 8. 2003-03-20. PMID:12145186. |
galectins, a family of soluble beta-galactosyl-binding lectins, are believed to mediate cell-cell and cell-extracellular matrix interactions during development, inflammation, apoptosis, and tumor metastasis. |
2003-03-20 |
2023-08-12 |
caenorhabditis_elegans |
| V A Tronov, E M Konstantinov, I I Kramarenk. [Hyperthermia induced signal for apoptosis and pathways of its transduction in the cell]. Tsitologiia. vol 44. issue 11. 2003-03-19. PMID:12561728. |
in this regard we analyse the membrane effect of ht, ht-induced chromatin and nuclear matrix structure changes, dna damage, effect of ht on dna-repair mechanism, and the role of heat shock proteins in apoptosis and cancerogenesis. |
2003-03-19 |
2023-08-12 |
Not clear |
| Philippe Clézardi. The antitumor potential of bisphosphonates. Seminars in oncology. vol 29. issue 6 Suppl 21. 2003-03-18. PMID:12584693. |
bisphosphonates reduce proliferation and induce apoptosis of tumor cell lines, and they inhibit tumor cell adhesion and invasion of the extracellular matrix in vitro. |
2003-03-18 |
2023-08-12 |
Not clear |
| Ze'ev Hochber. Mechanisms of steroid impairment of growth. Hormone research. vol 58 Suppl 1. 2003-03-17. PMID:12373012. |
direct effects at the growth plate include the suppression of multiple gene expression, chondrocyte proliferation and matrix proteoglycan synthesis, sulfation, release and mineralization as well as the augmentation of hypertrophic cell apoptosis. |
2003-03-17 |
2023-08-12 |
Not clear |
| Vincent H Gattone, Justin L Ricker, Chad M Trambaugh, Robert M Klei. Multiorgan mRNA misexpression in murine autosomal recessive polycystic kidney disease. Kidney international. vol 62. issue 5. 2003-03-12. PMID:12371956. |
in cystic kidneys, misexpressed mrnas were found in one of four general groups: proliferation/cell growth, apoptosis, differentiation or extracellular matrix. |
2003-03-12 |
2023-08-12 |
mouse |
| Marco Tucci, Daniela Grinello, Paola Cafforio, Franco Silvestris, Franco Dammacc. Anemia in multiple myeloma: role of deregulated plasma cell apoptosis. Leukemia & lymphoma. vol 43. issue 8. 2003-03-12. PMID:12400594. |
besides the altered cytokine network, chronic erythropoietin deficiency, blood loss and hemolysis, we have shown that deregulated myeloma cell apoptosis may contribute to progressive destruction of the erythroid matrix by inducing erythroblast cytotoxicity. |
2003-03-12 |
2023-08-12 |
Not clear |
| Wataru Yoshida, Miwa Uzuki, Akira Kurose, Masaaki Yoshida, Jun Nishida, Tadashi Shimamura, Takashi Sawa. Cell characterization of mononuclear and giant cells constituting pigmented villonodular synovitis. Human pathology. vol 34. issue 1. 2003-03-11. PMID:12605368. |
five methods were used for cell analysis: (1) enzyme-histochemistry for tartrate-resistant acid phosphatase (trap); (2) immunohistochemistry using antibodies for cd68, macrophage colony-stimulating factor (m-csf), mib-1, p53, p21, p16, and cathepsin-l (cath l); (3) tdt-mediated deoxyuridine triphosphate-biotin terminal end labeling (tunel) as a measure of apoptosis; (4) fluorescence-based polymerase chain reaction single-strand conformation polymorphism analyses (fpcr-sscp) to detect p53 gene mutations; and (5) in situ hybridization using gene-specific oligoprobes for matrix metalloproteinase (mmp)-2, mmp-9, receptor activator of nuclear factor kappab ligand (rankl), and calcitonin receptor (ctr). |
2003-03-11 |
2023-08-12 |
Not clear |
| Robert M Moore, David W Lundgren, Rebecca J Silver, John J Moor. Lactosylceramide-induced apoptosis in primary amnion cells and amnion-derived WISH cells. Journal of the Society for Gynecologic Investigation. vol 9. issue 5. 2003-03-07. PMID:12383912. |
apoptosis was confirmed by agarose gel electrophoretic dna fragmentation analysis, nuclear matrix protein (nmp), and nucleosome enzyme-linked immunosorbent assay. |
2003-03-07 |
2023-08-12 |
Not clear |
| Mingyu Liang, Baozhi Yuan, Elizabeth Rute, Andrew S Greene, Michael Olivier, Allen W Cowle. Insights into Dahl salt-sensitive hypertension revealed by temporal patterns of renal medullary gene expression. Physiological genomics. vol 12. issue 3. 2003-02-28. PMID:12488510. |
thirty of these genes could be linked to the regulation of arterial blood pressure or renal injury based on their known involvement in functional pathways such as renal tubular transport, metabolism of vasoactive substances, extracellular matrix formation, and apoptosis. |
2003-02-28 |
2023-08-12 |
rat |
| Sergei Kochlatyi, Nora Gibbons, Joseph Mattan. Extracellular matrix oxidation modulates survival, NF-kappaB translocation, and MAPK activity in mesangial cells. Experimental and molecular pathology. vol 73. issue 3. 2003-02-27. PMID:12565794. |
in this study we evaluated how extracellular matrix oxidation could modulate the development of apoptosis as well as the activity of the transcription factor nf-kappab and that of the mapk family members erk-1,2 and jnk. |
2003-02-27 |
2023-08-12 |
Not clear |
| Takeshi Shimamura, Michiie Sakamoto, Yoshinori Ino, Kazuaki Shimada, Tomoo Kosuge, Yasuto Sato, Katsuaki Tanaka, Hisahiko Sekihara, Setsuo Hirohash. Clinicopathological significance of galectin-3 expression in ductal adenocarcinoma of the pancreas. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 8. issue 8. 2003-02-26. PMID:12171885. |
galectin-3, a member of the beta-galactoside-binding lectin family, has multiple biological functions including cell-cell interactions and cell-extracellular matrix adhesion, cellular proliferation, cellular differentiation, and apoptosis. |
2003-02-26 |
2023-08-12 |
Not clear |
| Paul Sweeney, Takashi Karashima, Sun-Jin Kim, Daniel Kedar, Badar Mian, Samuel Huang, Cheryl Baker, Zhen Fan, Daniel J Hicklin, Curtis A Pettaway, Colin P N Dinne. Anti-vascular endothelial growth factor receptor 2 antibody reduces tumorigenicity and metastasis in orthotopic prostate cancer xenografts via induction of endothelial cell apoptosis and reduction of endothelial cell matrix metalloproteinase type 9 production. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 8. issue 8. 2003-02-26. PMID:12171905. |
anti-vascular endothelial growth factor receptor 2 antibody reduces tumorigenicity and metastasis in orthotopic prostate cancer xenografts via induction of endothelial cell apoptosis and reduction of endothelial cell matrix metalloproteinase type 9 production. |
2003-02-26 |
2023-08-12 |
Not clear |
| Hironobu Ih. Pathogenesis of fibrosis: role of TGF-beta and CTGF. Current opinion in rheumatology. vol 14. issue 6. 2003-02-26. PMID:12410091. |
transforming growth factor (tgf)-beta regulates diverse biologic activities including cell growth, cell death or apoptosis, cell differentiation, and extracellular matrix (ecm) synthesis. |
2003-02-26 |
2023-08-12 |
Not clear |
| Koji Ishida, Hikaru Nagahara, Tomomi Kogiso, Tomoko Aso, Naoaki Hayashi, Toshihiro Akaik. Cell adhesion aside from integrin system can abrogate anoikis in rat liver cells by down-regulation of FasL expression, not by activation of PI-3K/Akt and ERK signaling pathway. Biochemical and biophysical research communications. vol 300. issue 1. 2003-02-13. PMID:12480544. |
epithelial cells require contact with extracellular matrix (ecm) to inhibit detachment-induced apoptosis (anoikis). |
2003-02-13 |
2023-08-12 |
rat |
| Razao Issa, Xiaoying Zhou, Nathan Trim, Harry Millward-Sadler, Stephen Krane, Christopher Benyon, John Iredal. Mutation in collagen-1 that confers resistance to the action of collagenase results in failure of recovery from CCl4-induced liver fibrosis, persistence of activated hepatic stellate cells, and diminished hepatocyte regeneration. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 17. issue 1. 2003-02-10. PMID:12475903. |
recovery from liver fibrosis is accompanied by hepatocyte regeneration, matrix degradation, and hsc apoptosis. |
2003-02-10 |
2023-08-12 |
mouse |
| D Mangoldt, B Sinn, M Lein, H W Krell, D Schnorr, S A Loening, K Jun. The novel synthetic inhibitor of matrix metalloproteinases Ro 28-2653 induces apoptosis in Dunning tumor cells. Apoptosis : an international journal on programmed cell death. vol 7. issue 3. 2003-02-07. PMID:11997665. |
the novel synthetic inhibitor of matrix metalloproteinases ro 28-2653 induces apoptosis in dunning tumor cells. |
2003-02-07 |
2023-08-12 |
rat |