| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Morten A Karsdal, Lykke Larsen, Michael T Engsig, Henriette Lou, Mercedes Ferreras, Andre Lochter, Jean-Marie Delaissé, Niels T Foge. Matrix metalloproteinase-dependent activation of latent transforming growth factor-beta controls the conversion of osteoblasts into osteocytes by blocking osteoblast apoptosis. The Journal of biological chemistry. vol 277. issue 46. 2003-01-02. PMID:12226090. |
upon termination of bone matrix synthesis, osteoblasts either undergo apoptosis or differentiate into osteocytes or bone lining cells. |
2003-01-02 |
2023-08-12 |
mouse |
| Morten A Karsdal, Lykke Larsen, Michael T Engsig, Henriette Lou, Mercedes Ferreras, Andre Lochter, Jean-Marie Delaissé, Niels T Foge. Matrix metalloproteinase-dependent activation of latent transforming growth factor-beta controls the conversion of osteoblasts into osteocytes by blocking osteoblast apoptosis. The Journal of biological chemistry. vol 277. issue 46. 2003-01-02. PMID:12226090. |
in this study, we investigated the role of matrix metalloproteinases (mmps) and growth factors in the differentiation of osteoblasts into osteocytes and in osteoblast apoptosis. |
2003-01-02 |
2023-08-12 |
mouse |
| A Mezzogiorno, V Esposit. Potential role for high and low molecular weight tissue transglutaminases in transforming mammalian cell properties. Current drug targets. Immune, endocrine and metabolic disorders. vol 1. issue 3. 2002-12-23. PMID:12477288. |
tissue transglutaminase (ttgase, ttg) is known as being implicated in the intracellular cross-linking of proteins occurring in a growing series of physiological conditions including--just to mention the most relevant ones--programmed cell death (apoptosis), cell adhesion, growth, spreading and differentiation, tumor growth, metastasis, cell adhesion, proliferation, differentiation, extra cellular matrix (ecm) stabilization. |
2002-12-23 |
2023-08-12 |
Not clear |
| C Gerner, J Gotzmann, U Fröhwein, C Schamberger, A Ellinger, G Sauerman. Proteome analysis of nuclear matrix proteins during apoptotic chromatin condensation. Cell death and differentiation. vol 9. issue 6. 2002-12-18. PMID:12032676. |
the nuclear matrix (nm) is considered a proteinaceous scaffold spatially organizing the interphase nucleus, the integrity of which is affected during apoptosis. |
2002-12-18 |
2023-08-12 |
Not clear |
| X Leschelle, V Robert, S Delpal, B Mouillé, C Mayeur, P Martel, F Blachie. Isolation of pig colonic crypts for cytotoxic assay of luminal compounds: effects of hydrogen sulfide, ammonia, and deoxycholic acid. Cell biology and toxicology. vol 18. issue 3. 2002-12-17. PMID:12083425. |
using colonocytes isolated with edta, we found that the initial cell viability, estimated by the membrane integrity and oxidative capacity measurement, fell rapidly despite several experimental attempts to preserve it such as the use of a medium designed to increase the adherence of epithelial cells and of a coated extracellular matrix, the presence in the culture medium of the oxidative substrate butyrate, and the use of an inhibitor of the caspases involved in cell apoptosis. |
2002-12-17 |
2023-08-12 |
human |
| Francis J Giles, Hagop M Kantarjian, B Nebiyou Bekele, Jorge E Cortes, Stephan Faderl, Deborah A Thomas, Taghi Manshouri, Anna Rogers, Michael J Keating, Moshe Talpaz, Susan O'Brien, Maher Albita. Bone marrow cyclooxygenase-2 levels are elevated in chronic-phase chronic myeloid leukaemia and are associated with reduced survival. British journal of haematology. vol 119. issue 1. 2002-12-13. PMID:12358901. |
cox-2 may also reduce apoptosis and reduce cellular attachment to the extracellular matrix (ecm). |
2002-12-13 |
2023-08-12 |
Not clear |
| K J Langenbach, T A Rand. Inhibition of dystroglycan binding to laminin disrupts the PI3K/AKT pathway and survival signaling in muscle cells. Muscle & nerve. vol 26. issue 5. 2002-12-13. PMID:12402286. |
because apoptosis is an early feature of muscular dystrophy in vivo, and perturbation of cell-extracellular matrix associations is known to induce apoptosis, we investigated the role of dystroglycan-laminin interactions in the propagation and maintenance of cell survival signals in muscle cells. |
2002-12-13 |
2023-08-12 |
Not clear |
| K J Langenbach, T A Rand. Inhibition of dystroglycan binding to laminin disrupts the PI3K/AKT pathway and survival signaling in muscle cells. Muscle & nerve. vol 26. issue 5. 2002-12-13. PMID:12402286. |
we found that disrupting the interaction between alpha-dystroglycan and the extracellular matrix protein laminin induces apoptosis in muscle cells. |
2002-12-13 |
2023-08-12 |
Not clear |
| Rolf Christofferson, Lena Claesson-Welsh, Carin Muh. [Anti-angiogenic drugs probable complement in cancer therapy]. Lakartidningen. vol 99. issue 42. 2002-12-09. PMID:12448292. |
in addition, substances that are inhibitors of matrix metalloproteinases or agents that induce programmed cell death (apoptosis) of endothelial cells are being tested. |
2002-12-09 |
2023-08-12 |
Not clear |
| James A Wallace, Susan Alexander, Eduardo Y Estrada, Curt Hines, Lee Anna Cunningham, Gary A Rosenber. Tissue inhibitor of metalloproteinase-3 is associated with neuronal death in reperfusion injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 22. issue 11. 2002-12-04. PMID:12439287. |
tissue inhibitor of metalloproteinase-3 (timp-3), which is bound to the extracellular matrix, has been shown to promote apoptosis in cancer cell lines by inhibiting cell surface sheddases. |
2002-12-04 |
2023-08-12 |
rat |
| O Fuch. [Role of cytokine signaling pathways of the transforming growth factor-beta (TGF-beta) family in the regulation of hematopoiesis]. Casopis lekaru ceskych. vol 141 Suppl. 2002-12-03. PMID:12428417. |
this family regulates a broad spectrum of biological functions, including cell proliferation, differentiation, apoptosis, migration, and extracellular matrix production. |
2002-12-03 |
2023-08-12 |
Not clear |
| Sukumar Chattopadhyay, Sraboni Bhaumik, Madhumita Purkayastha, Srabanti Basu, Aditi Nag Chaudhuri, Shyamal Das Gupt. Apoptosis and necrosis in developing brain cells due to arsenic toxicity and protection with antioxidants. Toxicology letters. vol 136. issue 1. 2002-12-02. PMID:12368058. |
the morphological analyses showed growth of viable cells, neural networking vis-à-vis apoptosis on exposure to arsenic for 24 h and necrosis and loss of ground matrix on arsenic exposure for 18 days. |
2002-12-02 |
2023-08-12 |
human |
| Andrew E Aplin, Brian P Hogan, Jeannie Tomeu, R L Julian. Cell adhesion differentially regulates the nucleocytoplasmic distribution of active MAP kinases. Journal of cell science. vol 115. issue Pt 13. 2002-11-26. PMID:12077368. |
cells decide whether to undergo processes, such as proliferation, differentiation and apoptosis, based upon the cues they receive from both circulating factors and integrin-mediated adhesion to the extracellular matrix. |
2002-11-26 |
2023-08-12 |
Not clear |
| Won-Jing Wang, Jean-Cheng Kuo, Chung-Chen Yao, Ruey-Hwa Che. DAP-kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signals. The Journal of cell biology. vol 159. issue 1. 2002-11-19. PMID:12370243. |
dap-kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signals. |
2002-11-19 |
2023-08-12 |
Not clear |
| O P Zhirnov, A L Ksenofontov, S G Kuzmina, H D Klen. Interaction of influenza A virus M1 matrix protein with caspases. Biochemistry. Biokhimiia. vol 67. issue 5. 2002-11-15. PMID:12059772. |
in this investigation, an ability of influenza a virus m1 matrix protein to bind intracellular caspases, the key enzymes of cell apoptosis, has been examined. |
2002-11-15 |
2023-08-12 |
Not clear |
| T G Frey, C W Renken, G A Perkin. Insight into mitochondrial structure and function from electron tomography. Biochimica et biophysica acta. vol 1555. issue 1-3. 2002-10-18. PMID:12206915. |
results of structural studies of mitochondria during apoptosis demonstrate that cytochrome c is released without detectable disruption of the outer membrane or extensive swelling of the mitochondrial matrix, suggesting the formation of an outer membrane pore large enough to allow passage of holo-cytochrome c. the possible compartmentation of inner membrane function between the ibm and the cristae membrane is also discussed. |
2002-10-18 |
2023-08-12 |
Not clear |
| George M Yousef, Eleftherios P Diamandi. Expanded human tissue kallikrein family--a novel panel of cancer biomarkers. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 23. issue 3. 2002-10-16. PMID:12218299. |
preliminary reports indicate a possible role of kallikreins in controlling vital processes, like apoptosis, angiogenesis and tumor metastasis by cleavage of critical substrates such as growth factors, hormones or extracellular matrix. |
2002-10-16 |
2023-08-12 |
human |
| Steven D Webb, Jonathan A Sherratt, Reginald G Fis. Cells behaving badly: a theoretical model for the Fas/FasL system in tumour immunology. Mathematical biosciences. vol 179. issue 2. 2002-10-10. PMID:12208611. |
the model predicts that (a) the production of soluble forms of fas and fasl will lead to the down-regulation of the immune response; (b) matrix metalloproteinase (mmp) inactivation should lead to increased membrane fasl and result in a higher rate of fas-mediated apoptosis for lymphocytes than for tumour cells. |
2002-10-10 |
2023-08-12 |
Not clear |
| Jean-Yves Jouzeau, Sandrine Pacquelet, Christelle Boileau, Emmanuelle Nedelec, Nathalie Presle, Patrick Netter, Bernard Terlai. Nitric oxide (NO) and cartilage metabolism: NO effects are modulated by superoxide in response to IL-1. Biorheology. vol 39. issue 1-2. 2002-10-04. PMID:12082283. |
in vitro evidence includes the decreased synthesis of extracellular matrix components, the abnormal cell renewal, the decreased production of il-1 receptor antagonist, the induction of apoptosis and the enhanced sensitivity of chondrocytes to oxidative stress. |
2002-10-04 |
2023-08-12 |
mouse |
| J Barry Wright, Kan Lam, Andre G Buret, Merle E Olson, Robert E Burrel. Early healing events in a porcine model of contaminated wounds: effects of nanocrystalline silver on matrix metalloproteinases, cell apoptosis, and healing. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 10. issue 3. 2002-09-27. PMID:12100375. |
early healing events in a porcine model of contaminated wounds: effects of nanocrystalline silver on matrix metalloproteinases, cell apoptosis, and healing. |
2002-09-27 |
2023-08-12 |
Not clear |