| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anthony J Valentijn, Anthony D Metcalfe, Jane Kott, Charles H Streuli, Andrew P Gilmor. Spatial and temporal changes in Bax subcellular localization during anoikis. The Journal of cell biology. vol 162. issue 4. 2003-10-01. PMID:12925707. |
cells can be rescued from apoptosis if they are replated onto extracellular matrix within an hour, whereas cells detached for longer could not. |
2003-10-01 |
2023-08-12 |
Not clear |
| Ronald M Bukowsk. AE-941, a multifunctional antiangiogenic compound: trials in renal cell carcinoma. Expert opinion on investigational drugs. vol 12. issue 8. 2003-09-30. PMID:12882625. |
at the molecular level, ae-941 appears to exhibit four different potential mechanisms of action: modulation of matrix proteases; inhibition of vascular endothelial growth factor binding to its receptor; induction of endothelial cell apoptosis; and stimulation of angiostatin production. |
2003-09-30 |
2023-08-12 |
Not clear |
| Maria Nataatmadja, Malcolm West, Jenny West, Kim Summers, Philip Walker, Michio Nagata, Teruo Watanab. Abnormal extracellular matrix protein transport associated with increased apoptosis of vascular smooth muscle cells in marfan syndrome and bicuspid aortic valve thoracic aortic aneurysm. Circulation. vol 108 Suppl 1. 2003-09-30. PMID:12970255. |
abnormal extracellular matrix protein transport associated with increased apoptosis of vascular smooth muscle cells in marfan syndrome and bicuspid aortic valve thoracic aortic aneurysm. |
2003-09-30 |
2023-08-12 |
Not clear |
| Maria Nataatmadja, Malcolm West, Jenny West, Kim Summers, Philip Walker, Michio Nagata, Teruo Watanab. Abnormal extracellular matrix protein transport associated with increased apoptosis of vascular smooth muscle cells in marfan syndrome and bicuspid aortic valve thoracic aortic aneurysm. Circulation. vol 108 Suppl 1. 2003-09-30. PMID:12970255. |
this study examined the relationship among the secretion of extracellular matrix proteins fibrillin, fibronectin, tenascin, and vascular smooth muscle cell (vsmc) apoptosis. |
2003-09-30 |
2023-08-12 |
Not clear |
| Maria Nataatmadja, Malcolm West, Jenny West, Kim Summers, Philip Walker, Michio Nagata, Teruo Watanab. Abnormal extracellular matrix protein transport associated with increased apoptosis of vascular smooth muscle cells in marfan syndrome and bicuspid aortic valve thoracic aortic aneurysm. Circulation. vol 108 Suppl 1. 2003-09-30. PMID:12970255. |
the role of matrix metalloproteinase (mmp)-2 in vsmc apoptosis was studied in ms aneurysm. |
2003-09-30 |
2023-08-12 |
Not clear |
| Denis Gingras, Dominique Boivin, Christophe Deckers, Sébastien Gendron, Chantal Barthomeuf, Richard Bélivea. Neovastat--a novel antiangiogenic drug for cancer therapy. Anti-cancer drugs. vol 14. issue 2. 2003-09-24. PMID:12569294. |
it interferes with several steps associated with the development of angiogenesis through its ability to induce endothelial cell apoptosis, and to inhibit matrix metalloproteinase activities and vascular endothelial growth factor-mediated signaling pathways, suggesting that neovastat behaves as a multifunctional antiangiogenic drug. |
2003-09-24 |
2023-08-12 |
Not clear |
| Wen-Bin Wu, Tur-Fu Huan. Activation of MMP-2, cleavage of matrix proteins, and adherens junctions during a snake venom metalloproteinase-induced endothelial cell apoptosis. Experimental cell research. vol 288. issue 1. 2003-09-24. PMID:12878166. |
activation of mmp-2, cleavage of matrix proteins, and adherens junctions during a snake venom metalloproteinase-induced endothelial cell apoptosis. |
2003-09-24 |
2023-08-12 |
Not clear |
| Wen-Bin Wu, Tur-Fu Huan. Activation of MMP-2, cleavage of matrix proteins, and adherens junctions during a snake venom metalloproteinase-induced endothelial cell apoptosis. Experimental cell research. vol 288. issue 1. 2003-09-24. PMID:12878166. |
we showed that the apoptosis was initiated with cell shape change and extracellular matrix degradation and occurred before cell detachment. |
2003-09-24 |
2023-08-12 |
Not clear |
| Amnon Zisman, Allan J Pantuck, Matthew H T Bui, Jonathan W Said, Randy R Caliliw, Nagesh Rao, Peter Shintaku, Frank Berger, Sanjiv S Gambhir, Arie S Belldegru. LABAZ1: A metastatic tumor model for renal cell carcinoma expressing the carbonic anhydrase type 9 tumor antigen. Cancer research. vol 63. issue 16. 2003-09-24. PMID:12941820. |
subsequent xenograft generations have conserved immunohistochemical and ultrastructural properties typical for malignant renal epithelium-derived neoplasia (vimentin+, ck-19+, ca ix+ with hypoxia-inducible factor (hif)-1 alpha constitutive expression) and have demonstrated extensive proliferation, lack of apoptosis, severe genetic alterations, and molecular expression alterations; transforming growth factor beta 1 (tgf-beta 1), hepatocyte growth factor (hgf), proto-oncogene (c-met), matrix metalloproteinase (mmp)-1, and vascular endothelial growth factor (vegf) c and d were overexpressed, whereas human epidermal growth factor receptor (her)-2, mmp-2 and mmp-9, vegf-r3, p53, and p27 were severely down-regulated, suggesting a proangiogenic environment, local invasiveness, and facilitated lymphatic metastasis. |
2003-09-24 |
2023-08-12 |
mouse |
| G Gabbian. The myofibroblast in wound healing and fibrocontractive diseases. The Journal of pathology. vol 200. issue 4. 2003-09-16. PMID:12845617. |
myofibroblasts synthesize extracellular matrix components such as collagen types i and iii and during normal wound healing disappear by apoptosis when epithelialization occurs. |
2003-09-16 |
2023-08-12 |
Not clear |
| Mauricio J Reginato, Kenna R Mills, Jessica K Paulus, Danielle K Lynch, Dennis C Sgroi, Jayanta Debnath, Senthil K Muthuswamy, Joan S Brugg. Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis. Nature cell biology. vol 5. issue 8. 2003-09-12. PMID:12844146. |
epithelial cells must adhere to the extracellular matrix (ecm) for survival, as detachment from matrix triggers apoptosis or anoikis. |
2003-09-12 |
2023-08-12 |
Not clear |
| Pieter A van der Velden, Wieke Zuidervaart, Monique H M H Hurks, Sandra Pavey, Bruce R Ksander, Elise Krijgsman, Rune R Frants, Cornelis P Tensen, Rein Willemze, Martine J Jager, Nelleke A Grui. Expression profiling reveals that methylation of TIMP3 is involved in uveal melanoma development. International journal of cancer. vol 106. issue 4. 2003-09-09. PMID:12845640. |
these genes are involved in processes like angiogenesis, apoptosis, macrophage stimulation, and extracellular matrix regulation. |
2003-09-09 |
2023-08-12 |
Not clear |
| E J Macki. Osteoblasts: novel roles in orchestration of skeletal architecture. The international journal of biochemistry & cell biology. vol 35. issue 9. 2003-09-08. PMID:12798343. |
following a period of secretory activity, osteoblasts undergo either apoptosis or terminal differentiation to form osteocytes surrounded by bone matrix. |
2003-09-08 |
2023-08-12 |
Not clear |
| Yusuke Hashimoto, Takami Tomiyama, Yoshiki Yamano, Hiroshi Mor. Mutation (D472Y) in the type 3 repeat domain of cartilage oligomeric matrix protein affects its early vesicle trafficking in endoplasmic reticulum and induces apoptosis. The American journal of pathology. vol 163. issue 1. 2003-09-03. PMID:12819015. |
mutation (d472y) in the type 3 repeat domain of cartilage oligomeric matrix protein affects its early vesicle trafficking in endoplasmic reticulum and induces apoptosis. |
2003-09-03 |
2023-08-12 |
Not clear |
| D Y Kim, H W Taylor, R M Moore, D B Paulsen, D-Y Ch. Articular chondrocyte apoptosis in equine osteoarthritis. Veterinary journal (London, England : 1997). vol 166. issue 1. 2003-09-02. PMID:12788017. |
topographical distributions of chondrocyte apoptosis, cartilage matrix degeneration, and no production overlapped in equine oa cartilages, suggesting that these pathological phenomena are closely interrelated. |
2003-09-02 |
2023-08-12 |
Not clear |
| Deborah A Swartz-Basile, Lihua Wang, Yuzhu Tang, Henry A Pitt, Deborah C Rubin, Marc S Levi. Vitamin A deficiency inhibits intestinal adaptation by modulating apoptosis, proliferation, and enterocyte migration. American journal of physiology. Gastrointestinal and liver physiology. vol 285. issue 2. 2003-08-29. PMID:12711591. |
these studies indicate that vitamin a deficiency inhibits intestinal adaptation following partial small bowel resection by reducing crypt cell proliferation, by enhancing early crypt cell apoptosis, and by markedly reducing enterocyte migration rates, which may be related to changes in the expression of collagen iv and other extracellular matrix components. |
2003-08-29 |
2023-08-12 |
rat |
| Abdelkarim Sabri, Sasha G Alcott, Hasnae Elouardighi, Elena Pak, Claudia Derian, Patricia Andrade-Gordon, Kathleen Kinnally, Susan F Steinber. Neutrophil cathepsin G promotes detachment-induced cardiomyocyte apoptosis via a protease-activated receptor-independent mechanism. The Journal of biological chemistry. vol 278. issue 26. 2003-08-20. PMID:12707281. |
of note, prolonged incubation of cardiomyocytes with cathepsin g results in the activation of caspase-3, cleavage of fak and akt, sarcomeric disassembly, cell rounding, cell detachment from underlying matrix, and morphologic features of apoptosis. |
2003-08-20 |
2023-08-12 |
mouse |
| Mònica Comalada, Marina Cardó, Jordi Xaus, Annabel F Valledor, Jorge Lloberas, Francesc Ventura, Antonio Celad. Decorin reverses the repressive effect of autocrine-produced TGF-beta on mouse macrophage activation. Journal of immunology (Baltimore, Md. : 1950). vol 170. issue 9. 2003-08-13. PMID:12707320. |
like the major macrophage activator ifn-gamma, the extracellular matrix protein decorin inhibits proliferation and protects macrophages from the induction of apoptosis. |
2003-08-13 |
2023-08-12 |
mouse |
| Robert A Gatenby, Edward T Gawlinsk. The glycolytic phenotype in carcinogenesis and tumor invasion: insights through mathematical models. Cancer research. vol 63. issue 14. 2003-08-13. PMID:12873971. |
this leads to normal cell death via p53-dependent apoptosis pathways, as well as degradation of the interstitial matrix, loss of intercellular gap junctions, enhanced angiogenesis, and inhibition of the host immune response to tumor antigens. |
2003-08-13 |
2023-08-12 |
human |
| Chrishan S Samuel, Hongsheng Tian, Ling Zhao, Edward P Ament. Relaxin is a key mediator of prostate growth and male reproductive tract development. Laboratory investigation; a journal of technical methods and pathology. vol 83. issue 7. 2003-08-12. PMID:12861045. |
the marked differences in the extracellular matrix of the testis and prostate in rlx-/- males also correlated with an increase in the rate of cell apoptosis. |
2003-08-12 |
2023-08-12 |
mouse |