| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nathalie Ortega, Danielle Behonick, Dominique Stickens, Zena Wer. How proteases regulate bone morphogenesis. Annals of the New York Academy of Sciences. vol 995. 2003-07-22. PMID:12814943. |
apoptosis of the terminal hypertrophic chondrocytes, degradation of the cartilage matrix, and deposition of bone matrix by osteoblasts accompanies neovascularization of the growth plate. |
2003-07-22 |
2023-08-12 |
mouse |
| Q Yao, S Wang, A Gambotto, J C Glorioso, C H Evans, P D Robbins, S C Ghivizzani, T J Oligin. Intra-articular adenoviral-mediated gene transfer of trail induces apoptosis of arthritic rabbit synovium. Gene therapy. vol 10. issue 12. 2003-07-21. PMID:12776164. |
in a rabbit model of arthritis, intra-articular gene transfer of trail induced apoptosis in cells within the synovial lining, reduced leukocytic infiltration and stimulated new matrix synthesis by cartilage. |
2003-07-21 |
2023-08-12 |
human |
| Jirí Ehrmann, Antonín Kolek, Rostislav Kod'ousek, Jana Zapletalová, Sona Lísová, Paul Gerard Murray, Jirí Drábek, Zdenek Kolá. Immunohistochemical study of the apoptotic mechanisms in the intestinal mucosa during children's coeliac disease. Virchows Archiv : an international journal of pathology. vol 442. issue 5. 2003-07-17. PMID:12698366. |
mechanisms leading to morphological changes of the small intestine during coeliac disease (cd) are not yet completely recognized; however, two main processes have been suggested recently: remodeling of mucosa by matrix metalloproteinases, and mucosal atrophy by apoptosis. |
2003-07-17 |
2023-08-12 |
Not clear |
| Mika Suzuki, Hiroshi Kobayashi, Yoshiko Tanaka, Yasuyuki Hirashima, Naohiro Kanayama, Yuji Takei, Yasushi Saga, Mitsuaki Suzuki, Hiroshi Itoh, Toshihiko Tera. Bikunin target genes in ovarian cancer cells identified by microarray analysis. The Journal of biological chemistry. vol 278. issue 17. 2003-07-16. PMID:12571229. |
these include transcriptional regulators, oncogenes/tumor suppressor genes, signaling molecules, growth/cell cycle, invasion/metastasis, cytokines, apoptosis, ion channels, extracellular matrix proteins, as well as some proteases. |
2003-07-16 |
2023-08-12 |
human |
| M Stubbs, C L Bashford, J R Griffith. Understanding the tumor metabolic phenotype in the genomic era. Current molecular medicine. vol 3. issue 1. 2003-07-15. PMID:12558074. |
hif-1 controls cellular and systemic responses to oxygen availability and coordinates up-regulation of genes involved in many pathways concerned with tumour growth and metabolism including angiogenesis, glucose and energy metabolism, cellular proliferation, differentiation and viability, apoptosis, ph regulation and matrix metabolism. |
2003-07-15 |
2023-08-12 |
Not clear |
| Shaker A Mous. Anti-integrin as novel drug-discovery targets: potential therapeutic and diagnostic implications. Current opinion in chemical biology. vol 6. issue 4. 2003-07-11. PMID:12133730. |
the role of integrin and extracellular matrix proteins in various pathological processes (including angiogenesis, thrombosis, apoptosis and cell migration and proliferation), leading to both acute and chronic disease states (e.g. |
2003-07-11 |
2023-08-12 |
Not clear |
| Franco Silvestris, Paola Cafforio, Daniela Grinello, Franco Dammacc. Upregulation of erythroblast apoptosis by malignant plasma cells: a new pathogenetic mechanism of anemia in multiple myeloma. Reviews in clinical and experimental hematology. vol Suppl 1. 2003-07-11. PMID:12735214. |
besides the altered cytokine network, chronic erythropoietn deficiency, blood loss and hemolysis, we have shown that deregulated myeloma cell apoptosis contributes to progressive destruction of the erythroid matrix by inducing erythroblast cytotoxicity. |
2003-07-11 |
2023-08-12 |
Not clear |
| Pradip Nair, Kumaravel Somasundaram, Sudhir Krishn. Activated Notch1 inhibits p53-induced apoptosis and sustains transformation by human papillomavirus type 16 E6 and E7 oncogenes through a PI3K-PKB/Akt-dependent pathway. Journal of virology. vol 77. issue 12. 2003-07-03. PMID:12768030. |
acn1 signaling has pleiotropic effects, and suggested oncogenic roles include driving proliferation through cyclin d1 or the generation of resistance to apoptosis on matrix withdrawal through a phosphatidylinositol 3-kinase (pi3k)-pkb/akt-dependent pathway. |
2003-07-03 |
2023-08-12 |
human |
| Dhyan Chandra, Dean G Tan. Mitochondrially localized active caspase-9 and caspase-3 result mostly from translocation from the cytosol and partly from caspase-mediated activation in the organelle. Lack of evidence for Apaf-1-mediated procaspase-9 activation in the mitochondria. The Journal of biological chemistry. vol 278. issue 19. 2003-06-30. PMID:12611882. |
cytochrome c and the mitochondrial matrix protein hsp60 are also rapidly released to the cytosol early during apoptosis. |
2003-06-30 |
2023-08-12 |
Not clear |
| Ruud P M Dings, Daisy W J van der Schaft, Balazs Hargittai, Judy Haseman, Arjan W Griffioen, Kevin H May. Anti-tumor activity of the novel angiogenesis inhibitor anginex. Cancer letters. vol 194. issue 1. 2003-06-30. PMID:12706859. |
anginex is a novel cytokine-like peptide with potent anti-angiogenic activity, which operates specifically against angiogenically-activated endothelial cells via prevention of cell adhesion/migration on the extracellular matrix and subsequent induction of apoptosis. |
2003-06-30 |
2023-08-12 |
mouse |
| Walter Nicke. The mystery of nonclassical protein secretion. A current view on cargo proteins and potential export routes. European journal of biochemistry. vol 270. issue 10. 2003-06-27. PMID:12752430. |
beyond solving a fundamental problem in current cell biology, the molecular analysis of these processes is of major biomedical importance as these export routes are taken by proteins such as angiogenic growth factors, inflammatory cytokines, components of the extracellular matrix which regulate cell differentiation, proliferation and apoptosis, viral proteins, and parasite surface proteins potentially involved in host infection. |
2003-06-27 |
2023-08-12 |
Not clear |
| Jeffrey W Streb, Joseph M Mian. Retinoids: pleiotropic agents of therapy for vascular diseases? Current drug targets. Cardiovascular & haematological disorders. vol 3. issue 1. 2003-06-24. PMID:12769644. |
a growing number of in vitro studies have reported desirable effects of retinoids on cell migration, proliferation, apoptosis, matrix remodeling, fibrinolysis, coagulation, and inflammation, all of which impinge on vascular disease. |
2003-06-24 |
2023-08-12 |
human |
| Isabel Zvibel, Françoise Smets, Humberto Sorian. Anoikis: roadblock to cell transplantation? Cell transplantation. vol 11. issue 7. 2003-06-18. PMID:12518889. |
apoptosis occurring due to cell detachment from the extracellular matrix is a phenomenon termed "anoikis." |
2003-06-18 |
2023-08-12 |
Not clear |
| Andréa M A Costa, Beatriz Tuchweber, Thierry Lamireau, Ibrahim M Yousef, Charles Balabaud, Jean Rosenbaum, Alexis Desmoulièr. Role of apoptosis in the remodeling of cholestatic liver injury following release of the mechanical stress. Virchows Archiv : an international journal of pathology. vol 442. issue 4. 2003-06-17. PMID:12715172. |
after anastomosis or decompression, apoptosis of both fibroblastic and bile ductular cells increased greatly and was accompanied by ultrastructural features of extracellular matrix degradation. |
2003-06-17 |
2023-08-12 |
rat |
| David J Hunter, Tim D Specto. The role of bone metabolism in osteoarthritis. Current rheumatology reports. vol 5. issue 1. 2003-06-10. PMID:12590880. |
the increased turnover of collagen, in particular, may affect the biomechanical competence of bone and is driven by a number of processes, including osteoblast phenotypic expression, chondrocyte apoptosis, matrix metalloproteinases, and growth factors. |
2003-06-10 |
2023-08-12 |
Not clear |
| Suresh C Tyagi, Brian D Hoi. Metalloproteinase in myocardial adaptation and maladaptation. Journal of cardiovascular pharmacology and therapeutics. vol 7. issue 4. 2003-06-04. PMID:12490970. |
ventricular remodeling is a compensatory response that comprises the processes of apoptosis, muscle cell hypertrophy, and rearrangement of the extracellular matrix fibers connecting the muscles. |
2003-06-04 |
2023-08-12 |
Not clear |
| Yuko Ibuki, Rensuke Got. The antiapoptotic effect of low-dose UVB irradiation in NIH3T3 cells involves caspase inhibitions. Photochemistry and photobiology. vol 77. issue 3. 2003-05-27. PMID:12685655. |
however, we have previously found that low doses of uvb irradiation inhibited apoptosis induced by both serum starvation and lack of extracellular matrix, involving a significant inhibition of caspase-3/7 activation. |
2003-05-27 |
2023-08-12 |
Not clear |
| Thierry Vincent, Laurence Molina, Lucile Espert, Nadir Mecht. Hyaluronan, a major non-protein glycosaminoglycan component of the extracellular matrix in human bone marrow, mediates dexamethasone resistance in multiple myeloma. British journal of haematology. vol 121. issue 2. 2003-05-27. PMID:12694247. |
in this study, hyaluronan (ha), a major non-protein glycosaminoglycan component of the extracellular matrix in mammalian bone marrow, acted as a survival factor against dexamethasone (dex)-induced apoptosis in mm cell lines. |
2003-05-27 |
2023-08-12 |
human |
| Tomohiko Fukuda, Lida Guo, Xiaohua Shi, Chuanyue W. CH-ILKBP regulates cell survival by facilitating the membrane translocation of protein kinase B/Akt. The Journal of cell biology. vol 160. issue 7. 2003-05-23. PMID:12654898. |
cells that are depleted of ch-ilkbp undergo extensive apoptosis despite the presence of cell-extracellular matrix contacts and soluble growth factors. |
2003-05-23 |
2023-08-12 |
Not clear |
| F Grabellus, C Schmid, B Levkau, J Stypmann, H H Scheld, H A Bab. [Myocardial alterations with mechanical left ventricular assist devices]. Der Pathologe. vol 24. issue 2. 2003-05-23. PMID:12673495. |
various molecular pathways of the human myocardium associated with apoptosis, response to stress, or matrix changes are known to be altered under conditions of heart failure, and some have been shown to be reversibly regulated during left ventricular mechanical support, suggesting that the descriptive term "reverse remodeling" is, at least in parts, a reversible mechanism. |
2003-05-23 |
2023-08-12 |
human |