| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Schliephak. Prognostic relevance of molecular markers of oral cancer--a review. International journal of oral and maxillofacial surgery. vol 32. issue 3. 2003-08-11. PMID:12767868. |
tumour markers were allocated to four groups according to their function: (i) enhancement of tumour growth: cell cycle acceleration and proliferation, (ii) tumour suppression and anti-tumour defence: immune response and apoptosis, (iii) angiogenesis, (iv) tumour invasion and metastatic potential: adhesion molecules and matrix degradation. |
2003-08-11 |
2023-08-12 |
Not clear |
| Tsutomu Yoshikaw. [Alterations in sympathoadrenal system in congestive heart failure]. Nihon rinsho. Japanese journal of clinical medicine. vol 61. issue 5. 2003-08-08. PMID:12754996. |
mechanisms underlying such adverse effects involve multiple biological events including production of oxygen free radicals, cytokines, matrix metalloproteinase, apoptosis, cardiac hypertrophy, and chamber remodeling as well as energy expenditure. |
2003-08-08 |
2023-08-12 |
mouse |
| E Grimaud, F Blanchard, C Charrier, F Gouin, F Redini, D Heyman. Leukaemia inhibitory factor (lif) is expressed in hypertrophic chondrocytes and vascular sprouts during osteogenesis. Cytokine. vol 20. issue 5. 2003-08-01. PMID:12550107. |
avascular cartilage is replaced by highly vascularized bone tissue during endochondral ossification, a process involving capillary invasion of calcified hypertrophic cartilage in association with apoptosis of hypertrophic chondrocytes, degradation of cartilage matrix and deposition of bone matrix. |
2003-08-01 |
2023-08-12 |
human |
| Keiji Inoue, Masakazu Chikazawa, Satoshi Fukata, Chiaki Yoshikawa, Taro Shui. Docetaxel enhances the therapeutic effect of the angiogenesis inhibitor TNP-470 (AGM-1470) in metastatic human transitional cell carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 9. issue 2. 2003-08-01. PMID:12576464. |
the combination of tnp-470 and docetaxel inhibited intratumor neovascularization, the expression of bfgf and matrix metalloproteinases type-9 compared with controls (p < 0.005), and enhanced apoptosis in tumors compared with each therapy alone (p < 0.005). |
2003-08-01 |
2023-08-12 |
mouse |
| Keiji Inoue, Masakazu Chikazawa, Satoshi Fukata, Chiaki Yoshikawa, Taro Shui. Docetaxel enhances the therapeutic effect of the angiogenesis inhibitor TNP-470 (AGM-1470) in metastatic human transitional cell carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 9. issue 2. 2003-08-01. PMID:12576464. |
these effects are mediated, in part, by the complementary cytotoxicities of angiogenesis inhibition, down-regulation of bfgf and matrix metalloproteinases type-9, and induction of apoptosis. |
2003-08-01 |
2023-08-12 |
mouse |
| Henry O Trowbridg. Pulp biology: progress during the past 25 years. Australian endodontic journal : the journal of the Australian Society of Endodontology Inc. vol 29. issue 1. 2003-08-01. PMID:12772964. |
topics to be considered include: differentiation of odontoblasts, dentine matrix proteins, extent of odontoblast processes, pulpal stem cells, apoptosis, interstitial fluid pressure in normal and inflamed pulps, class ii antigen-presenting cells of the pulp, cytokines, antibodies, pulpal calcifications, tertiary dentine and pulpal inflammation associated with bacterial contamination of exposed dentine beneath restorations. |
2003-08-01 |
2023-08-12 |
Not clear |
| Laurent Baud, Bruno Fouqueray, Agnès Bellocq, Julie Peltie. [Calpains participate in inflammatory reaction development]. Medecine sciences : M/S. vol 19. issue 1. 2003-07-31. PMID:12836194. |
they could participate in cellular responses such as apoptosis, proliferation, extracellular matrix adhesion and motility, that have relevance to pathophysiological issues in ischemia, inflammation, repair and tumor progression. |
2003-07-31 |
2023-08-12 |
Not clear |
| Nathalie Ortega, Danielle Behonick, Dominique Stickens, Zena Wer. How proteases regulate bone morphogenesis. Annals of the New York Academy of Sciences. vol 995. 2003-07-22. PMID:12814943. |
apoptosis of the terminal hypertrophic chondrocytes, degradation of the cartilage matrix, and deposition of bone matrix by osteoblasts accompanies neovascularization of the growth plate. |
2003-07-22 |
2023-08-12 |
mouse |
| Q Yao, S Wang, A Gambotto, J C Glorioso, C H Evans, P D Robbins, S C Ghivizzani, T J Oligin. Intra-articular adenoviral-mediated gene transfer of trail induces apoptosis of arthritic rabbit synovium. Gene therapy. vol 10. issue 12. 2003-07-21. PMID:12776164. |
in a rabbit model of arthritis, intra-articular gene transfer of trail induced apoptosis in cells within the synovial lining, reduced leukocytic infiltration and stimulated new matrix synthesis by cartilage. |
2003-07-21 |
2023-08-12 |
human |
| Jirí Ehrmann, Antonín Kolek, Rostislav Kod'ousek, Jana Zapletalová, Sona Lísová, Paul Gerard Murray, Jirí Drábek, Zdenek Kolá. Immunohistochemical study of the apoptotic mechanisms in the intestinal mucosa during children's coeliac disease. Virchows Archiv : an international journal of pathology. vol 442. issue 5. 2003-07-17. PMID:12698366. |
mechanisms leading to morphological changes of the small intestine during coeliac disease (cd) are not yet completely recognized; however, two main processes have been suggested recently: remodeling of mucosa by matrix metalloproteinases, and mucosal atrophy by apoptosis. |
2003-07-17 |
2023-08-12 |
Not clear |
| Mika Suzuki, Hiroshi Kobayashi, Yoshiko Tanaka, Yasuyuki Hirashima, Naohiro Kanayama, Yuji Takei, Yasushi Saga, Mitsuaki Suzuki, Hiroshi Itoh, Toshihiko Tera. Bikunin target genes in ovarian cancer cells identified by microarray analysis. The Journal of biological chemistry. vol 278. issue 17. 2003-07-16. PMID:12571229. |
these include transcriptional regulators, oncogenes/tumor suppressor genes, signaling molecules, growth/cell cycle, invasion/metastasis, cytokines, apoptosis, ion channels, extracellular matrix proteins, as well as some proteases. |
2003-07-16 |
2023-08-12 |
human |
| M Stubbs, C L Bashford, J R Griffith. Understanding the tumor metabolic phenotype in the genomic era. Current molecular medicine. vol 3. issue 1. 2003-07-15. PMID:12558074. |
hif-1 controls cellular and systemic responses to oxygen availability and coordinates up-regulation of genes involved in many pathways concerned with tumour growth and metabolism including angiogenesis, glucose and energy metabolism, cellular proliferation, differentiation and viability, apoptosis, ph regulation and matrix metabolism. |
2003-07-15 |
2023-08-12 |
Not clear |
| Shaker A Mous. Anti-integrin as novel drug-discovery targets: potential therapeutic and diagnostic implications. Current opinion in chemical biology. vol 6. issue 4. 2003-07-11. PMID:12133730. |
the role of integrin and extracellular matrix proteins in various pathological processes (including angiogenesis, thrombosis, apoptosis and cell migration and proliferation), leading to both acute and chronic disease states (e.g. |
2003-07-11 |
2023-08-12 |
Not clear |
| Franco Silvestris, Paola Cafforio, Daniela Grinello, Franco Dammacc. Upregulation of erythroblast apoptosis by malignant plasma cells: a new pathogenetic mechanism of anemia in multiple myeloma. Reviews in clinical and experimental hematology. vol Suppl 1. 2003-07-11. PMID:12735214. |
besides the altered cytokine network, chronic erythropoietn deficiency, blood loss and hemolysis, we have shown that deregulated myeloma cell apoptosis contributes to progressive destruction of the erythroid matrix by inducing erythroblast cytotoxicity. |
2003-07-11 |
2023-08-12 |
Not clear |
| Pradip Nair, Kumaravel Somasundaram, Sudhir Krishn. Activated Notch1 inhibits p53-induced apoptosis and sustains transformation by human papillomavirus type 16 E6 and E7 oncogenes through a PI3K-PKB/Akt-dependent pathway. Journal of virology. vol 77. issue 12. 2003-07-03. PMID:12768030. |
acn1 signaling has pleiotropic effects, and suggested oncogenic roles include driving proliferation through cyclin d1 or the generation of resistance to apoptosis on matrix withdrawal through a phosphatidylinositol 3-kinase (pi3k)-pkb/akt-dependent pathway. |
2003-07-03 |
2023-08-12 |
human |
| Dhyan Chandra, Dean G Tan. Mitochondrially localized active caspase-9 and caspase-3 result mostly from translocation from the cytosol and partly from caspase-mediated activation in the organelle. Lack of evidence for Apaf-1-mediated procaspase-9 activation in the mitochondria. The Journal of biological chemistry. vol 278. issue 19. 2003-06-30. PMID:12611882. |
cytochrome c and the mitochondrial matrix protein hsp60 are also rapidly released to the cytosol early during apoptosis. |
2003-06-30 |
2023-08-12 |
Not clear |
| Ruud P M Dings, Daisy W J van der Schaft, Balazs Hargittai, Judy Haseman, Arjan W Griffioen, Kevin H May. Anti-tumor activity of the novel angiogenesis inhibitor anginex. Cancer letters. vol 194. issue 1. 2003-06-30. PMID:12706859. |
anginex is a novel cytokine-like peptide with potent anti-angiogenic activity, which operates specifically against angiogenically-activated endothelial cells via prevention of cell adhesion/migration on the extracellular matrix and subsequent induction of apoptosis. |
2003-06-30 |
2023-08-12 |
mouse |
| Walter Nicke. The mystery of nonclassical protein secretion. A current view on cargo proteins and potential export routes. European journal of biochemistry. vol 270. issue 10. 2003-06-27. PMID:12752430. |
beyond solving a fundamental problem in current cell biology, the molecular analysis of these processes is of major biomedical importance as these export routes are taken by proteins such as angiogenic growth factors, inflammatory cytokines, components of the extracellular matrix which regulate cell differentiation, proliferation and apoptosis, viral proteins, and parasite surface proteins potentially involved in host infection. |
2003-06-27 |
2023-08-12 |
Not clear |
| Jeffrey W Streb, Joseph M Mian. Retinoids: pleiotropic agents of therapy for vascular diseases? Current drug targets. Cardiovascular & haematological disorders. vol 3. issue 1. 2003-06-24. PMID:12769644. |
a growing number of in vitro studies have reported desirable effects of retinoids on cell migration, proliferation, apoptosis, matrix remodeling, fibrinolysis, coagulation, and inflammation, all of which impinge on vascular disease. |
2003-06-24 |
2023-08-12 |
human |
| Isabel Zvibel, Françoise Smets, Humberto Sorian. Anoikis: roadblock to cell transplantation? Cell transplantation. vol 11. issue 7. 2003-06-18. PMID:12518889. |
apoptosis occurring due to cell detachment from the extracellular matrix is a phenomenon termed "anoikis." |
2003-06-18 |
2023-08-12 |
Not clear |