| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M A Karsdal, T A Andersen, L Bonewald, C Christianse. Matrix metalloproteinases (MMPs) safeguard osteoblasts from apoptosis during transdifferentiation into osteocytes: MT1-MMP maintains osteocyte viability. DNA and cell biology. vol 23. issue 3. 2004-05-03. PMID:15068585. |
osteoblasts undergo apoptosis or differentiate into either osteocytes or bone-lining cells after termination of bone matrix synthesis. |
2004-05-03 |
2023-08-12 |
mouse |
| M A Karsdal, T A Andersen, L Bonewald, C Christianse. Matrix metalloproteinases (MMPs) safeguard osteoblasts from apoptosis during transdifferentiation into osteocytes: MT1-MMP maintains osteocyte viability. DNA and cell biology. vol 23. issue 3. 2004-05-03. PMID:15068585. |
in this study, we investigated the role of matrix metalloproteinases (mmps) in differentiation of osteoblasts, bone formation, transdifferentiation into osteocytes, and osteocyte apoptosis. |
2004-05-03 |
2023-08-12 |
mouse |
| Mohamed H Lareef, Quivo Tahin, Joon Song, Irma H Russo, Dana Mihaila, Carolyn M Slater, Binaifer Balsara, Joseph R Testa, Dominique Broccoli, Jennifer V Grobelny, Gil Mor, Andrew Cuthbert, Jose Russ. Chromosome 17p13.2 transfer reverts transformation phenotypes and Fas-mediated apoptosis in breast epithelial cells. Molecular carcinogenesis. vol 39. issue 4. 2004-04-30. PMID:15057875. |
transformation of the human breast epithelial cells (hbec) mcf-10f with the carcinogen benz(a)pyrene (bp) into bp1-e cells resulted in the loss of the chromosome 17 p13.2 locus (d17s796 marker) and formation of colonies in agar-methocel (colony efficiency (ce)), loss of ductulogenic capacity in collagen matrix, and resistance to anti-fas monoclonal antibody (mab)-induced apoptosis. |
2004-04-30 |
2023-08-12 |
mouse |
| Dietlind Zohlnhöfer, Thomas G Nührenberg, Franz-Josef Neumann, Thomas Richter, Andreas E May, Roland Schmidt, Katja Denker, Matthias A Clauss, Albert Schömig, Patrick A Baeuerl. Rapamycin effects transcriptional programs in smooth muscle cells controlling proliferative and inflammatory properties. Molecular pharmacology. vol 65. issue 4. 2004-04-21. PMID:15044617. |
in addition, we found changes in the expression of genes associated with replication, apoptosis, and extracellular matrix formation. |
2004-04-21 |
2023-08-12 |
human |
| Dietlind Zohlnhöfer, Thomas G Nührenberg, Franz-Josef Neumann, Thomas Richter, Andreas E May, Roland Schmidt, Katja Denker, Matthias A Clauss, Albert Schömig, Patrick A Baeuerl. Rapamycin effects transcriptional programs in smooth muscle cells controlling proliferative and inflammatory properties. Molecular pharmacology. vol 65. issue 4. 2004-04-21. PMID:15044617. |
the effects reported here of rapamycin on the down-regulation of genes involved in cell cycle progression, apoptosis, proliferation, and extracellular matrix formation in casmcs provide an explanation of how rapamycin reduces casmc proliferation. |
2004-04-21 |
2023-08-12 |
human |
| R D Catalano, A Yanaihara, A L Evans, D Rocha, A Prentice, S Saidi, C G Print, D S Charnock-Jones, A M Sharkey, S K Smit. The effect of RU486 on the gene expression profile in an endometrial explant model. Molecular human reproduction. vol 9. issue 8. 2004-04-16. PMID:12837923. |
endometrial biopsies from five normal fertile women at mid-secretory phase were cultured in the presence of estradiol and progesterone with or without ru486 for 12 h. cdna arrays were produced containing approximately 1000 sequence-verified clones which included genes known to be important in angiogenesis, apoptosis, cell signalling, extracellular matrix remodelling and cell cycle regulation. |
2004-04-16 |
2023-08-12 |
Not clear |
| Begoña Santiago, María Galindo, Guillermo Palao, José L Pablo. Intracellular regulation of Fas-induced apoptosis in human fibroblasts by extracellular factors and cycloheximide. Journal of immunology (Baltimore, Md. : 1950). vol 172. issue 1. 2004-04-02. PMID:14688367. |
exogenous growth factors, cytokines, and adherence to the extracellular matrix shifted the balance of flip-caspase-8 proteins and modified the susceptibility of df to fas- or fas-chx-induced apoptosis. |
2004-04-02 |
2023-08-12 |
human |
| Jiale He, Linda G Bau. Presentation of galectin-1 by extracellular matrix triggers T cell death. The Journal of biological chemistry. vol 279. issue 6. 2004-04-01. PMID:14617626. |
t cell apoptosis can be initiated by a variety of triggers, including galectin-1, a soluble, secreted lectin that binds to oligosaccharide ligands on cell surface glycoproteins, or to oligosaccharide ligands on extracellular matrix glycoproteins in tissue stroma. |
2004-04-01 |
2023-08-12 |
Not clear |
| Ryuzaburo Kanazawa, Daizo Yoshida, Hiroshi Takahashi, Yuichi Sugisaki, Satoru Suzuki, Akira Teramot. Drug-induced apoptosis by a matrix metalloproteinase inhibitor, SI-27 on human malignant glioma cell lines; in vitro study. Journal of neuro-oncology. vol 66. issue 1-2. 2004-04-01. PMID:15015774. |
drug-induced apoptosis by a matrix metalloproteinase inhibitor, si-27 on human malignant glioma cell lines; in vitro study. |
2004-04-01 |
2023-08-12 |
human |
| H Paul Ehrlich, Tammy Die. Role for gap junctional intercellular communications in wound repair. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 11. issue 6. 2004-03-26. PMID:14617290. |
the participation of fibroblasts in wound repair is a coordinated effort requiring sequential cellular modulations to behavior including migration (entering), proliferation (increasing cell numbers), synthesis (depositing a collagen matrix), remodeling (organizing collagen), transformation into myofibroblasts, apoptosis, and elimination. |
2004-03-26 |
2023-08-12 |
rat |
| Sam J Wadsworth, Anette M Freyer, Randolph L Corteling, Ian P Hal. Biosynthesized matrix provides a key role for survival signaling in bronchial epithelial cells. American journal of physiology. Lung cellular and molecular physiology. vol 286. issue 3. 2004-03-26. PMID:14617518. |
beas-2b cells secrete their own biosynthesized matrix (bsm), which also provides rescue from apoptosis. |
2004-03-26 |
2023-08-12 |
Not clear |
| Sandra Hodge, Greg Hodge, Raffaele Scicchitano, Paul N Reynolds, Mark Holme. Alveolar macrophages from subjects with chronic obstructive pulmonary disease are deficient in their ability to phagocytose apoptotic airway epithelial cells. Immunology and cell biology. vol 81. issue 4. 2004-03-19. PMID:12848850. |
while chronic inflammation, extracellular matrix destruction and increased airway epithelial cell apoptosis are reported in chronic obstructive pulmonary disease, the understanding of the basic pathogenesis of the disease is limited and there are no effective treatments. |
2004-03-19 |
2023-08-12 |
human |
| Emmanuelle Charafe-Jauffret, François Bertucci, Olivier Ramuz, Elisabeth Devilard, Philippe Gaulard, Pierre Brousset, Remi Houlgatte, J Hassoun, Daniel Birnbaum, Luc Xerr. Characterization of Hodgkin's lymphoma-like undifferentiated carcinoma of the nasopharyngeal type as a particular UCNT subtype mimicking Hodgkin's lymphoma. International journal of oncology. vol 23. issue 1. 2004-03-18. PMID:12792781. |
significant differences were detected in the expression of genes involved in the matrix modelling, angiogenesis, apoptosis and regulation of the th-2 interleukins. |
2004-03-18 |
2023-08-12 |
Not clear |
| Qi Qian, Larry W Hunter, Ming Li, Miguel Marin-Padilla, Y S Prakash, Stefan Somlo, Peter C Harris, Vicente E Torres, Gary C Siec. Pkd2 haploinsufficiency alters intracellular calcium regulation in vascular smooth muscle cells. Human molecular genetics. vol 12. issue 15. 2004-03-16. PMID:12874107. |
based on these findings, and the fact that [ca(2+)](i) signaling is essential to the regulation of contraction, production and secretion of extracellular matrix, cellular proliferation and apoptosis, we propose that the abnormal intracellular ca(2+) regulation associated with pkd2 haploinsufficiency is directly related to the vascular phenotype. |
2004-03-16 |
2023-08-12 |
mouse |
| Verena M Dirsch, Irina M Müller, Sören T Eichhorst, George R Pettit, Yoshiaki Kamano, Masuo Inoue, Jun-Ping Xu, Yoshitatsu Ichihara, Gerhard Wanner, Angelika M Vollma. Cephalostatin 1 selectively triggers the release of Smac/DIABLO and subsequent apoptosis that is characterized by an increased density of the mitochondrial matrix. Cancer research. vol 63. issue 24. 2004-03-11. PMID:14695204. |
cephalostatin 1 selectively triggers the release of smac/diablo and subsequent apoptosis that is characterized by an increased density of the mitochondrial matrix. |
2004-03-11 |
2023-08-12 |
Not clear |
| Reiko Inagi, Masaomi Nangaku, Toshio Miyata, Kiyoshi Kurokaw. Mesangial cell-predominant functional gene, megsin. Clinical and experimental nephrology. vol 7. issue 2. 2004-03-09. PMID:14586725. |
megsin may play a role in the regulation of a wide variety of processes in mesangial cells, such as matrix metabolism, cell proliferation, and apoptosis. |
2004-03-09 |
2023-08-12 |
mouse |
| Sergio Ruiz-Llorente, Jerónimo Bravo, Arancha Cebrián, Alberto Cascón, Marina Pollan, Dolores Tellería, Rocío Letón, Miguel Urioste, Raquel Rodríguez-López, Jose M de Campos, María J Muñoz, Carmen Lacambra, Javier Benítez, Mercedes Robled. Genetic characterization and structural analysis of VHL Spanish families to define genotype-phenotype correlations. Human mutation. vol 23. issue 2. 2004-03-08. PMID:14722919. |
this gene, located in the 3p25-26 chromosome, is a tumor suppressor gene associated with the inhibition of angiogenesis and apoptosis, cell cycle exit, fibronectin matrix assembly, and proteolysis. |
2004-03-08 |
2023-08-12 |
Not clear |
| Z Dzierzewicz, A Orchel, B Parfiniewicz, L Weglarz, J Stojko, G Swierczek-Zieba, T Wilczo. The delay of anoikis due to the inhibition of protein tyrosine dephosphorylation enables the maintenance of normal rat colonocyte primary culture. Folia histochemica et cytobiologica. vol 41. issue 4. 2004-03-04. PMID:14677762. |
apoptosis induced by detachment of cells from the extracellular matrix (anoikis) appears to be one of the main obstacles in attempts to establish long-term primary culture of normal colonocytes. |
2004-03-04 |
2023-08-12 |
rat |
| R Bendardaf, H Lamlum, P Vihinen, R Ristamäki, J Laine, S Pyrhöne. Low collagenase-1 (MMP-1) and MT1-MMP expression levels are favourable survival markers in advanced colorectal carcinoma. Oncology. vol 65. issue 4. 2004-02-27. PMID:14707454. |
extracellular matrix degradation is required for invasive growth and metastasis formation in colorectal carcinoma; therefore, we examined matrix metalloproteinases expression (mmp-1, mmp-13 and mt1-mmp) and apoptosis in tumours from 49 patients with advanced colorectal disease. |
2004-02-27 |
2023-08-12 |
Not clear |
| Arantxa González, Begoña López, Javier Díe. Fibrosis in hypertensive heart disease: role of the renin-angiotensin-aldosterone system. The Medical clinics of North America. vol 88. issue 1. 2004-02-24. PMID:14871052. |
structural homogeneity of cardiac tissue is governed by mechanical and humoral factors that regulate cell growth, apoptosis, phenotype, and extracellular matrix turnover. |
2004-02-24 |
2023-08-12 |
Not clear |