| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jason B Garrison, Natasha Kypriano. Novel targeting of apoptosis pathways for prostate cancer therapy. Current cancer drug targets. vol 4. issue 1. 2004-08-05. PMID:14965270. |
most epithelial and endothelial cells undergo apoptosis when they loose contact with the extracellular matrix (ecm), via the phenomenon of anoikis. |
2004-08-05 |
2023-08-12 |
Not clear |
| Hélène Chanut-Delalande, Christelle Bonod-Bidaud, Sylvain Cogne, Marilyne Malbouyres, Francesco Ramirez, Agnès Fichard, Florence Ruggier. Development of a functional skin matrix requires deposition of collagen V heterotrimers. Molecular and cellular biology. vol 24. issue 13. 2004-08-04. PMID:15199158. |
furthermore, reduced thickness of the basement membranes underlying the epidermis and increased apoptosis of the stromal fibroblasts in pn/pn skin strongly indicate additional roles of collagen v in the development of a functional skin matrix. |
2004-08-04 |
2023-08-12 |
mouse |
| Takao Nakagawa, Joan P Schwart. Gene expression patterns in in vivo normal adult astrocytes compared with cultured neonatal and normal adult astrocytes. Neurochemistry international. vol 45. issue 2-3. 2004-07-26. PMID:15145538. |
the cultured neonatal astrocytes expressed many genes at a two-fold or greater level than their expression in cultured adult astrocytes, including genes in the adhesion, cytoskeleton, and extracellular matrix (ecm) family, signal transduction genes, and genes related to apoptosis, dna-binding, and cell cycle regulation. |
2004-07-26 |
2023-08-12 |
rat |
| Shang-Tian Yang, Jun Luo, Chunnuan Che. A fibrous-bed bioreactor for continuous production of monoclonal antibody by hybridoma. Advances in biochemical engineering/biotechnology. vol 87. 2004-07-22. PMID:15217104. |
it was also found that the cells present inside the fibrous matrix had a higher viability and lower apoptosis than those present in the liquid suspension, indicating that the fibrous matrix had selectively retained healthy, nonapoptotic cells and dislodged apoptotic and dead cells; this also might have contributed to the stability of the long-term culture. |
2004-07-22 |
2023-08-12 |
Not clear |
| Chunnuan Chen, Kathryn Chen, Shang-Tian Yan. Effects of three-dimensional culturing on osteosarcoma cells grown in a fibrous matrix: analyses of cell morphology, cell cycle, and apoptosis. Biotechnology progress. vol 19. issue 5. 2004-07-21. PMID:14524722. |
effects of three-dimensional culturing on osteosarcoma cells grown in a fibrous matrix: analyses of cell morphology, cell cycle, and apoptosis. |
2004-07-21 |
2023-08-12 |
Not clear |
| Chunnuan Chen, Kathryn Chen, Shang-Tian Yan. Effects of three-dimensional culturing on osteosarcoma cells grown in a fibrous matrix: analyses of cell morphology, cell cycle, and apoptosis. Biotechnology progress. vol 19. issue 5. 2004-07-21. PMID:14524722. |
osteosarcoma cells were cultured in stirred tank bioreactors with either a fibrous matrix or nonporous microcarriers to study the environmental effects on cell growth, morphology, cell cycle, and apoptosis. |
2004-07-21 |
2023-08-12 |
Not clear |
| Chunnuan Chen, Kathryn Chen, Shang-Tian Yan. Effects of three-dimensional culturing on osteosarcoma cells grown in a fibrous matrix: analyses of cell morphology, cell cycle, and apoptosis. Biotechnology progress. vol 19. issue 5. 2004-07-21. PMID:14524722. |
the three-dimensional (3-d) fibrous culture had better cell growth and higher metabolic rates than the two-dimensional (2-d) microcarrier culture because cells in the fibrous matrix were protected from shear stress and had lower apoptosis and cell death even under suboptimal conditions (e.g., nutrient depletion). |
2004-07-21 |
2023-08-12 |
Not clear |
| Antonio De Luca, Maria De Falco, Valentina Fedele, Luigi Cobellis, Annunziata Mastrogiacomo, Vincenza Laforgia, Ioana L Tuduce, Mara Campioni, Domenico Giraldi, Marco G Paggi, Alfonso Bald. The serine protease HtrA1 is upregulated in the human placenta during pregnancy. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 52. issue 7. 2004-07-20. PMID:15208355. |
it is generally accepted that the simultaneous activity of proteins involved in cell proliferation, apoptosis, and extracellular matrix degradation plays an important role in correct placental development. |
2004-07-20 |
2023-08-12 |
human |
| Kosei Arimura, Naomichi Arima, Kakushi Matsushita, Hideo Ohtsubo, Hiroshi Fujiwara, Toshimasa Kukita, Atsuo Ozaki, Takafumi Hagiwara, Heiichiro Hamada, Kohichiro Yoshino, Chuwa Te. Matrix metalloproteinase inhibitor reduces apoptosis induction of bone marrow cells in MDS-RA. European journal of haematology. vol 73. issue 1. 2004-07-15. PMID:15182333. |
matrix metalloproteinase inhibitor reduces apoptosis induction of bone marrow cells in mds-ra. |
2004-07-15 |
2023-08-12 |
Not clear |
| Xiaoying Zhou, Frank R Murphy, Nitu Gehdu, Junlong Zhang, John P Iredale, R Christopher Benyo. Engagement of alphavbeta3 integrin regulates proliferation and apoptosis of hepatic stellate cells. The Journal of biological chemistry. vol 279. issue 23. 2004-07-08. PMID:15044441. |
stellate cells incubated with active recombinant matrix metalloproteinase-9 showed enhanced apoptosis, while cells treated with a synthetic inhibitor of this protease showed increased survival. |
2004-07-08 |
2023-08-12 |
human |
| Xiaoying Zhou, Frank R Murphy, Nitu Gehdu, Junlong Zhang, John P Iredale, R Christopher Benyo. Engagement of alphavbeta3 integrin regulates proliferation and apoptosis of hepatic stellate cells. The Journal of biological chemistry. vol 279. issue 23. 2004-07-08. PMID:15044441. |
degradation of alpha(v)beta(3) ligands surrounding activated stellate cells during resolution of liver fibrosis might decrease alpha(v)beta(3) integrin ligation, suppressing stellate cell proliferation and inducing a fibrolytic, matrix metalloproteinase-secreting phenotype that may prime stellate cells for apoptosis. |
2004-07-08 |
2023-08-12 |
human |
| Philip B Sugerman, Sara B Faber, Lucy M Willis, Aleksandra Petrovic, George F Murphy, Jacques Pappo, David Silberstein, Marcel R M van den Brin. Kinetics of gene expression in murine cutaneous graft-versus-host disease. The American journal of pathology. vol 164. issue 6. 2004-07-08. PMID:15161652. |
the sequential infiltration and activation of effector cells correlated with the histopathological development of cutaneous gvhd and was accompanied by up-regulated expression of many chemokines and their receptors (cxcl-1, -2, -9, and -10; ccl-2, -5, -6, -7, -8, -9, -11, and -19; ccr-1 and ccr-5), adhesion molecules (icam-1, cd18, ly69, psgl-1, vcam-1), molecules involved in antigen processing and presentation (tap1 and tap2, mhc class i and ii, cd80), regulators of apoptosis (granzyme b, caspase 7, bak1, bax, and bclii), interferon-inducible genes (stat1, irf-1, iigp, gtpi, igtp, ifi202a), stimulators of fibroblast proliferation and matrix synthesis (interleukin-1beta, transforming growth factor-beta1), and markers of keratinocyte proliferation (keratins 5 and 6), and differentiation (small proline-rich proteins 2e and 1b). |
2004-07-08 |
2023-08-12 |
mouse |
| A P Sutter, M Zeitz, H Scherüb. Recent results in understanding molecular pathways in the medical treatment of esophageal and gastric cancer. Onkologie. vol 27. issue 1. 2004-07-07. PMID:15007244. |
therapeutic strategies discussed include agents targeting the epidermal growth factor receptor (egfr) family, the mitogen-activated protein kinase (mapk) pathway, regulators of apoptosis (nf-kappab, bcl-2, and the peripheral benzodiazepine receptor), cyclooxygenase-2, the vascular-endothelial growth factor receptor and matrix metalloproteinases. |
2004-07-07 |
2023-08-12 |
Not clear |
| Rongfa Bu, Christopher W Borysenko, Yanan Li, Lihuan Cao, Afsie Sabokbar, Harry C Blai. Expression and function of TNF-family proteins and receptors in human osteoblasts. Bone. vol 33. issue 5. 2004-07-06. PMID:14623051. |
mg63 cells were resistant to apoptosis by exogenous tnfalpha except when grown in media promoting osteoblast-like growth or matrix nodules. |
2004-07-06 |
2023-08-12 |
human |
| Jong Bin Kim, Robert Stein, Mike J O'Har. Three-dimensional in vitro tissue culture models of breast cancer-- a review. Breast cancer research and treatment. vol 85. issue 3. 2004-07-01. PMID:15111767. |
three dimensional in vitro models allow the study of cell-cell and cell-extracellular matrix interactions, in addition to the influence of the microenvironment on cellular differentiation, proliferation, apoptosis and gene expression. |
2004-07-01 |
2023-08-12 |
Not clear |
| Raïd Kassis, Florence Larrous, Jérôme Estaquier, Hervé Bourh. Lyssavirus matrix protein induces apoptosis by a TRAIL-dependent mechanism involving caspase-8 activation. Journal of virology. vol 78. issue 12. 2004-06-29. PMID:15163747. |
lyssavirus matrix protein induces apoptosis by a trail-dependent mechanism involving caspase-8 activation. |
2004-06-29 |
2023-08-12 |
Not clear |
| Raïd Kassis, Florence Larrous, Jérôme Estaquier, Hervé Bourh. Lyssavirus matrix protein induces apoptosis by a TRAIL-dependent mechanism involving caspase-8 activation. Journal of virology. vol 78. issue 12. 2004-06-29. PMID:15163747. |
transfection of cells with the matrix protein induced apoptosis using pathways similar to those described in the context of viral infection. |
2004-06-29 |
2023-08-12 |
Not clear |
| Raïd Kassis, Florence Larrous, Jérôme Estaquier, Hervé Bourh. Lyssavirus matrix protein induces apoptosis by a TRAIL-dependent mechanism involving caspase-8 activation. Journal of virology. vol 78. issue 12. 2004-06-29. PMID:15163747. |
furthermore, our data suggest that the matrix protein of lyssaviruses plays a major role in the early induction of trail-mediated apoptosis by the release of a soluble, active form of trail. |
2004-06-29 |
2023-08-12 |
Not clear |
| Vito Turk, Janko Kos, Boris Tur. Cysteine cathepsins (proteases)--on the main stage of cancer? Cancer cell. vol 5. issue 5. 2004-06-28. PMID:15144947. |
cysteine cathepsins are involved in degradation of extracellular matrix, facilitating growth, invasion, and metastasis of tumor cells, in tumor angiogenesis, in apoptosis, and in events of inflammatory and immune responses. |
2004-06-28 |
2023-08-12 |
mouse |
| Neeraj Vij, Luke Roberts, Sarah Joyce, Shukti Chakravart. Lumican suppresses cell proliferation and aids Fas-Fas ligand mediated apoptosis: implications in the cornea. Experimental eye research. vol 78. issue 5. 2004-06-25. PMID:15051477. |
we further investigated the implications of lumican's proliferation and apoptosis regulatory role in the cornea where lumican is a major component of the stromal matrix. |
2004-06-25 |
2023-08-12 |
mouse |