| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dian J Cao, Yan-Lin Guo, Robert W Colma. Urokinase-type plasminogen activator receptor is involved in mediating the apoptotic effect of cleaved high molecular weight kininogen in human endothelial cells. Circulation research. vol 94. issue 9. 2004-10-07. PMID:15044324. |
we have shown that hka-induced apoptosis correlated with its antiadhesive effect and was regulated by extracellular matrix (ecm) proteins. |
2004-10-07 |
2023-08-12 |
human |
| Tongalp H Tezel, Lucian V Del Priore, Henry J Kapla. Reengineering of aged Bruch's membrane to enhance retinal pigment epithelium repopulation. Investigative ophthalmology & visual science. vol 45. issue 9. 2004-10-07. PMID:15326159. |
the present study was undertaken to determine the effect of cleaning and/or an extracellular matrix (ecm) protein coating on the reattachment, apoptosis, proliferation, and final surface coverage of the transplanted rpe cells. |
2004-10-07 |
2023-08-12 |
human |
| Christina K Yung, Victoria L Halperin, Gordon F Tomaselli, Raimond L Winslo. Gene expression profiles in end-stage human idiopathic dilated cardiomyopathy: altered expression of apoptotic and cytoskeletal genes. Genomics. vol 83. issue 2. 2004-10-06. PMID:14706457. |
these regulated genes take part in diverse cellular processes, including transcription, apoptosis, sarcomeric and cytoskeletal function, remodeling of the extracellular matrix, membrane transport, and metabolism. |
2004-10-06 |
2023-08-12 |
human |
| M Kasper, D Seidel, L Knels, N Morishima, A Neisser, S Bramke, R Koslowsk. Early signs of lung fibrosis after in vitro treatment of rat lung slices with CdCl2 and TGF-beta1. Histochemistry and cell biology. vol 121. issue 2. 2004-10-05. PMID:14752665. |
three days of cdcl(2) exposure in combination with tgf-beta(1) seem to be sufficient to induce lung injury with alterations similar to changes observed in early lung fibrogenesis: (1) extracellular matrix accumulation and myofibroblast transdifferentiation (sirius red staining, collagen type iv, alpha-smooth muscle actin), (2) type i cell injury with loss of type i cell antigens (t1alpha antigen, aquaporin-5, rage), (3) increased apoptosis of pulmonary cells (active caspase-3, vimentin cleavage product v1 of caspase-9), and (4) activation of microvascular endothelial cells (podocalyxin, caveolin-1). |
2004-10-05 |
2023-08-12 |
rat |
| Masaharu Yamazaki, Takemi Akahane, Todd Buck, Hitoshi Yoshiji, Daniel E Gomez, Daniel J Schoeffner, Eijiro Okajima, Steven R Harris, Opal R Bunce, Snorri S Thorgeirsson, Unnur P Thorgeirsso. Long-term exposure to elevated levels of circulating TIMP-1 but not mammary TIMP-1 suppresses growth of mammary carcinomas in transgenic mice. Carcinogenesis. vol 25. issue 9. 2004-10-05. PMID:15166086. |
tissue inhibitor of metalloproteinases-1 (timp-1) regulates matrix metalloproteinase activity, acts as a growth stimulator and inhibits apoptosis. |
2004-10-05 |
2023-08-12 |
mouse |
| Laura de la Cruz, Kristin Steffgen, Andrea Martin, Carli McGee, Helen Hathawa. Apoptosis and involution in the mammary gland are altered in mice lacking a novel receptor, beta1,4-Galactosyltransferase I. Developmental biology. vol 272. issue 2. 2004-10-04. PMID:15282149. |
apoptosis and involution in the mammary gland are altered in mice lacking a novel receptor, beta1,4-galactosyltransferase i. receptor-mediated cell-extracellular matrix (ecm) interactions are critical regulators of cell survival, and perturbing these signaling pathways can disrupt cellular differentiation and function in a variety of tissues, including the mammary gland. |
2004-10-04 |
2023-08-12 |
mouse |
| Sarah Kraus, Gal Levy, Tamar Hanoch, Zvi Naor, Rony Sege. Gonadotropin-releasing hormone induces apoptosis of prostate cancer cells: role of c-Jun NH2-terminal kinase, protein kinase B, and extracellular signal-regulated kinase pathways. Cancer research. vol 64. issue 16. 2004-09-30. PMID:15313914. |
interestingly, extracellular signal-regulated kinase is also activated by gnrh-a, and this occurs via a pathway that involves matrix metalloproteinases and epidermal growth factor receptor, but its activation does not affect jnk activation and the gnrh-a-induced apoptosis. |
2004-09-30 |
2023-08-12 |
Not clear |
| X H Luo, E Y Liao, H J Liao, Y Jin, H D Zhou, G Huan. Recombinant matrix metalloproteinase-14 catalytic domain induces apoptosis in human osteoblastic SaOS-2 cells. Journal of endocrinological investigation. vol 26. issue 11. 2004-09-28. PMID:15008250. |
recombinant matrix metalloproteinase-14 catalytic domain induces apoptosis in human osteoblastic saos-2 cells. |
2004-09-28 |
2023-08-12 |
human |
| Allan Lipto. Pathophysiology of bone metastases: how this knowledge may lead to therapeutic intervention. The journal of supportive oncology. vol 2. issue 3. 2004-09-28. PMID:15328823. |
bisphosphonates bind avidly to the bone matrix, are released during bone resorption, and are subsequently internalized by osteoclasts, where they interfere with biochemical pathways and induce osteoclast apoptosis. |
2004-09-28 |
2023-08-12 |
Not clear |
| A Amour, M Bird, L Chaudry, J Deadman, D Hayes, C Ka. General considerations for proteolytic cascades. Biochemical Society transactions. vol 32. issue Pt 1. 2004-09-24. PMID:14748703. |
four major proteolytic cascades with disease relevance are candidates for therapeutic intervention, namely caspase-mediated apoptosis, blood coagulation, the matrix metalloproteinase cascade and the complement cascade. |
2004-09-24 |
2023-08-12 |
Not clear |
| Jens M Kelm, Elisabeth Ehler, Lars K Nielsen, Stefan Schlatter, Jean-Claude Perriard, Martin Fussenegge. Design of artificial myocardial microtissues. Tissue engineering. vol 10. issue 1-2. 2004-09-24. PMID:15009946. |
embedded in a three-dimensional environment, cells are expected to develop tissue-like higher order intercellular structures (cell-cell contacts, extracellular matrix) that orchestrate cellular functions including proliferation, differentiation, apoptosis, and angiogenesis with unmatched quality. |
2004-09-24 |
2023-08-12 |
mouse |
| Eva Hammar, Géraldine Parnaud, Domenico Bosco, Nadja Perriraz, Kathrin Maedler, Marc Donath, Dominique G Rouiller, Philippe A Halba. Extracellular matrix protects pancreatic beta-cells against apoptosis: role of short- and long-term signaling pathways. Diabetes. vol 53. issue 8. 2004-09-17. PMID:15277383. |
extracellular matrix protects pancreatic beta-cells against apoptosis: role of short- and long-term signaling pathways. |
2004-09-17 |
2023-08-12 |
rat |
| Eva Hammar, Géraldine Parnaud, Domenico Bosco, Nadja Perriraz, Kathrin Maedler, Marc Donath, Dominique G Rouiller, Philippe A Halba. Extracellular matrix protects pancreatic beta-cells against apoptosis: role of short- and long-term signaling pathways. Diabetes. vol 53. issue 8. 2004-09-17. PMID:15277383. |
the purpose of this study was to investigate whether this matrix protects beta-cells against apoptosis and to elucidate signaling pathways involved. |
2004-09-17 |
2023-08-12 |
rat |
| Eva Hammar, Géraldine Parnaud, Domenico Bosco, Nadja Perriraz, Kathrin Maedler, Marc Donath, Dominique G Rouiller, Philippe A Halba. Extracellular matrix protects pancreatic beta-cells against apoptosis: role of short- and long-term signaling pathways. Diabetes. vol 53. issue 8. 2004-09-17. PMID:15277383. |
matrix protected sorted rat beta-cells against apoptosis under standard conditions (11.2 mmol/l glucose, 10% serum), after serum deprivation (1% serum), and in response to interleukin-1beta (il-1beta; 2 ng/ml), compared with control (poly-l-lysine [pll]). |
2004-09-17 |
2023-08-12 |
rat |
| Warren B Nothnick, Xuan Zhang, Han-E Zho. Steroidal regulation of uterine edema and tissue inhibitors of metalloproteinase (TIMP)-3 messenger RNA expression is altered in TIMP-1-deficient mice. Biology of reproduction. vol 70. issue 2. 2004-09-16. PMID:14568914. |
tissue inhibitors of metalloproteinases (timps) are expressed within the uteri of virtually all species where they are postulated to control extracellular matrix turnover, cellular apoptosis, and proliferation. |
2004-09-16 |
2023-08-12 |
mouse |
| Yuying Liu, Lawrence H Cheung, Walter N Hittelman, Michael G Rosenblu. Targeted delivery of human pro-apoptotic enzymes to tumor cells: In vitro studies describing a novel class of recombinant highly cytotoxic agents. Molecular cancer therapeutics. vol 2. issue 12. 2004-09-16. PMID:14707275. |
the serine protease granzyme b (grb, 25 kda) can initiate apoptosis by multiple mechanisms including directly activating caspases, inducing dna fragmentation, activating the mitochondrial death pathway, and directly cleaving the nuclear matrix. |
2004-09-16 |
2023-08-12 |
human |
| Orla M Casey, Richard Fitzpatrick, James O McInerney, Dermot G Morris, Richard Powell, Joseph M Sreena. Analysis of gene expression in the bovine corpus luteum through generation and characterisation of 960 ESTs. Biochimica et biophysica acta. vol 1679. issue 1. 2004-09-16. PMID:15245912. |
several previously unidentified bovine genes encoding proteins associated with key aspects of cl function including extracellular matrix remodelling, lipid metabolism/steroid biosynthesis and apoptosis, were identified. |
2004-09-16 |
2023-08-12 |
human |
| Masatoshi Takahara, Takuji Naruse, Michiaki Takagi, Hiroshi Orui, Toshihiko Ogin. Matrix metalloproteinase-9 expression, tartrate-resistant acid phosphatase activity, and DNA fragmentation in vascular and cellular invasion into cartilage preceding primary endochondral ossification in long bones. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 22. issue 5. 2004-09-16. PMID:15304278. |
recently it has been shown that matrix metalloproteinase-9 (mmp-9)/gelatinase b is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. |
2004-09-16 |
2023-08-12 |
Not clear |
| Masatoshi Takahara, Takuji Naruse, Michiaki Takagi, Hiroshi Orui, Toshihiko Ogin. Matrix metalloproteinase-9 expression, tartrate-resistant acid phosphatase activity, and DNA fragmentation in vascular and cellular invasion into cartilage preceding primary endochondral ossification in long bones. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 22. issue 5. 2004-09-16. PMID:15304278. |
tartrate-resistant acid phosphatase (trap) activity, in situ hybridization for matrix metalloproteinase-9 (mmp-9), immunostaining for cd31, and in situ detection of apoptosis (tunel) were studied. |
2004-09-16 |
2023-08-12 |
Not clear |
| Masatoshi Takahara, Takuji Naruse, Michiaki Takagi, Hiroshi Orui, Toshihiko Ogin. Matrix metalloproteinase-9 expression, tartrate-resistant acid phosphatase activity, and DNA fragmentation in vascular and cellular invasion into cartilage preceding primary endochondral ossification in long bones. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 22. issue 5. 2004-09-16. PMID:15304278. |
these results suggest that chondrocytes separated from the cartilage matrix may undergo apoptosis. |
2004-09-16 |
2023-08-12 |
Not clear |