| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nestor F Gonzalez-Cadavid, Jacob Rajfe. Therapy of erectile dysfunction: potential future treatments. Endocrine. vol 23. issue 2-3. 2004-08-30. PMID:15146097. |
in the second approach, the first type of correction comprises regulators of endogenous cell number and integrity and extracellular matrix turnover (inhibitors of apoptosis and fibrosis, neurotrophic and angiogenic factors), testosterone, and tissue and cell explants (nerve and smooth muscle grafting, adult pluripotent cells), whereas the second includes in vivo gene therapy with different genes and vectors, and ex vivo gene therapy, combining gene transfer with stem cell implants. |
2004-08-30 |
2023-08-12 |
Not clear |
| Lynn B Eckert, Gretchen A Repasky, Aylin S Ulkü, Aidan McFall, Hong Zhou, Carolyn I Sartor, Channing J De. Involvement of Ras activation in human breast cancer cell signaling, invasion, and anoikis. Cancer research. vol 64. issue 13. 2004-08-26. PMID:15231670. |
we then examined the role of ras signaling in mediating resistance to matrix deprivation-induced apoptosis (anoikis). |
2004-08-26 |
2023-08-12 |
human |
| Carlos A Murillo, Piotr G Rychahou, B Mark Ever. Inhibition of alpha5 integrin decreases PI3K activation and cell adhesion of human colon cancers. Surgery. vol 136. issue 2. 2004-08-24. PMID:15300173. |
poorly differentiated colon cancers are characterized by increased integrin-mediated extracellular matrix interactions; disruption of this integrin-mediated adhesion leads to apoptosis and involves reduced pi3k activity. |
2004-08-24 |
2023-08-12 |
human |
| Fumio Tamura, Rumiko Nakagawa, Teruo Akuta, Shigefumi Okamoto, Shigeyuki Hamada, Hiroshi Maeda, Shigetada Kawabata, Takaaki Akaik. Proapoptotic effect of proteolytic activation of matrix metalloproteinases by Streptococcus pyogenes thiol proteinase (Streptococcus pyrogenic exotoxin B). Infection and immunity. vol 72. issue 8. 2004-08-20. PMID:15271946. |
in this study, we examined the involvement of matrix metalloproteinases (mmps) in speb-induced apoptosis. |
2004-08-20 |
2023-08-12 |
human |
| Jonathan P Coxon, Grenville M Oades, Roger S Kirby, Kay W Colsto. Zoledronic acid induces apoptosis and inhibits adhesion to mineralized matrix in prostate cancer cells via inhibition of protein prenylation. BJU international. vol 94. issue 1. 2004-08-18. PMID:15217454. |
zoledronic acid induces apoptosis and inhibits adhesion to mineralized matrix in prostate cancer cells via inhibition of protein prenylation. |
2004-08-18 |
2023-08-12 |
Not clear |
| Jonathan P Coxon, Grenville M Oades, Roger S Kirby, Kay W Colsto. Zoledronic acid induces apoptosis and inhibits adhesion to mineralized matrix in prostate cancer cells via inhibition of protein prenylation. BJU international. vol 94. issue 1. 2004-08-18. PMID:15217454. |
to investigate effects of zoledronic acid on apoptosis and adhesion to mineralized matrix in prostate cancer cells, to quantify these actions, and to elucidate some of the underlying molecular mechanisms, in terms of dependence on caspase activation and involvement of protein prenylation. |
2004-08-18 |
2023-08-12 |
Not clear |
| Paul Thelen, Stefan Schweyer, Bernhard Hemmerlein, Wolfgang Wuttke, Florian Seseke, Rolf-Hermann Ringer. Expressional changes after histone deacetylase inhibition by valproic acid in LNCaP human prostate cancer cells. International journal of oncology. vol 24. issue 1. 2004-08-17. PMID:14654937. |
pro-apoptotic factor caspase-3, tissue inhibitor of matrix metalloproteinase-3 and insulin-like growth factor binding protein-3 were up-regulated resulting in apoptosis of tumor cells. |
2004-08-17 |
2023-08-12 |
human |
| M Böhm, T A Luge. [Alpha-melanocyte-stimulating hormone. Its current significance for dermatology]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete. vol 55. issue 5. 2004-08-17. PMID:15085280. |
accordingly, alpha-msh elicits a plethora of biological actions in these cell types including immunomodulation, protection from oxidative stress and uv-induced apoptosis, modulation of secretory epithelial function and regulation of extracellular matrix composition. |
2004-08-17 |
2023-08-12 |
Not clear |
| Jung Weon Lee, Rudy Julian. Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways. Molecules and cells. vol 17. issue 2. 2004-08-10. PMID:15179030. |
engagement of cells with the extracellular matrix (ecm) proteins is crucial for various biological processes, including cell adhesion, spreading, proliferation, differentiation, migration, apoptosis, and gene induction, contributing to maintenance of tissue integrity, embryogenesis, wound healing, and the metastasis of tumor cells (hynes, 2002b; juliano, 2002). |
2004-08-10 |
2023-08-12 |
Not clear |
| Noriaki Kum. [Measurement of oxidized LDL and its soluble receptors]. Nihon rinsho. Japanese journal of clinical medicine. vol 62. issue 6. 2004-08-10. PMID:15206153. |
oxidized ldl, in fact, induces foam cell transformation of macrophages, production of matrix metalloproteinases(mmps), and apoptosis of smooth muscle cells. |
2004-08-10 |
2023-08-12 |
human |
| Stephanie E Ostrowski, Andrew A Reilly, Doris N Collins, Arlene I Ramsing. Progression or resolution of coxsackievirus B4-induced pancreatitis: a genomic analysis. Journal of virology. vol 78. issue 15. 2004-08-06. PMID:15254194. |
acute pancreatitis that progressed to chronic pancreatitis was characterized by lack of tissue repair, and the expression map highlighted genes involved in apoptosis, acinoductular metaplasia, remodeling of the extracellular matrix, and fibrosis. |
2004-08-06 |
2023-08-12 |
Not clear |
| Stephanie E Ostrowski, Andrew A Reilly, Doris N Collins, Arlene I Ramsing. Progression or resolution of coxsackievirus B4-induced pancreatitis: a genomic analysis. Journal of virology. vol 78. issue 15. 2004-08-06. PMID:15254194. |
our hypothesis is that growth and differentiation signals coupled with the m2/th2 milieu favor acinar cell proliferation, while diminished growth signals and the m1/th1 milieu favor apoptosis of acinar cells and remodeling/proliferation of the extracellular matrix, resulting in fibrosis. |
2004-08-06 |
2023-08-12 |
Not clear |
| Jason B Garrison, Natasha Kypriano. Novel targeting of apoptosis pathways for prostate cancer therapy. Current cancer drug targets. vol 4. issue 1. 2004-08-05. PMID:14965270. |
most epithelial and endothelial cells undergo apoptosis when they loose contact with the extracellular matrix (ecm), via the phenomenon of anoikis. |
2004-08-05 |
2023-08-12 |
Not clear |
| Hélène Chanut-Delalande, Christelle Bonod-Bidaud, Sylvain Cogne, Marilyne Malbouyres, Francesco Ramirez, Agnès Fichard, Florence Ruggier. Development of a functional skin matrix requires deposition of collagen V heterotrimers. Molecular and cellular biology. vol 24. issue 13. 2004-08-04. PMID:15199158. |
furthermore, reduced thickness of the basement membranes underlying the epidermis and increased apoptosis of the stromal fibroblasts in pn/pn skin strongly indicate additional roles of collagen v in the development of a functional skin matrix. |
2004-08-04 |
2023-08-12 |
mouse |
| Takao Nakagawa, Joan P Schwart. Gene expression patterns in in vivo normal adult astrocytes compared with cultured neonatal and normal adult astrocytes. Neurochemistry international. vol 45. issue 2-3. 2004-07-26. PMID:15145538. |
the cultured neonatal astrocytes expressed many genes at a two-fold or greater level than their expression in cultured adult astrocytes, including genes in the adhesion, cytoskeleton, and extracellular matrix (ecm) family, signal transduction genes, and genes related to apoptosis, dna-binding, and cell cycle regulation. |
2004-07-26 |
2023-08-12 |
rat |
| Shang-Tian Yang, Jun Luo, Chunnuan Che. A fibrous-bed bioreactor for continuous production of monoclonal antibody by hybridoma. Advances in biochemical engineering/biotechnology. vol 87. 2004-07-22. PMID:15217104. |
it was also found that the cells present inside the fibrous matrix had a higher viability and lower apoptosis than those present in the liquid suspension, indicating that the fibrous matrix had selectively retained healthy, nonapoptotic cells and dislodged apoptotic and dead cells; this also might have contributed to the stability of the long-term culture. |
2004-07-22 |
2023-08-12 |
Not clear |
| Chunnuan Chen, Kathryn Chen, Shang-Tian Yan. Effects of three-dimensional culturing on osteosarcoma cells grown in a fibrous matrix: analyses of cell morphology, cell cycle, and apoptosis. Biotechnology progress. vol 19. issue 5. 2004-07-21. PMID:14524722. |
effects of three-dimensional culturing on osteosarcoma cells grown in a fibrous matrix: analyses of cell morphology, cell cycle, and apoptosis. |
2004-07-21 |
2023-08-12 |
Not clear |
| Chunnuan Chen, Kathryn Chen, Shang-Tian Yan. Effects of three-dimensional culturing on osteosarcoma cells grown in a fibrous matrix: analyses of cell morphology, cell cycle, and apoptosis. Biotechnology progress. vol 19. issue 5. 2004-07-21. PMID:14524722. |
osteosarcoma cells were cultured in stirred tank bioreactors with either a fibrous matrix or nonporous microcarriers to study the environmental effects on cell growth, morphology, cell cycle, and apoptosis. |
2004-07-21 |
2023-08-12 |
Not clear |
| Chunnuan Chen, Kathryn Chen, Shang-Tian Yan. Effects of three-dimensional culturing on osteosarcoma cells grown in a fibrous matrix: analyses of cell morphology, cell cycle, and apoptosis. Biotechnology progress. vol 19. issue 5. 2004-07-21. PMID:14524722. |
the three-dimensional (3-d) fibrous culture had better cell growth and higher metabolic rates than the two-dimensional (2-d) microcarrier culture because cells in the fibrous matrix were protected from shear stress and had lower apoptosis and cell death even under suboptimal conditions (e.g., nutrient depletion). |
2004-07-21 |
2023-08-12 |
Not clear |
| Antonio De Luca, Maria De Falco, Valentina Fedele, Luigi Cobellis, Annunziata Mastrogiacomo, Vincenza Laforgia, Ioana L Tuduce, Mara Campioni, Domenico Giraldi, Marco G Paggi, Alfonso Bald. The serine protease HtrA1 is upregulated in the human placenta during pregnancy. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 52. issue 7. 2004-07-20. PMID:15208355. |
it is generally accepted that the simultaneous activity of proteins involved in cell proliferation, apoptosis, and extracellular matrix degradation plays an important role in correct placental development. |
2004-07-20 |
2023-08-12 |
human |