| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Allan Lipto. Pathophysiology of bone metastases: how this knowledge may lead to therapeutic intervention. The journal of supportive oncology. vol 2. issue 3. 2004-09-28. PMID:15328823. |
bisphosphonates bind avidly to the bone matrix, are released during bone resorption, and are subsequently internalized by osteoclasts, where they interfere with biochemical pathways and induce osteoclast apoptosis. |
2004-09-28 |
2023-08-12 |
Not clear |
| A Amour, M Bird, L Chaudry, J Deadman, D Hayes, C Ka. General considerations for proteolytic cascades. Biochemical Society transactions. vol 32. issue Pt 1. 2004-09-24. PMID:14748703. |
four major proteolytic cascades with disease relevance are candidates for therapeutic intervention, namely caspase-mediated apoptosis, blood coagulation, the matrix metalloproteinase cascade and the complement cascade. |
2004-09-24 |
2023-08-12 |
Not clear |
| Jens M Kelm, Elisabeth Ehler, Lars K Nielsen, Stefan Schlatter, Jean-Claude Perriard, Martin Fussenegge. Design of artificial myocardial microtissues. Tissue engineering. vol 10. issue 1-2. 2004-09-24. PMID:15009946. |
embedded in a three-dimensional environment, cells are expected to develop tissue-like higher order intercellular structures (cell-cell contacts, extracellular matrix) that orchestrate cellular functions including proliferation, differentiation, apoptosis, and angiogenesis with unmatched quality. |
2004-09-24 |
2023-08-12 |
mouse |
| Eva Hammar, Géraldine Parnaud, Domenico Bosco, Nadja Perriraz, Kathrin Maedler, Marc Donath, Dominique G Rouiller, Philippe A Halba. Extracellular matrix protects pancreatic beta-cells against apoptosis: role of short- and long-term signaling pathways. Diabetes. vol 53. issue 8. 2004-09-17. PMID:15277383. |
extracellular matrix protects pancreatic beta-cells against apoptosis: role of short- and long-term signaling pathways. |
2004-09-17 |
2023-08-12 |
rat |
| Eva Hammar, Géraldine Parnaud, Domenico Bosco, Nadja Perriraz, Kathrin Maedler, Marc Donath, Dominique G Rouiller, Philippe A Halba. Extracellular matrix protects pancreatic beta-cells against apoptosis: role of short- and long-term signaling pathways. Diabetes. vol 53. issue 8. 2004-09-17. PMID:15277383. |
the purpose of this study was to investigate whether this matrix protects beta-cells against apoptosis and to elucidate signaling pathways involved. |
2004-09-17 |
2023-08-12 |
rat |
| Eva Hammar, Géraldine Parnaud, Domenico Bosco, Nadja Perriraz, Kathrin Maedler, Marc Donath, Dominique G Rouiller, Philippe A Halba. Extracellular matrix protects pancreatic beta-cells against apoptosis: role of short- and long-term signaling pathways. Diabetes. vol 53. issue 8. 2004-09-17. PMID:15277383. |
matrix protected sorted rat beta-cells against apoptosis under standard conditions (11.2 mmol/l glucose, 10% serum), after serum deprivation (1% serum), and in response to interleukin-1beta (il-1beta; 2 ng/ml), compared with control (poly-l-lysine [pll]). |
2004-09-17 |
2023-08-12 |
rat |
| Warren B Nothnick, Xuan Zhang, Han-E Zho. Steroidal regulation of uterine edema and tissue inhibitors of metalloproteinase (TIMP)-3 messenger RNA expression is altered in TIMP-1-deficient mice. Biology of reproduction. vol 70. issue 2. 2004-09-16. PMID:14568914. |
tissue inhibitors of metalloproteinases (timps) are expressed within the uteri of virtually all species where they are postulated to control extracellular matrix turnover, cellular apoptosis, and proliferation. |
2004-09-16 |
2023-08-12 |
mouse |
| Yuying Liu, Lawrence H Cheung, Walter N Hittelman, Michael G Rosenblu. Targeted delivery of human pro-apoptotic enzymes to tumor cells: In vitro studies describing a novel class of recombinant highly cytotoxic agents. Molecular cancer therapeutics. vol 2. issue 12. 2004-09-16. PMID:14707275. |
the serine protease granzyme b (grb, 25 kda) can initiate apoptosis by multiple mechanisms including directly activating caspases, inducing dna fragmentation, activating the mitochondrial death pathway, and directly cleaving the nuclear matrix. |
2004-09-16 |
2023-08-12 |
human |
| Orla M Casey, Richard Fitzpatrick, James O McInerney, Dermot G Morris, Richard Powell, Joseph M Sreena. Analysis of gene expression in the bovine corpus luteum through generation and characterisation of 960 ESTs. Biochimica et biophysica acta. vol 1679. issue 1. 2004-09-16. PMID:15245912. |
several previously unidentified bovine genes encoding proteins associated with key aspects of cl function including extracellular matrix remodelling, lipid metabolism/steroid biosynthesis and apoptosis, were identified. |
2004-09-16 |
2023-08-12 |
human |
| Masatoshi Takahara, Takuji Naruse, Michiaki Takagi, Hiroshi Orui, Toshihiko Ogin. Matrix metalloproteinase-9 expression, tartrate-resistant acid phosphatase activity, and DNA fragmentation in vascular and cellular invasion into cartilage preceding primary endochondral ossification in long bones. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 22. issue 5. 2004-09-16. PMID:15304278. |
recently it has been shown that matrix metalloproteinase-9 (mmp-9)/gelatinase b is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. |
2004-09-16 |
2023-08-12 |
Not clear |
| Masatoshi Takahara, Takuji Naruse, Michiaki Takagi, Hiroshi Orui, Toshihiko Ogin. Matrix metalloproteinase-9 expression, tartrate-resistant acid phosphatase activity, and DNA fragmentation in vascular and cellular invasion into cartilage preceding primary endochondral ossification in long bones. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 22. issue 5. 2004-09-16. PMID:15304278. |
tartrate-resistant acid phosphatase (trap) activity, in situ hybridization for matrix metalloproteinase-9 (mmp-9), immunostaining for cd31, and in situ detection of apoptosis (tunel) were studied. |
2004-09-16 |
2023-08-12 |
Not clear |
| Masatoshi Takahara, Takuji Naruse, Michiaki Takagi, Hiroshi Orui, Toshihiko Ogin. Matrix metalloproteinase-9 expression, tartrate-resistant acid phosphatase activity, and DNA fragmentation in vascular and cellular invasion into cartilage preceding primary endochondral ossification in long bones. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 22. issue 5. 2004-09-16. PMID:15304278. |
these results suggest that chondrocytes separated from the cartilage matrix may undergo apoptosis. |
2004-09-16 |
2023-08-12 |
Not clear |
| Agnieszka Chrobak, Grzegorz B Gmyrek, Rafał Sozański, Urszula Sieradzka, Maria Paprocka, Marian Gabryś, Małgorzata Jerza. The influence of extracellular matrix proteins on T-cell proliferation and apoptosis in women with endometriosis or uterine leiomyoma. American journal of reproductive immunology (New York, N.Y. : 1989). vol 51. issue 2. 2004-09-15. PMID:14748838. |
the influence of extracellular matrix proteins on t-cell proliferation and apoptosis in women with endometriosis or uterine leiomyoma. |
2004-09-15 |
2023-08-12 |
Not clear |
| Małgorzata Jerzak, Monika Kasprzycka, Włodzimierz Baranowski, Andrzej Górsk. Extracellular Matrix Protein-dependent Apoptosis of T Cells in Women with a History of Recurrent Spontaneous Abortion. American journal of reproductive immunology (New York, N.Y. : 1989). vol 51. issue 2. 2004-09-15. PMID:14748839. |
extracellular matrix protein-dependent apoptosis of t cells in women with a history of recurrent spontaneous abortion. |
2004-09-15 |
2023-08-12 |
Not clear |
| Małgorzata Jerzak, Monika Kasprzycka, Włodzimierz Baranowski, Andrzej Górsk. Extracellular Matrix Protein-dependent Apoptosis of T Cells in Women with a History of Recurrent Spontaneous Abortion. American journal of reproductive immunology (New York, N.Y. : 1989). vol 51. issue 2. 2004-09-15. PMID:14748839. |
the purpose of the study was to determine the role of t-cell apoptosis in extracellular matrix (ecm) environment in pregnancy maintenance in women with a history of recurrent spontaneous abortion (rsa). |
2004-09-15 |
2023-08-12 |
Not clear |
| Xifeng Wu, Hua Zhao, Rebecca Suk, David C Christian. Genetic susceptibility to tobacco-related cancer. Oncogene. vol 23. issue 38. 2004-09-15. PMID:15322521. |
these pathways include regulation of xenobiotic metabolism; control of genomic stability, including dna repair mechanisms, cell-cycle checkpoints, apoptosis and telomere length; and control of microenvironmental factors, such as matrix metalloproteinases, inflammation and growth factors. |
2004-09-15 |
2023-08-12 |
Not clear |
| Anthony J Valentijn, Andrew P Gilmor. Translocation of full-length Bid to mitochondria during anoikis. The Journal of biological chemistry. vol 279. issue 31. 2004-09-10. PMID:15148322. |
epithelial cells require adhesion to the extracellular matrix for survival, and in the absence of adhesion they undergo apoptosis (anoikis). |
2004-09-10 |
2023-08-12 |
Not clear |
| Hong Xia, Richard Seonghun Nho, Judy Kahm, Jill Kleidon, Craig A Henk. Focal adhesion kinase is upstream of phosphatidylinositol 3-kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway. The Journal of biological chemistry. vol 279. issue 31. 2004-09-10. PMID:15166238. |
the beta(1) integrin, functioning as a mechanoreceptor, senses a mechanical stimulus generated during collagen matrix contraction and down-regulates the phosphatidylinositol 3-kinase (pi3k)/akt survival signal triggering apoptosis. |
2004-09-10 |
2023-08-12 |
Not clear |
| Tamara Vanhaecke, Tom Henkens, George E N Kass, Vera Rogier. Effect of the histone deacetylase inhibitor trichostatin A on spontaneous apoptosis in various types of adult rat hepatocyte cultures. Biochemical pharmacology. vol 68. issue 4. 2004-09-08. PMID:15276083. |
in contrast, in hepatocyte culture models in which spontaneous apoptosis is already minimised through the addition of either extracellular matrix components (sandwich cultures) or non-parenchymal liver cells (co-cultures), tsa did not have any additional anti-apoptotic effect. |
2004-09-08 |
2023-08-12 |
rat |
| Doan H Nguyen, Hiroshi Toshida, Jill Schurr, Roger W Beuerma. Microarray analysis of the rat lacrimal gland following the loss of parasympathetic control of secretion. Physiological genomics. vol 18. issue 1. 2004-08-30. PMID:15084711. |
conversely, transcripts for cytoskeleton and extracellular matrix components, inflammation, and apoptosis were upregulated. |
2004-08-30 |
2023-08-12 |
rat |