| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Robert Zivadino. Steroids and brain atrophy in multiple sclerosis. Journal of the neurological sciences. vol 233. issue 1-2. 2005-08-22. PMID:15882880. |
it has been shown that chronic use of high dose intravenous methylprednisolone (ivmp) in patients with ms may limit brain atrophy progression over the long-term via different immunological mechanisms, including downregulation of adhesion molecule expression on endothelial cells, decreased cytokine and matrix metalloproteinase secretion, decreased autoreactive t-cell-mediated inflammation and t-cell apoptosis induction, blood-brain barrier closure, demyelination inhibition and, possibly, remyelination promotion. |
2005-08-22 |
2023-08-12 |
Not clear |
| Yi-Xun Liu, Fei Gao, Peng Wei, Xin-Lei Chen, Hong-Juan Gao, Ru-Jin Zou, Li-Juan Siao, Fu-Hua Xu, Qing Feng, Kui Liu, Zhao-Yuan H. Involvement of molecules related to angiogenesis, proteolysis and apoptosis in implantation in rhesus monkey and mouse. Contraception. vol 71. issue 4. 2005-08-18. PMID:15792644. |
we have established the well-defined cycling, pseudo-pregnant and pregnant rhesus monkey models, and used these to analyze expression of the common molecules specifically related to angiogenesis, apoptosis or proteolysis, such as vascular endothelial growth factor (vegf) and its receptors kdr, flt-1, flt-4 and flk-1, basic fibroblast growth factor (bfgf) and its receptors flg, transforming growth factor-alpha and beta1 (tgf-a/beta1), and tgf-beta1 receptor type i (tbetar-i) and type ii (tbetar-ii), as well as steroidogenic acute regulatory protein (star), tissue type plasminogen activator/urokinase plasminogen activator/plasminogen activator inhibitor type 1 (tpa/upa/pai-1) and matrix matalloproteinase type 1, -3/tissue inhibitor matalloproteinase type 1, -2, -3 (mmp-1, -3/timp-1, -2, -3), fas/fasl, bcl-2/bax, in the corpus luteum (cl), in the functional layer of the endometrium and in the materno-fetal boundary of the implantation site. |
2005-08-18 |
2023-08-12 |
rat |
| Daryl T-Y Lau, Bruce A Luxon, Shu-Yuan Xiao, Michael R Beard, Stanley M Lemo. Intrahepatic gene expression profiles and alpha-smooth muscle actin patterns in hepatitis C virus induced fibrosis. Hepatology (Baltimore, Md.). vol 42. issue 2. 2005-08-18. PMID:15986378. |
transcripts with increased abundance in stages 1 and 2 fibrosis were associated with oxidative stress, apoptosis, inflammation, proliferation, and matrix degradation, whereas transcripts increased in stages 3 and 4 were associated with fibrogenesis and cellular proliferation. |
2005-08-18 |
2023-08-12 |
Not clear |
| Jian-Jun Li, Yuan-Lin Guo, Yue-Jin Yan. Enhancing anti-inflammatory cytokine IL-10 may be beneficial for acute coronary syndrome. Medical hypotheses. vol 65. issue 1. 2005-08-16. PMID:15893126. |
interluekine-10 (il-10), which is produced by various inflammatory cells, especially macrophages, has multifaceted anti-inflammatory properties, including inhibition of the prototypic pro-inflammatory transcription factor nuclear factor-kappab, leading to suppressed cytokine production, inhibition of matrix degrading metalloproteinase production, reduction of tissue factor expression, inhibition of apoptosis of macrophages and monocytes after infection, and promotion of the phenotypic switch of lymphocytes into the th2 phenotype. |
2005-08-16 |
2023-08-12 |
Not clear |
| Chada S Redd. Protein kinase C and chemical-induced abnormal palate development. Human & experimental toxicology. vol 24. issue 4. 2005-08-11. PMID:15957537. |
the protein kinase c (pkc) family of proteins mediates the action of growth factors and other ligands by activating a network of transcription factors that bind to tre sequences in the promoters of many genes that regulate cell proliferation, differentiation, extracellular matrix synthesis, apoptosis and others in a cell type-, isozyme- and context-specific manner. |
2005-08-11 |
2023-08-12 |
Not clear |
| S Mukaratirw. Prognostic and predictive markers in canine tumours: rationale and relevance. A review. The veterinary quarterly. vol 27. issue 2. 2005-08-10. PMID:16022341. |
the markers are allocated to four groups according to their function: (i) proliferation markers, (ii) apoptosis, (iii) extracellular matrix and cell adhesion molecules, (iv) angiogenesis and (v) cell cycle regulators. |
2005-08-10 |
2023-08-12 |
Not clear |
| Asa Nilsdotter-Augustinsson, Carina Claesson, Per-Eric Lindgren, Helen Lundqvist-Gustafsson, Lena Ohma. Adherence of Staphylococcus epidermidis to extracellular matrix proteins and effects of fibrinogen-bound bacteria on oxidase activity and apoptosis in neutrophils. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. vol 113. issue 5. 2005-08-09. PMID:16011663. |
adherence of staphylococcus epidermidis to extracellular matrix proteins and effects of fibrinogen-bound bacteria on oxidase activity and apoptosis in neutrophils. |
2005-08-09 |
2023-08-12 |
Not clear |
| Haruyo Ichikawa, Yasunari Takada, Akira Murakami, Bharat B Aggarwa. Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products. Journal of immunology (Baltimore, Md. : 1950). vol 174. issue 11. 2005-08-08. PMID:15905586. |
consequently, aca suppressed the expression of tnf-induced nf-kappab-regulated proliferative (e.g., cyclin d1 and c-myc), antiapoptotic (survivin, inhibitor of apoptosis protein-1 (iap1), iap2, x-chromosome-linked iap, bcl-2, bcl-x(l), bfl-1/a1, and flip), and metastatic (cyclooxygenase-2, icam-1, vascular endothelial growth factor, and matrix metalloprotease-9) gene products. |
2005-08-08 |
2023-08-12 |
Not clear |
| Gunter Wolf, Sheldon Chen, Fuad N Ziyade. From the periphery of the glomerular capillary wall toward the center of disease: podocyte injury comes of age in diabetic nephropathy. Diabetes. vol 54. issue 6. 2005-08-04. PMID:15919782. |
tgf-beta1 causes an increase in mesangial matrix deposition and glomerular basement membrane (gbm) thickening and may promote podocyte apoptosis or detachment. |
2005-08-04 |
2023-08-12 |
Not clear |
| N I Kalinina, Iu A Antropova, A Agrotis, O P il'inskaia, é M Tararak, A Bobi. [Expression, regulation, and pathophysiological role of NAD(P)H oxidases in atherogenesis]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 90. issue 10. 2005-08-02. PMID:15628177. |
significant increase of reactive oxygen species production by vascular cells can lead to progression of atherosclerotic lesions and development of unstable plaques due to triggering the apoptosis of endothelial and smooth muscle cells, expression of matrix metalloproteases and inflammatory cytokines. |
2005-08-02 |
2023-08-12 |
human |
| Ashwini Kucknoor, Vasanthakrishna Mundodi, John F Alderet. Trichomonas vaginalis adherence mediates differential gene expression in human vaginal epithelial cells. Cellular microbiology. vol 7. issue 6. 2005-08-02. PMID:15888089. |
the identified genes were found to encode functional proteins with specific functions associated with cell structure maintenance and extracellular matrix components, proinflammatory molecules and apoptosis. |
2005-08-02 |
2023-08-12 |
human |
| Calogera M Simonaro, Marina D'Angelo, Mark E Haskins, Edward H Schuchma. Joint and bone disease in mucopolysaccharidoses VI and VII: identification of new therapeutic targets and biomarkers using animal models. Pediatric research. vol 57. issue 5 Pt 1. 2005-07-28. PMID:15746260. |
bromodeoxyuridine incorporation studies also revealed that mps chondrocytes proliferated up to 5-fold faster than normal chondrocytes, and released elevated levels of transforming growth factor-beta, presumably to counteract the marked chondrocyte apoptosis and matrix degradation associated with mmp expression. |
2005-07-28 |
2023-08-12 |
Not clear |
| Mélanie Bérubé, Mariève Talbot, Charles Collin, Carine Paquet-Bouchard, Lucie Germain, Sylvain L Guérin, Eric Petitcler. Role of the extracellular matrix proteins in the resistance of SP6.5 uveal melanoma cells toward cisplatin. International journal of oncology. vol 26. issue 2. 2005-07-26. PMID:15645125. |
analysis of cell death by flow cytometry demonstrated that culturing sp6.5 cells in the presence of fn, civ and lm, substantially reduced the percentage of cells undergoing apoptosis after cisplatin treatment when compared with those seeded on a non-permissive matrix. |
2005-07-26 |
2023-08-12 |
Not clear |
| Bindu Menon, Mahipal Singh, Krishna Sing. Matrix metalloproteinases mediate beta-adrenergic receptor-stimulated apoptosis in adult rat ventricular myocytes. American journal of physiology. Cell physiology. vol 289. issue 1. 2005-07-25. PMID:15728709. |
matrix metalloproteinases mediate beta-adrenergic receptor-stimulated apoptosis in adult rat ventricular myocytes. |
2005-07-25 |
2023-08-12 |
rat |
| P Imirzalioĝlu, S Uckan, E E Alaaddinoĝlu, A Haberal, D Ucka. Cigarette smoking and apoptosis. Journal of periodontology. vol 76. issue 5. 2005-07-25. PMID:15898934. |
thus we analyzed soluble fas and nuclear matrix protein (nmp) levels in the saliva of smokers (n = 13) and non-smokers (n = 14) to assess apoptosis. |
2005-07-25 |
2023-08-12 |
human |
| Tamara Tanos, Maria Julia Marinissen, Federico Coluccio Leskow, Daniel Hochbaum, Horacio Martinetto, J Silvio Gutkind, Omar A Cos. Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light. The Journal of biological chemistry. vol 280. issue 19. 2005-07-12. PMID:15708845. |
among them, the rapid activation of genes coding for two subfamilies of proto-oncoproteins, fos and jun, which constitute the ap-1 transcription factor, plays a key role in the subsequent regulation of expression of genes involved in dna repair, cell proliferation, cell cycle arrest, death by apoptosis, and tissue and extracellular matrix remodeling proteases. |
2005-07-12 |
2023-08-12 |
Not clear |
| In-Hyuk Chung, Sook-Hwan Lee, Kyo-Won Lee, Sang-hee Park, Kwang-Yul Cha, Nam-Soon Kim, Hyang-Sook Yoo, Yong Sung Kim, Suman Le. Gene expression analysis of cultured amniotic fluid cell with Down syndrome by DNA microarray. Journal of Korean medical science. vol 20. issue 1. 2005-07-11. PMID:15716609. |
to analyze differential gene expressions in amniotic fluid (af) cells of ds, we used a dna microarray system to analyze 102 genes, which included 24 genes on chromosome 21, 28 genes related to the function of brain and muscle, 36 genes related to apoptosis, 4 genes related to extracellular matrix, 8 genes related to other molecular function and 2 house-keeping genes. |
2005-07-11 |
2023-08-12 |
human |
| Elizabeth Tafolla, Shaohui Wang, Benita Wong, Jeffrey Leong, Yvonne L Kapil. JNK1 and JNK2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectin matrix: JNK links FAK and p53. The Journal of biological chemistry. vol 280. issue 20. 2005-07-08. PMID:15778501. |
jnk1 and jnk2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectin matrix: jnk links fak and p53. |
2005-07-08 |
2023-08-12 |
Not clear |
| Elizabeth Tafolla, Shaohui Wang, Benita Wong, Jeffrey Leong, Yvonne L Kapil. JNK1 and JNK2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectin matrix: JNK links FAK and p53. The Journal of biological chemistry. vol 280. issue 20. 2005-07-08. PMID:15778501. |
the extracellular matrix regulates many cellular processes, including survival, and alterations in the matrix or in matrix survival signals can trigger apoptosis. |
2005-07-08 |
2023-08-12 |
Not clear |
| Elizabeth Tafolla, Shaohui Wang, Benita Wong, Jeffrey Leong, Yvonne L Kapil. JNK1 and JNK2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectin matrix: JNK links FAK and p53. The Journal of biological chemistry. vol 280. issue 20. 2005-07-08. PMID:15778501. |
previously, we showed that an altered fibronectin matrix triggers apoptosis in primary cells via a novel pathway regulated by transcriptionally mediated decreases in p53 and c-myc levels. |
2005-07-08 |
2023-08-12 |
Not clear |