| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Moisés Selman, Annie Pard. Idiopathic pulmonary fibrosis: misunderstandings between epithelial cells and fibroblasts? Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG. vol 21. issue 3. 2005-02-07. PMID:15554072. |
active fibroblasts/myofibroblasts from these foci may in turn disturb alveolar re-epithelialization, by provoking basement membrane disruption and epithelial cell apoptosis finally resulting in exaggerated extracellular matrix accumulation. |
2005-02-07 |
2023-08-12 |
Not clear |
| Sen Rong Yan, Kusum Sapru, Andrew C Issekut. The CD11/CD18 (beta2) integrins modulate neutrophil caspase activation and survival following TNF-alpha or endotoxin induced transendothelial migration. Immunology and cell biology. vol 82. issue 4. 2005-02-04. PMID:15283855. |
thus, engagement of ligands on extracellular matrix and endothelium by the beta2 integrins mac-1 and lfa-1 plays a role in delaying apoptosis in pmn recruited in response to lps and tnf-alpha. |
2005-02-04 |
2023-08-12 |
Not clear |
| Meinhard Schiller, Delphine Javelaud, Alain Mauvie. TGF-beta-induced SMAD signaling and gene regulation: consequences for extracellular matrix remodeling and wound healing. Journal of dermatological science. vol 35. issue 2. 2005-02-02. PMID:15265520. |
members of the transforming growth factor-beta (tgf-beta) superfamily are pleiotropic cytokines that have the ability to regulate numerous cell functions, including proliferation, differentiation, apoptosis, epithelial-mesenchymal transition, and production of extracellular matrix, allowing them to play an important role during embryonic development and for maintenance of tissue homeostasis. |
2005-02-02 |
2023-08-12 |
Not clear |
| M J Martin, J C Buckland-Wrigh. Sensitivity analysis of a novel mathematical model identifies factors determining bone resorption rates. Bone. vol 35. issue 4. 2005-02-02. PMID:15454099. |
growth factors released from the matrix during phase i were assumed to cause two negative feedback effects: (1) the inhibitory effect of transforming growth factor-beta1 (tgfbeta1)-induced production of opg by marrow osteoblast stromal cells, reducing effective rankl; (2) the apoptosis of osteoclast nuclei assumed to occur at high concentrations of tgfbeta. |
2005-02-02 |
2023-08-12 |
Not clear |
| Jang-Soo Chu. Expression, activity, and regulation of MAP kinases in cultured chondrocytes. Methods in molecular medicine. vol 100. 2005-01-31. PMID:15280602. |
the map kinase subtypes are constitutively expressed in articular chondrocytes and they regulate chondrocyte function, including differentiation, apoptosis, inflammatory responses, and activation of matrix metalloproteinases. |
2005-01-31 |
2023-08-12 |
Not clear |
| Tetsuya Watanabe, Kinya Ots. [Signal transduction in heart failure]. Nihon rinsho. Japanese journal of clinical medicine. vol 62. issue 12. 2005-01-28. PMID:15597806. |
meanwhile, not only myocyte apoptosis but also myocardial interstitial changes such as extracellular matrix deposition, activation of fibroblasts, and narrowing of vessel lumens play important roles for the progression of heart failure. |
2005-01-28 |
2023-08-12 |
Not clear |
| Patricia Saravia-Otten, Teresa Frisan, Monica Thelestam, José María Gutiérre. Membrane independent activation of fibroblast proMMP-2 by snake venom: novel roles for venom proteinases. Toxicon : official journal of the International Society on Toxinology. vol 44. issue 7. 2005-01-27. PMID:15500851. |
activation of prommp-2 by snake venom proteinases, independently of the mt1-mmp/timp-2 pathway, extracellular matrix degradation or apoptosis, represents a novel mechanism in human fibroblasts. |
2005-01-27 |
2023-08-12 |
mouse |
| W Kimryn Rathmell, Michele M Hickey, Natalie A Bezman, Christie A Chmielecki, Natalie C Carraway, M Celeste Simo. In vitro and in vivo models analyzing von Hippel-Lindau disease-specific mutations. Cancer research. vol 64. issue 23. 2005-01-27. PMID:15574766. |
the vhl protein (pvhl) has been implicated in many cellular activities including the hypoxia response, cell cycle arrest, apoptosis, and extracellular matrix remodeling. |
2005-01-27 |
2023-08-12 |
mouse |
| Tracey Hanks, Brent Lee Atkinso. Comparison of cell viability on anorganic bone matrix with or without P-15 cell binding peptide. Biomaterials. vol 25. issue 19. 2005-01-25. PMID:15120530. |
two routinely utilized bone graft materials, anorganic bone matrix (abm) and abm carrying the cell binding peptide p-15 were compared for cell viability and apoptosis. |
2005-01-25 |
2023-08-12 |
human |
| Yan Zhang, Hai Lu, Paul Dazin, Yvonne Kapil. Squamous cell carcinoma cell aggregates escape suspension-induced, p53-mediated anoikis: fibronectin and integrin alphav mediate survival signals through focal adhesion kinase. The Journal of biological chemistry. vol 279. issue 46. 2005-01-21. PMID:15331608. |
resistance to anoikis, or apoptosis triggered by detachment from the extracellular matrix (ecm), lengthens the survival of malignant cells, facilitating reattachment and colonization of secondary sites. |
2005-01-21 |
2023-08-12 |
human |
| Rama Garimella, Xiahong Bi, Nancy Camacho, Joseph B Sipe, H Clarke Anderso. Primary culture of rat growth plate chondrocytes: an in vitro model of growth plate histotype, matrix vesicle biogenesis and mineralization. Bone. vol 34. issue 6. 2005-01-14. PMID:15193542. |
chondrocytes of growth plate undergo proliferation, maturation, hypertrophy, matrix vesicle (mv) biogenesis and programmed cell death (pcd, apoptosis). |
2005-01-14 |
2023-08-12 |
rat |
| A J Valentijn, N Zouq, A P Gilmor. Anoikis. Biochemical Society transactions. vol 32. issue Pt3. 2005-01-12. PMID:15157151. |
adhesion on the extracellular matrix is important to determine whether a cell is in the correct location and to delete displaced cells by apoptosis. |
2005-01-12 |
2023-08-12 |
Not clear |
| Laura España, Yolanda Fernández, Nuria Rubio, Angels Torregrosa, Jeronimo Blanco, Angels Sierr. Overexpression of Bcl-xL in human breast cancer cells enhances organ-selective lymph node metastasis. Breast cancer research and treatment. vol 87. issue 1. 2005-01-07. PMID:15377849. |
additionally, in vitro experiments show that in 435 cells bcl-xl-antisense can override the emergence of resistance to apoptosis induced by tnf- alpha and tgf- beta in cells overexpressing bcl-xl, increasing also adhesion to extracellular matrix proteins. |
2005-01-07 |
2023-08-12 |
mouse |
| João Carlos das Neves Pereira, Alecsander Guilharman Pereira da Silva, Fabiana Soares, Alexandre Muxfeldt Ab'Saber, Aurelino Schmidt, Olavo Ribeiro Rodrigues, Ana Garippo, Marisa Capelozzi, José Ribas Milanez de Campos, Tereza Takagaki, Fábio Biscegli Jatene, Sandro Martins, Vera Luiza Capelozz. Nuclear and environment morphometric profile in tumor size and nodal metastasis of resected typical pulmonary carcinoid. Pathology, research and practice. vol 200. issue 6. 2005-01-06. PMID:15310149. |
as the biologic behavior in lung tumors with neuroendocrine differentiation is highly dependent on cell death (apoptosis) and extracellular matrix invasion, bcl2 and extracellular matrix density have been targeted as potentially useful tumor markers. |
2005-01-06 |
2023-08-12 |
Not clear |
| H P Monteiro, E F Silva, A Ster. Nitric oxide: a potential inducer of adhesion-related apoptosis--anoikis. Nitric oxide : biology and chemistry. vol 10. issue 1. 2005-01-04. PMID:15050529. |
among the many initiating events that lead to apoptosis or programmed cell death, loss of contact between the cell and the extracellular matrix has been extensively studied. |
2005-01-04 |
2023-08-12 |
Not clear |
| Paulo Castro-Chaves, Adelino F Leite-Moreir. [Renin-angiotensin system and its role in cardiovascular physiopathology and therapy]. Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology. vol 23 Suppl 2. 2005-01-04. PMID:15222251. |
at these levels it is involved in cellular proliferation and apoptosis, cellular migration, inflammation, synthesis and release of various mediators such as platelet-derived growth factor and endothelin-1) and in the synthesis of extracellular matrix. |
2005-01-04 |
2023-08-12 |
Not clear |
| Dennis R Warner, Vasker Bhattacherjee, Xiaolong Yin, Saurabh Singh, Partha Mukhopadhyay, M Michele Pisano, Robert M Green. Functional interaction between Smad, CREB binding protein, and p68 RNA helicase. Biochemical and biophysical research communications. vol 324. issue 1. 2004-12-28. PMID:15464984. |
the transforming growth factors beta control a diversity of biological processes including cellular proliferation, differentiation, apoptosis, and extracellular matrix production, and are critical effectors of embryonic patterning and development, including that of the orofacial region. |
2004-12-28 |
2023-08-12 |
mouse |
| Martin P Playford, Michael D Schalle. The interplay between Src and integrins in normal and tumor biology. Oncogene. vol 23. issue 48. 2004-12-28. PMID:15489911. |
we will identify the key players in the integrin-mediated signaling pathways involved in cell motility and apoptosis, such as fak, paxillin and p130(cas), and discuss how src signaling affects the formation of focal adhesions and the extracellular matrix. |
2004-12-28 |
2023-08-12 |
human |
| Jonathan R Gree. Bisphosphonates: preclinical review. The oncologist. vol 9 Suppl 4. 2004-12-22. PMID:15459425. |
as a result of their biochemical effects on protein prenylation, n-bps induce caspase-dependent apoptosis, inhibit matrix metalloproteinase activity, and downregulate alpha(v)beta(3) and alpha(v)beta(5) integrins. |
2004-12-22 |
2023-08-12 |
Not clear |
| Ghassan M Saed, Michael P Diamon. Molecular characterization of postoperative adhesions: the adhesion phenotype. The Journal of the American Association of Gynecologic Laparoscopists. vol 11. issue 3. 2004-12-21. PMID:15559339. |
these events are reduced plasminogen activator activity, extracellular matrix deposition, increased cytokine production, increased angiogenesis, and reduced apoptosis (programmed cell death). |
2004-12-21 |
2023-08-12 |
Not clear |