| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jérôme Jourquin, Evelyne Tremblay, Anne Bernard, Gérard Charton, Franck A Chaillan, Evelyne Marchetti, François S Roman, Paul D Soloway, Vincent Dive, Athanasios Yiotakis, Michel Khrestchatisky, Santiago River. Tissue inhibitor of metalloproteinases-1 (TIMP-1) modulates neuronal death, axonal plasticity, and learning and memory. The European journal of neuroscience. vol 22. issue 10. 2006-01-17. PMID:16307599. |
the tissue inhibitor of metalloproteinases-1 (timp-1) belongs to a family of multifunctional proteins that inhibit matrix metalloproteinases (mmps), but also regulate cell growth, proliferation, migration and apoptosis in non-nervous tissues. |
2006-01-17 |
2023-08-12 |
mouse |
| Yuki Kishida, Makoto Hirao, Noriyuki Tamai, Akihide Nampei, Tetsuho Fujimoto, Takanobu Nakase, Nobuyuki Shimizu, Hideki Yoshikawa, Akira Myou. Leptin regulates chondrocyte differentiation and matrix maturation during endochondral ossification. Bone. vol 37. issue 5. 2006-01-12. PMID:16039170. |
effects of leptin on chondrocyte gene expression, cell cycle, apoptosis and matrix mineralization were assessed using primary chondrocyte culture and the atdc5 cell differentiation culture system. |
2006-01-12 |
2023-08-12 |
mouse |
| Yuki Kishida, Makoto Hirao, Noriyuki Tamai, Akihide Nampei, Tetsuho Fujimoto, Takanobu Nakase, Nobuyuki Shimizu, Hideki Yoshikawa, Akira Myou. Leptin regulates chondrocyte differentiation and matrix maturation during endochondral ossification. Bone. vol 37. issue 5. 2006-01-12. PMID:16039170. |
during atdc5 cell differentiation culture, exogenous leptin at a concentration of 1-10 ng/ml (equivalent to the normal serum concentration of leptin) altered type x collagen mrna expression and suppressed apoptosis, cell growth and matrix calcification. |
2006-01-12 |
2023-08-12 |
mouse |
| Zaiping Liu, Hongbing Li, Mathieu Derouet, Jorge Filmus, Eric C LaCasse, Robert G Korneluk, Robert S Kerbel, Kirill V Rose. ras Oncogene triggers up-regulation of cIAP2 and XIAP in intestinal epithelial cells: epidermal growth factor receptor-dependent and -independent mechanisms of ras-induced transformation. The Journal of biological chemistry. vol 280. issue 45. 2006-01-12. PMID:16115895. |
detachment of normal epithelial cells from the extracellular matrix (ecm) triggers apoptosis, a phenomenon called anoikis. |
2006-01-12 |
2023-08-12 |
Not clear |
| Jean-Loup Bascands, Joost P Schanstr. Obstructive nephropathy: insights from genetically engineered animals. Kidney international. vol 68. issue 3. 2006-01-11. PMID:16105023. |
this model mimics, in an accelerated manner, the different stages of obstructive nephropathy leading to tubulointerstitial fibrosis: cellular infiltration, tubular proliferation and apoptosis, epithelial-mesenchymal transition (emt), (myo)fibroblast accumulation, increased extracellular matrix (ecm) deposition, and tubular atrophy. |
2006-01-11 |
2023-08-12 |
Not clear |
| Shin-Ichi Manabe, Zezong Gu, Stuart A Lipto. Activation of matrix metalloproteinase-9 via neuronal nitric oxide synthase contributes to NMDA-induced retinal ganglion cell death. Investigative ophthalmology & visual science. vol 46. issue 12. 2006-01-11. PMID:16303975. |
another factor is the abnormal activation of matrix metalloproteinases (mmps), in particular mmp-9, which triggers an extracellular signaling cascade leading to apoptosis. |
2006-01-11 |
2023-08-12 |
Not clear |
| Christopher A Derderian, Nicholas Bastidas, Oren Z Lerman, Kirit A Bhatt, Shin-E Lin, Jeremy Voss, Jeffrey W Holmes, Jamie P Levine, Geoffrey C Gurtne. Mechanical strain alters gene expression in an in vitro model of hypertrophic scarring. Annals of plastic surgery. vol 55. issue 1. 2006-01-10. PMID:15985794. |
these results suggest that mechanical strain up-regulates matrix remodeling genes and down-regulates normal cellular apoptosis, resulting in more cells, each of which produces more matrix. |
2006-01-10 |
2023-08-12 |
Not clear |
| Matthew J Naylor, Na Li, Julia Cheung, Emma T Lowe, Elise Lambert, Rebecca Marlow, Pengbo Wang, Franziska Schatzmann, Timothy Wintermantel, Günther Schüetz, Alan R Clarke, Ulrich Mueller, Nancy E Hynes, Charles H Streul. Ablation of beta1 integrin in mammary epithelium reveals a key role for integrin in glandular morphogenesis and differentiation. The Journal of cell biology. vol 171. issue 4. 2006-01-06. PMID:16301336. |
in vivo, epithelial cells became detached from the extracellular matrix but remained associated with each other and did not undergo overt apoptosis. |
2006-01-06 |
2023-08-12 |
mouse |
| Alexander V Ovechkin, Neetu Tyagi, Walter E Rodriguez, Melvin R Hayden, Karni S Moshal, Suresh C Tyag. Role of matrix metalloproteinase-9 in endothelial apoptosis in chronic heart failure in mice. Journal of applied physiology (Bethesda, Md. : 1985). vol 99. issue 6. 2006-01-05. PMID:16081621. |
role of matrix metalloproteinase-9 in endothelial apoptosis in chronic heart failure in mice. |
2006-01-05 |
2023-08-12 |
mouse |
| Alexander V Ovechkin, Neetu Tyagi, Walter E Rodriguez, Melvin R Hayden, Karni S Moshal, Suresh C Tyag. Role of matrix metalloproteinase-9 in endothelial apoptosis in chronic heart failure in mice. Journal of applied physiology (Bethesda, Md. : 1985). vol 99. issue 6. 2006-01-05. PMID:16081621. |
although ventricular remodeling is accompanied by increased matrix metalloproteinase (mmp)-9 activity, it is unclear whether mmp-9 plays a role in endothelial apoptosis in chronic volume overload congestive heart failure. |
2006-01-05 |
2023-08-12 |
mouse |
| Alexander V Ovechkin, Neetu Tyagi, Walter E Rodriguez, Melvin R Hayden, Karni S Moshal, Suresh C Tyag. Role of matrix metalloproteinase-9 in endothelial apoptosis in chronic heart failure in mice. Journal of applied physiology (Bethesda, Md. : 1985). vol 99. issue 6. 2006-01-05. PMID:16081621. |
we tested the hypothesis that, in chronic volume overload, myocardial dysfunction involves endocardial endothelial (ee) apoptosis in response to mmp-9 activation, extracellular matrix accumulation, and endothelium-myocytes uncoupling. |
2006-01-05 |
2023-08-12 |
mouse |
| Yi-Xin Wang, Baby Martin-McNulty, Valdeci da Cunha, Jon Vincelette, Xiangru Lu, Qingping Feng, Meredith Halks-Miller, Mithra Mahmoudi, Miriam Schroeder, Babu Subramanyam, Jih-Lie Tseng, Gary D Deng, Sabine Schirm, Anthony Johns, Katalin Kauser, William P Dole, David R Ligh. Fasudil, a Rho-kinase inhibitor, attenuates angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice by inhibiting apoptosis and proteolysis. Circulation. vol 111. issue 17. 2005-12-27. PMID:15851596. |
in this study, we tested the hypothesis that fasudil, a rho-kinase inhibitor, could attenuate ang ii-induced aaa formation by inhibiting vascular wall apoptosis and extracellular matrix proteolysis. |
2005-12-27 |
2023-08-12 |
mouse |
| Barbara G Heerdt, Michele A Houston, Leonard H Augenlich. The intrinsic mitochondrial membrane potential of colonic carcinoma cells is linked to the probability of tumor progression. Cancer research. vol 65. issue 21. 2005-12-22. PMID:16267009. |
subcloned cell lines with higher deltapsim were more likely to exhibit elevated steady-state levels of vascular endothelial growth factor and matrix metalloproteinase 7, and increased invasive behavior (properties associated with tumor progression), than cells with lower intrinsic deltapsim, whereas cells with lower deltapsim were more likely to respond to the chemopreventive activities of butyrate, including deltapsim dissipation, growth arrest, and apoptosis, than cells with higher deltapsim. |
2005-12-22 |
2023-08-12 |
human |
| Arturo Garcia-Touchard, Timothy D Henry, Giuseppe Sangiorgi, Luigi Giusto Spagnoli, Alessandro Mauriello, Cheryl Conover, Robert S Schwart. Extracellular proteases in atherosclerosis and restenosis. Arteriosclerosis, thrombosis, and vascular biology. vol 25. issue 6. 2005-12-21. PMID:15802622. |
in addition to their matrix degradation capabilities, they have other less well known biologic functions that include angiogenesis, growth factor bioavailability, cytokine modulation, receptor shedding, enhancing cell migration, proliferation, invasion, and apoptosis. |
2005-12-21 |
2023-08-12 |
Not clear |
| John M Stewart, Lajos Gera, Daniel C Chan, Eunice J York, Vitalija Simkeviciene, Paul A Bunn, Laimute Taraseviciene-Stewar. Combination cancer chemotherapy with one compound: pluripotent bradykinin antagonists. Peptides. vol 26. issue 8. 2005-12-21. PMID:15878795. |
these promising multitargeted anti-cancer compounds selectively stimulate apoptosis in cancers and also inhibit both angiogenesis and matrix metalloprotease (mmp) action in treated lung and prostate tumors in nude mice. |
2005-12-21 |
2023-08-12 |
mouse |
| Alexander G Marneros, Thomas Krie. Keloids--clinical diagnosis, pathogenesis, and treatment options. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG. vol 2. issue 11. 2005-12-20. PMID:16281608. |
experiments with cells derived from keloid tissue revealed a number of abnormalities in cellular functions, such as in proliferation, apoptosis, or expression of growth factors and extracellular matrix proteins. |
2005-12-20 |
2023-08-12 |
Not clear |
| Anna Trauzold, Christian Röder, Bence Sipos, Kristin Karsten, Alexander Arlt, Ping Jiang, Jose Ignacio Martin-Subero, Daniela Siegmund, Susanne Müerköster, Laia Pagerols-Raluy, Reiner Siebert, Harald Wajant, Holger Kalthof. CD95 and TRAF2 promote invasiveness of pancreatic cancer cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 6. 2005-12-14. PMID:15670977. |
introduction of a traf2 expression vector in cd95-sensitive colo357 cells resulted in (i) resistance to cd95-induced apoptosis; (ii) increased constitutive nf-kappab and ap-1 activity; and (iii) higher basal secretion of matrix metalloproteinases (mmps), urokinase-type plasminogen activator (upa), and il-8, leading to increased invasiveness. |
2005-12-14 |
2023-08-12 |
Not clear |
| G Anumanthan, S K Halder, H Osada, T Takahashi, P P Massion, D P Carbone, P K Datt. Restoration of TGF-beta signalling reduces tumorigenicity in human lung cancer cells. British journal of cancer. vol 93. issue 10. 2005-12-14. PMID:16251876. |
members of the transforming growth factor-beta (tgf-beta) family regulate a wide range of biological processes including cell proliferation, migration, differentiation, apoptosis, and extracellular matrix deposition. |
2005-12-14 |
2023-08-12 |
mouse |
| Gillian Hughes, Michael P Murphy, Elizabeth C Ledgerwoo. Mitochondrial reactive oxygen species regulate the temporal activation of nuclear factor kappaB to modulate tumour necrosis factor-induced apoptosis: evidence from mitochondria-targeted antioxidants. The Biochemical journal. vol 389. issue Pt 1. 2005-12-12. PMID:15727562. |
mitovit e {[2-(3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2h-1-benzopyran-2-yl)ethyl]triphenylphosphonium bromide} (vitamin e attached to a lipophilic cation that facilitates accumulation of the antioxidant in the mitochondrial matrix) enhanced tnf-induced apoptosis of u937 cells. |
2005-12-12 |
2023-08-12 |
Not clear |
| Gillian Hughes, Michael P Murphy, Elizabeth C Ledgerwoo. Mitochondrial reactive oxygen species regulate the temporal activation of nuclear factor kappaB to modulate tumour necrosis factor-induced apoptosis: evidence from mitochondria-targeted antioxidants. The Biochemical journal. vol 389. issue Pt 1. 2005-12-12. PMID:15727562. |
tnf caused maximal nuclear translocation of nf-kappab within 15 min, compared with 1 h in cells pretreated with mitovit e. thus the accumulation of an antioxidant within the mitochondrial matrix enhances tnf-induced apoptosis by decreasing or delaying the expression of the protective antiapoptotic proteins. |
2005-12-12 |
2023-08-12 |
Not clear |