| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Toshiaki Monkawa, Jeffrey Pippin, Yoshikage Yo, Jeffrey B Kopp, Charles E Alpers, Stuart J Shanklan. The cyclin-dependent kinase inhibitor p21 limits murine mesangial proliferative glomerulonephritis. Nephron. Experimental nephrology. vol 102. issue 1. 2006-04-27. PMID:16179805. |
mesangial cell (mc) proliferation underlies increased matrix accumulation in glomerulonephritis (gn), and the resolution of mc proliferation occurs largely through apoptosis. |
2006-04-27 |
2023-08-12 |
Not clear |
| Fu-Tong Li. Galectins: novel anti-inflammatory drug targets. Expert opinion on therapeutic targets. vol 6. issue 4. 2006-04-26. PMID:16353421. |
extracellularly, they have the potential to bind to various surface receptors on a variety of cell types as well as extracellular matrix (ecm) proteins, thus causing cell activation or apoptosis, modulating cell adhesion and inducing cell migration. |
2006-04-26 |
2023-08-12 |
Not clear |
| Yatsuki Aratake, Hajime Nomura, Tomio Kotani, Kosuke Marutsuka, Kaoru Kobayashi, Kanji Kuma, Akira Miyauchi, Akihiko Okayama, Kazuo Tamur. Coexistent anaplastic and differentiated thyroid carcinoma: an immunohistochemical study. American journal of clinical pathology. vol 125. issue 3. 2006-04-25. PMID:16613343. |
these findings indicate high proliferative properties, suppression of apoptosis, disruption of cell-cell interaction, and induction of matrix metalloproteinases in the undifferentiated areas. |
2006-04-25 |
2023-08-12 |
Not clear |
| Deepak Kumar, Willa Fung, Robert M Moore, Vishal Pandey, Jennifer Fox, Bradley Stetzer, Joseph M Mansour, Brian M Mercer, Raymond W Redline, John J Moor. Proinflammatory cytokines found in amniotic fluid induce collagen remodeling, apoptosis, and biophysical weakening of cultured human fetal membranes. Biology of reproduction. vol 74. issue 1. 2006-04-17. PMID:16148217. |
we have recently reported that fm weaken, at least in part, because of a developmental process of extracellular matrix remodeling and apoptosis. |
2006-04-17 |
2023-08-12 |
human |
| Deepak Kumar, Willa Fung, Robert M Moore, Vishal Pandey, Jennifer Fox, Bradley Stetzer, Joseph M Mansour, Brian M Mercer, Raymond W Redline, John J Moor. Proinflammatory cytokines found in amniotic fluid induce collagen remodeling, apoptosis, and biophysical weakening of cultured human fetal membranes. Biology of reproduction. vol 74. issue 1. 2006-04-17. PMID:16148217. |
matrix metalloproteinase 9 (mmp9) protein increased, tissue inhibitor of matrix metalloproteinase 3 (timp3) protein decreased, and poly (adp-ribose) polymerase (parp1) cleavage increased with increasing tnf or il1b doses (all p < 0.05), suggesting collagen remodeling and apoptosis. |
2006-04-17 |
2023-08-12 |
human |
| Dimcho Bachvarov, Magdalena Bachvarova, Rainelli Koumangaye, Julie Klein, João Bosco Pesquero, Eric Neau, Michael Bader, Joost P Schanstra, Jean Loup Bascand. Renal gene expression profiling using kinin B1 and B2 receptor knockout mice reveals comparable modulation of functionally related genes. Biological chemistry. vol 387. issue 1. 2006-04-17. PMID:16497160. |
recent data evidenced a role for bk in many other biological processes, such as apoptosis, development, extracellular matrix regulation and angiogenesis. |
2006-04-17 |
2023-08-12 |
mouse |
| Angela M Meyer zum Gottesberge, Heidi Feli. Abnormal basement membrane in the inner ear and the kidney of the Mpv17-/- mouse strain: ultrastructural and immunohistochemical investigations. Histochemistry and cell biology. vol 124. issue 6. 2006-04-13. PMID:16041630. |
these studies explain the cellular responses to missing mpv17-protein, such as accumulation of the extracellular matrix, degeneration, and apoptosis in the inner ear. |
2006-04-13 |
2023-08-12 |
mouse |
| A Haisch, U Marzahn, A Mobasheri, G Schulze-Tanzil, M Shakibae. Development and phenotypic characterization of a high density in vitro model of auricular chondrocytes with applications in reconstructive plastic surgery. Histology and histopathology. vol 21. issue 5. 2006-04-13. PMID:16493577. |
western blotting was used to analyse the expression of cartilage-specific markers, such as collagen type ii and cartilage specific proteoglycan, fibronectin, cell adhesion and signal transduction receptor beta1-integrin, matrix metalloproteinases (mmp-9, mmp-13), cyclo-oxygenase (cox)-2 and the apoptosis commitment marker, activated caspase-3. |
2006-04-13 |
2023-08-12 |
Not clear |
| Guixia Wang, Kashif A Ahmad, Khalil Ahme. Modulation of death receptor-mediated apoptosis by CK2. Molecular and cellular biochemistry. vol 274. issue 1-2. 2006-04-10. PMID:16342415. |
we originally documented that removal of survival or growth stimuli resulted in rapid loss of ck2 from the nuclear matrix and chromatin which preceded induction of apoptosis. |
2006-04-10 |
2023-08-12 |
Not clear |
| Ladislav Senolt, Mariam Grigorian, Eugene Lukanidin, Beat A Michel, Renate E Gay, Steffen Gay, Karel Pavelka, Michel Neidhar. S100A4 (Mts1): is there any relation to the pathogenesis of rheumatoid arthritis? Autoimmunity reviews. vol 5. issue 2. 2006-04-10. PMID:16431343. |
s100a4 binds to distinct intracellular target proteins and regulates specific functions involved in tumor progression such as cell motility, proliferation and apoptosis as well as remodelling of the extracellular matrix. |
2006-04-10 |
2023-08-12 |
Not clear |
| Da-wei Guan, Rui Zhao, Yu D. [Expressions of NOS isoforms and roles of NO during skin wound healing]. Fa yi xue za zhi. vol 20. issue 4. 2006-04-07. PMID:15751659. |
nitric oxide synthase (nos) isoforms, as important factors during skin wound healing, synthesize nitric oxide (no) which may be involved in the whole event of skin wound healing and play important roles in cell proliferation, differentiation and apoptosis, angiogenesis, matrix deposits and remolding. |
2006-04-07 |
2023-08-12 |
Not clear |
| Bharat B Aggarwal, Yasunari Takada, Oommen V Oomme. From chemoprevention to chemotherapy: common targets and common goals. Expert opinion on investigational drugs. vol 13. issue 10. 2006-04-06. PMID:15461561. |
these targets include the activation of apoptosis; suppression of growth factor expression or signalling; downregulation of antiapoptotic proteins; suppression of phosphatidylinositol-3'-kinase/akt, nf-kappab, janus kinase-signal transducer and activator of transcription and activator protein-1 signalling pathways; and downregulation of angiogenesis through inhibition of vascular endothelial growth factor expression, cyclooxygenase-2, matrix metalloproteinase-9, urokinase-type plasminogen activator, adhesion molecules and cyclin d1. |
2006-04-06 |
2023-08-12 |
Not clear |
| Kazuo Yudoh, Hiroshi Nakamura, Kayo Masuko-Hongo, Tomohiro Kato, Kusuki Nishiok. Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1 alpha in articular chondrocytes: involvement of HIF-1 alpha in the pathogenesis of osteoarthritis. Arthritis research & therapy. vol 7. issue 4. 2006-04-06. PMID:15987493. |
transcription factor hypoxia-inducible factor (hif)-1 protein accumulates and activates the transcription of genes that are of fundamental importance for oxygen homeostasis - including genes involved in energy metabolism, angiogenesis, vasomotor control, apoptosis, proliferation, and matrix production - under hypoxic conditions. |
2006-04-06 |
2023-08-12 |
human |
| Kazuo Yudoh, Hiroshi Nakamura, Kayo Masuko-Hongo, Tomohiro Kato, Kusuki Nishiok. Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1 alpha in articular chondrocytes: involvement of HIF-1 alpha in the pathogenesis of osteoarthritis. Arthritis research & therapy. vol 7. issue 4. 2006-04-06. PMID:15987493. |
we investigated the levels of energy generation, cartilage matrix production, and apoptosis induction in hif-1alpha-deficient chondrocytes under normoxic and hypoxic conditions. |
2006-04-06 |
2023-08-12 |
human |
| Wei Li, Hua He, Tetsuya Kawakita, Edgar M Espana, Scheffer C G Tsen. Amniotic membrane induces apoptosis of interferon-gamma activated macrophages in vitro. Experimental eye research. vol 82. issue 2. 2006-03-31. PMID:16109408. |
in conclusion, am stromal matrix induces apoptosis of ifn-gamma activated, but not non-activated macrophages, not through the generation of no, but instead by down-regulating anti-apoptotic nf-kappab and akt-fkhr signalling pathways. |
2006-03-31 |
2023-08-12 |
mouse |
| Katalin Susztak, Amanda C Raff, Mario Schiffer, Erwin P Böttinge. Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy. Diabetes. vol 55. issue 1. 2006-03-29. PMID:16380497. |
chronic inhibition of nadph oxidase prevented podocyte apoptosis and ameliorated podocyte depletion, uae, and mesangial matrix expansion in db/db mice. |
2006-03-29 |
2023-08-12 |
mouse |
| K Breitkopf, P Godoy, L Ciuclan, M V Singer, S Doole. TGF-beta/Smad signaling in the injured liver. Zeitschrift fur Gastroenterologie. vol 44. issue 1. 2006-03-29. PMID:16397841. |
besides hepatic stellate cells (hscs), which are induced by tgf-beta to transdifferentiate to myofibroblasts and to produce extracellular matrix, hepatocytes are also strongly responsive for this cytokine, which induces apoptosis during fibrogenesis and provides growth control in regeneration processes. |
2006-03-29 |
2023-08-12 |
Not clear |
| Yao-Ching Hung, Meng-Yen Hong, G Steve Huan. Cholesterol loading augments oxidative stress in macrophages. FEBS letters. vol 580. issue 3. 2006-03-28. PMID:16414045. |
functional annotation of the differentially expressed genes indicated that apoptosis, extracellular matrix, oxidative stress, and cell proliferation was deregulated. |
2006-03-28 |
2023-08-12 |
human |
| J-F Cailhier, P Laplante, M-J Héber. Endothelial apoptosis and chronic transplant vasculopathy: recent results, novel mechanisms. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. vol 6. issue 2. 2006-03-28. PMID:16426308. |
third, apoptosis of ec triggers extracellular matrix (ecm) proteolysis thus initiating the production of fibroproliferative/fibrogenic ecm fragments. |
2006-03-28 |
2023-08-12 |
human |
| C Marcela Díaz-Montero, Bradley W McIntyr. Acquisition of anoikis resistance in human osteosarcoma cells does not alter sensitivity to chemotherapeutic agents. BMC cancer. vol 5. 2006-03-27. PMID:15829011. |
since cell adhesion to the extracellular matrix acts as a survival factor that homeostatically maintains normal tissue architecture, it was tested whether acquisition of resistance to deadhesion-induced apoptosis (anoikis) in human osteosarcoma would result in resistance to chemotherapy. |
2006-03-27 |
2023-08-12 |
human |