| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christophe F Chantrain, Patrick Henriet, Sonata Jodele, Hervé Emonard, Olivier Feron, Pierre J Courtoy, Yves A DeClerck, Etienne Marbai. Mechanisms of pericyte recruitment in tumour angiogenesis: a new role for metalloproteinases. European journal of cancer (Oxford, England : 1990). vol 42. issue 3. 2006-03-09. PMID:16406506. |
here, we discuss the possibility for mmps to contribute to pericyte recruitment at six levels: (1) direct promotion of pericyte invasion by extracellular matrix degradation; (2) stimulation of pericyte proliferation and protection against apoptosis by modification of the ecm; (3) activation of pericytes through the release of growth factor bound to the ecm; (4) transactivation of angiogenic cell surface receptor; (5) propagation of angiogenic signalling as cofactor; and (6) recruitment of bone marrow-derived stem cells. |
2006-03-09 |
2023-08-12 |
Not clear |
| Neveen Said, Kouros Motame. Absence of host-secreted protein acidic and rich in cysteine (SPARC) augments peritoneal ovarian carcinomatosis. The American journal of pathology. vol 167. issue 6. 2006-03-08. PMID:16314484. |
immunohistochemical analysis of tumor nodules from sparc-null mice revealed higher proliferation and lower apoptosis indices with minimal staining for major extracellular matrix constituents. |
2006-03-08 |
2023-08-12 |
mouse |
| Soraya Labied, Takeshi Kajihara, Patricia A Madureira, Luca Fusi, Marius C Jones, Jenny M Higham, Rana Varshochi, Julia M Francis, Georgia Zoumpoulidou, Abdelkader Essafi, Silvia Fernandez de Mattos, Eric W-F Lam, Jan J Brosen. Progestins regulate the expression and activity of the forkhead transcription factor FOXO1 in differentiating human endometrium. Molecular endocrinology (Baltimore, Md.). vol 20. issue 1. 2006-03-07. PMID:16123151. |
this breakdown of the endometrium in response to falling ovarian progesterone levels is a complex process, characterized by local leukocyte infiltration, expression and activation of matrix metalloproteinases, and apoptosis. |
2006-03-07 |
2023-08-12 |
human |
| Gerhard Fritz, Bernd Kain. Rho GTPases: promising cellular targets for novel anticancer drugs. Current cancer drug targets. vol 6. issue 1. 2006-03-07. PMID:16475973. |
members of the rho family of small gtpases are key regulators of actin reorganization, cell motility, cell-cell and cell-extracellular matrix (ecm) adhesion as well as of cell cycle progression, gene expression and apoptosis. |
2006-03-07 |
2023-08-12 |
Not clear |
| Zezong Gu, Jiankun Cui, Stephen Brown, Rafael Fridman, Shahriar Mobashery, Alex Y Strongin, Stuart A Lipto. A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 27. 2006-02-28. PMID:16000631. |
a highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia. |
2006-02-28 |
2023-08-12 |
mouse |
| Zezong Gu, Jiankun Cui, Stephen Brown, Rafael Fridman, Shahriar Mobashery, Alex Y Strongin, Stuart A Lipto. A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 27. 2006-02-28. PMID:16000631. |
the aberrant, excessive activity of matrix metalloproteinases (mmps), especially mmp-9, contributes directly to neuron apoptosis and brain damage (rosenberg et al., 1996; asahi et al., 2001; gu et al., 2002; horstmann et al., 2003). |
2006-02-28 |
2023-08-12 |
mouse |
| Zezong Gu, Jiankun Cui, Stephen Brown, Rafael Fridman, Shahriar Mobashery, Alex Y Strongin, Stuart A Lipto. A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 27. 2006-02-28. PMID:16000631. |
we determined that mmp-9 degrades the extracellular matrix protein laminin and that this degradation induces neuronal apoptosis in a transient focal cerebral ischemia model in mice. |
2006-02-28 |
2023-08-12 |
mouse |
| Qing Lu, Elizabeth O Harrington, Sharon Round. Apoptosis and lung injury. The Keio journal of medicine. vol 54. issue 4. 2006-02-27. PMID:16452828. |
we have determined that adenosine/homocysteine causes lung vascular endothelial cell apoptosis by inhibition of carboxyl methylation of the small gtpase, ras, through inhibition of isoprenylcysteine carboxyl methyltransferase(icmt) activity, leading to inactivation of ras and the subsequent disruption of focal adhesion complexes, resulting in cell-extracellular matrix detachment and anoikis. |
2006-02-27 |
2023-08-12 |
Not clear |
| Gabriela Rennebeck, Matthew Martelli, Natasha Kypriano. Anoikis and survival connections in the tumor microenvironment: is there a role in prostate cancer metastasis? Cancer research. vol 65. issue 24. 2006-02-23. PMID:16357123. |
normal epithelial and endothelial cells can undergo apoptosis when detached from the extracellular matrix (ecm), via the anoikis phenomenon. |
2006-02-23 |
2023-08-12 |
Not clear |
| Danielle Paixão-Cavalcante, Carmen W van den Berg, Matheus de Freitas Fernandes-Pedrosa, Rute M Gonçalves de Andrade, Denise V Tambourg. Role of matrix metalloproteinases in HaCaT keratinocytes apoptosis induced by loxosceles venom sphingomyelinase D. The Journal of investigative dermatology. vol 126. issue 1. 2006-02-23. PMID:16417218. |
role of matrix metalloproteinases in hacat keratinocytes apoptosis induced by loxosceles venom sphingomyelinase d. envenomation by the spider loxosceles (brown spider) can result in dermonecrosis and severe ulceration. |
2006-02-23 |
2023-08-12 |
human |
| Jianing He, Yiming King, Jin Jiang, Kamran E Safavi, Larz S W Spångberg, Qiang Zh. Enamel matrix derivative inhibits TNF-alpha-induced apoptosis in osteoblastic MC3T3-E1 cells. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. vol 99. issue 6. 2006-02-21. PMID:15897865. |
enamel matrix derivative inhibits tnf-alpha-induced apoptosis in osteoblastic mc3t3-e1 cells. |
2006-02-21 |
2023-08-12 |
Not clear |
| Jianing He, Yiming King, Jin Jiang, Kamran E Safavi, Larz S W Spångberg, Qiang Zh. Enamel matrix derivative inhibits TNF-alpha-induced apoptosis in osteoblastic MC3T3-E1 cells. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. vol 99. issue 6. 2006-02-21. PMID:15897865. |
the purpose of this study was to examine the effect of enamel matrix derivative (emd) on tnf-alpha-induced apoptosis in osteoblastic mc3t3-e1 cells. |
2006-02-21 |
2023-08-12 |
Not clear |
| Masanori Ii, Hiroyuki Yamamoto, Yasushi Adachi, Yumiko Maruyama, Yasuhisa Shinomur. Role of matrix metalloproteinase-7 (matrilysin) in human cancer invasion, apoptosis, growth, and angiogenesis. Experimental biology and medicine (Maywood, N.J.). vol 231. issue 1. 2006-02-16. PMID:16380641. |
role of matrix metalloproteinase-7 (matrilysin) in human cancer invasion, apoptosis, growth, and angiogenesis. |
2006-02-16 |
2023-08-12 |
human |
| Philippe Clézardi. Anti-tumour activity of zoledronic acid. Cancer treatment reviews. vol 31 Suppl 3. 2006-02-14. PMID:16225995. |
they not only inhibit proliferation and induce apoptosis in cultured cancer cells, but additionally interfere with adhesion of cancer cells to the bone matrix and inhibit cell migration and invasion. |
2006-02-14 |
2023-08-12 |
Not clear |
| J Tabernero, T Macarulla, F J Ramos, J Baselg. Novel targeted therapies in the treatment of gastric and esophageal cancer. Annals of oncology : official journal of the European Society for Medical Oncology. vol 16. issue 11. 2006-02-09. PMID:15980157. |
these therapeutic strategies include egfr inhibitors, antiangiogenic agents, cell cycle inhibitors, apoptosis promoters and matrix metalloproteinases inhibitors. |
2006-02-09 |
2023-08-12 |
Not clear |
| Sandra L Merklinger, Peter L Jones, Eliana C Martinez, Marlene Rabinovitc. Epidermal growth factor receptor blockade mediates smooth muscle cell apoptosis and improves survival in rats with pulmonary hypertension. Circulation. vol 112. issue 3. 2006-02-09. PMID:16027270. |
we showed in pulmonary artery (pa) organ culture that the mechanism by which elastase inhibitors induce smc apoptosis involves repression of matrix metalloproteinase (mmp) activity and subsequent signaling through alphavbeta3-integrins and epidermal growth factor receptors (egfrs). |
2006-02-09 |
2023-08-12 |
rat |
| Marco Rossi, Andrew M Sharkey, Paola Viganò, Giovina Fiore, Rob Furlong, Pasquale Florio, Guido Ambrosini, Stephen K Smith, Felice Petragli. Identification of genes regulated by interleukin-1beta in human endometrial stromal cells. Reproduction (Cambridge, England). vol 130. issue 5. 2006-02-09. PMID:16264101. |
these cdna arrays were produced containing 15 164 sequence-verified clones, which included genes known to be important in angiogenesis, immune modulators, apoptosis, cell signalling, extra-cellular matrix (ecm) remodelling and cell cycle regulation. |
2006-02-09 |
2023-08-12 |
human |
| Sita Aggarwal, Haruyo Ichikawa, Yasunari Takada, Santosh K Sandur, Shishir Shishodia, Bharat B Aggarwa. Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation. Molecular pharmacology. vol 69. issue 1. 2006-02-07. PMID:16219905. |
such tnf-induced nf-kappab-regulated gene products involved in cellular proliferation [cyclooxygenase-2 (cox-2), cyclin d1, and c-myc], antiapoptosis [inhibitor of apoptosis protein (iap)1, iap2, x-chromosome-linked iap, bcl-2, bcl-x(l), bfl-1/a1, tnf receptor-associated factor 1, and cellular fas-associated death domain protein-like interleukin-1beta-converting enzyme inhibitory protein-like inhibitory protein], and metastasis (vascular endothelial growth factor, matrix metalloproteinase-9, and intercellular adhesion molecule-1) were also down-regulated by curcumin. |
2006-02-07 |
2023-08-12 |
Not clear |
| Suk Keun Lee, Yeon Sook Kim, Sang Shin Lee, Young Joon Lee, In Sun Song, Sang Chul Park, Je Geun Chi, Soo Il Chun. Antisense inhibition of transglutaminase 2 affects development of mouse embryo submandibular gland in organ culture. Archives of oral biology. vol 50. issue 9. 2006-02-03. PMID:15970210. |
tissue transglutaminase (tgase 2) has been implicated in numerous cellular functions, i.e., apoptosis, differentiation, extracellular matrix protein cross-linking and organogenesis. |
2006-02-03 |
2023-08-12 |
mouse |
| Gabriele A Losa, Christian Castell. Nuclear patterns of human breast cancer cells during apoptosis: characterisation by fractal dimension and co-occurrence matrix statistics. Cell and tissue research. vol 322. issue 2. 2006-02-03. PMID:16059703. |
nuclear patterns of human breast cancer cells during apoptosis: characterisation by fractal dimension and co-occurrence matrix statistics. |
2006-02-03 |
2023-08-12 |
human |